Volume Emission Research Articles

Development of fin-LEDs for next-generation inorganic displays using face-selective dielectrophoretic assembly

Micro-light-emitting diodes offer vibrant colors and energy-efficient performance, holding promise for next-generation inorganic displays. However, their widespread adoption requires the development of cost-effective chips and low-defect pixelation processes. Addressing these challenges, nanorod-light-emitting diodes utilize inkjet and dielectrophoretic assembly techniques. Nevertheless, the small volume and edge-directed emission of nanorod-light-emitting diodes necessitate brightness and light extraction improvements. As an alternative, we propose dielectrophoretic-friendly fin-light-emitting diodes, designed to enhance brightness and light extraction efficiency through face-selective dielectrophoretic assembly technology. Our results confirm the potential for next-generation inorganic displays, with a wafer utilization ratio exceeding 90%, a vertical assembly ratio of 91.3%, and a pixel production yield of 99.93%. Moreover, blue fin-light-emitting diodes achieve an external quantum efficiency of 9.1% and a brightness of 8640 cd m−2 at 5.0 V, which, even at this early stage, are comparable to existing technologies.

Auroral 3D structure retrieval from the Juno/UVS data

Context. Jovian auroras, the most powerful in the Solar System, result from the interaction between the magnetosphere and atmosphere of Jupiter. While the horizontal morphology of these phenomena has been widely studied, their vertical structure, determined by the penetration depth of the magnetospheric electron into the auroral regions, remains relatively unexplored. Previous observations, including those from the Hubble Space Telescope (HST), have addressed this question to a limited extent. Aims. In this study we aim to map the vertical structure of Jovian auroral emissions. Methods. Using observations from Juno’s UltraViolet Spectrograph (UVS), we examined the vertical structure of the auroral emissions. Building on a recent study of auroral energy mapping based on UVS observations that mapped the average energy of precipitating electrons in the Jovian auroral regions, we find a relationship between this average energy and the volume emission rate (VER) of H2 for two types of electron energy distributions: monoenergetic and a kappa distribution with κ = 2.5. Results. Using brightness maps, we derived the 3D VER structure of Jovian auroras in both northern and southern regions, across multiple spacecraft perijoves (PJs). By considering the example of PJ11, we find that the average altitude of the VER peak in the polar emission region is approximately ~250 km for the monoenergetic distribution case and ~190 km for kappa distribution case. In the main emission region, we find that the average altitude of the VER peak is approximately ~260 km for the case of monoenergetic distribution and ~197 km for kappa distribution case. For the other PJs, we obtained results that are very similar to those of PJ11. Conclusions. Our findings are, on average, consistent with measurements from the Galileo probe and the HST observations. This study contributes to a better understanding of the complexity of Jovian auroras and highlights the importance of using Juno observations when probing their vertical structure. Considering the variability in the κ parameter in the auroral region, we also studied the impact of this variability on the vertical structure of the auroral emission. This sensitivity study reveals that the influence of the κ parameter on our results was very weak. However, the impact of the κ variability on the VER amplitude shows that there is an influence on the thermal structure and chemical composition of the atmosphere in the auroral regions.

Comprehensive analysis of particle emissions from miniature turbojet engine

Emission of particulate matter from jet engines contribute to deterioration of air quality in the vicinty of the airports and to formation of contrails in higher layers of the atmosphere. This article presents the results of the measurements of particle emissions from a miniature jet engine GTM-120 fueled conventional aviation fuel Jet A-1. Analysis of particle size distribution, number, mass and volume emission indexes has been made, as well as the analysis of the emission intenisty and mass emission rate. Obtained results were related to LTO cycle phases. The results shows, that the particle number concentration was the lowest for low engine loads, with characteristic diameter of 69.8 nm and the particles concentration of 7.7 x 106 particles/cm3. For thrust increase, the characteristic diameter is smaller, and the particles distribution is no longer single-mode. The highest particles concentration for cm3 is for 100% thrust and is equal to 1.55 x 107 particles, with characteristic diameter of 34 nm.

REVEALING THE ENVIRONMENTAL COST OF GLOBALIZATION: AN EMPIRICAL ANALYSIS ON TRADE OPENNESS, FDI, AND CO2 EMISSIONS IN THE APEC COUNTRIES

Recently, the issue of how trade openness affects environmental degradation has gained importance. The fact that about 60% of the world's total CO2 emissions into the atmosphere are from APEC countries has made the economic activities of these countries a source of concern for the world. Although there have been many studies on the relationship between CO2 emissions and trade openness, there has yet to be a consensus. This study investigates how trade volume affects CO2 emissions in APEC countries, which account for a significant share of international trade volume and CO2 emissions. In addition, the empirical model of this research also investigates EKC. The panel data analysis method is used considering the data of APEC countries. According to the results, while trade openness increases CO2 emissions in APEC countries, FDI decreases CO2 emissions. Finally, EKC is valid in APEC countries from 1990 to 2016.

Recurrent Coronal Mass Ejections and Their Geomagnetic Storms Association on 2012 January 19: Solar Surface to Upper Earth’s Atmosphere Analyses

In this study, we have conducted an analysis of space weather disruptions that occurred on 19 January 2012. Our analysis identified three coronal mass ejections (CMEs), CME1, CME2, and CME3—which were ejected at 09:48:05 universal time (UT), 14:36:05 UT, and 16:12:06 UT, respectively. Nonrecurrent disturbances in space weather, such as geomagnetic storms, result from CMEs originating from the Sun and traveling toward Earth. We assess the contribution of CME–CME interactions on 2012 January 19 and the volume emission rate of nitric oxide (NO) near the Earth's upper atmosphere in prolonging the geomagnetic disturbances observed on 2012 January 23. The findings suggest an increase in intensity at the interacting boundaries of CME1 and CME2, indicating an increase in pressure and density, leading to the compression of the magnetosphere. The 3D reconstructions of the CMEs provide evidence of unequal expansion and rotations within coronagraphic frames attributed to structural variability in the background solar wind during the eruptions. Furthermore, highlights from the in situ observations suggest that the impact of the recurrent CMEs on the geomagnetic disturbance was more pronounced within the auroral region synchronizing with a significant increase in NO volume emission rate on 2012 January 23, near the upper Earth's atmosphere. Our focus is on exploring the interactions between these CMEs to understand their potential contribution to the extended duration of the observed geomagnetic disturbance.

Retrieval of Nighttime Distributions of Mesosphere–Lower Thermosphere Characteristics from Satellite Data

The database of SABER/TIMED satellite campaign includes the distributions of nighttime O, H and some other characteristics of mesosphere – lower thermosphere region which are retrieved from the measurements of OH* volume emission rate (near 2 μm), temperature and ozone. In the core of the retrieval procedure lies the assumption about photochemical equilibrium of nighttime ozone and airglow model that considers two excited states of OH (levels ν = 9, 8). In this work, a modified OH* model (with the rate constants updated according to contemporary publications) is used to retrieve O, H, OH, HO2 and the chemical heating rate at 80–100 km altitudes from to SABER/TIMED measurements in 2002–2021. It was found that the use of new parameters in the retrieval procedure leads to significant (up to 2 times or more) changes in the resulting spatial distributions of O, H and chemical heating rate, while the corresponding changes in OH and HO2 distributions are minor.

Interventions to Reduce Surgical Waste Burden: A Systematic Review.

Operating suites are significant drivers of waste, pollution, and costs. Surgeons can help fight the climate crisis by implementing innovative strategies aimed at mitigating the environmental impact of surgical procedures and decreasing operational costs, and moving toward a more sustainable healthcare system. This study aims to review the literature describing interventions that reduce surgical waste. PubMed, Cochrane, and Embase were searched. Studies reporting interventions to reduce operative waste, including emissions, energy, trash, and other, were included. Case reports, opinion-based reports, reviews, and meta-analyses were excluded. Study quality was rated using MINORS and Jadad scales. Data were extracted from each study to calculate waste on a per case basis. Narrative review of studies was performed rather than meta-analysis. The search yielded 675 unique hits, of which 13 (level of evidence: I-III) met inclusion criteria. Included studies were categorized by intervention type in relation to the operating and procedure room. Three studies evaluated provider education initiatives, three evaluated setup of instruments, two evaluated single-use items, four evaluated technique changes, and one evaluated surgical venue. Seven studies reported significant reductions in disposable surgical waste throughput, and seven reported significant reductions in cost. The results of this systemic review demonstrated the effectiveness of surgical waste reduction initiatives in reducing waste volume, cost, and carbon emissions. Within plastic surgery, minimal surgical packs resulted in reduced gross waste and cost while promoting patient satisfaction in hand surgery, supporting the continued development and implementation of such initiatives in a surgical context.

Impacts of trade and institutional quality on carbon emissions in transition economies

We examine the effects of trade and institutional quality on carbon emissions from European transition economies. Trade initially negatively impacts the environment through greater CO2 emissions but eventually contributes to a reduction of CO2 emissions beyond a certain threshold. Institutional quality including control of corruption contributes to CO2 emission reductions. Connecting trade with environmental solutions, we identify an inverted U-shaped relationship between trade volume and carbon emissions.

Clinical Utility of Tumor-Naïve Presurgical Circulating Tumor DNA Detection in Early-Stage NSCLC

ObjectivesThe use of tumor-informed circulating tumor DNA (ctDNA) testing in patients with early-stage disease before surgery is limited, mainly owing to restricted tissue access and extended turnaround times. This study aimed to evaluate the clinical value of a tumor-naïve, methylation-based cell-free DNA assay in a large cohort of patients with resected NSCLC. MethodWe analyzed presurgical plasma samples from 895 patients with EGFR and anaplastic lymphoma kinase-wild-type, clinical stage I or II NSCLC. The ctDNA status was evaluated for its prognostic significance in relation to tumor volume, metabolic activity, histologic diagnosis, histologic subtypes, and clinical-to-pathologic TNM upstaging. ResultsPresurgical ctDNA detection was observed in 55 of 414 patients (13%) with clinical stage I lung adenocarcinoma (LUAD) and was associated with poor recurrence-free survival (2-year recurrence-free survival 69% versus 91%; log-rank p < 0.001), approaching that of clinical stage II LUAD. Presurgical ctDNA detection was not prognostic in patients with clinical stage II LUAD or non-LUAD. Within LUAD, tumor volume and positron emission tomography avidity interacted to predict presurgical ctDNA detection. Moreover, presurgical ctDNA detection was predictive of the postsurgical discovery of International Association for the Study of Lung Cancer grade 3 tumors (p < 0.001) and pathologic TNM upstaging (p < 0.001). Notably, presurgical ctDNA detection strongly correlated with higher programmed death-ligand 1 expression in tumors (positive rates 28% versus 55%, p < 0.001), identifying a subgroup likely to benefit from anti–programmed death-ligand 1 therapies. ConclusionThese findings support the integration of ctDNA testing into routine diagnostic workflows in early-stage NSCLC without the need for tumor tissue profiling. Furthermore, it is clinically useful in identifying patients at high risk who might benefit from innovative treatments, including neoadjuvant immune checkpoint inhibitors.

Unraveling the Nexus Between Financial Openness and Environmental Quality: Green Finance as the Catalyst in CEE Countries

The use of fossil fuels, which is still seen as the cheapest energy source today, has increased carbon emissions and contributed to the formation of greenhouse gases, and this gas has reached levels that threaten world health. While studies on this problem often question the relationship between production volume, energy use, and carbon emissions, few studies question the effects of the financial assets, which are the providers of investments made for production purposes, on environmental degradation. This study used the fixed effect model and system GMM technique to analyse the moderating effect of green finance in connection to financial openness and environmental quality from 2015 to 2020 in the CEE countries. Findings show, among other things that (1) CO2 in CEE countries is still growing; (2) financial openness is a positive and significant indicator of CO2 emission; and (3) that green finance usage reduces the positive impact of financial openness on CO2 emissions. The study suggests that financial openness, renewable energy (RE) investment, and green technology innovation (GTI)– consistently drive CO2 emissions in CEE countries. The study suggests that policies promoting green finance, particularly RE investment and GTI, can help mitigate environmental degradation and reduce CO2 emissions.

Latest Evolution of the X-Ray Remnant of SN 1987A: Beyond the Inner Ring

Based on our Chandra imaging-spectroscopic observations, we present the latest evolution of the X-ray remnant of SN 1987A. Recent changes in the electron temperatures and volume emission measures suggest that the blast wave in SN 1987A is moving out of the dense inner ring structure, also called the equatorial ring (ER). The 0.5–2.0 keV X-ray light curve shows a linearly declining trend (by ∼4.5% yr−1) between 2016 and 2020 as the blast wave heats the hitherto unknown circumstellar medium (CSM) outside the ER. While the peak X-ray emission in the latest 0.3–8.0 keV image is still within the ER, the radial expansion rate in the 3.0–8.0 keV images suggests an increasing contribution of the X-ray emission from less dense CSM since 2012, at least partly from beyond the ER. It is remarkable that, since 2020, the declining soft X-ray flux has stabilized around ∼7 × 10−12 erg s−1 cm−2, which may signal a contribution from the reverse-shocked outer layers of ejecta as predicted by the three-dimensional magnetohydrodynamic models. In the latest ACIS spectrum of supernova remnant 1987A in 2022 we report a significant detection of the Fe K line at ∼6.7 keV, which may be due to changing thermal conditions of the X-ray emitting CSM and/or the onset of reverse shock interactions with the Fe ejecta.

Influence of temperature changes and vertically transported trace species on the structure of MLT region during major SSW events

Sudden stratospheric warming (SSW) events are large-scale dynamic phenomena which can significantly affect the circulation, temperature, and composition of different atmospheric layers. The circulation changes during these events induce variations in the atmospheric neutral and ion densities and cause the vertical transport of various trace species. The severity of effects induced by major SSW events in the mesosphere and lower thermosphere (MLT) region has received less attention than that in the lower atmosphere. The major influence of temperature and vertically transported trace species on the energetics, thermal and compositional structure of the MLT region has been investigated during two major SSW events with elevated stratopause. Variations in the nitric oxide volume emission rates (NO-VER), a measure of infrared radiative cooling by NO, are reported for the first time in the context of the dynamical changes during SSW events. This study investigates the role of temperature and NO variability on the energetics of the MLT region, particularly during the formation of elevated stratopause. The effects of supplemented NO density on the secondary ozone layer has also been investigated during these events, the anti-correlation between secondary ozone and NO does not conclude on the role of NO in the secondary ozone peak density variations. Notwithstanding the similarity in terms of defining characteristics, both SSW events impact the secondary ozone layer differently. In contrast to earlier studies, it is suggested that along with temperature, the availability of atomic oxygen is the major factor for the observed variation in secondary ozone during the SSW events.

Experimental research and estimation model of gasoline evaporative emissions from vehicles in China

Evaporative emission is an important source of vehicle pollutant emission and volatile organic compounds (VOCs), causing serious environmental pollution. Carbon canisters are used to store fuel vapor in evaporative emission control (EVAP) system, but canisters are prone to saturation, leading to the direct release of fuel vapor into the atmosphere. Therefore, accurate estimation of fuel vapor generation is crucial for EVAP system. Gasoline evaporation rate is mainly influenced by vapor-liquid interface area, gasoline saturated vapor pressure, filling level and temperature. The quantitative relation between different parameters and gasoline evaporation rate has rarely been reported, and a gasoline evaporative emission estimation model suitable for China needs to be proposed urgently. In this study, gasoline evaporative emission tests have been carried out in VT-SHED, and the effects of vapor-liquid interface area, filling level and temperature on gasoline evaporative emissions have been analyzed under the premise of consistent gasoline temperature and ambient temperature. Some valuable conclusions are obtained. The results show that different from expectation, gasoline evaporative emissions are not positively correlated with the vapor-liquid interface area. There is an approximately exponential relationship between the headspace volume and gasoline evaporative emissions. The widely used Reddy equation and Hata equation underestimate the gasoline vapor generation in China. Based on China VI test program and gasoline, accurate estimation of mass transfer coefficient has been conducted, and a new semi-empirical estimation model for vapor generation has been proposed. The model can accurately estimate the fuel evaporation of vehicles in China, providing guidance for the matching and optimization of EVAP system.

Using ICON Satellite Data to Forecast Equatorial Ionospheric Instability Throughout 2022

AbstractNumerical forecasts of plasma convective instability in the postsunset equatorial ionosphere are made based on data from the Ionospheric Connections Explorer satellite (ICON) following the method outlined in a previous study. Data are selected from pairs of successive orbits. Data from the first orbit in the pair are used to initialize and force a numerical forecast simulation, and data from the second orbit are used to validate the results 104 min later. Data from the IVM plasma density and drifts instrument and the MIGHTI red‐line thermospheric winds instrument are used to force the forecast model. Thirteen (16) data set pairs from August (October), 2022, are considered. Forecasts produced one false negative in August and another false negative in October. Possible causes of forecast discrepancies are evaluated including the failure to initialize the numerical simulations with electron density profiles measured concurrently. Volume emission 135.6‐nm OI profiles from the Far Ultraviolet (FUV) instrument on ICON are considered in the evaluation.

Vertical Wind Profiles in the Mesosphere and Lower Thermosphere Driven by Meteor Radar and Ionospheric Connection Explorer Observations Over the Korean Peninsula

AbstractMeteor radar observations provide wind data ranging from 80 to 100 km altitude, while the Michaelson Interferometer for Global High‐resolution Thermospheric Imaging (MIGHTI) onboard the Ionospheric Connection Explorer satellite offers wind data above 90 km altitude. This study aims to generate wind profiles in the mesosphere and lower thermosphere by combining the winds derived from meteor radar and MIGHTI observations over the Korean Peninsula from January 2020 to December 2021. The wind profiles derived from the two instruments are continuous at night, but they show discrepancies during the day. The atomic oxygen 557.7 nm (green line) emission intensity measured by MIGHTI peaks at approximately 100 km during the day and 94 km at night. The vertical gradient of the airglow volume emission rate is more pronounced during the day. These differences can cause day‐night differences in the MIGHTI wind retrieval accuracy, potentially leading to discrepancies during the day.

Evolution characteristics of fracture volume and acoustic emission entropy of monzogranite under cyclic loading

The volume evolution behavior of rock fissures and the characteristics of acoustic emission under cyclic loading are critical for rock stability analysis. To study the volume change behavior of monzogranite fissures and the characteristics of acoustic emission signals under cyclic loading, we selected samples of monzogranite at − 1600 m from a gold mine located in the Jiaodong Peninsula at a depth of − 1600 m and investigated the samples using triaxial cyclic loading—unloading tests and acoustic emission monitoring. As the volume change behavior of the monzogranite fissures and acoustic emission signals were monitored and recorded, the calculated fracture volume strain ratio coefficient and acoustic emission entropy value were proposed to describe the evolution process of fissures inside the rock. The research results showed that the volume strain ratio curve of the rock fractures exhibited a logarithmic variation characteristic during the cyclic loading and unloading, and the fracture volume strain ratio better reflected the relative scale of the internal fracture strain in the rock to the total volume strain. The acoustic emission entropy value reflected the crack evolution behavior during the loading and failure processes, which was a rapid decline in the initial stage of loading and a rapid upward trend in the failure stage. The observed “V”-shaped change in the acoustic emission entropy can be used as an early warning for rock failure. The research results can provide theoretical guidance for rock stability analysis.

Evaluation of calcium carbide residue and fly ash as sustainable binders for environmentally friendly loess soil stabilization

The incorporation of waste materials into cementitious binders serves as a strategy to diminish waste volume and lower carbon emissions. This study presents an in-depth evaluation of calcium carbide residue and coal fly ash as alternative binders. The assessment of raw materials emphasized their chemical composition and potential for pozzolanic reactions. Based on these factors, the optimal ratio of Ca/(SiO2 + Al2O3) in the raw materials was determined to be 1.5. Therefore, this study was designed to vary the raw material composition with a CaO/(SiO2 + Al2O3) ratio ranging from 1.7 to 0.9. Upon investigating the effect of the raw material proportion on the compressive strength of pastes and mortars, the composition yielding the highest compressive strength was selected for its potential application as a stabilizer for loess soil. A mixture of calcium carbide residue and coal fly ash with a Ca/(SiO2 + Al2O3) ratio of 1.5 resulted in the highest compressive strength at long curing periods in both pastes and mortars. Mineralogical and microstructural analyses revealed several products, beyond those formed from the pozzolanic reactions, that occurred and enhanced the compressive strength of samples. The highest performing mixture of carbide residue and coal fly ash was then used to stabilize loess soil at 10–25 wt%. The unconfined compressive strength, along with mass and strength loss due to wetting and drying cycles, was also studied. It was observed that the unconfined compressive strength of the stabilized soils remained consistent after six wet-dry cycles but decreased after twelve cycles due to microcracks. The findings suggest that carefully designed mixtures based on the chemical interactions of calcium carbide residue and coal fly ash can offer a sustainable, efficient approach for soil stabilization, potentially revolutionizing construction practices.

Response of ICON/MIGHTI Measured Low‐Mid Latitude OI630.0 and OI557.7 nm Dayglow Emissions to the 27 August 2021 Geomagnetic Storm

AbstractObservations from the Michelson Interferometer for Global High‐Resolution Thermospheric Imaging onboard the Ionospheric Connection Explorer spacecraft are used to study the response of OI630.0 and OI557.7 nm dayglow to a moderate geomagnetic storm on 27 August 2021. The storm reaches a minimum Dst index of −82 nT, significantly impacting the dayglow within the latitudinal range of approximately 20°N–42°N, where the dayglow observations are of good quality. During the geomagnetic storm, the OI630.0 dayglow intensity slightly increases, while the peak volume emission rate (VER) decreases, and the peak height rises noticeably. The F‐layer intensity, peak VER, and the entire‐layer intensity of OI557.7 dayglow decrease significantly. The rise in peak height is not noticeable for the OI557.7 dayglow. The VERs of the both dayglow emissions respond differently to the geomagnetic storm at different altitudes. The OI630.0 dayglow layer as a whole extends upward and rises in altitude. For dayglow averaged above 35°N, the OI630.0 dayglow VER increases above approximately 225 km but decreases below this altitude. The largest increase occurs near 300 km, reaching approximately 82.8%, while the largest decrease occurs around 160 km, reaching about −22.0%. The OI630.0 dayglow intensity increases by approximately 6.3%, the peak VER decreases by about −8.0%, and the peak height rises by approximately 16.3 km, corresponding to a 7.8% increase. The F‐layer intensity, peak VER, and the entire‐layer intensity of OI557.7 dayglow decrease by approximately −27.5%, −32.4% and −17.4%, respectively. The response of the dayglow also depends on longitude and is accompanied by a southward meridional wind.

Diurnal Response of CO2 Radiative Cooling to September 7-9, 2017 Storm

The solar and magnetospheric energy deposition into Earth’s high latitude region modulates the magnetosphere-ionospherethermosphere system during geomagnetic storm periods. One of the impacts of geomagnetic storm is the significant thermosphere temperature increment. This temperature increase is regulated by radiative cooling emissions via CO2 at 15 µm and NO 5.3 µm. We utilized CO2 15 µm radiative emissions observations by SABER (Sounding of the Atmosphere using Broadband Emission Radiometry) instrument onboard NASA’s TIMED (Thermosphere Ionosphere Mesosphere Energetics Dynamics) satellite, to investigate the diurnal response during September 7-9, 2017 storm. The volume emission rate of CO2 emission, in the altitude of 100-140 km, is integrated vertically to estimate cooling flux. The geomagnetic storm induced a significant enhancement in CO2 emission across all latitudes and altitudes considered. While the storm typically has stronger impacts on high latitudes, the response in CO2 emission was notably stronger in mid and low latitude regions both during day and night. The nighttime value is generally lower, with a faster response time, as compared to the day time counterpart. Further a strong hemispheric asymmetry is observed both during day and night. This study highlights a complex interplay of solar and magnetospheric influences on the diurnal variation of Earth's upper atmosphere.

A low total metabolic tumor volume independently predicts for a longer time to first treatment in initially observed, low tumor burden follicular lymphoma.

Watchful waiting is an acceptable management strategy for advanced-stage, low tumor burden (LTB) patients with follicular lymphoma (FL). However, the prediction of how long this treatment-free observation period will last remains imperfect. We explored whether total metabolic tumor volume (TMTV) and other positron emission tomography parameters were predictive of time to first treatment (TTFT). We analyzed 97 grade 1-3A advanced-stage LTB FL patients and found that a high TMTV was associated with other tumor burden features at diagnosis. Patients with a TMTV above our established cutoff of 50mL had a significantly shorter median duration of observation (2.6 vs. 8.8years; p=0.001). At 5years, 77% of patients with a high TMTV and 46% of patients with a low TMTV required treatment. In the multivariable analysis, a high TMTV was the only independent factor predicting TTFT (hazard ratio=2.09; p=0.017). Overall, TMTV is a strong predictor of the duration of observation in LTB FL patients. Upon validation of our cutoff in external series and standardization of the methodology, the TMTV could become an additional factor to consider deferring or initiating treatment in otherwise LTB patients.