The performance of voltage stability indices in the multiobjective optimal power flow of modern power systems is presented in this work. Six indices: the Voltage Collapse Proximity Index (VCPI), Line Voltage Stability Index (LVSI), Line Stability Index (Lmn), Fast Voltage Stability Index (FVSI), Line Stability Factor (LQP), and Novel Line Stability Index (NLSI) were considered as case studies on a modified IEEE 30-bus consisting of thermal, wind, solar and hybrid wind-hydro generators. A multiobjective evaluation using the multiobjective mayfly algorithm (MOMA) was performed in two operational scenarios: normal and contingency conditions, using the MATLAB–MATPOWER toolbox. Fuzzy Decision-Making technique was used to determine the best compromise solutions for each Pareto front. To evaluate the computational efficiency of the case studies, a preference selection index was used. The results indicate that VCPI and NLSI yielded the best-optimized system performance in minimizing generation costs, transmission loss reduction, and simulation time for normal and contingency conditions. The best-case studies also promoted the most scheduled reactive power generation from renewable energy sources (RES). On average, the VCPI index contributed the highest penetration level from RES (13.40%), while the Lmn index had the lowest. Overall, VCPI and Lmn index provided the best and worst average performance in both operating scenarios, respectively. Also, the MOMA algorithm demonstrated superior performance against the multiobjective harris hawks algorithm (MHHO), multiobjective Jaya algorithm (MOJAYA), multiobjective particle swarm algorithm (MOPSO), and nondominated sorting genetic algorithm III (NSGA-III) algorithms. In all, the proposed approach yields the lowest system cost and loss compared to other methods.