Substantiation. The article presents the structure and medical and social aspects of the primary disablement of the adult population of the Altai Region due to schizophrenia for the period from 2015 to 2019. Purpose of the study: to investigate the structure of primary disablement of the adult population of the Altai Region due to schizophrenia (by sex, age, place of residence, the main types, and degree of impairment of body functions and life limitations) and present the medical and social characteristics of patients first recognized as disabled. Material and methods. During the study, statistical data of the Federal State Institution «Main Bureau of Medical and Social Expert Examination for the Altai Region» of the Ministry of Labor and Social Protection of the Russian Federation were used. The material of the study included reporting forms No. 7‑sobes (n=5), protocols for conducting medical and social expert examination in the federal state institution of medical and social expert examination (n=745), and forms No. 088 / u of medical organizations (n=745). The research period was 2015‑2019. Research methods: documentary, data copying, statistical, and analytical methods. Results. The study has indicated that in the structure of primary disablement of the adult population of the Altai Region due to schizophrenia, urban residents predominate, while men prevail in the gender category. More than 90.0 % of the patients first recognized as disabled due to schizophrenia are citizens of working age. The vast majority of the patients did not work at the time of examination, while having a professional education. More than half of the patients,mostly men, were not married, had no children, and lived with their parents. In more than 90.0 % of the patients, the paranoid type of schizophrenia led to disability, and the main maladapting syndrome involved emotional and volitional disorders. More than 60.0 % of the patients had persistent moderate impairment of body functions; life limitations were more frequently detected in the following categories: the ability to work, the ability to communicate, and the ability to control one»s behavior. More often, patients with schizophrenia obtained the third group of disability during the initial examination. Conclusion. The results of the study can be a scientific and practical basis for planning and effective implementation of comprehensive rehabilitation of disabled patients with this pathology.