Voiding Parameters Research Articles

Comparison of Diagnostic Accuracies of Commonly Used Trial of Void Parameters.

Understanding the diagnostic accuracy of postoperative trial of void (TOV) parameters is important for decision making related to postoperative catheterization. The aim of the study was to compare the diagnostic accuracies of common postoperative TOV parameters. The study population comprised a prospective cohort undergoing outpatient urogynecologic procedures at a tertiary referral center from September 2018 to June 2021. Participants recorded their postvoid residual volume (PVR), voided volume, and subjective force of stream (sFOS) for all postoperative voids until meeting criteria to stop. The primary outcome was the sensitivity of TOV parameters in predicting postoperative urinary retention, defined as PVR ≥1/2 voided volume on the first 2 postoperative voids. Sample size was set at 183 to detect a 20% difference (α = 0.05, β = 0.2, up to 20% with missing data) in sensitivity between TOV parameters. Diagnostic accuracies were compared with McNemar's test for paired proportions, with Youden's index calculated to determine optimal thresholds. The 160 participants had a mean age of 52.1 ± 11.4 years and a mean body mass index of 28.9 ± 5.8 kg/m2 (calculated as weight in kilograms divided by height in meters squared). Mean preoperative PVR was 25.8 ± 29.9 mL. Most participants had surgery that included a midurethral sling (137/160, 85.6%). Thirty-four (34/160, 21.3%) participants met criteria for postoperative urinary retention. The optimal recovery room TOV thresholds to predict postoperative urinary retention were PVR ≥87 mL (sensitivity 96.8%, specificity 60.0%), voided volume ≤ 150 mL (sensitivity 83.9%, specificity 72.3%), and sFOS ≤60% (sensitivity 100%, specificity 50.8%). Voided volume ≤ 150 mL had greater diagnostic accuracy than PVR ≥100 mL (156.2 vs 151.8). In this cohort, PVR ≥87 mL, voided volume ≤ 150 mL, and sFOS ≤60% had optimal diagnostic accuracy for postoperative urinary retention.

Phase velocity of love waves as function of heterogeneity and void parameter

The present study looks at the Love wave propagating through an elastic layer containing empty pores situated above a heterogeneous elastic semi-infinite space. We have constructed separate formulations of equations of motion for both media under congruous boundary conditions. The separation of variables approach is used to build the phase velocity frequency relation in compact form using the Whittaker function. The resulting closed-form dispersion equation matches the conventional Love wave equation when heterogeneity has been removed. The propagation of Love waves is strongly influenced by a porous layer of limited thickness across an elastic semi-infinite space. Three wave fronts are demonstrated to have the potential to propagate. The equilibrated inertia and the variation in the void volume fraction are related to two wave fronts that are connected to the characteristics of the void pores. Numerical treatments are applied and graphically illustrated to implement these effects associated to Love waves’ phase velocity.

Evaluating the efficacy and safety of Holmium laser enucleation of the prostate in patients with obstructive uropathy attributable to bladder outlet obstruction.

To evaluate outcomes of Holmium laser enucleation of the prostate (HoLEP) in individuals presenting with obstructive-uropathy (OU) attributable to bladder outlet obstruction (BOO). We performed a retrospective review of patients who underwent HoLEP from August 2017 to January 2023 at our institution. We identified patients with preoperative OU defined by presence of chronic hydronephrosis suggestive of BOO and conducted a matched-pair analysis (1:2) with patients undergoing HoLEP without OU. Patients' demographic, perioperative and postoperative voiding parameters, serum creatinine level, and complications were analyzed up to one-year of follow-up. Preoperative OU was present in 42 patients. Demographic and preoperative parameters were comparable except median preoperative creatinine (1.245 vs. 1.065 ng/ml, p < 0.001) and catheterization rates (76.2% vs. 25%, p < 0.001) were higher in the OU group. The mean duration of postoperative catheterization was longer in the OU group (3.83 vs. 2.26 days, p = 0.048). Two patients in the OU group developed postoperative acute kidney injury. There was no difference in the rate of postoperative complications, improvement in International Prostate Symptom Score and maximum urinary flow amongst both groups except a higher post-void residual volume at 3- and 12-months (p = 0.001 and p = 0.037, respectively) in OU patients. Patients noted significant improvement in serum creatinine level at 6-12 weeks postoperatively from peak baseline level (P = 0.002). HoLEP is effective and safe in patients with OU suggestive of BOO, though they are at higher risk of postoperative acute kidney injury.

Clinical features and sequelae of detrusor underactivity: a study of possible cause and effect.

To describe the clinical presentation and urodynamic findings in detrusor underactivity (DU) patients and investigate the association between DU and straining related complications such as pelvic organ prolapse (POP), inguinal hernia, and hemorrhoids. We retrospectively reviewed all consecutive patients who underwent urodynamic studies (UDS) from 2012 to 2023, divided into two groups: those with evidence of DU (n = 573), and control subjects with normal voiding parameters (n = 522). Exclusion criteria were patients who lacked sufficient data, those with obstructive voiding parameters, and those who had received intravesical botulinum toxin injections within the previous nine months. Demographic information, clinical presentation, straining related complications, and UDS findings were compared between the two groups using univariate statistical analysis. The male DU group had a statistically significant higher prevalence of spinal disease and previous cerebrovascular accidents, while the female DU group had a statistically significant higher prevalence of spinal disease, multiple sclerosis, diabetes, previous colorectal surgery, previous transabdominal gynecological surgery, POP surgery, and recurrent UTIs. Female DU patients had a higher prevalence of pronounced vaginal bulging symptoms, recurrent POP, inguinal hernia, and hemorrhoids. The predominant LUTS were voiding symptoms (81.2% in males and 77.9% in females), followed closely by storage symptoms (66.2% in males and 74.7% in females). The median Qmax, PdetQmax, and PVR were 6ml/sec, 18 cmH2O, 190ml for male DU patients, and 8ml/sec, 11 cmH2O, and 200ml for female DU patients, respectively. Risk factors for DU that were identified include age, neurological diseases (spinal disease, CVA in men, MS in women), diabetes and transabdominal surgery (colorectal, gynecological) that can cause pelvic denervation in women. DU patients commonly present with both voiding and storage symptoms. There is approximately twice the risk of having POP surgery and inguinal hernia, an eight-fold risk of hemorrhoids, and a three-fold risk of recurrent UTIs for females. This is thought to be secondary to increased intra-abdominal pressure during urinary straining.

Evolution of structural safety for tunnel arch crown linings under the coupled influence of void and insufficient thickness

The existence of voids behind tunnel linings constitutes a recognized inherent defect in tunnel engineering. Void and insufficient thickness can significantly compromise structural safety, especially at the tunnel arch crown. In this study, we employed similar model tests and numerical analysis methods to examine how the coupling of voids and insufficient thickness affects the structural performance of arch crown linings. Key findings reveal that the coupling of arch crown voids and insufficient thickness causes notable shifts in displacement patterns and internal force distribution. The displacement pattern of the arch shifts from the inner side to the outer side of the tunnel, resulting in the concrete stress state on the inner side of the arch crown changing to compression. Spatial distribution characteristics of voids and insufficient thickness defects were analyzed to assess their impact on structural degradation, with quantitative analysis using the safety factor index. Geometric parameters of voids and insufficient thickness (longitudinal length, thickness, circumferential range) were chosen based on analysis under various conditions to predict the structural safety factor using a Wide Neural Network regression model with 98 % accuracy. This method offers a new approach for rapidly predicting the safety status of lining structures. These findings are crucial for comprehending the effects of arch crown voids and insufficient thickness defects and for devising effective strategies to address tunnel lining defects.

Long-Term Outcomes of Recurrent Bulbar Urethral Stricture Treatment With the Optilume Drug-Coated Balloon: Five-Year Results From the ROBUST I Study.

We report the 5-year study closeout results for the ROBUST I trial evaluating the safety and efficacy of the Optilume drug-coated balloon (DCB) for men with short, recurrent bulbar urethral strictures. Adult men with recurrent bulbar urethral strictures ≤ 2 cm long and lumen < 12F were included in the study and treated with the Optilume DCB. Outcome measures included symptom questionnaires, maximum urinary flow rate, postvoid residual, and freedom from repeat intervention. Functional success was defined as improvement in International Prostate Symptom Score ≥ 50% without re-treatment. Fifty-three men were enrolled and treated, and 31 subjects completed all follow-up. Functional success was achieved in 58% (25/43) patients at 5 years. Average International Prostate Symptom Score improved from a mean of 25.2 at baseline to 7.2 at 5 years (P < .001). Freedom from repeat intervention was maintained through 5 years at 71.7% estimated by Kaplan-Meier. Maximum urinary flow rate improved from 5.0 mL/s at baseline to 19.9 (P < .01), and average postvoid residual was reduced from 141.4 mL to 59.5 mL (P < .01) at 5 years of follow-up. Erectile function remained unaffected. There were no serious treatment-related adverse events. In this challenging cohort of men with failed prior endoscopic treatment, the Optilume DCB shows sustained improvement in subjective and objective voiding parameters at 5 years. Optilume is a safe and effective treatment option for appropriately selected men with recurrent bulbar urethral stricture who wish to avoid urethroplasty. Results are in line with the ROBUST III randomized controlled trial that will continue follow-up through 5 years. : NCT03014726.

Automated analysis of the void structure in hardened concrete based on shape from focus

The quality of the air void system is essential for the frost resistance of concrete. Therefore, it is crucial to assess the quality of the air void system in hardened concrete in an appropriate way. In this study, the shape from focus (SFF) method is applied to identify the focused image of each point on the polished surface of hardened concrete and thereby acquire the depth information of the entire surface. The performance of various focus measure operators and window sizes is evaluated. Thereafter, the selected focus measure operator and window size are applied for the SFF analysis of all samples. Based on the obtained depth map, the voids are identified, and the void parameters of the hardened concrete are determined by an automated procedure. The main advantage of the SFF method is that it is possible to carry out an automated air void analysis without contrast enhancement.

Comparative analysis of double and single porosity effects on SH-wave induced vibrations in periodic porous lattices

The manuscript presents a novel study comparing the impact of single and double porosity on horizontally polarized shear wave (SH-wave) propagation in corrugated elastic void materials. The considered mathematical model comprises two cases; the first one depicts SH-wave propagation through a void porous layer having creased boundaries and resting over a heterogeneous anisotropic fluid-saturated fractured porous half-space, whereas according to the second case, heterogeneous anisotropic fluid-saturated porous semi-infinite medium without fractures has been considered. In both cases, rigidity and density of the half-space vary quadratically with depth. The separable variable method is used to attain the complex frequency equation for each case that leads to two different dispersion relations associated with two distinct wave fronts. The first wave front depends on the void parameters, whereas the second wave front defines the propagation of SH-waves in an elastic layer without void pores. In each case, the complex dispersion relation has been separated into two equations that illustrate the dispersion and attenuation properties of SH-waves. Using the variations in the inhomogeneity, position, fluctuation, flatness, total porosity, and anisotropy parameters, case I and case II have been compared in each graphical execution. In addition, the surface response of shear stress and displacement have been implemented graphically.

Clinical Outcomes in Patients With Hypocontractile Bladders Undergoing Holmium Laser Enucleation of the Prostate

To compare post-operative outcomes in patients who underwent holmium laser enucleation of the prostate (HoLEP) for benign prostatic hyperplasia (BPH) and had urodynamic evidence of bladder hypocontractility versus those with normocontractile bladders. We retrospectively reviewed HoLEP patients with pre-operative urodynamic studies at a single institution, categorizing them into normocontractile and hypocontractile groups based on the bladder contractility index (BCI) (hypocontractile defined as BCI < 100). Post-void residual (PVR) volume was measured at 6 weeks and 6 months. Secondary outcomes included maximum flow rate (Qmax) and catheterization status. Among 114 HoLEP patients with pre-operative urodynamic data, 49 had hypocontractile bladders. The median pre-operative PVR was 305 (202-446) ml in the hypocontractile group, higher than the median PVR of 190 (60-361) ml in the normocontractile group (p=.013). At 6 weeks post-op, the median PVR was higher in the hypocontractile compared to normocontractile group [38 (3-61) vs. 5 (0-44) ml, p=.016], but at 6 months post-op there was no significant difference [18 (0-39) vs. 12 (0-70) ml, p=.97]. Among men who were catheter-dependent pre-operatively, 98% of hypocontractile and 100% of normocontractile patients were catheter-free postoperatively. Qmax and symptom scores were similar at both follow-up time points. HoLEP can be an effective surgical option for BPH patients with hypocontractile bladders, including those who are catheter-dependent, with minimal differences in post-operative voiding parameters compared to those with normal bladder function.

A novel one-dimensional thiocyanate-bridged cobalt(III) complex: synthesis, crystal structure characterization and Hirshfeld surface analysis.

A new one-dimensional thiocyanate-bridged cobalt(III) Schiff base complex, namely, catena-poly[[[4-bromo-2-((Z)-{[2-(thiophen-2-yl)ethyl]imino}methyl)phenolato-κ2N,O]cobalt(III)]-μ-thiocyanato-κ2N:S], [Co(SCN)(C13H11BrNOS)2]n or [Co(μ1,3-SCN)L2]n (1), where HL is 4-bromo-2-((Z)-{[2-(thiophene-2-yl)ethyl]imino}methyl)phenol, a bidentate Schiff base prepared from the condensation reaction of 5-bromosalicylaldehyde and 2-(thiophen-2-yl)ethylamine, has been synthesized by stirring Co(ClO4)2·6H2O, the Schiff base HL and ammonium thiocyanate (in a 1:2:1 molar ratio) in ethanol medium. The complex was characterized by FT-IR, electronic spectra and single-crystal X-ray diffraction (SC-XRD) studies. The SC-XRD data suggest that the compound crystallizes in the orthorhombic space group Pca21. The CoIII ion in 1 adopts a distorted octahedral geometry, the metal sites being six-coordinated by one thiocyanate N atom and one thiocyanate S atom in apical positions, and by two imine N atoms and two phenolate O atoms from two anionic L- ligands which form the basal plane. The thiocyanate ligand acts as a μ-1,3 bridge, joining neighbouring CoIII atoms and forming a uniform zigzag one-dimensional polymeric chain. The crystallographic data were also used in the Hirshfeld surface (HS) analysis, which aimed to investigate the nature and quantitative significance of any noncovalent intermolecular interactions inside the crystal lattice. The crystal void parameters have also been computed and show the molecules to be tightly packed.

Cosmological forecast of the void size function measurement from the CSST spectroscopic survey

ABSTRACT Void size function (VSF) contains the information of the cosmic large-scale structure (LSS), and can be used to derive the properties of dark energy and dark matter. We predict the VSFs measured from the spectroscopic galaxy survey operated by China’s Space Survey Telescope (CSST), and study the strength of cosmological constraint. We employ a high-resolution Jiutian simulation to get CSST galaxy mock samples based on an improved semi-analytical model. We identify voids from this galaxy catalogue using the watershed algorithm without assuming a spherical shape, and estimate the VSFs at different redshift bins from $z=0.5$ to 1.1. We propose a void selection method based on the ellipticity, and assume the void linear underdensity threshold $\delta _{\rm v}$ in the theoretical model is redshift-dependent and set it as a free parameter in each redshift bin. The Markov Chain Monte Carlo method is adopted to implement the constraints on the cosmological and void parameters. We find that the CSST VSF measurement can constrain the cosmological parameters to a few per cent level. The best-fitting values of $\delta _{\rm v}$ are ranging from $\sim -0.4$ to $-0.1$ as the redshift increases from 0.5 to 1.1, which has a distinct difference from the theoretical calculation with $\delta _{\rm v}\simeq -2.7$ assuming the spherical evolution and using particles as tracer. Our method can provide a good reference for the void identification and selection in the VSF analysis of the spectroscopic galaxy surveys.

Study on the influence of void evolution of porous asphalt concrete on acoustic absorption performance under high-temperature loading

This paper investigated the void evolution in porous asphalt concrete (PAC) under high-temperature loading and the resulting decay in acoustic absorption performance. The specimen of PAC-13 with a void content of 20.2 % was designed and loaded with MMLS3 for 0–100,000 cycles at 60℃. Computed tomography techniques were employed to extract the distribution characteristics and structural parameters of voids. Subsequently, the acoustic absorption coefficients were measured at different loading stages. The results indicate that PAC experienced both rapid and gradual reduction phases in air void content under high-temperature loading. After 100,000 cycles of loading, the air void content decreased by 5.44 %, void connectivity decreased by 4.32 %, and the average number of voids in section reduced by 8.30 %. The distribution range of nearly 90 % of void sizes shifted from below 7 mm to below 6 mm after 100,000 cycles. At different loading stages, the void content, average number and average equivalent diameter of connected voids exhibited a positive correlation and similar trends with the absorption capacity of PAC for small vehicle noise. This study provides novel insights and perspectives into the acoustic performance degradation of PAC due to void evolution under high-temperature loading.

Early Results after Thulium Laser Enucleation of the Prostate in Patients with Urodynamically Proven Detrusor Underactivity

Objectives: Benign prostatic hyperplasia is one of the most common urological diseases. Among these patients, the presence of detrusor underactivity or acontractility represents a challenging condition since no medical treatment is available. Our objective is to evaluate early term outcomes following transurethral anatomical enucleation of the prostate with Tm:YAG support. Methods: In a retrospective analysis of 115 patients who underwent this procedure between January 2019 and March 2022 due to lower urinary tract symptoms, 8 patients with urodynamic evidence of detrusor underactivity secondary to a non-neurogenic aetiology were identified. Detrusor underactivity was defined as a bladder contractility index of &lt;100. Results: Median age, prostate volume and bladder contractility index were 73.2 years, 78.5 cm3 and 63.9, respectively. Median International Prostate Symptom Score/quality of life, Qmax and post-void residual volume were 15/3.5 points, 4.4 mL/s and 189 mL, respectively. Postoperatively, immediate catheter-removal success rate was 87.5% (7/8), at 2 months all patients were catheter-free and remained so at 1-year follow-up. Significant improvements for quality of life, Qmax and post-void residual volume were detected. Median postoperative International Prostate Symptom Score/Quality of life, Qmax and post-void residual volume were 7/2, 21.6 mL/s and 0 mL, respectively. Conclusions: This surgical approach offers high catheter-free rates, significantly improves functional voiding parameters and increases patient satisfaction in patients with benign prostatic hyperplasia and concomitant detrusor underactivity. Therefore, it can be regarded as an effective approach for such patients.

A multi-gradient analysis of microscopic void characteristics' influence on the mechanical properties of open-graded friction course bituminous pavement

The mechanical properties of the open-graded friction course (OGFC) bituminous pavement are tied to its microscopic void structure, but multiple void parameters influence void formation and distribution. Solely using air voids as an indicator of pavement stability is challenging. Thus, a multi-gradient analysis of void structure factors is vital for advancing OGFC pavement's mechanical property research. This study used computerized tomography (CT) and digital image processing (DIP) to gather data on void structure distribution, size, and complexity in OGFC bituminous mixtures. Mechanical experiments assessed high-temperature deformation, low-temperature cracking, and water damage resistance. Analysis of void parameters' influence led to a predictive model for mechanical property in OGFC mixtures. The study found that as air voids increase within the 18 %–24 % range, both equivalent void diameter and void fractal dimension increase, while void count decreases. Conversely, coarser gradation and a larger nominal maximum aggregate size (NMAS) lead to increased equivalent void diameter but decreased void fractal dimension, reducing void complexity. The mechanical properties of OGFC mixtures decline with rising air voids but improve with coarser gradation and larger NMAS. The predictive model highlights the void fractal dimension and NMAS as critical indicators, with other factors showing weaker influence or multicollinearity issues that are unfit for model fitting. The findings could provide useful references for the structural design, property evaluation, and quality control of OGFC bituminous pavements in actual road construction.

A Concrete Core Void Imaging Approach and Parameter Analysis of Concrete-Filled Steel Tube Members Using Travel Time Tomography: Multi-Physics Simulations and Experimental Studies.

Concrete-filled steel tube (CFST) members have been widely used in civil engineering due to their advanced mechanical properties. However, internal defects such as the concrete core voids and interface debonding in CFST structures are likely to weaken their load-carrying capacity and stiffness, which affects the safety and serviceability. Visualizing the inner defects of the concrete cores in CFST members is a critical requirement and a challenging task due to the obvious difference in the material mechanical parameters of the concrete core and steel tube in CFST members. In this study, a curved ray theory-based travel time tomography (TTT) with a least square iterative linear inversion algorithm is first introduced to quantitatively identify and visualize the sizes and positions of the concrete core voids in CFST members. Secondly, a numerical investigation of the influence of different parameters on the inversion algorithm for the defect imaging of CFST members, including the effects of the model weighting matrix, weighting factor and grid size on the void's imaging quality and accuracy, is carried out. Finally, an experimental study on six CFST specimens with mimicked concrete core void defects is performed in a laboratory and the mimicked defects are visualized. The results demonstrate that TTT can identify the sizes and positions of the concrete core void defects in CFST members efficiently with the use of optimal parameters.

Minimally-Invasive Surgical Techniques (MIST): Shedding Light on the Mist

As life expectancy increases and there is growing demand for BPH treatments, innovative technologies have been developed, allowing for swift recovery, symptom relief, low complication rates, and the possibility of performing procedures on an outpatient basis, often under local anaesthesia. This review aims to describe the outcomes of newly developed minimally-invasive surgical therapies (MIST) for BPH treatment in terms of functional voiding parameters and sexual function. These therapies are categorized into primarily ablative (Aquablation [Aquabeam]), non-ablative (Prostatic Urethral Lift (PUL, Urolift), temporary implantable devices [iTind]), and secondarily ablative procedures (convective water vapor ablation, Rezum, Prostate Artery Embolization [PAE]). All MIST technologies have advanced the medical care of patients with BPH while preserving ejaculation. However, there is a shortage of long-term data specifically addressing re-intervention rates and the preservation of functional voiding parameters. Although there is promising data from regulatory trials and randomized studies, all MIST therapies are potentially associated with severe complications. Patients considering such methods must be thoroughly informed about their inferiority compared with established transurethral procedures like TUR-P and enucleation.

Single-dose Tadalafil Reduces Opening Urethral Pressure: A Randomized, Double-blind, Placebo-controlled, Crossover Trial in Healthy Women

Introduction and HypothesisPhosphodiesterase enzymes are widely distributed in female urogenital tissues. Yet, the understanding of their physiological roles and the impact of phosphodiesterase inhibitors on lower urinary tract symptoms in women remains limited. Current hypotheses are conflicting: one suggests that vasodilation might expand the periurethral vascular plexus, leading to increased urethral pressure, whereas the other proposes a relaxation of urethral musculature, resulting in decreased pressure. To further clarify this, we investigated the effect of tadalafil on the opening urethral pressure and voiding function in healthy women.MethodsWe conducted a randomized, double-blind, placebo-controlled crossover trial involving 24 healthy women. Participants were randomly assigned to receive a single dose of tadalafil (40 mg) or placebo during their initial visit and then switched to the alternative treatment during their second visit. Opening urethral pressure was measured with urethral pressure reflectometry during both resting and squeezing conditions of the pelvic floor. Subsequently, voiding parameters were recorded.ResultsCompared with placebo, a single dose of tadalafil significantly reduced opening urethral pressure during both resting (-6.8 cmH20; 95% confidence interval [CI], -11.8 to -1.9; p = 0.009) and squeezing conditions (-8.8 cmH20; 95% CI, -14.6 to -3.1; p = 0.005). Voiding parameters did not show significant differences (average flow rate: -0.8 ml/s [95% CI, -2.0 to 0.4; p = 0.2]; maximum flow rate: -1.7 ml/s [95% CI, -4.8 to 1.5; p = 0.3]).ConclusionsA single dose of 40 mg tadalafil moderately reduced urethral pressure in healthy women, without affecting voiding parameters. The clinical implications of this are yet to be determined.

Proposed automated contrast-enhanced microscopical method for evaluating air void structure in compacted asphalt concrete mixtures

There is no direct, less expensive, and practical method to measure the interconnectivity and parameters of air voids in asphalt mixtures other than the total air void volume calculated traditionally using bulk and maximum theoretical specific gravities. Unlike the conventional method, this paper proposes a method that is suitable for advanced applications and studies, such as for the evaluation of air void distribution and air void gradient to model and simulate long-term aging, predict top-down fatigue cracking, evaluate the effectiveness of compaction of thick lifts, and satisfy the representative volume element (RVE) requirements (a homogenous and representative specimen) for performance tests. Developing the proposed compact asphalt evaluation method included modifying the sample preparation methods and analysis from the American Society of Testing & Materials (ASTM), C457 Method C, and recently applied in the analyses of two independent studies at the Federal Highway Administration (FHWA). The first study was focused on checking the air void distribution within the small specimen for dynamic modulus and uniaxial cyclic fatigue tests using AASHTO TP 132 and TP 133, respectively. Results of air void analyses conducted on the interior and exterior sides of several slices sawn from different compacted asphalt mixtures consistently showed that the air void contents on the external sides are higher than on the interior. The second study was to evaluate whether the thicker-than-typical lift thickness to nominal maximum aggregate (NMAS) ratio was causing any top-to-bottom air void gradient in the pavement. Results showed that air void sizes and contents are consistently higher along the top ends of all the cores, and the total air void contents measured using the new method on several specimens from the field were comparable with the indirectly calculated air void percent with up to ± 0.4 percent random error. Overall, the new method is practical to apply to larger-size samples and is a tool that both agencies and contractors can use for confirming in situ void uniformity. Its application can support innovations and improve performance in asphalt pavement construction.

Nonlocal and dual‐phase‐lag effects in a transversely isotropic exponentially graded thermoelastic medium with voids

AbstractThe aim of the present work is to examine the thermally induced disturbances in a transversely isotropic nonlocal exponentially graded (nonhomogeneous) thermoelastic half‐space with voids within the framework of dual‐phase‐lag (DPL) theory. It is supposed that the material's properties are graded in ‐direction. By employing normal mode technique, the exact expressions of the temperature field, the change in volume fraction field, displacement and stress components are obtained. The obtained results are computed numerically for a magnesium crystal‐like material and depicted graphically to display the effects of material's anisotropy, non‐homogeneity parameter, generalized theories, nonlocal parameter, void parameter and time on the variations of different physical fields. Certain limiting cases of interest have been deduced from the present investigation.

De-obstruction of bladder outlet in humans reverses organ remodelling by normalizing the expression of key transcription factors

BackgroundBenign prostatic hyperplasia in elderly males often causes bladder outlet obstruction termed benign prostatic obstruction (BPO). BPO induces lower urinary tract symptoms and quantifiable urodynamic alterations in bladder function. When conservative medical treatments are exhausted, surgical interventions like transurethral resection of the prostate (TURP) are employed for bladder outlet de-obstruction. Elucidating the molecular changes in the human bladder resulting from BPO and their reversal post-de-obstruction is pivotal for defining the “point of no return”, when the organ deterioration becomes irreversible. In this study we carried out a comprehensive molecular and urodynamic characterization of the bladders in men with BPO before TURP and 3 months after the relief of obstruction.MethodsWe report integrated transcriptome and proteome analysis of bladder samples from male patients with BPO before and 3 months after de-obstruction surgery (TURP). mRNA and protein profiles were correlated with urodynamic findings, specifically voiding detrusor pressure (PdetQmax) before TURP. We delineated the molecular classifiers of each group, pointing at the different pre-TURP bladder status.ResultsAge-matched patients with BPO without DO were divided into two groups based on the PdetQmax values recorded by UDI before de-obstruction: high and medium pressure (HP and MP) groups. Three months after de-obstruction surgery, the voiding parameters PdetQmax, Qmax and RV were significantly improved in both groups, without notable inter-group differences in the values after TURP. Patients with high PdetQmax showed less advanced remodeling and inflammatory changes than those with lower values. We detected significant dysregulation of gene expression, which was at least partially reversed by de-obstruction in both patients’ groups. Transcription factor SOX21 and its target thrombospondin 4 (THBS4) demonstrated normalization post-TURP.ConclusionsOur findings reveal substantial yet incomplete reversal of cell signalling pathways three months after TURP, consistent with improved urodynamic parameters. We propose a set of biomarker genes, indicative of BPO, and possibly contributing to the bladder changes. This study unveils the stages of progressive obstruction-induced bladder decompensation and offers insights into selecting an optimal intervention point to mitigate loss of contractility.