The development of TED Talks textbooks has been a welcoming addition to English for Academic Purposes (EAP) pedagogy. The textbooks offer educators and learners a suitable framework for practicing all four of the language skills (i.e., listening, reading, speaking, and writing). However, the use of TED Talk resources could create specific vocabulary challenges for learners as they progress through each unit in the textbook. Research suggests that although textbook frameworks encompassing listening resources benefit learners with a familiar lesson approach, the varying vocabulary load and the presence of academic vocabulary and multiword units (MWUs) presented between the chosen resources and the textbook itself could lead to comprehension difficulties for learners. This study investigates the vocabulary of 12 TED Talks included in the commercial textbook Keynote 2 to understand the lexical profile, vocabulary load, and the academic and multiword unit coverage for each of the chosen listening texts. The results showed that the TED Talks selections and the textbook provided inadequate vocabulary practice, limited academic vocabulary exposure, and a lack of item repetition for learners. The study suggests the inclusion of ideal supplementary materials and appropriate TED Talk selections to help provide educators with suitable guidance to support their learners’ varying vocabulary knowledge.