Dream Research Articles

Getting lucid about lucid dreaming

Abstract Lucid dreams are a distinctive and intriguing phenomenon where subjects apparently possess, inter alia, conscious knowledge that they are dreaming while they are dreaming. I here develop and defend a new model of lucid dreaming, what I call the ‘Dyadic Model’, according to which lucid dreams involve the tokening of both dreaming and non-dreaming states. The model is developed to successfully defend the Imagination Theory of dreams, according to which to dream is to imagine, against the underexplored objection that it cannot account for lucid dreams. Moreover, as I explain, a range of theories of dreaming have reason to adopt the Dyadic Model, and it has further potential applications, including to false awakening and emotional responses to dreams. Hence, getting lucid about lucid dreaming reveals general insights for dream theorizing.

The Antecedents of the Experience of Light in Dreams

The experience of inner light and ecstasy is widely accepted as a universal mystical experience, regardless of cultural or religious context. While one can read first-hand accounts in the historical record, the direct experience of light remains elusive for most people. This study analyzes a series of dream-based experiences of light provided by a single subject. In our analysis of 19 dreams, we pursue a process-oriented, relational analysis based on co-creative dream theory, which views the dream as an interactive experience in real time rather than a fixed product of the unconscious mind. By analyzing dreams as relational events, in which the metaphoric content emerges alongside the dreamer’s responses, we see how the dream ego influences the outcome through feelings, choices, and reactions. Through this analysis, we identify an array of subjective antecedents to the experience of light and provide a potential avenue of access to the core mystical experience.

»Meine furchtbaren Träume / habe ich erlebt!«

Abstract This article focuses on Paula Ludwig’s dream texts (›Traumtexte‹) and her dream conception. Fundamental to understand her concept of dreams is her stay in Munich, where she encountered numerous intellectuals and lovers of culture, including Grete Weisberger and Karl Wolfskehl. It is likely in this context that she came into contact with Ludwig Klages’ dream theories, which have left clear traces in the paratexts of her dream collections. However the development of National Socialism and the outbreak of the Second World War soon disrupted European and world history, which was reflected in Paula Ludwig’s life and work. Accordingly, the article aims to shed light on the incursion of history into Paula Ludwig’s dream world, using a philological and hermeneutic method that also considers biographical, historical and cultural aspects.

The brain simulates actions and their consequences during REM sleep.

Vivid dreams mostly occur during a phase of sleep called REM 1-5 . During REM sleep, the brain's internal representation of direction keeps shifting like that of an awake animal moving through its environment 6-8 . What causes these shifts, given the immobility of the sleeping animal? Here we show that the superior colliculus of the mouse, a motor command center involved in orienting movements 9-15 , issues motor commands during REM sleep, e.g. turn left, that are similar to those issued in the awake behaving animal. Strikingly, these motor commands, despite not being executed, shift the internal representation of direction as if the animal had turned. Thus, during REM sleep, the brain simulates actions by issuing motor commands that, while not executed, have consequences as if they had been. This study suggests that the sleeping brain, while disengaged from the external world, uses its internal model of the world to simulate interactions with it.

Psychodynamics of Dreams

The discovery of psychodynamics formed the foundation of psychoanalytic theory, the core of which was S. Freud’s work “The Interpretation of Dreams.” The passage of the psyche through three key psychodynamic points (cathexis, catharsis and basic anxiety) determines the “scene” and character of dreams. For researchers of psychoanalysis and the psychoanalytic theory of dreams, this factor is one of the fundamental ones in practical work.

Critical dynamics in spontaneous EEG predict anesthetic-induced loss of consciousness and perturbational complexity

Consciousness has been proposed to be supported by electrophysiological patterns poised at criticality, a dynamical regime which exhibits adaptive computational properties, maximally complex patterns and divergent sensitivity to perturbation. Here, we investigate dynamical properties of the resting-state electroencephalogram (EEG) of healthy subjects undergoing general anesthesia with propofol, xenon or ketamine. Importantly, all participants were unresponsive under anesthesia, while consciousness was retained only during ketamine anesthesia (in the form of vivid dreams), enabling an experimental dissociation between unresponsiveness and unconsciousness. For each condition, we measure (i) avalanche criticality, (ii) chaoticity, and (iii) criticality-related metrics, revealing that states of unconsciousness are characterized by a distancing from both avalanche criticality and the edge of chaos. We then ask whether these same dynamical properties are predictive of the perturbational complexity index (PCI), a TMS-based measure that has shown remarkably high sensitivity in detecting consciousness independently of behavior. We successfully predict individual subjects’ PCI values with considerably high accuracy from resting-state EEG dynamical properties alone. Our results establish a firm link between perturbational complexity and criticality, and provide further evidence that criticality is a necessary condition for the emergence of consciousness.

Varenicline OTC Trial on Efficacy and Safety.

Varenicline helps people who smoke quit at rates 2-3 times greater than placebo. Currently in the U.S., varenicline is not available over the counter (OTC). In this study, we assessed the safety and efficacy of 1mg and 0.5mg varenicline as an OTC medication for smoking cessation in comparison to placebo. This randomized, double-blind, placebo-controlled study was performed at two clinical sites in the United States of n=313 people. The treatment period was 12 weeks. During the COVID pandemic, the protocol was modified to allow remote participation; verification of smoking status was via breath carbon monoxide levels for in-person visits and mailed urine cotinine kits for the remote participants. There was no difference in biologically confirmed continuous abstinence by condition between Weeks 8-12; however, the odds of biologically confirmed point prevalence abstinence were higher for those in the 1mg b.i.d. condition than for those in the placebo condition at Week 12 (OR 3.39; 95% CI 1.49, 7.71), and were higher for those assigned to the 1.0mg b.i.d. condition than the 0.5mg b.i.d. condition at Week 12 (OR 2.37; 95% CI 1.11, 5.05). Adverse events were modest, and as expected (vivid dreams and nausea in the medication conditions). The results are suggestive that varenicline is safe and effective as an OTC medication.

Homeostatic regulation of rapid eye movement sleep by the preoptic area of the hypothalamus

Rapid eye movement sleep (REMs) is characterized by activated electroencephalogram (EEG) and muscle atonia, accompanied by vivid dreams. REMs is homeostatically regulated, ensuring that any loss of REMs is compensated by a subsequent increase in its amount. However, the neural mechanisms underlying the homeostatic control of REMs are largely unknown. Here, we show that GABAergic neurons in the preoptic area of the hypothalamus projecting to the tuberomammillary nucleus (POAGAD2→TMN neurons) are crucial for the homeostatic regulation of REMs in mice. POAGAD2→TMN neurons are most active during REMs, and inhibiting them specifically decreases REMs. REMs restriction leads to an increased number and amplitude of calcium transients in POAGAD2→TMN neurons, reflecting the accumulation of REMs pressure. Inhibiting POAGAD2→TMN neurons during REMs restriction blocked the subsequent rebound of REMs. Our findings reveal a hypothalamic circuit whose activity mirrors the buildup of homeostatic REMs pressure during restriction and that is required for the ensuing rebound in REMs.

Homeostatic regulation of rapid eye movement sleep by the preoptic area of the hypothalamus

Rapid eye movement sleep (REMs) is characterized by activated electroencephalogram (EEG) and muscle atonia, accompanied by vivid dreams. REMs is homeostatically regulated, ensuring that any loss of REMs is compensated by a subsequent increase in its amount. However, the neural mechanisms underlying the homeostatic control of REMs are largely unknown. Here, we show that GABAergic neurons in the preoptic area of the hypothalamus projecting to the tuberomammillary nucleus (POAGAD2→TMN neurons) are crucial for the homeostatic regulation of REMs in mice. POAGAD2→TMN neurons are most active during REMs, and inhibiting them specifically decreases REMs. REMs restriction leads to an increased number and amplitude of calcium transients in POAGAD2→TMN neurons, reflecting the accumulation of REMs pressure. Inhibiting POAGAD2→TMN neurons during REMs restriction blocked the subsequent rebound of REMs. Our findings reveal a hypothalamic circuit whose activity mirrors the buildup of homeostatic REMs pressure during restriction and that is required for the ensuing rebound in REMs.

Between Reality and Imagination an in-depth Analysis of Dreams

Abstract: Dreams have intrigued and fascinated humans for centuries, serving as a unique window into the human mind.It revolves around understanding how thehuman mind navigates the complex interplay between the real world and imaginative constructs within the realm ofdreams. Dreams are a unique psychological phenomenon where individuals experience a wide array of scenarios, emotions, and situations that often blur the boundaries between what isreal and what is a product of the imagination. This research paper exploresthe multifaceted nature of dreams, aimingto delve into the biological, psychological, and cultural dimensions of this phenomenon. By examining the historicalsignificance, the science of dreaming, Freudian and Jungian dream theories, contemporary perspectives, and cultural variations, this study provides a comprehensive analysis of dreams and their importance in understanding humanconsciousness.

Driving while dreaming: oneiric automobility

This paper responds to the call made by mobilities scholars to deepen attention to imagination and imaginaries by proposing that oneiric experiences – nighttime dreams – be investigated as significant but under-examined artifacts of mobile cultures. Based on a long-term, ethnographically-informed study of the dreams of young adults in the US and grounded in both contemporary dream theory and the automobilities literature, I argue that dreams of car trouble serve to expose otherwise overlooked and taken-for-granted dimensions of waking-life automobility, automotive consciousness, and lifecourse transitions. Targeting two commonly seen themes within this subgenre of dreams – that of failed brakes and driving from the backseat – I argue that oneiric automobility draws on conceptual metaphors and waking-life automotive biographies. Such dreams, moreover, draw liberally from and comment on larger and often silenced dimensions of emerging automobility – the patterned processes and performances by which (usually young) adults habituate to their lives as drivers. Attention to the common experience of driving while dreaming, I argue, enhances efforts to theorize the multiple ontologies of mobile lifeways.

Personality Functioning Improvement during Psychotherapy Is Associated with an Enhanced Capacity for Affect Regulation in Dreams: A Preliminary Study.

Clinical case illustrations of patients with an impairment of personality functioning (IPF) have repeatedly reported that progress during psychotherapy is reflected by alterations in dream content. However, quantitative studies based on samples of psychotherapy patients are scarce. As a core component of both personality functioning and contemporary psychodynamic dream theory, the construct of affect regulation is of specific significance in this context. To test if improvement in personality functioning in the course of psychotherapy is associated with an increasing ability to regulate affects in dreams. In a longitudinal design, affect regulation was compared in N = 94 unsolicited dream reports from the first vs. last third of long term psychotherapy of ten patients with initial IPF. Dream reports were transcribed from recordings of the sessions. Expert ratings of the level of personality functioning were obtained using the Scales of Psychological Capacities. The capacity for affect regulation was assessed using the Zurich Dream Process Coding System. Group differences were assessed using linear mixed models, controlling for dream length as well as the nested structure of this data set. Patients demonstrated an increased capacity for affect regulation in dreams that was primarily evident in three core features: the complexity of dream elements (cf., e.g., parameter attributes, p = 0.024); the extent of affective involvement in the dream ego (cf., e.g., parameter subject feeling, p = 0.014); and the flexibility to regulate the dynamics of safety/involvement processes (p ≤ 0.001). This pattern was especially prominent in a subgroup (n = 7) of patients with more pronounced improvements in personality functioning. These findings support the hypotheses that decreasing IPF during psychotherapy is associated with increases in the capacity for affect regulation in dreams. Thus, researchers and therapists can utilize dream reports to illuminate the important aspects of treatment progress in clinical practice.

Genetic and phenotypic characterization of Parkinson’s disease at the clinic-wide level

Observational studies in Parkinson’s disease (PD) deeply characterize relatively small numbers of participants. The Molecular Integration in Neurological Diagnosis Initiative seeks to characterize molecular and clinical features of every PD patient at the University of Pennsylvania (UPenn). The objectives of this study are to determine the feasibility of genetic characterization in PD and assess clinical features by sex and GBA1/LRRK2 status on a clinic-wide scale. All PD patients with clinical visits at the UPenn PD Center between 9/2018 and 12/2022 were eligible. Blood or saliva were collected, and a clinical questionnaire administered. Genotyping at 14 GBA1 and 8 LRRK2 variants was performed. PD symptoms were compared by sex and gene groups. 2063 patients were approached and 1,689 (82%) were enrolled, with 374 (18%) declining to participate. 608 (36%) females were enrolled, 159 (9%) carried a GBA1 variant, and 44 (3%) carried a LRRK2 variant. Compared with males, females across gene groups more frequently reported dystonia (53% vs 46%, p = 0.01) and anxiety (64% vs 55%, p < 0.01), but less frequently reported cognitive impairment (10% vs 49%, p < 0.01) and vivid dreaming (53% vs 60%, p = 0.01). GBA1 variant carriers more frequently reported anxiety (67% vs 57%, p = 0.04) and depression (62% vs 46%, p < 0.01) than non-carriers; LRRK2 variant carriers did not differ from non-carriers. We report feasibility for near-clinic-wide enrollment and characterization of individuals with PD during clinical visits at a high-volume academic center. Clinical symptoms differ by sex and GBA1, but not LRRK2, status.

Charles Darwin: towards a bio-religious and colonial genealogy of evolutionary being

ABSTRACT While studies have examined Charles Darwin's wide social and political impact, they have not adequately centred the combined influence of colonial systems of human differentiation and religion within them. To address this, I draw from Sylvia Wynter's critique concerning how religious and colonial discourses contribute to the shifting development of Man within the Western tradition. Specifically, I explore how Darwin focused his evolutionary gaze towards one of the unique foundations of what it meant to be human in his time: religion. Tracing the entangled religious and colonial filiations of Darwin's thought, I show that he established an evolutionary link between human and non-human animals by proposing both Indigenous peoples and dogs held superstitious beliefs. To illustrate this, I show that Darwin transposed Victorian anthropological conceptions of religion - as a quantifiable object of knowledge corresponding to the intellect and associated with phrenology, dream theory and the apparitional soul - into a bio-religious conception of evolution. Furthermore, I argue that Darwin's bio-evolutionism assumes Christianity is most closely associated with abstract reason. Finally, analyzing the role of race in Darwin's thought, I suggest that theology is not what was before modern scientific bio-evolutionary conceptions of race, but at its very core.

Alcohol-Induced Psychosis: Beyond Korsakoff. Case report and Literature Review

IntroductionChronic consumption of alcohol has clear deleterious effects on the nervous system. Among its less-recognized consequences are subacute and chronic alcohol-induced psychotic disorders. Lasègue, Garnier, Magnan, and Michaux provided exhaustive clinical descriptions of different presentations of subacute alcoholic delusional disorder, while Kraepelin, Allamagny, and Neveu defined the characteristics of chronic alcoholic hallucinatory psychosis. Both conditions are characterized by the occurrence of hallucinations and vivid dream-like content in their delusions, along with potential emotional detachment from the symptoms. Presently, both conditions are categorized under the generic term ‘Alcohol-Induced Psychotic Disorder,’ with limited available scientific literature.ObjectivesOur goal is to bring attention to the existence of subacute and chronic alcohol-induced psychosis in individuals with long-term alcohol users.MethodsCase report using clinical records and a non-systematic literature review.ResultsA 63-year-old male, with a forty-year history of chronic alcoholism and no other prior mental health issues, was admitted in the emergency department. He conveyed vague delusional notions regarding his roommate and described vivid morning dreams in which he tried to communicate but couldn’t speak. This led him to believe his roommate harboured harmful intentions. Additionally, he mentioned that for the past two months, he had developed a telepathic connection with his sister and his deceased mother, with whom he felt he communicated without speaking. He described feeling strangement and anxiety concerning these experiences, which he firmly believed to be undeniably real. He reported being able to hear the voices of his mother and sister. He also described short-term memory problems dating back two years. He denied any other psychopathology and exhibited probable ideational and emotional impoverishment secondary to chronic alcohol consumption. Confirmation of the patient’s account was provided by his family members. The prescribed treatment included antipsychotic medication and a recommendation for alcohol abstinence.ConclusionsDescriptions of chronic and subacute alcohol-induced psychoses are found in early psychiatric textbooks but have been omitted from contemporary classifications. While their incidence is low among chronic alcohol users, they represent a severe clinical entity. These disorders are usually distinguished by the presence of delusions and vivid hallucinations characterized by dream-like content. This distinct symptomatology aids in the accurate differentiation from other psychotic disorders and clinicians should be aware of their existence.Disclosure of InterestNone Declared

The neuroscience of lucid dreaming: Past, present, future

Lucid dreaming allows conscious awareness and control of vivid dream states; however, its rarity and instability make neuroscientific experimentation challenging. Recent advances in wearable neurotechnology, large-scale collaborations, citizen neuroscience, and artificial intelligence increasingly facilitate the decoding of this intriguing phenomenon.

Potential Serotonin 5-HT2A Receptor Agonist of Psychoactive Components of Silene undulata Aiton: LC-MS/MS, ADMET, and Molecular Docking Studies.

Silene undulata is historically used for inducing vivid and prophetic lucid dreams, but limited information exists on its phytochemical composition and potential pharmacological properties. This study aimed to investigate the phytochemical composition of S. undulata through LC-MS/MS analysis and explore its potential serotonergic activity, which could support and confirm the traditional use of S. undulata as a dream-inducing plant. LC-MS/MS analysis was conducted on S. undulata extract, identifying 51 phytochemicals, including norharman, harmalol, harmaline, harmine, and ibogaine alkaloids. ADMET and Molecular docking investigations were employed to assess the serotonergic potential of these compounds. The analysis revealed the presence of β-carboline alkaloids, such as norharman, harmalol, harmaline, harmine, and ibogaine, within S. undulata extract. ADMET analysis showed that these compounds have a favourable pharmacokinetic properties. In addition, molecular docking investigations showed that harmaline (-8.90 Kcal/mol), harmalol (-8.56 Kcal/mol), and ibogaine (-8.75 Kcal/mol) exhibited binding affinities comparable to the control molecule, LSD (-9.14 Kcal/mol), indicating potential agonistic activity at serotonin 5-HT2A receptor. These findings provide insights into the potential therapeutic benefits of S. undulata, supporting its traditional use as a psychoactive plant. This study investigated the chemical constituents and potential serotonergic agonist activity of S. undulata for the first time. While promising, further research is necessary to uncover additional medicinal properties associated with the identified phytochemical components.

Psychology of dreams: justification and development of a synthetic approach

The object of the study is the mental reality of a personality, and the subject is its dream activity, which is considered in the context of a multilevel and multidimensional structure of personality as a system. Thus, the function of dream activity is considered through the prism of a dialogic (transcendental) function that allows consciousness to perceive mental facts beyond its boundaries, that is, to acquire the ability to metareflexion, combining the ontological and epistemological paradigms. It follows from this that the study touches on the "multi-dimensionality" of the personal structure, both on the surface and in the deep planes, combined in the space of a dream through conscious perception of symbols. It is proposed to combine the idea of the structure of the psyche according to S. Groff and an understanding of the specifics of the material manifested in specific dreams of a particular person. The research methodology is based on the idea of mental reality as a self-regulating system, within which dreams serve the inherent desire for integrity of the personality. The author uses the following methods: case studies, interpretation, analysis and synthesis, introspection and self-report. The article attempts to develop an integrative-synthetic theory of dreams based on the works of V.V. Kozlov, S.A. Parfentiev, V.V. Maikov and other modern authors working in the field of practical depth psychology. Based on the author's vision and generalization of many years of experience, the concept of seven "dimensions" (levels) is proposed for working with dream material for the purposes of psychological psychotherapy and personal development. The results of an experiment are presented, proving both the effectiveness of this algorithm and the scientific validity of understanding dreams as a multidimensional natural psychotherapeutic space, process and mechanism at the same time. In general, the work is very relevant from the point of view of both theory and practice, while being characterized by a certain scientific novelty.

Nightmares and Dreams on Progesterone: Trans* Embodiment and Intermedia

This essay theorizes the connection between trans* embodiment and intermedia, using historical intermedia practice and score-based creative practices by artists such as Yoko Ono, CA Conrad, Pauline Oliveros, Dick Higgins, and Allan Kaprow, as precedent. This paper describes foundational thought to my work as a trans* intermedia artist and serves as an introduction to Nightmare and Dreams on Progesterone: Action Art Scores for Trans Becoming; a text work of 150 poetic action art scores designed for, and birthed from, trans* becoming. Each score is generated from dream journal entries translated into instructions that complicate the art/life divide. As I began taking progesterone as part of my hormone replacement therapy, I started experiencing vivid dreaming as a side effect. As my body changed, so did my dreams. These dreams, from my own trans* subconscious and altered by transsexual action, often directly engage with my identity or arts practice as subject matter. When translated, the scores are written poetically and have a diverse range of abstraction, for example:&#x0D; Score #77: Fellowship&#x0D; Three queer people talk about visibility The most beautiful woman in costume makeup Takes several ladders to climb towards&#x0D; &#x0D; Score #58: Insane Clown Posse&#x0D; Come out to your family&#x0D; &#x0D; Score #69: Huge&#x0D; A trans woman Surrounded by other trans women All bathing&#x0D; I believe avant-garde art practices can be liberatory for trans* bodies and that this methodology and these performances have the potential to be instructional for other trans* people for coming into their identity. This introduction provides an intimate portrait of myself as an artist, including biographical information on my Hormone Replacement Therapy (HRT) journey and how it has affected my creative practice.

Результат комплексного подхода к диагностике и лечению коморбидного пациента: клинический случай

AIM. Show the feasibility and possibility of diagnosing and treating a comorbid patient (neurology, dentistry) MATERIAL AND METHODS. Clinical example of a patient with concomitant pathology; dynamic observation for 5 years. CASE PRESENTATION. A male patient has been observed in the clinic for 5 years. The positive dynamics of neurological and dental statuses as a result of therapeutic measures is shown. Undifferentiated connective tissue dysplasia was revealed, manifested by the following symptom complex: asthenic physique, Gothic palate, distal occlusion, ingrown earlobes, hypermobility of joints. Dynamic monitoring throughout the entire period of observation, diagnosis and treatment. In the neurological status, emotional and vegetative lability can be distinguished (the patient gets tired quickly, there is daytime drowsiness, there is a violation of concentration, and as a result, memory problems), sleep disturbance — insomnia. Manifested by difficulties falling asleep, frequent awakenings, restless sleep, with vivid dreams, as well as difficulties waking up (a symptom of sleep intoxication). RESULTS AND DISCUSSION. The dynamics and the result of the treatment process are presented using the example of a patient with comorbid pathology in the dental and jaw system. CONCLUSION. Patients with undifferentiated connective tissue dysplasia who have neurological and dental disorders should be observed as part of comorbid pathology, jointly by neurologists and dentists, to obtain successful results. KEYWORDS: emotional disorders, distal occlusion, sagittal fissure, connective tissue dysplasia, clinic, diagnosis, treatment