Endophthalmitis Vitrectomy Research Articles

LUARAN VISUAL ANTARA VITREKTOMI YANG DILAKUKAN SECARA DINI DAN TERTUNDA PADA PASIEN ENDOFTALMITIS YANG DIOPERASI DI RUMAH SAKIT KARIADI SEMARANG : STUDI DESKRIPTIF SELAMA DUA TAHUN

Introduction : Endophthalmitis is a medical emergency caused by infection of tissue or fluids inside the eyeball. Vitrectomy for endophthalmitis is one of the treatment choice and leads to VA gains in some cases. Timing of surgery and visual outcome after surgery are vital to acknowledge. This study aims to analyze the difference of visual outcome between early and delayed vitrectomy in endophthalmitis patients operated in Dr. Kariadi General Hospital Methods : A Retrospective study held from medical record of patients with endophthalmitis underwent vitrectomy surgery from January 2021 – January 2023 in Dr. Kariadi General Hospital, Semarang. Endophthalmitis patients caused by trauma were excluded. All of the patients had immediate vitrectomy, and based on the onset, the patients were divided into two groups, early vitrectomy (onset ? 7 days) and delayed vitrectomy (onset > 7 days). Independent t- test method was used to analyze the data (significant if p<0.05) Result : Totally 30 endophthalmitis patients (30 eyes) were obtained. There were 18 patients (60%) had early vitrectomy and 12 patients (40%) had delayed vitrectomy. Postoperative examination showed 13 (72%) patients with early vitrectomy had improved VA, and 5 (28%) had constant VA. On the other hand, patients with delayed vitrectomy showed 5 (42%) had improved VA, 6 (50%) had constant VA, and 1 (8%) had decreased VA. The difference between two groups was significant (p=0.014) Conclusion : This study found endophthalmitis patients with early vitrectomy had significant better visual outcome than delayed vitrectomy.

Treatment of long-term endophthalmitis developing after intraocular lens implantation in children: a retrospective study

BackgroundTo discussed the risk factor and the management of vitrectomy for long-term endophthalmitis developing after intraocular lens (IOL) implantation in children.MethodsWe retrospectively investigated the clinical characteristics and surgical outcomes of long-term endophthalmitis developing after IOL implantation in children.ResultsFour eyes of four children were included in the study. The mean time to endophthalmitis development after IOL implantation was 3.0 ± 0.8 years. The corneal or scleral sutures may have been caused the infection. All 4 patients underwent vitrectomy and received intravitreal antibiotics with or without IOL removal. At the last follow-up, the outcomes were satisfactory; the fundus was clear, the retina remained attached, the visual acuity improved, and there were no severe complications.ConclusionsThe use of scleral sutures and the exposure of conceal sutures may induce the onset of long-term endophthalmitis after IOL implantation. Complete vitrectomy and appropriate use of antibiotics are effective in the treatment of long-term endophthalmitis developing after IOL implantation in children.

PARS PLANA VITRECTOMY IN POST-CATARACT SURGERY ENDOPHTHALMITIS IN CIPTO MANGUNKUSOMO HOSPITAL

Background: Endophthalmitis is one of the emergencies in ophthalmology and can cause blindness. The most common cause of endophthalmitis in intraocular surgery is cataract surgery. Immediate diagnosis and treatment can provide optimal final vision. This research aimed to describe the demographic data, and causative microorganisms, as well as the success rate of visual outcome after pars plana vitrectomy (PPV) in post-cataract surgery endophthalmitis in Cipto Mangunkusumo Hospital.
 Methods: A retrospective descriptive study of post-cataract surgery endophthalmitis underwent vitrectomy in Cipto Mangunkusumo Hospital, Indonesia, from January 2017 - June 2017.
 Results: There were twenty one cases of post-cataract surgery endophthalmitis undergoes PPV within the period of January 2017-June 2017. The most frequently identified causative microorganism was Staphylococcus (23%). There was an improvement of visual acuity after PPV procedure in 47,6% post-cataract surgery endophthalmitis.
 Conclusion: Immediate PPV is an effective treatment and leads to vision improvement in post-cataract surgery endophthalmitis.
 
 Keywords: pars plana vitrectomy, endophthalmitis, cataract surgery

Klebsiella Cluster Endophthalmitis following Intravitreal Bevacizumab: Role of Early Detection, Pars Plana Vitrectomy, and Intracameral Moxifloxacin

ABSTRACT Aim To report the clinical profile, outcomes of early vitrectomy for cluster endophthalmitis developing after intravitreal Bevacizumab (IVB), and discuss the role of prophylactic intracameral moxifloxacin for eyes undergoing combined cataract surgery with IVB. Methods Single center, retrospective analysis of 35 consecutive eyes developing post-IVB inflammation. Results Of the 35 eyes that were administered IVB (27 eyes ‘IVB alone’ and 8 eyes ‘IVB with cataract surgery’). Endophthalmitis developed in 28 eyes, 6 eyes were managed with Intravitreal antibiotic (IVAB) alone, while 22 eyes required early vitrectomy. Only one eye undergoing a combined phacoemulsification with IVB developed endophthalmitis. Majority(26/28) of the eyes achieved visual acuity equal to/greater than pre-IVB injection vision over a period of 3.15 ± 3.2 months. Conclusion Early detection and prompt PPV were effectual for achieving good functional outcomes in our cluster of post-IVB Klebsiella endophthalmitis. Intracameral moxifloxacin was protective in cases undergoing combined cataract surgery with IVB.

Vitrectomy for endophthalmitis: 5-year study of outcomes and complications

Background/AimsTo analyse the complications and outcomes of vitrectomy surgery for endophthalmitis.MethodsThis was a retrospective case series. All cases that underwent 23-gauge vitrectomy surgery for endophthalmitis at a tertiary centre between...

Does ophthalmic-grade silicone oil possess antimicrobial properties?

PurposeTo test the antimicrobial properties of silicon oil (Aurosil 1000 cSt, Aurosil Plus 5000 cSt) on in vitro growth of common microorganisms causing endophthalmitis.Materials and methodsStaphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, multi-drug resistant (MDR) strain of Klebsiella pneumoniae, Escherichia coli, Candida albicans, and Aspergillus flavus were prepared to 0.5 McFarland turbidity. The bacteria and fungi were inoculated into the silicone oils, brain heart infusion (BHI) broth for bacteria and Sabouraud dextrose agar (SDA) broth for fungi, respectively, and cultured aerobically for 30 days. From each sample, 10 μl was plated onto nutrient agar and potato dextrose agar (PDA) for testing growth of bacteria and fungi respectively. Cultures from specimens, overnight incubation, and CFU counting were repeated on days 1, 3, 5, 7, 14, 21, 24, and 30. Negative controls were brain heart infusion and physiologic saline as well as silicone oils without any inoculations.ResultsAll bacteria showed a decrease in CFUs by the fifth day and eliminated between 21 and 30 days in silicone oil. The silicon oil, irrespective of its viscosity, had only fungistatic effect up to 30 days. Colony-forming units of microorganisms remained stable in physiologic saline during the study. In BHI and Sabouraud broth, both bacteria and fungi showed a growth pattern that was compatible with the growth curve of microorganisms.ConclusionMedical-grade silicone oil used in ophthalmology exhibited in vitro bactericidal and fungistatic activity over 30 days. Insertion of silicone oil in vitrectomy for endophthalmitis, when required, could supplement the antimicrobial activities of intravitreal antibiotics in management of endophthalmitis.

Antivascular Endothelial Growth Factor Treatment Might Be Continued Even After Vitrectomy for Endophthalmitis in Neovascular Age-Related Macular Degeneration.

This article studies visual outcome and frequency of antivascular endothelial growth factor (anti-VEGF) injections continued in patients with neovascular age-related macular degeneration (AMD) who had an earlier vitrectomy for postinjection endophthalmitis. A retrospective interventional study was conducted reviewing our database for patients with a diagnosis of endophthalmitis in the course of anti-VEGF injections. Endophthalmitis diagnosis was made on clinical examination of pain, rapid decrease in visual acuity (VA), conjunctival hyperemia, hypopyon, and vitritis. In all eyes, core vitrectomy with intravitreal antibiotics was performed. Spectral-domain optical coherence tomography was performed monthly before and after surgery during follow-up. Anti-VEGF injections were continued after surgery in all cases. Eight eyes with postinjection endophthalmitis were included. Mean VA immediately before endophthalmitis was 20/50 Snellen with a mean of 19 intravitreal anti-VEGF injections (P = .45). At time of endophthalmitis diagnosis, mean VA was 20/1000 (range, 20/2000-20/200). Mean time from injection to when the patient noted first symptoms was 4.3 days (range, 1-8 days). Mean time from first symptoms to surgery was 12 hours (range, 2.5-26 hours). Final mean VA at the end of follow-up (range, 12-84 months) did not statistically differ from VA at the visit immediately before endophthalmitis diagnosis (P = .69). Mean frequency of injections after vitrectomy did not significantly differ from the presurgical course of treatment (P =.97). Anti-VEGF treatment might be continued after vitrectomy for endophthalmitis and results in satisfactory anatomical and visual outcome. Surgery did not influence the frequency of anti-VEGF injections for neovascular AMD.

Efficacy of 23-gauge minimally invasive vitrectomy for exogenous endophthalmitis

Objective To analyze the efficacy of 23 G minimally invasive vitrectomy for exogenous endophthalmitis. Methods A retrospective case series study. The data of 105 eyes of 105 patients with exogenous infectious endophthalmitis from May 2008 to May 2016 were analyzed. All cases received local and systemic sufficient antibiotics treatment, intravitreal injection or 23 G minimally invasive vitrectomy. Follow-up time was 1-6 months after treatment. The efficacy and complications of 23 G vitrectomy were analyzed. Results Among 105 cases, endophthalmitis were cured in 97 cases(92.38%), in which vitrectomy combined with antibiotics adjuvant therapy were received in 57 cases, accounting for 54.29%. No iatrogenic retinal tear occurred. At the end of follow-up, BCVA were improved after surgery, the difference was statistically significant between before and after surgery(P 0.05). Conclusion The 23-gauge minimally invasive vitrectomy is safe and effective for exogenous endophthalmitis. Key words: Endophthalmitis , exogenous; Vitrectomy, minimally invasive

Hybrid 20/23-G pars plana vitrectomy in endophthalmitis and trauma: a strategic approach.

To assess the safety and efficacy of hybrid vitreous surgery combining active 23-G ports with a sutured 20-G 6-mm infusion cannula for performing vitrectomy in endophthalmitis and trauma. This is a retrospective analysis of 10 eyes with endophthalmitis and 10 eyes with trauma requiring vitreous surgery, having corneal clarity suitable for vitrectomy and best-corrected visual acuity (BCVA) greater than or equal to light perception. All patients underwent hybrid 20/23-G vitrectomy. Intraoperative notes were analyzed for peroperative complications. The BCVA and retinal status at 3 months were analyzed. In the endophthalmitis group, patients ranged from 5 to 85 years of age and showed varied etiologies. Retinal detachment was present in 5 eyes, which received silicone oil tamponade. Mean preoperative logMAR visual acuity (VA) was 2.29 ± 0.45, which improved to 1.10 ± 0.72 at 3 months postoperatively (p<0.001). Trauma cases ranged from 21 to 75 years of age. Retinal detachment was present in 9 out of 10 eyes, all of which received silicone oil tamponade. Preoperative logMAR VA was 2.26 ± 0.71, which improved to 1.33 ± 0.50 postoperatively (p<0.001). At 3 months postsurgery, the retina was attached in all eyes in both groups. The longer sutured 20-G cannula was easier to visualize through fibrin, exudates, and hemorrhage and did not slip out or enter the suprachoroidal space in any of our cases. The 23-G active ports and vitrectomy cutter enhanced safety and efficacy. Hybrid vitrectomy enabled safe surgery in these difficult cases.

Clinical effect of vitrectomy for the treatment of traumatic suppurative endophthalmitis

Objective To evaluate the clinical effects of vitrectomy for the treatment of traumatic suppurative endophthalmitis due to ocular penetrating injury. Methods The clinical effects of vitrectomy for traumatic suppurative endophthalmitis of 16 eyes of 16 cases from March 2012 to June 2014 were retrospectively analyzed. Results The intraocular infection was controlled and the eyeballs were successfully saved in all 16 cases. The visual acuities were improved at varied degrees in 14 cases(87.50%), and the best visual acuity got up to 0.8, and that of 2 eyes had no change. Conclusion Vitrectomy can effectively control the traumatic suppurative endophthalmitis, can save the eyeballs and maintain the visual functions. Key words: Endophthalmitis, suppurative, traumatic; Ocular penetrating injury; Vitrectomy; Effect, clinical

Comparison of microbiology and visual outcomes of patients undergoing small-gauge and 20-gauge vitrectomy for endophthalmitis.

BackgroundThe role of pars plana vitrectomy (PPV) for endophthalmitis has evolved over recent decades but the literature is lacking on comparisons between small-gauge and 20-gauge vitrectomy.ObjectiveTo evaluate evolving etiological and microbiological trends in patients undergoing vitrectomy for endophthalmitis and to compare culture-positive rates and visual outcomes between small-gauge (23- and 25-gauge) and 20-gauge instrumentation during vitrectomy for endophthalmitis.MethodsTen-year retrospective comparative case series and prospective laboratory in vitro testing. Tertiary care academic referral center. Patients who underwent PPV for endophthalmitis between 2003 and 2013. Vitreous biopsies were obtained in all cases. The effect of vitrectomy gauge (20-, 23-, and 25-gauge) and vitreous cutting rate (1,500 and 5,000 cuts per minute) on the viability of bacterial culture was evaluated in an in vitro prospective laboratory investigation.Main outcome measuresComparison of etiology, microbiology culture-positive rates, and visual outcomes between small-gauge and 20-gauge instrumentation in patients undergoing PPV for infectious endophthalmitis.ResultsA total of 61 cases of vitrectomy for endophthalmitis were identified over a 10-year period; of these, 34 were treated with small-gauge (23- and 25-gauge) vitrectomy and 27 were treated with 20-gauge vitrectomy. In the small-gauge group, 12 cases (35.3%) yielded culture-positive results versus 20 cases (74.1%) with culture positivity in the 20-gauge cohort (P=0.002). The most common cause of endophthalmitis was cataract surgery and the most frequently identified organism was coagulase-negative Staphylococci in both groups. There was no significant difference in mean postoperative visual acuities between groups (P=0.33). Etiological trends indicate an increase in endophthalmitis due to intravitreal injection in the small-gauge group (n=9) compared to the 20-gauge group (n=3) (P=0.001). In vitro laboratory testing revealed no significant difference in rates of culture growth for different vitrectomy gauge sizes or vitreous cutting speeds.Conclusion and relevanceSmall-gauge vitrectomy for endophthalmitis yields final visual outcomes comparable to 20-gauge instrumentation. A significant difference in culture-positive rates was observed between small-gauge and 20-gauge instrumentation for vitrectomy in endophthalmitis; however, laboratory testing indicates this is not related to either vitreous gauge size or cutter speed. Intravitreal injections are emerging as a common etiology of vitrectomy for endophthalmitis.

Clinical analysis of 23-gauge vitrectomy for the treatment of acute endophthalmitis after cataract surgery.

We performed a retrospective study to evaluate the surgical efficacy and timing of 23-G vitrectomy for acute endophthalmitis following cataract surgery, and to determine when silicone oil tamponade and intraocular lens (IOL) removal are indicated during vitrectomy for endophthalmitis. We enrolled 21 patients (21 eyes) diagnosed with acute endophthalmitis following cataract surgery who underwent endoscope-assisted 23-G vitrectomy using a wide-angle noncontact lens. Silicone oil tamponade was performed when retinal tear or detachment occurred. The IOL was not removed during primary vitrectomy. Postoperative systemic broad-spectrum antibiotics were used. All infections were controlled by treatment. Best-corrected visual acuity was &gt;0.05 in 14 patients (66.7%) after treatment, which was significantly higher than that before treatment (2/21, 9.5%). Two patients experienced retinal detachment at 10 and 14 days after primary vitrectomy; the IOL was removed during secondary surgery, and silicone oil tamponade was performed. One patient experienced endophthalmitis recurrence 2 months after vitrectomy; secondary surgery was performed to remove the peripheral vitreous body, the pars plana of the ciliary body, and the IOL and capsule. Vitrectomy should be performed when acute endophthalmitis is diagnosed following cataract surgery. Silicone oil tamponade should be performed only when retinal break or detachment occurs. The IOL does not necessarily require removal.

Vitreoretinal Complications and Vitreoretinal Surgery in Osteo-Odonto-Keratoprosthesis Surgery

To describe the indications for and approaches to vitreoretinal surgery in patients with osteo-odonto-keratoprosthesis (OOKP). Retrospective case series. This was a retrospective review of all patients who had undergone OOKP surgery between 2003 and 2012 at our center. OOKP procedures were performed for severe ocular surface disease according to the indications and techniques described in the patient demographics of the Rome-Vienna Protocol. Indications for retinal surgery, surgical outcomes, and intraoperative and postoperative complications were documented. Operative techniques were reviewed from the surgical records, and any subsequent surgeries were also recorded. Thirty-six patients underwent OOKP, and retinal surgery was indicated in 13 (36%). The indications for and approaches to surgery were retinal detachment repair using an Eckardt temporary keratoprosthesis; assessment of retina and optic nerve health prior to OOKP surgery, using either a temporary keratoprosthesis or an endoscope; endoscopic cyclophotocoagulation for intractable glaucoma; endoscopic trimming of a retroprosthetic membrane; or vitrectomy for endophthalmitis with visualization through the OOKP optic using the binocular indirect viewing system. In all cases, retinal surgical aims were achieved with a single procedure. Postoperative vitreous hemorrhage occurred in 16 patients (44%), but all resolved spontaneously. OOKPs represent the last hope for restoration of vision in severe ocular surface disease, and the retinal surgeon is frequently called upon in the assessment and management of these patients. Temporary keratoprostheses and endoscopic vitrectomies are valuable surgical tools in these challenging cases, improving functional outcomes without compromising OOKP success.

Vitrectomy for treating traumatic endophthalmitis in children

Objective To study the therapeutic effect and the operation time of vitrectomy for traumatic endophthatmitis in children.Methods The traumatic causes,traumatic objects,visiting time,clinical findings,treatment and effects were retrospectively analyzed for 17 eyes of 17 cases.Results 4 cases were treated with drug injection into the vitreous cavity only.13 cases were treated with vitrectomy (2 cases were treated by vitrectomy and silicone oil tamponade.1 cases were treated by vitrectomy and C3 F8 tamponade.10 cases were treated by vitrectomy,lensectomy and silicone oil tamponade.) The visual acuity was improved in 9 eyes(52.94％).Visual acuity of 5 eyes (29.41％) did not change,while visual acuity of 3 eyes (17.65％) decreased.Conclusion As for the clinic features of endophthalmitis in children,Vitrectomy combined with sensitive antibiotics is the effective method to control traumatic endophthalmatis.The lens could be reserved only in cases of slight symptom. Key words: Children; Endophthalmitis,traumatic; Vitrectomy; Drugs injection,intravitreal

Bibliometric analysis of vitrectomy based on web of science database

Objective To learn the distribution pattern and worldwide research tendency of vitrectomy literatures.Methods Articles were searched from American Institute of Scientific Information (ISI) online database of web of science (WOS) database as a data source,to analyze the age distribution,national and regional,funding agency and citation of the vitrectomy literatures included during the year of 1971 - 2011.The analysis software BibExcel and SPSS 19.0 were used to cluster high-frequency of them.Results Totally 8540 literatures were included, the numbers of them were gradually increased since 1971,significantly after 1991.The literatures were mainly in English,the literatures of our country capacity ranked 6th; funded institutions in all article,the National Natural Science Foundation of China ranked No.5.Citation gradually increased since 1991,increased significantly after 2004.There were 50 highfrequency subjects,and hot topics were clustered into 6 categories which including vitrectomy for diseases of macula lutea,new techniques and complication of vitrectomy,medical treatment and surgical therapy of diabetic retinopathy,vitrectomy for endophthalmitis caused by cataract surgery,intraocular injection and eye injury.Conclusions There is a growing trend on the research of vitrectomy. The hot topics include vitrectomy for diseases of macula lutea,new techniques and complication of vitrectomy.It may provide references for the scholars in scientific research and clinical studies. Key words: Vitrectomy/statistics & numerical data; Vitrectomy/trends; Bibliometrics; Cluster analysis

Colletotrichum truncatum: an Unusual Pathogen Causing Mycotic Keratitis and Endophthalmitis

In recent years, the well-known plant pathogens of the Colletotrichum genus were increasingly reported to cause ophthalmic infections in humans. Among 66 species in the Colletotrichum genus, only a few are known to be pathogenic for humans. We report here five cases of ophthalmic infections due to Colletotrichum truncatum, a species never reported earlier to cause human infection. The isolates were identified by morphological characteristics and the sequencing of internal spacer regions of ribosomal DNA. The progress of lesions in those patients was slow compared to that of lesions caused by Aspergillus or Fusarium infections. The surgical management included total penetrating keratoplasty in patients with keratitis and pars plana vitrectomy in endophthalmitis. Two patients were treated additionally with intravitreal amphotericin B deoxycholate, one patient with oral itraconazole, and another patient with oral and topical fluconazole therapy. The present series therefore highlights the expanding spectrum of agents causing eye infections and the inclusion of C. truncatum as a human pathogen.

Regression of choroidal neovascularization after vitrectomy for postinjection endophthalmitis.

To report regression of choroidal neovascularization following vitrectomy for endophthalmitis after antivascular endothelial growth factor injections. Observational case series of two patients with exudative age-related macular degeneration. Endophthalmitis developed 2 days after the fourth ranibizumab injection in 1 case and 1 day after the ninth bevacizumab injection in another case. Vitrectomy and intravitreal antibiotic injections were performed. There was no bacterial growth on the cultures. Postoperative fluorescein angiography and combined optical coherence tomography/scanning laser ophthalmoscopy showed regression of choroidal neovascularization that was sustained after 29 and 32 months follow-up. In both patients with active exudative age-related macular degeneration, regression of choroidal new vessels occurred after vitrectomy and injection of intravitreal antibiotics for the treatment of endophthalmitis. Removal of the posterior vitreous during vitrectomy may have eliminated the contribution of vitreous to exudative age-related macular degeneration and choroidal neovascularization.

Comparative outcomes of pars plana vitrectomy in acute postoperative endophthalmitis with 25-gauge and 20-gauge techniques

To evaluate the safety and outcomes of 25-gauge pars plana vitrectomy (PPV) in the treatment of postoperative endophthalmitis and compare it with 20-gauge PPV. The medical records of all patients diagnosed with acute endophthalmitis following cataract surgery who underwent PPV between December 2000 and December 2007 were reviewed. Main outcome measures included final visual acuity (VA), additional interventions, and both intraoperative and postoperative complications. Records of 70 eyes of 70 patients with a condition diagnosed as postoperative endophthalmitis were evaluated. Fifty-eight eyes underwent 20-gauge PPV (group 1), and 12 eyes underwent 25-gauge PPV (group 2). Mean follow-up time for group 1 was 9.6 +/- 8.8 months, and for group 2, 7.9 +/- 12.7 months (P = 0.57). Median VA at presentation was hand motion in both groups. The differences between the two groups in frequencies of visual outcome levels of 20/800 and 20/100 were significant in favor of group 2 (20/800, P = 0.006; 20/100, P = 0.01). In group 2, fewer additional interventions were required, and postoperative complications tended to be less frequent. Twenty-five-gauge PPV seems to be safe and effective in the management of postoperative endophthalmitis. This sutureless technique may have some advantages over 20-gauge surgery, but controlled studies are needed to confirm the results.

Sympathetic Ophthalmia Following Vitrectomy for Endophthalmitis After Intravitreal Bevacizumab

Purpose: To describe a case of sympathetic ophthalmia following vitrectomy for endophthalmitis after an intravitreal injection of bevacizumab. Design: Retrospective case report. Methods: An 84-year-old male developed sympathetic ophthalmia 4 months after vitrectomy for endophthalmitis following an intravitreal injection. The inciting blind eye was enucleated. Results: Histopathology demonstrated sympathetic ophthalmia and phacoanaphylactic endophthalmitis. Visual acuity improved from 20/200 to 20/30 in the sympathizing eye with a combination of oral prednisone and azathioprine. Conclusions: Sympathetic ophthalmia can develop following exogenous endophthalmitis but has a good visual prognosis with appropriate treatment.

ONE-PORT 25-GAUGE PARS PLANA VITRECTOMY WITH INDIRECT OPHTHALMOSCOPY FOR TREATMENT OF ENDOPHTHALMITIS

To describe the technique and outcome of one-port transconjunctival 25-gauge core vitrectomy with indirect ophthalmoscopy in endophthalmitis. The charts of 7 patients (7 eyes) who underwent 25-gauge vitrectomy with indirect ophthalmoscopy for postoperative endophthalmitis were retrospectively reviewed. Visual outcomes, intraoperative and postoperative complications, and culture results were documented. Visual acuity improved from a mean of light perception before surgery to 20/100 (range, 20/25 to 20/200) at a mean follow-up of 24 weeks (range, 12-52 weeks). There were no operative or postoperative complications, except rhegmatogenous retinal detachment in one eye. One-port 25-gauge pars plana vitrectomy with indirect ophthalmoscopy is both safe and practical for core vitrectomy in endophthalmitis.