Vital Side Effects Research Articles

Levetiracetam "Narrative Review of Neuropsychiatric Issues"

Introduction
 Levetiracetam, an anti-epileptic drug, is usually used as an adjunctive treatment of partial-onset seizures with or without secondary generalization. In this article, various neuropsychiatric effects of Levetiracetam are investigated.
 Methods
 The following databases were searched: PUBMED, Google Scholar, MEDLINE, Embase, ProQuest, and Science Direct. The articles searched in the mentioned databases were from 2003 to 2021. Ninety-nine articles were selected, fifteen articles such as case reports and letters to the editor were removed due to low scientific credibility, and eighty-four articles were selected. Due to the small number of articles, articles in the form of case reports and letters to the editor were also used to write about mania.
 Results
 Case reports showed that some cases of behavioral disorders, aggression, and depression had been observed following the use of Levetiracetam. In this study, various evidence were collected to determine the performance of Levetiracetam and to what extent it can have important and vital side effects. This drug can strengthen suicidal thoughts and aggression in consuming patients, especially the patients with other underlying diseases.
 Conclusion
 According to the side effects mentioned for Levetiracetam, it is suggested that psychiatrists and neurologists pay more attention to these side effects when prescribing.

Preparation of magnetic nanoparticle integrated nanostructured lipid carriers for controlled delivery of ascorbyl palmitate

Most cancer treatments can cause vital side effects on healthy tissues. Ascorbic acid (AA) is a water-soluble antioxidant molecule and possesses a variety of functions such as prevention of tumor proliferation and treatment of cancer. However, AA, is very sensitive to air, heat and light. Its high hydrophilicity also makes the controlled delivery difficult. To overcome these problems, AA can be chemically-modified and made more hydrophobic by the esterification. Palmitic acid is one of the most common long-chain fatty acids that can be used for this purpose. It is known that Ascorbyl palmitate (AP) which is a lipopihilic derivative of AA, can inhibit cell proliferation and DNA synthesis in many types of cancer. Although AP has higher stability, its bioavailability and therapeutic effect is low due to its lipophilicity and low release capacity.•In this study, nanostructured lipid carriers (NLC) which are colloidal nanoparticles with high biocompatibility, low crystallinity and high hydrophobic-drug encapsulation capacity was prepared to increase the bioavailability of AP.•To provide triggered drug release via hyperthermia, magnetic nanoparticles (MNps) were integrated into the NLCs besides AP.•The synthesis of biocompatible NLCs with controlled and triggered release ability, is successfully completed and controlled release of AP as an antitumor agent is achieved.

IMPORTANCE OF HERBAL ANTI-HYPERLIPIDEMICS IN CARDIAC DISORDERS AND HYPERGLYCAEMIA

In recent years, herbal remedies have evolved with enormous impending of alleviate. Â Herbal medicine progress against the non-communicable disease like diabetes is one of the propel area of research in the field of worldwide medicine. Hyperlipidemia is a disorder of lipid metabolism manifested by increase of plasma concentrations of the assortment of lipid and lipoprotein fractions. Hyperlipidemia has been one of the maximum risk factors contributing to the occurrence and relentlessness of coronary heart diseases. HMG Co A reductase is a key enzyme involving in rate limiting step of cholesterol biosynthesis. Conservative anti-hyperlipidemic drugs have restricted efficacies and vital side effects, so that alternative lipid lowering agents are required. This review explains the plants possessing significant anti-hyperlipidemic activity with their botanical name, family, part used, extract used and inducing agent of hyperlipidemia Keywords: Herbal sources, Coronary heart diseases, Anti-hyperlipidemic activity, HMG Co A reductase