ABSTRACT Previous studies have identified vital urban spaces through the concentration of people, the diversity of land uses and buildings, accessibility, and the existence of a compact urban fabric. However, the relationship between urban vitality and social sustainability has not been studied in these terms. This paper seeks to analyse the social implications of the vital city model for residents in the context of a Latin American city: Santiago de Chile. To do so, we use the JANE index to measure the formal conditions of the built environment for urban vitality, and the Longitudinal Social Study of Chile to measure urban social sustainability. We first use a PCA technique to reveal six core components of urban social sustainability: Sense of belonging, Safety, Sociability, Well-being, Satisfaction with housing, and Conservation of the neighbourhood. We then test the associations between the strength of these six core components and the conditions for urban vitality by means of a multiple linear regression model. Significant associations between urban vitality conditions and urban social sustainability suggest that socially sustainable neighbourhoods are found in sectors with the presence of old buildings, accessibility to public transportation, and far from mega infrastructures.