Purpose. To compare visual and clinical outcomes of wavefront-guided VISX CustomVue (VISX, Santa Clara, CA) LASIK and conventional LASIK. Methods. This study retrospectively evaluated 130 eyes of 65 patients, including 40 eyes of 20 patients in the CustomVue group and 90 eyes of 45 patients in conventional LASIK group. Uncorrected distance visual acuity (UDVA), corrected distance visual acuity, and refractive error were measured. Higher-order aberration (HOA) were measured by WaveScan system using a Hartmann-Shack sensor as their root mean square values (RMS HO), and individual Zernike coefficients of 3rd to 4th order before and 1 year after the surgery and compared using Mann-Whitney test or Student's t-test. Results. There was no significant difference in spherical equivalent between the groups. CV eyes showed superiority in number of eyes seeing 20/20 or better. RMS HO was less in CV group than that induced by conventional LASIK (0.37 ± 0.15 µm and 0.62 ± 0.26 µm, respectively). Preoperative mean RMS HO more than 0.3 µm was associated with a decrease in postoperative HOA in CV group. CV system induced significantly less spherical aberration (0.149 ± 0.157 µm and 0.364 ± 0.284 µm, respectively, р < 0,002). Conclusions. CustomVue seems to have better uncorrected visual acuity outcomes. It generally increases HOA, but statistically significant by less, compared with conventional LASIK. The most benefits have patients with RMS HO higher than 03 µm. Key words: CustomVue, conventional LASIK, wavefront-guided LASIK.