Visuospatial Span Research Articles

Association between social networks and cognition among middle-aged and older adults in rural India.

Prior studies using global cognitive measures have shown that social connectedness is linked with cognitive performance. We investigate the role of different social network dimensions on performance across distinct cognitive domains among dementia-free middle-aged and older rural Indians. We utilized baseline assessment data of 2,525 participants (≥45 years) of an ongoing, prospective, aging cohort in rural India (Srinivaspura Aging, Neuro Senescence, and COGnition) for this study. We evaluated social networks using Cohen's Social Network Index on three dimensions: network diversity, network size, and network embeddedness. We measured cognitive performance on memory (narrative recall), visuospatial ability (geometric figure spatial recognition, visuospatial span), language (verbal fluency, semantic association, word comprehension, reading comprehension), and attention domains of a culturally adapted, computerized, neurocognitive test battery. Linear regression models, adjusted for age and sex, were used for statistical analysis. In the linear regression model adjusted for age and sex, we found that greater network diversity was significantly associated with better performance in narrative recall, geometric figure spatial recognition, reading comprehension, semantic association, and attention tests. Participants with a larger network size had significantly better performance in verbal fluency and semantic association tests. Further, participants with greater network embeddedness had better visuospatial span and verbal fluency. Individuals having a greater network diversity, larger network size, and greater network embeddedness had better cognitive performance in multiple distinct cognitive domains. Following up these participants with serial cognitive monitoring can help understand if social networks play a role in delaying cognitive decline and protecting against dementia. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Executive functions and processing speed in covert cerebral small vessel disease.

Executive dysfunction and slowed processing speed are central cognitive impairments in cerebral small vessel disease (cSVD). It is unclear whether the subcomponents of executive functions become equally affected and whether computerized tests are more sensitive in detecting early cognitive changes over traditional tests. The associations of specific executive abilities (cognitive flexibility, inhibitory control, working memory) and processing speed with white matter hyperintensities (WMHs) and Instrumental Activities of Daily Living (IADL) were examined. In the Helsinki Small Vessel Disease Study, 152 older individuals without stroke or dementia were assessed with brain magnetic resonance imaging and comprehensive neuropsychological evaluation. WMH volumes were obtained with automated segmentation. Executive functions and processing speed measures included established paper-and-pencil tests and the computer-based Flexible Attention Test (FAT), Simon task and Sustained Attention to Response Task. White matter hyperintensity volume and IADL were associated with multiple cognitive measures across subdomains independently of demographic factors. The highest effect sizes were observed for FAT numbers and number-letter tasks (tablet modifications from the Trail Making Test), FAT visuospatial span, Simon task and semantic verbal fluency. Some of the widely used tests such as Stroop inhibition, phonemic fluency and digit span were not significantly associated with either WMHs or IADL. Processing speed and executive function subcomponents are broadly related to functional abilities and WMH severity in covert cSVD, but the strength of associations within subdomains is heavily dependent on the assessment method. Digital tests providing precise measures of reaction times and response accuracy seem to outperform many of the conventional paper-and-pencil tests.

Forward versus backward recall: Modality testing

Objectives One of the most frequently applied paradigms in the clinical and experimental fields for assessing working memory is the simple span task, composed of forward and backward recall conditions. However, the utility of the simple span measures and their relation to working memory modalities has yet to be elucidated. The current study aimed to address which of the span measures is more sensitive to the differentiation between forward and backward recall in the tactile, verbal, and visuo-spatial modalities, and to test if working memory modalities differ in the disparity between the two conditions. Methods 134 healthy young adults performed the Tactual, Digit, and Visuo-spatial Span tasks, producing Total Correct scores and Longest Sequence score measures. Results There was an interaction effect for condition and modality type, showing better performance for the forward compared to the backward recall in both measures. However, the effect size of the Longest Sequence score was significantly higher than the Total Correct score in all tasks. Furthermore, the Visuo-spatial Span exhibited a larger difference between forward and backward recall compared to the Digit and Tactual Span, whereas no difference was found between the latter two. Conclusions Forward and backward recall are distinguished in all three modalities, and the Longest Sequence score is more sensitive to differentiate between storage and manipulation components of working memory than the Total Correct score. Additionally, the cognitive demand imposed by manipulation compared to storage is the greatest in the visuo-spatial modality.

An immersive virtual reality-based object-location memory task reveals spatial long-term memory alterations in Long-COVID

Object-location memory (OLM) is a type of declarative memory for spatial information and consists of the individual's ability to establish accurate associations between objects and their spatial locations. Long-COVID describes the long-term effects of the COVID-19 disease. Long-COVID patients show medial temporal lobe dysfunction and neuropsychological alterations affecting memory. This study aimed to assess OLM in a group of Long-COVID patients, n=66, and a Control group of healthy individuals with similar age and sex composition, n=21, using an immersive virtual reality (iVR)-based OLM task. We also explored associations between the performance in the iVR-based OLM task and general cognitive function (MoCA), and both verbal (VSTM) and visuospatial (SSTM) span. The Long-COVID group showed fewer correct responses, made more task attempts, and invested more time in the iVR-based OLM task than the Control group. Delayed memory was more severely altered than immediate memory in Long-COVID participants. Better MoCA scores of the Long-COVID group were strongly associated with shorter times to complete the immediate recall of the iVR-based OLM task. Besides, the months elapsed since the COVID-19 infection were slightly associated with fewer correct responses in the immediate and 24-hour recalls. These results corroborate previous findings of memory alterations in the Long-COVID syndrome using an iVR-based OLM task, adding new evidence on spatial memory and long-term memory in this population. Implementing spatial iVR tasks to clinical research may improve our understanding of neuropsychological disorders.

Aging's Effect on Working Memory-Modality Comparison.

Research exploring the impact of development and aging on working memory (WM) has primarily concentrated on visual and verbal domains, with limited attention paid to the tactile modality. The current study sought to evaluate WM encompassing storage and manipulation across these three modalities, spanning from childhood to old age. The study included 134 participants, divided into four age groups: 7-8, 11-12, 25-35, and 60-69. Each participant completed the Visuospatial Span, Digit Span, and Tactual Span, with forward and backward recall. The findings demonstrated a consistent trend in both forward and backward stages. Performance improved until young adulthood, progressively diminishing with advancing age. In the forward stage, the Tactual Span performance was worse than that of the Digit and Visuospatial Span for all participants. In the backward stage, the Visuospatial Span outperformed the Digit and Tactual Span across all age groups. Furthermore, the Tactual Span backward recall exhibited significantly poorer performance than the other modalities, primarily in the youngest and oldest age groups. In conclusion, age impacts WM differently across modalities, with tactile storage capacity being the most vulnerable. Additionally, tactile manipulation skills develop later in childhood but deteriorate sooner in adulthood, indicating a distinct component within tactile WM.

Comparison of Executive Functioning between Ageing Urban and Rural Participants in India: A Cross‐sectional Analysis

AbstractBackgroundOlder adults living in urban areas differ from their rural counterparts in many ways, including the cognitive performance. Executive functioning is one of the few cognitive domains that is implicated to be affected in early stages of dementia. However, there are very few studies that have explored differences in cognitive functioning across rural and urban contexts in India. Our objective was to evaluate differences in executive functioning across urban and rural participants.MethodOur study sample includes ageing individuals (≥ 45 years): 1089 from the urban Tata Longitudinal Study on Ageing (TLSA) cohort and 4913 from the rural Srinivaspura Ageing, Neuro Senescence and COGnition (SANSCOG) study cohort. The TLSA and SANSCOG are parallel, harmonised, community‐based cohort studies in urban and rural India exploring the risk and protective factors associated with cognitive changes due to normal ageing, dementia and other related disorders. The difference in executive functioning measured by Categorical fluency, Letter fluency, Visuospatial span and Stroop tests were compared across both cohorts.ResultUrban participants were older, had more years of education had less Geriatric Depression Score (GDS) as shown in Table 1. They did not differ in gender and proportion of cognitive impairment. Multiple Linear Regression analysis was performed to examine the effects of each executive functioning tests between both the cohorts (urban participants were coded as reference category) while age, years of education and GDS were adjusted.Urban participants performed better than Rural participants on Categorical fluency (β = ‐2.379, p < 0.001), Letter fluency (β = ‐4.343, < 0.001), Visuospatial span (β = ‐0.279, < 0.001) and Stroop (β = 0.934, < 0.001). Similar results were obtained after gender stratification as shown in Table 2.ConclusionUrban participants performed better than their rural counterparts in all tests examining executive functioning. Poorer cognitive functioning in the rural ageing cohort could be due to a number of reasons including limited or less cognitively demanding occupations. There is a need for more such longitudinal studies in India that explore community environment on cognitive function across different cohorts.

Association between social networking and cognition among middle aged and older adults in rural India

AbstractBackgroundEmerging evidence suggests that better social networking is associated with better cognitive performance among older adults. However, most of the prior studies have used global cognitive measures to study the above relationship. In this study, we aim to investigate the role of social networking on distinct cognitive domains, among dementia‐free middle‐aged and older‐age adults from a rural Indian population.MethodBaseline assessment data of 2403 participants (≥45 years), who are part of an ongoing, prospective, aging cohort study in rural India (Srinivaspura Aging, NeuroSenescence, and COGnition, SANSCOG) and having a Clinical Dementia Rating (CDR) of ‘0’ who are cognitively healthy was utilized for this study. Social networking was assessed using Cohen’s Social Network Index (SNI), wherein three dimensions were examined – network diversity, number of people in social network and number of embedded networks. Cognitive functions were assessed using episodic memory, geometric figure spatial recognition, verbal fluency, semantic association, word comprehension, reading comprehension and visuospatial span subtests of a culturally validated, computerized, neurocognitive test battery. Linear regression models, adjusted with age and gender were used for statistical analysis.ResultIn the linear regression model, adjusted for age and gender, higher network diversity was significantly associated with better cognitive performance in episodic memory (β = 0.16, p = 0.001), attention function (β = 0.07, p = 0.004), geometric figure spatial recognition (β = 0.13, p = 0.001), verbal fluency phonemic cue (β = 0.11, p = 0.001), reading comprehension (β = 0.09, p = 0.001) and semantic language association function (β = 0.08, p = 0.001). Further, higher dimension of number of people in social network was significantly associated with better cognitive performances in semantic language association function (β = 0.002, p = 0.04). Furthermore, in the third dimension of SNI, higher dimension of number of embedded networks was significantly associated with better cognitive performances in visuospatial span (β = 0.05, p = 0.046) and verbal fluency phonemic cue (β = 0.103, p = 0.001).ConclusionThe findings suggest that better social networking in all three dimensions was associated with better cognitive functions in multiple distinct cognitive domains. It is important to follow‐up these participants longitudinally with serial cognitive monitoring to understand if social networking can potentially delay cognitive decline and thereby, serve as a protective factor for dementia.

Utility of online cognitive test in cognitive neurology unit

AbstractBackgroundDelirium is one of the most common complications in hospitalized elders and corresponds with a higher risk of cognitive decline and death. Numerous test batteries exist to assist clinicians in detecting delirium, but it continues to be undiagnosed in up to 88% of patients, particularly those with AD where “confusion” is mistakenly attributed to impaired baseline (1). This pilot study investigated the utility of a digital cognitive assessment (D‐Cog), in the form of an iPad game, which would allow for rapid and routine baseline testing in patients with AD so that delirium‐induced changes can be easily detected.MethodWhile collecting traditional vital signs, medical assistants in the Beth Israel Deaconess Center (BIDMC) Cognitive Neurology Unit (CNU) prompted 67 willing patients to complete the D‐Cog assessment, an adaptive visuospatial span task, on an iPad. We then retrospectively reviewed the medical records of each patient to collect diagnosis, demographics, and pen‐and‐paper neuropsychological scores (e.g., MoCA or MMSE). Of the 67 patients (mean age 67, 29 female), 22 were clinically diagnosed with mild cognitive impairment (MCI) or varying severities of AD.ResultThe assessment was successfully completed by 52 participants. 15 participants, including 5 participants with moderate AD, experienced great difficulty during the task and were subsequently excluded. The 17 included participants with AD (mean age 75, 6 female) averaged a D‐Cog score of 4.1 and a MMSE score of 23.1. In comparison, a control group with no cognitive concerns (n = 16, mean age 60, 9 female) garnered a 6.7 average D‐Cog score and 29.3 MMSE score. The difference in D‐Cog scores was significantly different at p = 0.001.ConclusionThe D‐Cog assessment is feasible in clinical practice for patients with a wide range of cognitive impairments. These scores can act as an attentional baseline to compare against later testing in the event of suspected delirium. While the D‐Cog is derived from traditional pen‐and‐paper testing, its digital framework offers new opportunities for adaptive and remote testing.ReferenceFong TG, Davis D, Grodon ME, Albuquerque A, Inouye SK. The interface between delirium and dementia in elderly adults. Lancet Neruol. 2015; 14(8): 823–32

Neuropsychological Profile of Traumatic Brain Injury Patients with Medicolegal Cases: A Pilot Study

Abstract Introduction Traumatic brain injury (TBI) is a global health problem and is a silent epidemic of the modern times. Studies indicate litigation is a prominent factor that accounts for poor outcome and prolonged recovery from mild TBI. Depression is the most frequently diagnosed psychiatric disorder after TBI. Postconcussion symptoms, litigation, and suboptimal effort could contribute to the neuropsychological functioning of TBI patients medicolegal cases (MLCs). With increase in TBI and medicolegal cases, there is a requirement for comprehensive neuropsychological assessment. Method The aim of the study was to evaluate the cognitive functions, postconcussion, and depressive symptoms in TBI patients with MLC and without MLCs (non-MLC). Patients were also assessed on electrophysiological parameters. An observational cross-sectional design was adopted, the sample size was 30 TBI patients in total, 15 (MLC) and 15 (non-MLC), and 11 patients from each group for electrophysiological assessment. The patients were in the age range of 18 to 50 years. Results The MLC group had poor performance compared with the non-MLC group on both neuropsychological and electrophysiological measures. There was evidence of significant difference in verbal working memory, verbal learning, and memory and visuoconstructive ability. In the MLC group, postconcussion and depressive scores were negatively correlated with visuospatial span. Conclusion Findings from this study indicate differences in the neuropsychological performance and electroencephalographic measures in between MLC and non-MLC groups. The results could be indicative of persistent cognitive problems associated with TBI for patients pursuing litigation. Poor performance could also be attributed to suboptimal level of effort. However, being a preliminary study with a small sample size, the findings need to be treated with caution.

Working memory development in different modalities in children and young adults

Research on working memory (WM) development is concentrated largely on the verbal and visuospatial domains, whereas the tactile modality has received much less attention. The current study aimed to compare the development of storage and manipulation in the tactile sense with other modalities in children and young adults. A total of 96 typically developed individuals were divided into three equally numbered age groups in the ranges of 7 and 8, 11 and 12, and 20 to 29 years. They were asked to perform a battery of span tasks, including forward and backward stages, in the verbal, visual, visuospatial, and tactile modalities. Results showed improvement of WM performance across age in all modalities. In addition, in the forward stage, the Tactual Span was shorter than all other tasks and the Visuospatial Span was shorter than the Visual-Digit Span. In the backward stage, the Digit Span and Tactual Span had lower scores than the Visuospatial Span. Finally, interaction effects for the forward and backward stages were also significant, mainly indicating greater improvement in both storage and manipulation of the tactile sense compared with the other senses. It can be concluded that the tactile modality shows a course of WM development similar to the other modalities, in all of which the storage and manipulation components are affected differently. In addition, tactile WM improves more during growth than other modalities. Therefore, professionals in the field of education and neuropsychology are encouraged to use tactile tasks to assess and treat WM, particularly in response to the increased use of digital technology during recent years.

Verbal Short-Term Memory Disturbance in the Primary Progressive Aphasias: Challenges and Distinctions in a Clinical Setting.

Impaired verbal ‘phonological’ short-term memory is considered a cardinal feature of the logopenic variant of primary progressive aphasia (lv-PPA) and is assumed to underpin most of the language deficits in this syndrome. Clinically, examination of verbal short-term memory in individuals presenting with PPA is common practice and serves two objectives: (i) to help understand the possible mechanisms underlying the patient’s language profile and (ii) to help differentiate lv-PPA from other PPA variants or from other dementia syndromes. Distinction between lv-PPA and the non-fluent variant of PPA (nfv-PPA), however, can be especially challenging due to overlapping language profiles and comparable psychometric performances on verbal short-term memory tests. Here, we present case vignettes of the three PPA variants (lv-PPA, nfv-PPA, and the semantic variant (sv-PPA)) and typical Alzheimer’s disease (AD). These vignettes provide a detailed description of the short-term and working memory profiles typically found in these patients and highlight how speech output and language comprehension deficits across the PPA variants differentially interfere with verbal memory performance. We demonstrate that a combination of verbal short-term and working memory measures provides crucial information regarding the cognitive mechanisms underlying language disturbances in PPA. In addition, we propose that analogous visuospatial span tasks are essential for the assessment of PPA as they measure memory capacity without language contamination.

Visuospatial and Tactile Working Memory in Individuals with Congenital Deafness.

Studies examining visuospatial working memory (WM) in individuals with congenital deafness have yielded inconsistent results, and tactile WM has rarely been examined. The current study examined WM span tasks in the two modalities among 20 individuals with congenital deafness and 20 participants with typical hearing. The congenital deafness group had longer forward and backward spans than typical hearing participants in a computerized Corsi block-tapping test (Visuospatial Span), whereas no such difference was found in the Tactual Span (tactile WM). In the congenital deafness group, age of sign language acquisition was not correlated with either condition of the visuospatial task, and Tactual and Visuospatial Spans scores were correlated in the backward but not the forward condition. The typical hearing group showed no correlation between the tasks. The findings suggest that early deafness leads to visuospatial but not tactile superiority in WM, specifically with respect to the storage component. More broadly, it appears that deafness-related compensation mechanisms in WM do not affect the other modalities in a uniform manner.

Verbal and spatial memory spans in mild cognitive impairment.

Working memory (WM) for verbal and visual material may be affected early in individuals with mild cognitive impairment (MCI). Verbal and visuospatial span tasks, that is neuropsychological procedures commonly used for the clinical assessment of WM, have been scarcely investigated in these patients. Therefore, this study was aimed at evaluating whether performance on tests of verbal and visual-spatial span (which rely to different extents on distinct components of the WM system) is differently sensitive to the presence of MCI and, in particular, of a preclinical AD condition in patients with MCI. 99 patients with amnesic MCI were given the Digit Span Forward (DSF) and Digit Span Backward (DSB) tests and the Corsi span task (CS) at baseline and were followed up for two years. 32 MCI patients converted to Alzheimer's disease (MCIc), but 67 patients did not deteriorate to meet the criteria for AD (MCIs). Results showed that although performance on DSF did not differ between groups, performance on DSB and CS and ratio indexes indicative of a performance decline passing from DSF to DSB and from DSF to CS significantly discriminated between a group of matched healthy controls and the overall group of MCI patients. Moreover, the ratio indexes significantly discriminated between MCIc and MCIs individuals. These data are consistent with the hypothesis that individuals with MCI, particularly those destined to convert to AD, are affected by reduced central executive resources even though the phonological loop is still functioning normally.

Introducing the Tactual Span: A New Task for Assessing Working Memory in the Teactile Modality.

The span paradigm is commonly used to assess working memory (WM), predominantly through the visual and auditory routes and less often through the tactile modality. The current study aimed to validate the "Tactual Span", a new task developed to evaluate WM in the tactile modality. Participants were 140 healthy young adults, who performed the Tactual Span alongside span tasks in three additional modalities (auditory, visual, and visuospatial), as well as a selective attention task and a semantic verbal fluency task. The Tactual Span and other span tasks were found to correlate, while correlations with the selective attention and semantic fluency tasks were largely nonsignificant, indicating good construct validity. Cronbach's alpha for both stages as well as skewness and kurtosis were also adequate. An exploratory factor analysis for the forward stage showed that the Tactual Span and Visuospatial Span were loaded on one factor, whereas the Auditory and Visual Spans were loaded on another factor. In the backward stage, all span tasks were loaded on a single factor. The findings provide an initial indication that the Tactual Span task is a feasible and valid tool for assessing WM in the tactile modality.

The importance of the body-specificity in the evaluation of visuospatial working memory

ABSTRACT This work is rooted in the embodied cognition paradigm applied to the evaluation of visuospatial memory span. We aimed to test whether manuospatial incompatibility affects the evaluation of visuospatial working memory. Older and younger participants were tested under two different spatial field conditions, namely manuospatial incompatibility and manuospatial compatibility, using the standard Corsi Block Tapping Task. The results show that a manuospatial compatibility condition helped both younger and older participants to increase their visuospatial working memory span compared to the traditional manuospatial incompatibility condition. By analyzing the data, our results showed an increase of visuospatial memory span in manuospatial compatibility condition (i.e., the experimenter using his left hand and the participant his right hand) compared to manuospatial incompatibility condition for younger and older adults. We recommend that the interaction between body and cognition would be taken into account in clinical evaluation methods.

A Functional-Near-Infrared-Spectroscopy-Based Evaluation of Cognitive Lagging From Prefrontal Hemodynamics

Functional near infrared spectroscopy (fNIRS) devices capture the variability in oxygenated and deoxygenated blood flow in the cortical layers of the brain during execution of cognitive tasks. The present letter employs fNIRS device to study the cognitive lagging in working memory (WM) performance based on visuo-spatial forward span number search. The unsupervised learning-based clustering yields three distinct clusters of hemodynamic loads during the task performance. From these three clusters, we estimate cognitive lagging by computing the performance score per unit time and assigned three cognitive load classes: low, moderate, and high. Moving toward the classification approach of these three cognitive load classes, ensemble learning classifier produces higher classification accuracy, which reaches a maximum of 91.66%. The trend of shifting cognitive load from low toward high with performance score is observed from estimated Pearson's cross-correlation using the medoid points of cognitive load clusters and associated performance scores. The visualization of dynamic changes in cognitive load (low, moderate, and high) in temporal span of WM performance is obtained from the voxel plot approach, which advocates that regional deactivation of orbitofrontal cortex and augmented hemodynamic load in the dorsolateral prefrontal cortex has a possible relation with this cognitive lagging. In the view of experimental outcomes, the fNIRS-sensor-based measuring of cognitive load could be a future assessment tool for cognitive failure in higher task demand.

Spatial memory assessment reveals age-related differences in egocentric and allocentric memory performance

Humans move through the environment to reach a place mainly using two strategies: egocentric, taking the viewer’s position as a point of reference, and allocentric, employing external landmarks in order to create a mental map of the environment. Aging seems to be associated with a deterioration in these functions, and although participants are evaluated with both virtual and real-environment tasks, performance on these two strategies is not frequently compared. Our objective was to evaluate egocentric and allocentric spatial memory in young and older adult populations using three tasks performed in real environments that allow the perception of 3-D information present in our daily orientation and make it possible to analyse each strategy separately. Twenty-eight young adults and 27 older adults performed Egocentric and Allocentric Spatial Memory Tasks, the Spatial Span task from CANTAB to assess visuospatial span and visuospatial working memory, and Benton’s Judge of Line Orientation Test to measure the ability to establish judgments of spatial relations. Young adults outperformed older adults on spatial memory tasks. The older group improved across allocentric blocks. Young men outperformed older men on both the egocentric and allocentric tasks, whereas young women only achieved better scores than older women on the allocentric task. Our findings support the existence of age-related differences in spatial memory performance.

Patients with Parkinson's Disease Show Alteration in their Visuospatial Abilities and in their Egocentric and Allocentric Spatial Orientation Measured by Card Placing Tests.

Visuospatial skills are impaired in Parkinson's disease (PD). Other related skills exist, such as spatial orientation have been poorly studied. The egocentric (based on internal cues) and allocentric frameworks (based on external cues) are used in daily spatial orientation. Depending on PD onset, the allocentric framework may have a higher level of impairment in tremor-dominant and the egocentric one in akinetic-rigid. To evaluate spatial orientation and visuospatial functions in PD patients and controls, and to assess whether their performance is related to disease duration and the PD subtype (tremor-dominant and akinetic-rigid). We evaluated egocentric and allocentric spatial orientation (Egocentric and Allocentric Spatial Memory Tasks) and visuospatial abilities, span and working memory in 59 PD patients and 51 healthy controls. Visuospatial skills, visuospatial span, and egocentric and allocentric orientation are affected in PD. Visuospatial skills and allocentric orientation undergo deterioration during the first 5 years of the disease progression, while egocentric orientation and visuospatial span do so at later stages (9-11 years). The akinetic-rigid subtype presents worse results in all the spatial abilities that were measured when compared to controls, and worse scores in visuospatial working memory, visuospatial abilities and allocentric orientation when compared to the tremor-dominant group. The tremor-dominant group performed worse than controls in egocentric and allocentric orientation. PD patients show deficits in their visuospatial abilities and in their egocentric and allocentric spatial orientation compared to controls, specifically in akinetic-rigid PD. Only spatial orientation are affected in tremor-dominant PD patients. Allocentric orientation is affected earlier in the progression of the disease.

Assessment of Verbal and Visuospatial Performance Predicting Cognitive Impairment in a Monolingual, Spanish-Speaking Sample

Abstract Objective The Batería Neuropsicológica en Español (BNE) – Digit Span (DS) and Spatial Span (SS) subtests are popular instruments used to measure the capacity of verbal and visuospatial attention/working memory. Although deficits in working memory performance have been found in cases of mild cognitive impairment and dementia in analogous versions of these tasks among English speakers, very few studies have assessed the ability of verbal and visuospatial span tasks to identify impairment within a mono-lingual Spanish-speaking population. This study investigated the clinical utility of the BNE verbal and visuospatial span tasks for discriminating those with and without cognitive impairment in a Spanish-speaking Hispanic population. Participants and Method Participants were 46 monolingual, Spanish-speaking Hispanics, 28 women (60.9%) and 18 (39.1%) men (M age = 63.41 (SD = 14.54); M education = 8.41 (SD = 4.39), referred for neuropsychological evaluations, which included the BNE-DS/SS. Three patients with invalid performances were excluded. Of the remaining 46, 17 were cognitively intact following evaluation, whereas 29 met criteria for a neurocognitive disorder. Results Logistic regression analysis revealed that although DS backward model was significant, both DS forward age/education-corrected T- scores (p = .878) and DS backward (p = .67), were not significant predictors of cognitive impairment. In contrast, both SS forward (p = .002) and backward (p = .022) were significant predictors of impairment status with respective classification accuracies of 63% and 76.1%. Conclusions Findings suggest better performance on visuospatial working memory (SS) is associated with generally intact cognitive abilities and decreased odds of cognitive impairment in a sample of monolingual Spanish-Speaking Hispanics; whereas verbal working memory (DS) findings were less robust.

Social Adjustment in Adolescents Born Very Preterm: Evidence for a Cognitive Basis of Social Problems

To increase the understanding of social adjustment and autism spectrum disorder symptoms in adolescents born very preterm by studying the role of emotion recognition and cognitive control processes in the relation between very preterm birth and social adjustment. A Dutch cohort of 61 very preterm and 61 full-term adolescents aged 13years participated. Social adjustment was rated by parents, teachers, and adolescents and autism spectrum disorder symptoms by parents. Emotion recognition was assessed with a computerized task including pictures of child faces expressing anger, fear, sadness, and happiness with varying intensity. Cognitive control was assessed using a visuospatial span, antisaccade, and sustained attention to response task. Performance measures derived from these tasks served as indicators of a latent cognitive control construct, which was tested using confirmatory factor analysis. Mediation analyses were conducted with emotion recognition and cognitive control as mediators of the relation between very preterm birth and social problems. Very preterm adolescents showed more parent- and teacher-rated social problems and increased autism spectrum disorder symptomatology than controls. No difference in self-reported social problems was observed. Moreover, very preterm adolescents showed deficits in emotion recognition and cognitive control compared with full-term adolescents. The relation between very preterm birth and parent-rated social problems was significantly mediated by cognitive control but not by emotion recognition. Very preterm birth was associated with a 0.67-SD increase in parent-rated social problems through its negative effect on cognitive control. The present findings provide strong evidence for a central role of impaired cognitive control in the social problems of adolescents born very preterm.