IntroductionThe Positive and Negative Syndrome Scale (PANSS) has been used as a universal instrument for clinical assessment of psychopathology in schizophrenia. Different studies have analyzed the factorial structure of this scale and have suggested a five-factor model: positive, negative, excited, depressive, and cognitive/disorganized factors. Two of the most used models are the Marder´s solution and the Wallwork´s one.ObjectivesThe aim of this work was to study the correlations of the two cognitive factors (Marder and Wallwork) with a cognitive assessment performed with a standard cognitive battery, in a sample of patients with first psychotic episode of schizophrenia.MethodsSeventy four patients with first psychotic episode of schizophrenia (26.9, SD:7.8 years old; 70.3% male) were included. The cognitive assessment was performed with the MATRICS Consensus Cognitive Battery (MCCB). The MCCB present seven cognitive domains: Speed of processing, Working memory, Attention/Vigilance, Verbal Learning, Visual Learning, Reasoning and Problem Solving, and Social cognition). Pearson correlations were performed between MCCB scores and Marder´s PANSS cognitive factor (P2, N5, G5, G10, G11, G13, G15) and Wallwork´s one (P2, N5, G11).ResultsCorrelation between MCCB scores and cognitive factors of Marder and Wallwork can be seen in the table.Marder´s cognitive factorWallwork´s cognitive factorSpeed of processingr = -0.461; p<0.001r = -0.455; p<0.001Attention/Vigilancer = -0.414; p<0.001r = -0.415; p<0.001Working memoryr = -0.449; p<0.001r = -0.468; p<0.001Verbal Learningr = -0.511; p<0.001r = -0.405; p<0.001Visual Learningr = -0.252; p=0.024r = -0.254; p=0.029Reasoning and Problem Solvingr = -0.244; p=0.036r = -0.272; p=0.019Social cognitionr = -0.268; p=0.024r = -0.202; p=0.091ConclusionsBoth PANSS cognition factors show a moderate correlations with Speed of processing, Working memory, Attention/Vigilance and Verbal Learning assessed by MCCB. More discrete correlations were found with Visual Learning, Reasoning and Problem Solving, and with Social cognition (in fact, non-significant correlation with Wallwork´s cognitive factor was found).Acknowledgements. This study has been funded by Instituto de Salud Carlos III (ISCIII) through the project PI19/00766 and co-funded by the European Union.Disclosure of InterestNone Declared
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