Visual Paired Comparison Task Research Articles

Measuring Socioeconomic and Stress Disparities in Infant Declarative Memory Using the Visual Paired Comparison Task.

Research suggests that socioeconomic circumstances and stress predict memory skills in adults and older children, yet few studies have addressed this question in infancy. The current study used the visual-paired comparison paradigm to examine whether socioeconomic circumstances, maternal perceived stress, and/or maternal physiological stress, all measured prenatally, predict memory performance among 6-month-old infants. We found no significant associations between infant memory and any measure of socioeconomic circumstance or stress. Potential explanations for these null findings are discussed.

Evaluation of recognition memory through oculomotorius behavior in Alzheimer disease.

INTRODUCTION: The study of ocular movements in patients with Alzheimer disease is an useful tool to evaluate recognition memory. METHODS: assessment of this specific type of explicit memory in 15 individuals diagnosed with Alzheimer disease and 15 controls. The parameters of ocular fixation were examined using the Eye-Tracking Tobii Tx300 through Pair-wised ranking with the paradigm novel object recognition. RESULTS: People with Alzheimer disease present difficulties in the recognition of previously presented stimulus when the latency of presentation of the familiarization and the test period is longer than two minutes. DISCUSSION: The analysis of oculomotorius behavior can simplify the evaluation of recognition memory without appealing to verbal report and the visual paired comparison task. This contributes to the comprehension of the relationship among spatial attention, working memory and episodic memory.

Novelty preference assessed by eye tracking: A sensitive measure of impaired recognition memory in epilepsy

ObjectiveEpilepsy patients often report memory deficits despite normal objective testing, suggesting that available measures are insensitive or that non-mnemonic factors are involved. The Visual Paired Comparison Task (VPCT) assesses novelty preference, the tendency to fixate on novel images rather than previously viewed items, requiring recognition memory for the “old” images. As novelty preference is a sensitive measure of hippocampal-dependent memory function, we predicted impaired VPCT performance in epilepsy patients compared to healthy controls. MethodsWe assessed 26 healthy adult controls and 31 epilepsy patients (16 focal-onset, 13 generalized-onset, 2 unknown-onset) with the VPCT using delays of 2 or 30 s between encoding and recognition. Fifteen healthy controls and 17 epilepsy patients (10 focal-onset, 5 generalized-onset, 2 unknown-onset) completed the task at 2-, 5-, and 30-minute delays. Subjects also performed standard memory measures, including the Medical College of Georgia (MCG) Paragraph Test, California Verbal Learning Test-Second Edition (CVLT-II), and Brief Visual Memory Test-Revised (BVMT-R). ResultsThe epilepsy group was high functioning, with greater estimated IQ (p = 0.041), greater years of education (p = 0.034), and higher BVMT-R scores (p = 0.024) compared to controls. Both the control group and epilepsy cohort, as well as focal- and generalized-onset subgroups, had intact novelty preference at the 2- and 30-second delays (p-values ≤ 0.001) and declined at 30 min (p-values > 0.05). Only the epilepsy patients had early declines at 2- and 5-minute delays (controls with intact novelty preference at p = 0.003 and p ≤ 0.001, respectively; epilepsy groups’ p-values > 0.05). ConclusionsMemory for the “old” items decayed more rapidly in overall, focal-onset, and generalized-onset epilepsy groups. The VPCT detected deficits while standard memory measures were largely intact, suggesting that the VPCT may be a more sensitive measure of temporal lobe memory function than standard neuropsychological batteries.

Impact of language familiarity on abstract pattern recognition in 9- to 12-month-old infants

Previous studies found an impact of language familiarity on face recognition in 9- and 12-month-olds. Own race faces are better recognized when associated with native language, whereas for other race faces, it is with non-native language. The aim of this study is to investigate if language familiarity can also influence abstract pattern recognition. We tested 9- to 12-month-old monolingual infants with a visual paired-comparison task. During a 30-s familiarization phase, infants were shown an image of abstract patterns associated with an auditory soundtrack of a speaker reciting a story either in their native (French) or in a non-native language (German). After the familiarization, the familiar and a new abstract pattern were displayed side by side for the recognition test. We found a significant preference for the novel object in the native language condition but not in the non-native condition. These results suggest that language familiarity effects on infant memory are not specific to faces but also influence, on a larger scale, how infants process their immediate visual environment.

Differential effects of attachment security on visual fixation to facial expressions of emotion in 14-month-old infants: an eye-tracking study.

Models of attachment and information processing suggest that the attention infants allocate to social information might occur in a schema-driven processing manner according to their attachment pattern. A major source of social information for infants consists of facial expressions of emotion. We tested for differences in attention to facial expressions and emotional discrimination between infants classified as securely attached (B), insecure-avoidant (A), and insecure-resistant (C). Sixty-one 14-month-old infants participated in the Strange Situation Procedure and an experimental task of Visual Habituation and Visual Paired-Comparison Task (VPC). In the Habituation phase, a Low-Arousal Happy face (habituation face) was presented followed by a VPC task of 6 trials composed of two contrasting emotional faces always involving the same actress: the one used in habituation (trial old face) and a new one (trial new face) portraying changes in valence (Low-Arousal Angry face), arousal (High-Arousal Happy face), or valence + arousal (High-Arousal Angry face). Measures of fixation time (FT) and number of fixations (FC) were obtained for the habituation face, the trial old face, the trial new face, and the difference between the trial old face and the trial new face using an eye-tracking system. We found a higher FT and FC for the trial new face when compared with the trial old face, regardless of the emotional condition (valence, arousal, valence + arousal contrasts), suggesting that 14-month-old infants were able to discriminate different emotional faces. However, this effect differed according to attachment pattern: resistant-attached infants (C) had significantly higher FT and FC for the new face than patterns B and A, indicating they may remain hypervigilant toward emotional change. On the contrary, avoidant infants (A) revealed significantly longer looking times to the trial old face, suggesting overall avoidance of novel expressions and thus less sensitivity to emotional change. Overall, these findings corroborate that attachment is associated with infants' social information processing.

Associations of an eye-tracking task and pupillary metrics with age and ASA physical status score in a preoperative cohort.

Advanced age, American Society of Anesthesiologists physical status (ASA) classification and the presence of cognitive impairment are associated with an elevated risk of postoperative morbidity and mortality. The visual paired comparison (VPC) task, which relies on recognition of novel images, examines declarative memory. VPC scores have demonstrated the ability to detect mild cognitive impairment and track progression of neurodegenerative disease. Quantitative pupillometry may have similar value. We evaluate for associations between these variables of interest and the feasibility of performing these tests in the preoperative clinic. Prospective data from 199 patients seen in the preoperative clinic at a tertiary academic center were analyzed. A 5min VPC task (Neurotrack Technologies, Inc, Redwood City, CA) was administered during their scheduled preoperative clinic visit. Pupillary light reflexes were measured at the same visit (PLR-3000™, Neuroptics Corp, Irvine, California).Thirty-four percent of patients were categorized as ASA 2 and 58% as ASA 3. Median age was 57 (IQR: 44-69). Associations were demonstrated between age and ASA physical status (Mann-Whitney U Test, p < 0.0001), maximum pupil size (Spearman Rank Correlation, r = -0.40, p < 0.0001), and maximum constriction velocity (Spearman Rank Correlation, r = -0.39, p < 0.0001). Our data also revealed an association between VPC score and age (Spearman Rank Correlation, p = 0.0016, r = -0.21) but not ASA score (Kruskal-Wallis Test, p = 0.14). When compared to a nonsurgical cohort with no history of memory impairment, our population scored worse on the VPC task (Mann-Whitney U Test, p = 0.0002). A preoperative 5min VPC task and pupillometry are feasible tests in the preoperative setting and may provide a valuable window into an individual's cognition prior to elective surgery.

The impact of face masks on infants' learning of faces: An eye tracking study.

This preregistered study examined how face masks influenced face memory in a North American sample of 6- to 9-month-old infants (N=58) born during the COVID-19 pandemic. Infants' memory was tested using a standard visual paired comparison (VPC) task. We crossed whether or not the faces were masked during familiarization and test, yielding four trial types (masked-familiarization/masked-test, unmasked-familiarization/masked-test, masked-familiarization/unmasked-test, and unmasked-familiarization/unmasked-test). Infants showed memory for the faces if the faces were unmasked at test, regardless of whether or not the face was masked during familiarization. However, infants did not show robust evidence of memory when test faces were masked, regardless of the familiarization condition. In addition, infants' bias for looking at the upper (eye) region was greater for masked than unmasked faces, although this difference was unrelated to memory performance. In summary, although the presence of face masks does appear to influence infants' processing of and memory for faces, they can form memories of masked faces and recognize those familiar faces even when unmasked.

161-OR: Cognitive Impairment in Individuals with Post-Bariatric Hypoglycemia

Background: Post-bariatric hypoglycemia (PBH) is characterized by repeated episodes of severe hypoglycemia accompanied by neuroglycopenic signs and/or symptoms. Many individuals with PBH report chronic symptoms of cognitive impairment even when blood glucose values are not acutely low. In this study, cognitive function in individuals with PBH compared to age- and BMI-matched healthy controls (HC) was assessed using a quantitative visual paired comparison (VPC) task; a measurement validated to predict cognitive decline and Alzheimer’s disease. Methods: 20 patients with confirmed PBH (plasma glucose &amp;lt;50 mg/dL with concomitant insulin ≥3 uU/mL, other causes having been ruled out) following Roux-en-Y gastric bypass surgery were compared to 54 age- (46±vs. 50±9 yrs, p=0.05) and BMI- (31±vs. 28±4 kg/m2, p=0.07) matched HCs. Patient-reported frequency of clinically-important hypoglycemic events, defined as fingerstick or plasma glucose &amp;lt;60 mg/dL, was collected by standardized questionnaire. The VPC task, which measures cognitive function by utilizing infrared eye tracking to assess the participant’s novelty preference when presented with a series of novel and familiar images, was conducted under standardized conditions when blood glucose was in the normal range in the clinical research unit. Results: Compared to HCs, PBH patients scored 12% lower on the VPC task (0.65± 0.vs. 0.57 ±0.15, P= 0.005) . The mean VPC score in PBH patients was in the range that predicts a 22% risk of cognitive decline or Alzheimer’s disease over a 3-year period. Among PBH patients, patient-reported frequency of clinically important hypoglycemic events correlated significantly with VPC score (r=0.44, p=0.047) . Conclusions: Patients with PBH exhibit cognitive impairment when compared to age- and BMI-matched HCs and the degree of impairment correlates with the frequency of clinically important hypoglycemic events. Disclosure T.Shamloo: None. C.M.Craig: Employee; Eiger BioPharmaceuticals, Stock/Shareholder; Eiger BioPharmaceuticals. M.Snyder: Stock/Shareholder; January, Inc. T.Mclaughlin: Board Member; January, Inc., Research Support; Merck &amp; Co., Inc., Novo Nordisk, Stock/Shareholder; Eiger BioPharmaceuticals. Funding American Diabetes Association (1-19-ICTS-073) ; NIH 1U54DE02378901

Social visual attentional engagement and memory in Phelan-McDermid syndrome and autism spectrum disorder: a pilot eye tracking study

BackgroundThe current study used eye tracking to investigate attention and recognition memory in Phelan-McDermid syndrome (PMS), a rare genetic disorder characterized by intellectual disability, motor delays, and a high likelihood of comorbid autism spectrum disorder (ASD). Social deficits represent a core feature of ASD, including decreased propensity to orient to or show preference for social stimuli.MethodsWe used a visual paired-comparison task with both social and non-social images, assessing looking behavior to a novel image versus a previously viewed familiar image to characterize social attention and recognition memory in PMS (n = 22), idiopathic ASD (iASD, n = 38), and typically developing (TD) controls (n = 26). The idiopathic ASD cohort was divided into subgroups with intellectual disabilities (ID; developmental quotient < 70) and without (developmental quotient > 70) and the PMS group into those with and without a co-morbid ASD diagnosis.ResultsOn measures of attention, the PMS group with a comorbid ASD diagnosis spent less time viewing the social images compared to non-social images; the rate of looking back and forth between images was lowest in the iASD with ID group. Furthermore, while all groups demonstrated intact recognition memory when novel non-social stimuli were initially presented (pre-switch), participants with PMS showed no preference during the post-switch memory presentation. In iASD, the group without ID, but not the group with ID, showed a novelty preference for social stimuli. Across indices, individuals with PMS and ASD performed more similarly to PMS without ASD and less similarly to the iASD group.ConclusionThese findings demonstrate further evidence of differences in attention and memory for social stimuli in ASD and provide contrasts between iASD and PMS.

Predicting explicit memory for meaningful cartoons from visual paired comparison in infants and toddlers

We tested the memory of 18-, 33-, and 39-month-olds (N = 120) for dynamic stimulus material (simple cartoons) after 6 months in a visual paired comparison (VPC) task. We also tested the explicit recognition memory (ERM) for the same material. Only the oldest age group (39-month-olds) showed a significant visual (familiarity) preference at the test. Similarly, only the oldest group reliably chose the correct cartoon in the ERM test. Data from the VPC and ERM tasks did not correlate in any age group. However, we suggested a novel score (coined ΔVPC) measuring how much visual preference changes during the test phase in the VPC task. We found that this ΔVPC score (and vocabulary) predicted children’s performance in the ERM task, whereas other potential predictors such as age and conventional novelty preference did not. We discuss the impact of these findings in relation to the development of implicit and explicit memory. Furthermore, we propose that VPC measures are associated with explicit memory only when the participants processed the stimuli conceptually. In such cases, we suggest that the ΔVPC score is an approximation of how demanding it is to construct the mental representation of the familiar stimulus during the test phase.

Infants are sensitive to cultural differences in emotions at 11 months.

A myriad of emotion perception studies has shown infants’ ability to discriminate different emotional categories, yet there has been little investigation of infants’ perception of cultural differences in emotions. Hence little is known about the extent to which culture-specific emotion information is recognised in the beginning of life. Caucasian Australian infants of 10–12 months participated in a visual-paired comparison task where their preferential looking patterns to three types of infant-directed emotions (anger, happiness, surprise) from two different cultures (Australian, Japanese) were examined. Differences in racial appearances were controlled. Infants exhibited preferential looking to Japanese over Caucasian Australian mothers’ angry and surprised expressions, whereas no difference was observed in trials involving East-Asian Australian mothers. In addition, infants preferred Caucasian Australian mothers’ happy expressions. These findings suggest that 11-month-olds are sensitive to cultural differences in spontaneous infant-directed emotional expressions when they are combined with a difference in racial appearance.

Low Cognitive Function Is Associated With Reduced Functional Fitness Among Community-Dwelling Older Adults

Among older adults over 70, 22-30% report difficulty performing at least one activity of daily living (ADL). While the precipitants of ADL decline are multifactorial, over 50% of cognitively impaired adults require assistance with ADLs. The exact relationship between cognitive and functional decline remains unknown, but it is important to understand their relationship. Eighty-three older adults (80.9 + 5.4 years) enrolled in this study and completed functional fitness and cognitive assessments. Functional fitness assessments included: Short Physical Performance Battery (SPPB), 10-meter walk, dual-task, and power chair stand (average and peak). Cognition was assessed using the Montreal Cognitive Assessment (MoCA) and Visual Paired Comparison task (VPC). Categories of low cognitive function (LCF) and high cognitive function (HCF) were determined by VPC scores. SPPB was 10.2% greater among the HCF group. The HCF group walked 12.6% (0.16 m/s) faster than the LCF group. Dual-task (fast) performance was 13.2% faster among the HCF group. Additionally, when rising from a seated position during the average and peak power chair stand task, the HCF group moved 16.7% and 16.1% faster than the LCF group, respectively. MoCA scores were 2.8 points greater among the HCF group. Based on the current results, significant differences exist between cognitive groups suggesting a relationship between functional fitness and cognition. What remains unknown is the ability to influence functional fitness by changing cognition or vice versa. Future research is warranted to determine the relationship of change in either domain over time.

Functional status among community‐dwelling older adults is determined by cognitive status

AbstractBackgroundSince 2008, the number of older adults has increased by 34% and is expected to nearly double by 2060. Among US older adults over 70 years of age, 22‐30% report difficulty performing at least one activity of daily living (ADL). ADL performance is associated with functional fitness parameters. Negative longitudinal changes in functional performance among older adults are associated with cognitive decline and may be able to predict future cognitive impairment. Thus, it is imperative to understand the influence of cognition on functional fitness among older adults.Method84 older adults (80.9+5.4 years) consented to have their functional fitness and cognition assessed. Functional fitness parameters included the following assessments: Short Physical Performance Battery (SPPB), 10‐meter walk (habitual and fast), dual‐task (habitual and fast), power chair stand assessment (average and peak power and velocity). Cognition was assessed using the Montreal Cognitive Assessment (MoCA) and a digital Visual Paired Comparison (VPC) task. Categories of low and high cognitive function were determined using the VPC results. A one‐way ANOVA was conducted to determine differences between cognitive groups.ResultParticipants with high cognitive performance scored significantly better on the SPPB, 10‐meter fast walk, dual‐task fast condition, and average velocity during the power chair stand assessment. SPPB scores were 10.2% lower among older adults with low cognitive performance (p = .04). The high cognition group walked 16.5% (0.16 m/s) faster when compared to the low cognitive group (p = .04). Dual‐task (fast) performance was 13.2% slower among the low cognition group (p = .03). Additionally, low cognitive older adults moved 16.7% slower when rising from a seated position during the power chair stand task (p = .01). MoCA was 2.76 points lower among the low cognition group (p &lt; .001).ConclusionBased on the current results, a relationship exists between functional fitness and cognitive performance in older adults. However, it remains unknown whether functional fitness can influence cognition or vice versa and how these impact ADL performance. Future research is warranted to determine if and how the relationship between cognitive function and functional fitness changes over time in older adults.

A short digital eye-tracking assessment predicts cognitive status among adults.

Current cognitive assessments suffer from limited scalability and high user burden. This study aimed to (1) examine the relationship between a brief eye-tracking-based visual paired-comparison (VPC) and gold standard cognitive assessments, (2) examine longitudinal stability of the VPC task, (3) determine the ability of the VPC task to differentiate between cognitively normal (CN) individuals and individuals with mild cognitive impairment (MCI). Fifty-five adults (n = 44 CN, n = 11 MCI; 56.4 ± 26.7years) were tested on two occasions, separated by at least 14days. Visit 1 included VPC, Montreal Cognitive Assessment (MoCA), Digit Symbol Coding test (DSC), and NIH Toolbox Cognitive Battery (NIHTB-CB). Visit 2 included VPC, DSC, NIHTB-CB, and dual-task (DT). Significant differences existed between baseline VPC scores for CN and MCI groups (p < .001). VPC scores remained stable over time in both groups (p < .05). Significant associations existed between VPC and MoCA (p < .01), DSC (p < .001), and various NIHTB-CB subtests at both time points. The VPC test significantly predicts cognitive outcomes (p < .05), with age and VPC being the only significant predictors. Additionally, area under the curve (receiver operator characteristic = 0.80) for VPC scores demonstrated good classification accuracy. VPC reliably predicted cognitive status while remaining stable over time and displayed significant associations with gold standard cognitive assessments. VPC is a less burdensome and more scalable assessment than traditional tests, enabling longitudinal monitoring of cognitive status in resource-limited environments.

Early Diagnosis of Mild Cognitive Impairment Based on Eye Movement Parameters in an Aging Chinese Population.

Background: The pathogenesis of dementia often starts several years prior to clinical onset during which the individual is asymptomatic. Existing strategies for the accurate diagnosis of early dementia are limited by high cost and the invasive nature of the procedures. Eye movement parameters associated with cognitive functions may be helpful in the early identification of dementia and in the development and evaluation of preventive and therapeutic strategies.Objective: We aimed to assess differences in eye movement parameters between healthy elderly individuals and patients with mild cognitive impairment (MCI). Furthermore, we examined the correlations between eye movement parameters with cognitive functions and specific hemispheric region and neural structures in individuals with MCI.Method: Eighty individuals with MCI without dementia (based on DSM-IV criteria) identified by community screening and 170 healthy controls were administered Chinese versions of MoCA and NTB, and a long (20 min) or short (5 min) version of a visual paired comparison (VPC) task. Two weeks later, 44 MCI patients and 107 healthy controls completed a retest of the VPC task, 44 MCI patients and 43 healthy controls among them administered a MRI. At the end of 1-year follow-up, a subset of 26 individuals with MCI and 57 healthy controls were administered the long version of VPC task and MoCA test again. Eye movement parameters and the relationship of eye movement parameters with cognitive functions and with changes in neural structures were compared between groups.Results: Patients with MCI were older, had less education, and had lower scores on cognitive tests than healthy controls. After adjustment for age and level of education, patients with MCI had lower novelty preference scores on the VPC than healthy controls. Using the logistic regression model, the amount of time that subjects focused on these novel images could predict MCI patients from normal elderly with an out of sample area under the receiver operator characteristic curve of 0.62. Furthermore, the cognition score of subjects whose novelty preference score was low decreased more remarkably in 1 year. For both the patient and control groups, VPC novelty preference was significantly correlated with verbal fluency and delayed and short-term memory function. Novelty preference score was also significantly correlated with the cortical thickness of several structures in the right hemisphere.Conclusion: Eye movement parameters are stable indicators to distinguish patients with MCI and cognitively normal subjects and are not affected by different testing versions and numbers. Additionally, the patients’ cognitive deficits and eye movement indices were correlated. Future longitudinal studies should further explore the clinical utility of eye movement parameters as early markers of MCI.

FUNCTIONAL FITNESS LEVELS REFLECT COGNITIVE HEALTH STATUS

Alzheimer’s disease currently affects 5.8 million people in the US and the number is projected to triple by 2050. As the baby boomer population ages, it is important to identify measures that correlate with cognitive decline. Measures that show a relationship with cognitive decline can serve as early indicators that a person is in need of a cognitive evaluation. PURPOSE: : The purpose of this evaluation was to determine if functional fitness tasks could accurately discriminate between older adults with and without mild cognitive impairment. METHODS: Adults 60+ years participated in the present investigation (n = 107). Each participant completed demographic questionnaires; completed two stationary cognitive tasks: Montreal Cognitive Assessment (MoCA) and visual paired comparison (VPC); and completed four functional cognitive assessments: dual-task maximal speed (DTMS), dual-task habitual speed (DTHS), sit-to-stand power, timed up and go test (TUG). Participants with MoCA scores > 23 were classified as cognitively intact (CIN), whereas participants with MoCA scores < 23 were classified as cognitively impaired (CIM). A one-way ANOVA determined if there were significant differences between groups for each cognitive task. RESULTS: Eighty CIN and twenty-three CIM subjects completed all assessments. The CIN group had higher scores on the VPC task (p = .02), while exhibiting faster times to complete DTMS (p < .001), DTHS (p = .002), and TUG (p = .02) compared to the CIM group. No significant differences were found between the cognitive groups in sit-to-stand power variables: peak power (p = .08), average power (p = .07), and average velocity (p = .08). CONCLUSIONS: Functional fitness assessments distinguished between CIN and CIM groups. As these results indicate, functional fitness may be an indicator of cognitive status. Future investigations should longitudinally track both functional fitness and cognitive function to further elucidate this relationship.

Validation of a digitally delivered visual paired comparison task: reliability and convergent validity with established cognitive tests.

Alzheimer's disease (AD) affects the memory and cognitive function of approximately 5.7 million Americans. Early detection subsequently allows for earlier treatment and improves outcomes. Currently, there exists a validated 30-min eye-tracking cognitive assessment (VPC-30) for predicting AD risk. However, a shorter assessment would improve user experience and improve scalability. Thus, the purposes were to (1) determine convergent validity between the 5-min web camera-based eye-tracking task (VPC-5) and VPC-30, (2) examine the relationship between VPC-5 and gold-standard cognitive tests, and (3) determine the reliability and stability of VPC-5. This prospective study included two healthy cohorts: older adults (65+ years, n = 20) and younger adults (18-46years, n = 24). Participants were tested on two separate occasions. Visit 1 included the Montreal Cognitive Assessment (MoCA), Digit Symbol Coding test (DSC), NIH Toolbox Cognitive Battery (NIHTB-CB), VPC-30, and VPC-5. Visit 2 occurred at least 14days later; participants completed the VPC-5, DSC, NIHTB-CB, and dual-task walking assessments (DT). VPC-30 significantly correlated with VPC-5 at the first (p < .001) and second (p = .001) time points. VPC-5 and DSC (p < .01) and Pattern Comparison Processing Speed Test (PSPAC) (p = .01) were also correlated on day 1. Significant associations existed between VPC-5 and DSC (p < .001), Flanker Inhibitory Control Test (p = .05), PSPAC (p < .001), and Picture Sequence Memory Test (p = .02) during day 14 testing session. The test retest reliability of VPC-5 was significant (p < .001). VPC-5 displayed moderate convergent validity with the VPC-30 and gold-standard measures of cognition, while demonstrating strong stability, suggesting it is a valuable assessment for monitoring memory function.

Meaningful Memory? Eighteen-Month-Olds Only Remember Cartoons With a Meaningful Storyline.

In two studies we investigated the importance of a storyline for remembering cartoons across a delay of 2 weeks in 18-month-old infants by means of the visual paired-comparison (VPC) paradigm. In Study 1 seventy-one 18-month-olds were tested using similar cartoons as in a recent study from our lab while varying the richness of the storyline information. In a VPC task half of the infants watched uncompromised versions of the cartoons used in the recent study (Storyline Condition), whereas the other half watched Pixelized versions of the cartoons (number of pixels reduced by 98% covering up the narrative, but leaving perceptual details, e.g., colors, movements, the same, and Pixelized Condition). Two weeks later they were presented with the familiar cartoon and a novel cartoon from the same version (Storyline or Pixelized) simultaneously, while being eye-tracked. Results showed that only the infants in the Storyline Condition remembered the target cartoon, thus suggesting that the storyline is important for memory. However, an alternative interpretation of the results could be that what made the infants in the Storyline Condition remember the target cartoon was not the storyline, but the static conceptual information of the objects and agents present in the cartoon (which was not visible in the Pixelized version). To test this possibility, a control study was created. In Study 2 thirty-six infants were therefore presented with a version of the cartoon in which we broke down the temporal presentation into 1 s segments and presented these out of order. This was done to preserve the static conceptual information (e.g., objects and agents) while still disturbing the storyline. Results showed that the infants in this condition still did not remember the target cartoon, suggesting that the meaningfulness of the storyline – and not only static conceptual information – is important for later memory.

Attention, novelty preference and the visual paired comparison task

The innate ability of humans to identify, process and ascribe greater attentional resources (attention bias) to novel stimuli is essential for exploring new opportunities and consequently adapt to changing environments. One of the most common tests to assess attention bias to novel stimuli (Novelty Preference - NP) is the visual paired comparison task (VPC). In the VPC task subjects are presented with novel and previously seen images (repeated images) and NP is measured by parameters that describe visual scanning patterns on these images. The main objective of this study is to evaluate the effects of divided attention on NP. NP was measured in 26 healthy young individuals under two test conditions. In the first condition, subjects performed the VPC task and an audio task simultaneously (divided attention test condition), while in the second condition subjects performed only the VPC task (undivided attention test condition). For each test condition, repeated images were presented after delays ranging from 1.0 to 219.5 s and NP was measured by the mean difference between the relative fixation times on novel and repeated images at each delay. In the divided attention test condition, there were significant differences (p < 0.037) between the magnitudes of NPs for long delays (≥ 162 s) and short delays (≤12.5 s). Such differences were not detected in the undivided attention test condition. Analysis of variance revealed significant differences between the measured NPs during the divided and undivided attention test conditions (F(1, 25) = 18.38, p < 0.001, η2 = 0.424) and significant interaction effects between delays and testing conditions (F(5,125) = 2.88, p = 0.017, η2 = 0.103). Post-hoc t-tests showed significant differences between the measured NPs during the divided attention and undivided attention test conditions for long delays (162.0 and 219.5 s) but not for short delays (1.0 and 12.5 s). The results of the study are consistent with the hypothesis that for longer delays between the presentations of repeated images in the VPC task, NP is dependent on the recollection-based item recognition memory system, while for shorter delays NP is dependent on the automatic, familiarity-based item recognition memory system.

A - 01Web Camera Based Eye Tracking on a Visual Paired Comparison Task: Replication and Relationships with Preclinical Alzheimer Cognitive Indices

A - 01Web Camera Based Eye Tracking on a Visual Paired Comparison Task: Replication and Relationships with Preclinical Alzheimer Cognitive Indices