Visual Expectation Paradigm Research Articles

Modelling processes in infant research

AbstractThis peer commentary emphasizes the importance of implementing more sophisticated analytical techniques in infant research. It provides examples of information extracted from classical paradigms, the habituation–dishabituation paradigm, the visual pair preference task and the visual expectation paradigm, by means of models such as a latent variables mixture model. Although modelling techniques have been implemented in infant research for many years, they have always been a marginal phenomenon because infant data were mainly analysed using mean level comparisons. This commentary outlines the principal advantage of modelling infant behavioural data: there is no other way to obtain information on behaviour and its development at the individual infant level than through a model, and models can be adapted to the specific requirements of an experimental setting's data. However, there are expenses to such techniques: it takes time both to build and to understand a model for a specific experimental setting, and both data and code need to be made available (and thus readable, i.e. following certain style requirements). If as a field, we do not refrain from investing such time, modelling approaches can be a very useful tool for a more reliable infant research.

Infant EEG Band Power Analysis at 6 Months and 18 Months.

Neural development of infants has drawn increasing research interests from the community. In this paper, we investigated the frequency band power of 112 infants who participated in an auditory oddball experiment, and the visual expectation (VE) score of 177 infants who went through a visual expectation paradigm test. Analysis found that the frequency band power decreases in the delta and theta bands, and increases in the alpha and beta bands when the infants grow up from 6 months old to 18 months old. We also proposed a sustainability index to measure the capability of a subject to maintain their band power in the auditory oddball experiment when infants grow up from 6 months old to 18 months old. Analysis shows that the sustainability index increased significantly in the alpha and beta band, decreased in the delta and theta bands. Correlation between the VE score and frequency band power was investigated on 47 infants who participated in both auditory oddball experiment and visual expectation paradigm test. Analysis shows that the reaction speed to stimulus have statistical a significant correlation with the changes of band power and sustainability index in posterior and temporal section, and in the higher frequency bands.

Anticipatory eye movements and long-term memory in early infancy.

Advances in our understanding of long-term memory in early infancy have been made possible by studies that have used the Rovee-Collier's mobile conjugate reinforcement paradigm and its variants. One function that has been attributed to long-term memory is the formation of expectations (Rovee-Collier & Hayne, 1987); consequently, a long-term memory representation should be established during expectation formation. To examine this prediction and potentially open the door on a new paradigm for exploring infants' long-term memory, using the Visual Expectation Paradigm (Haith, Hazan, & Goodman, 1988), 3-month-old infants were trained to form an expectation for predictable color and spatial information of picture events and emit anticipatory eye movements to those events. One day later, infants' anticipatory eye movements decreased in number relative to the end of training when the predictable colors were changed but not when the spatial location of the predictable color events was changed. These findings confirm that information encoded during expectation formation are stored in long-term memory, as hypothesized by Rovee-Collier and colleagues. Further, this research suggests that eye movements are potentially viable measures of long-term memory in infancy, providing confirmatory evidence for early mnemonic processes.

Moderation of Stimulus Material on the Prediction of IQ with Infants' Performance in the Visual Expectation Paradigm: Do Greebles Make the Task More Challenging?

The objective of this study was to examine the role of the stimulus material for the prediction of later IQ by early learning measures in the Visual Expectation Paradigm (VExP). The VExP was assessed at 9months using two types of stimuli, Greebles and human faces. Greebles were assumed to be associated with a higher load on working memory in comparison to human faces. IQ was assessed at 3 years and 4 months of age. Sixty-four children participated at both assessments in this longitudinal study. The results show a moderation of the stimulus material on the prediction of IQ. With Greebles as stimulus material, a significant relationship between infants' learning and IQ was found. There was no relation when infants' learned in the VExP using human faces. Copyright (c) 2015 John Wiley & Sons, Ltd.

Early developmental outcomes of children with congenital HHV-6 infection.

The goal of this study was to determine if congenital human herpesvirus-6 (HHV-6) infection influences early neurodevelopment. We enrolled 57 newborns with HHV-6 congenital infection and 242 control newborns without congenital infection into a prospective, double-blind study with 4 visits between 4 and 30 months of age. Assessments included the Fagan Test of Infant Intelligence, the Visual Expectation Paradigm, and the Mental Development Index (MDI) of the Bayley Scales of Infant Development II. Newborn audiology screening and follow-up audiology examinations were completed at 12 to 24 months. No differences were noted in baseline characteristics between infants with HHV-6 congenital infection and control infants. No clinical syndrome due to congenital infection with HHV-6 was evident at birth. No differences were identified on the Fagan Test of Infant Intelligence or the Visual Expectation Paradigm between the two groups. In 39 infants with HHV-6 congenital infection, the mean ± SD Bayley Scale of Infant Development II MDI score was 103.4 ± 8.9 at 12 months of age. The matched control infants had a mean score of 105.4 ± 12.4. After controlling for covariates, HHV-6 congenital infection was associated with lower scores on the Bayley Scale of Infant Development II MDI at 12 months of age (mean difference: 4.3 [95% confidence interval: 0.4 to 8.1]; P = .03) compared with infants without HHV-6 congenital infection. Congenital HHV-6 infection may have a detrimental effect on neurodevelopment at 12 months of age and requires further study given that congenital infection with HHV-6 is present in ∼1 in every 101 births.

African Versus Caucasian Faces in a Visual Expectation Paradigm

This article focuses on sequence learning on the Visual Expectation Paradigm (VExP) using human faces as stimulus material. For a sample of 133 Caucasian German infants assessed longitudinally at 3 and 6 months of age, a previous study has shown that the response latency of 6-month-old infants was shorter when the infants solved the task with Caucasian own-race faces in contrast to African other-race faces. The advantage for own-race faces occurs at the same age the Other-Race-Effect (ORE) has been reported to emerge. As studies on ORE development have shown the phenomenon in infants from various cultural backgrounds, the follow-up question to be answered here is whether the performance differences on the VExP can also be found in other than Caucasian infants. As a complement to the German sample, 30 African infants from Cameroon were assessed longitudinally with the same VExP task at ages 3 and 6 months. Our results indicate that perception differences between own-race and other-race faces influence performance on the VExP in both samples. As expected, the Cameroonian infants improved performance on the VExP from 3 to 6 months only in their own-race African faces condition.

The influence of stimulus material on attention and performance in the visual expectation paradigm

This longitudinal study examined the influence of stimulus material on attention and expectation learning in the visual expectation paradigm. Female faces were used as attention-attracting stimuli, and non-meaningful visual stimuli of comparable complexity (Greebles) were used as low attention-attracting stimuli. Expectation learning performance was operationalized using the average reaction time and number of anticipations. For the measurement of attention, the percentage of trials with on-task attention behavior was calculated. To analyze attention and differences in performance, a total of 108 German infants (3–6 months of age) were assessed. Significant differences were found between the two types of stimuli concerning the infants’ rate of attention and anticipations. The results indicate learning material to influence attentional processes and expectation learning.

Association Learning with Own‐ and Other‐race Faces in three‐ and six‐month old infants – A longitudinal study

This longitudinal study assessed 133 Caucasian German infants at 3 and 6 months of age to investigate the influence of own‐race and other‐race faces as visual stimuli on association learning in the visual expectation paradigm (VExP). The study is related to the findings on the other‐race‐effect (ORE) which is said to emerge at 6 months of age. Caucasian faces were used as stimuli of a familiar ethnic category, whereas African faces were used as stimuli of an unfamiliar ethnic category. There was no significant difference between the two stimulus classes in infants' reaction time (RT) to stimulus shifts at 3 months. At 6 months of age, infants' RT decreased significantly in the Caucasian faces condition but not in the African faces condition. These results indicate that the processing of other‐race versus own‐race faces by the age of 6 months, which is also the relevant age for the onset of the ORE, has an important influence on the performance on the VExP. Copyright © 2011 John Wiley & Sons, Ltd.

Visual expectation paradigm and keypress identification compared: Mapping emotion category boundaries

Visual expectation paradigm and keypress identification compared: Mapping emotion category boundaries

Learning and retention in 3- and 6-month-old infants: A comparison of different experimental paradigms

Learning and retention effects in 3- and 6-month-old infants were analysed for the habituation, the novelty preference, and the visual expectation paradigm that are assumed to indicate processing speed. A total of 119 infants participated in the study. The tasks related to the different paradigms were presented on three different days within a week and were repeated two weeks later to analyse retention effects. The results showed clear learning effects in all paradigms. The learning effects shown for different tasks were interrelated for 6-month-old infants, thus supporting the assumption of a shared latent dimension like processing speed. Moreover, retention effects over an interval of two weeks could be shown for visual expectation (in both 3- and 6-month-old infants) and for novelty preference (only for 6-month-old infants). The comparably high retention rates especially in the visual expectation paradigm are discussed.

Infants' Visual Expectations and the Processing of Time

Visual events are defined by a number of dimensions—their location in space, content (color, shape, etc.), and time tags (onset, duration, etc.). The role of time in infants' performance in the Visual Expectation Paradigm (VExP) was studied to evaluate whether infants encode in their expectation representation the timing of events in addition to their spatial location and content. In Experiment 1, 3-month-olds produced more anticipations in a temporally predictable condition than in an unpredictable condition, suggesting that their expectations included a timing component. No evidence was found, however, that infants processed events' precise timing, but they instead appeared to process events' average temporal flow rate. This was supported in Experiment 2, in which infants trained with a shorter flow rate exhibited an increase in anticipations after being shifted to a longer flow rate, whereas those trained with a longer flow rate exhibited a decrease when shifted to a shorter flow rate. These findings indicate 3-month-olds encode in their expectation representation the average temporal flow rate rather than the precise timing of events. The findings also suggest that the VExP may be useful for exploring infants' ability to make time estimates that involve action. The research reported in this paper was supported by NICHD grant HD20026 to MMH and by NSERC grants 50860 and 506430 to SAA, and was facilitated by NIMH Research Scientist Award MH23412 to MMH. Some of the results of this study were presented at the annual meeting of the SRCD, Albuquerque, NM, 1999.

Assoziation zwischen der Kompetenz zur Kontingenzerkennung im Alter von drei und sechs Monaten und dem Entwicklungsstand im Alter von ein und zwei Jahren

Zusammenfassung. Berichtet wird über eine Längsschnittstudie mit vier Untersuchungszeitpunkten an 87 Kindern im Alter von 3 bis 24 Monaten. Ziel war es, die Assoziationen zwischen Kompetenzen zur nicht-sozialen Kontingenzwahrnehmung mit drei und sechs Monaten und dem späteren Entwicklungsstand mit einem bzw. zwei Jahren sowie der sprachlichen Entwicklung mit zwei Jahren zu analysieren. Die Kompetenz zur Wahrnehmung nicht-sozialer Kontingenzen wurde mittels Mobile Conjugate Reinforcement Paradigma (Mobiletest) sowie Visual Expectation Paradigma (VEP) erhoben. Der Entwicklungsstand wurde mit dem Entwicklungstest 6 Monate - 6 Jahre (ET 6-6) erhoben, die sprachliche Entwicklung mittels des Sprachtests für zweijährige Kinder (SETK-2). Es zeigte sich, dass die Ergebnisse des Mobiletests mit drei Monaten signifikante Bezüge zur Sprachentwicklung mit zwei Jahren aufwiesen. Das VEP mit sechs Monaten stand ebenfalls mit der Sprachentwicklung mit zwei Jahren, zusätzlich aber auch mit der kognitiven und sozialen Entwicklung mit einem Jahr in Verbindung. Diskutiert werden neben der Notwendigkeit zu einer altersspezifischen Differenzierung zwischen den beiden Paradigmen zur Wahrnehmung nicht-sozialer Kontingenzen auch die möglichen Verbindungslinien zwischen nicht-sozialer Kontingenzwahrnehmung und Entwicklung.

Eye contact and social contingency experiences from 3 to 6 months of age and their relation to the detection of non-social contingencies

This longitudinal study focuses on the development of eye contact and the contingency of maternal reactions to infants' signals from the age of 3 to 6 months. Eighty-seven 3-month-old infants participated in this study. The amount of eye contact and of social contingencies experienced as prompt maternal responses was assessed micro-analytically based on videotaped mother – infant interactions. The ability to detect contingencies in non-social contexts was assessed by a visual expectation paradigm. The general pattern of the results shows decreases in eye contact and increases in contingencies during development, although this general pattern was not shown by all mothers. Furthermore, the results show that increases in the experience of early social contingencies are related to the ability to detect contingencies in the visual expectation task. The unexpected increase in maternal contingencies over time is discussed as reflecting a possible increase in the significance of association learning after the age of 3 months.

Frames of reference for anticipatory action in 4-month-old infants

The spatial representations of 4-month-old infants were examined in two experiments using a modified version of the visual expectation paradigm (VExP). The experiments were designed in order to determine what spatial frames of reference were available to infants for making anticipatory saccades. In Experiment 1, we found that infants most often used a retinocentric frame of reference that did not take into account their current eye position in making an anticipatory saccade. However, Experiment 2 revealed that under certain conditions infants are more likely to make anticipatory saccades consistent with a body- or object-centred frame of reference. The main difference between the two experiments was the degree to which the featural properties of the stimuli varied. The results shed light on the development of spatial representations for action in infancy.

Regulation of sinus cardiac rhythm during different states of attention in full-term and preterm 5-month-old infants

Parasympathetic heart rate regulation was studied in full-term (FT) and very preterm (VPT) infants at the corrected age of 5 months during endogenous and exogenous sustained attention. Cardiac interval duration and the respiratory sinus arrhythmia (RSA) were used as indices of parasympathetic regulation of heart activity during infants’ sustained attention to a new visual stimulus (exogenous attention) and anticipatory attention to repeatedly appearing and disappearing stimuli in the visual expectation paradigm (endogenous attention). The psychomotor development and behavior regulation were assessed using the Bayley Scales of Infant Development, and the clinical risk was scored on the Ballard scale. A shift of attention state affected the RSA only in the FT infants. The endogenous attention was associated with a relatively high RSA level, with the higher RSA levels being significantly correlated with the Bayley Behavior Rating Scale scores. At the age of 5 months, the degree of clinical risk in the VPT infants was not correlated with specific features of parasympathetic regulation. The results are discussed in terms of the concepts of physiological mechanisms of exogenous and endogenous attention in infants. The central regulation of the autonomic functions during a shift of attention state is less efficient in healthy VPT infants as compared to their FT peers. The RSA reactivity can be a more sensitive indicator of CNS regulatory disorders than the standard indices of clinical risk.

Endogenous Attention in 5-Month-Old Full-Term and Premature Infants

Recent research has demonstrated that a deficit of endogenous attention (EA) is a main and stable characteristic of the mental development in healthy extremely premature (HEP) infants from the age of 2 years. A study was made of the differences in EA (anticipatory attention) between full-term (FT) and HEP infants, both aged 5 months (the HEP infants’ ages were corrected for prematurity). The general psychomotor development of the HEP infants was comparable to that of the age-matched FT infants. However, the HEP infants significantly differed from the FT infants in the ability to keep the attention on an object absent in the visual field. Unlike the HEP infants, the FT infants demonstrated a predominance of EA over all other types of attention in the visual expectation paradigm, as confirmed by ANOVA with the factors Maturity and Attention Type. Comparison of the frequency of different types of attention between the two groups showed that the EA frequency in the HEP infants was significantly lower than that in the FT infants. The findings showed that HEP infants, even those with a low risk for abnormal psychomotor development, demonstrate the impairment of EA control as early as at the age of 5 months.

Infants' Use of Constraints to Speed Information Processing and to Anticipate Events

AbstractTwo experiments were conducted with 28‐week‐old infants using a modification of the Visual Expectation Paradigm. The first sought to determine whether speed of information processing (SIP) could be assessed in infants using a reaction time (RT) measure and approach that is widely used to measure SIP in adults. Infants saw a center fixation cue followed by a peripheral target that could appear in 1, 2, or 4 locations. There was a linear increase in RT of eye movements as the number of locations increased from 1 to 2 and to 4 targets, suggesting that the paradigm does measure SIP. The second experiment asked whether varying the number of cue‐target pairings would augment or impair infant's SIP in the trade‐off between the benefit of additional information and the liability of additional memory load. The findings showed that the presence of cue information can eliminate the difference in RT between the 1‐ and 2‐location conditions, whereas no benefit of cue was obtained for the 4‐location condition.

Behavioral and Cortical Measures of Infants' Visual Expectations

AbstractFeatures of the habituation paradigm were combined with the visual expectation paradigm to examine behavioral and cortical indexes of infants' visual expectations. Eight 3‐month‐old infants watched an alternating picture sequence while their eye movements were videotaped and their cortical electrophysiological activity (event‐related potential [ERP]) was recorded. Two ERP epochs were examined: a 3,000‐msec stimulus‐locked epoch included 1,000 msec before stimulus onset through 1,000 msec after stimulus offset; and a 1,200‐msec response‐locked epoch included 700 msec before saccade onset through 500 msec after the saccade. All infants anticipated upcoming pictures, and eye movement latencies for pictures that were not anticipated were comparable to saccade latencies reported in other visual expectation studies of infants at this age. Three components were identified in the stimulus‐locked ERP waveform: a slowly developing negativity prior to picture onset, a postonset negative slow wave, and a late negative deflection that peaked about 750 msec after picture onset. All stimulus‐locked components were larger for familiar than for unfamiliar pictures; prestimulus negativity was also greater before anticipated pictures. The response‐locked waveform contained 2 prominent features: a slowly increasing negative shift (NS) that began about 500 msec before saccade onset and a positive presaccadic potential that occurred about 30 to 90 msec before the saccade. Response‐locked components were larger for anticipatory saccades at the frontal scalp site; for reactive saccades, response‐locked components were larger at the vertex. Results are informative about ERPs in infants, cortical control of eye movements, and the development of visual expectations.

Processing speed and working memory in infancy: Evidence from a dissociation in performance on the visual expectation paradigm

Several classes of antimalarial drugs are currently available, although issues of toxicity and the emergence of drug resistant malaria parasites have reduced their overall therapeutic efficiency. Quinoline based antiplasmodial drugs have unequivocally been long-established and continue to inspire the design of new antimalarial agents. Herein, a series of mono- and bisquinoline methanamine derivatives were synthesised through sequential steps; Vilsmeier-Haack, reductive amination, and nucleophilic substitution, and obtained in low to excellent yields. The resulting compounds were investigated for in vitro antiplasmodial activity against the 3D7 chloroquine-sensitive strain of Plasmodium falciparum, and compounds 40 and 59 emerged as the most promising with IC50 values of 0.23 and 0.93 µM, respectively. The most promising compounds were also evaluated in silico by molecular docking protocols for binding affinity to the {0 0 1} fast-growing face of a hemozoin crystal model.

Behavioral and cortical measures of infants' visual expectations

Features of the habituation paradigm were combined with the visual expectation paradigm to examine behavioral and cortical indexes of infants' visual expectations. Eight 3-month-old infants watched an alternating picture sequence while their eye movements were videotaped and their cortical electrophysiological activity (event-related potential [ERP]) was recorded. Two ERP epochs were examined: a 3,000-msec stimulus-locked epoch included 1,000 msec before stimulus onset through 1,000 msec after stimulus offset; and a 1,200-msec response-locked epoch included 700 msec before saccade onset through 500 msec after the saccade. All infants anticipated upcoming pictures, and eye movement latencies for pictures that were not anticipated were comparable to saccade latencies reported in other visual expectation studies of infants at this age. Three components were identified in the stimulus-locked ERP waveform: a slowly developing negativity prior to picture onset, a postonset negative slow wave, and a late negativ...