Visual Change Detection Research Articles

A distinct circuit for biasing visual perceptual decisions and modulating superior colliculus activity through the mouse posterior striatum.

The basal ganglia play a key role in visual perceptual decisions. Despite being the primary target in the basal ganglia for inputs from the visual cortex, the posterior striatum's (PS) involvement in visual perceptual behavior remains unknown in rodents. We reveal that the PS direct pathway is largely segregated from the dorsomedial striatum (DMS) direct pathway, the other major striatal target for visual cortex. We investigated the role of the PS in visual perceptual decisions by optogenetically stimulating striatal medium spiny neurons in the direct pathway (D1-MSNs) of mice performing a visual change-detection task. PS D1-MSN activation robustly biased visual decisions in a manner dependent on visual context, timing, and reward expectation. We examined the effects of PS and DMS direct pathway activation on neuronal activity in the superior colliculus (SC), a major output target of the basal ganglia. Activation of either direct pathway rapidly modulated SC neurons, but mostly targeted different SC neurons and had opposite effects. These results demonstrate that the PS in rodents provides an important route for controlling visual decisions, in parallel with the better known DMS, but with distinct anatomical and functional properties.

Macular OCT's Proficiency in Identifying Retrochiasmal Visual Pathway Lesions in Multiple Sclerosis-A Pilot Study.

Optical coherence tomography (OCT) is a non-invasive imaging technique based on the principle of low-coherence interferometry that captures detailed images of ocular structures. Multiple sclerosis (MS) is a neurodegenerative disease that can lead to damage of the optic nerve and retina, which can be depicted by OCT. The purpose of this pilot study is to determine whether macular OCT can be used as a biomarker in the detection of retrochiasmal lesions of the visual pathway in MS patients. We conducted a prospective study in which we included 52 MS patients and 27 healthy controls. All participants underwent brain MRI, visual field testing, and OCT evaluation of the thicknesses of the peripapillary retinal nerve fiber layer (pRNFL), macular ganglion cell layer (GCL), and macular inner plexiform layer (IPL). OCT measurements were adjusted for optic neuritis (ON). VF demonstrated poor capability to depict a retrochiasmal lesion identified by brain MRI (PPV 0.50). In conclusion, the OCT analysis of the macula appears to excel in identifying retrochiasmal MS lesions compared to VF changes. The alterations in the GCL and IPL demonstrate the most accurate detection of retrochiasmal visual pathway changes in MS patients.

Hearing fearful prosody impairs visual working memory maintenance

Interference by distractors has been associated multiple times with diminished visual and auditory working memory (WM) performance. Negative emotional distractors in particular lead to detrimental effects on WM. However, these associations have only been seen when distractors and items to maintain in WM are from the same sensory modality. In this study, we investigate cross-modal interference on WM. We invited 20 participants to complete a visual change-detection task, assessing visual WM (VWM), while hearing emotional (fearful) and neutral auditory distractors. Electrophysiological activity was recorded to measure contralateral delay activity (CDA) and auditory P2 event-related potentials (ERP), indexing WM maintenance and distractor salience respectively. At the behavioral level, fearful prosody didn't decrease significantly working memory accuracy, compared to neutral prosody. Regarding ERPs, fearful distractors evoked a greater P2 amplitude than neutral distractors. Correlations between the two ERP potentials indicated that P2 amplitude difference between the two types of prosody was associated with the difference in CDA amplitude for fearful and neutral trials. This association suggests that cognitive resources required to process fearful prosody detrimentally impact VWM maintenance. That result provides a piece of additional evidence that negative emotional stimuli produce greater interference than neutral stimuli and that the cognitive resources used to process stimuli from different modalities come from a common pool.

Behavioral strategy shapes activation of the Vip-Sst disinhibitory circuit in visual cortex

In complex environments, animals can adopt diverse strategies to find rewards. How distinct strategies differentially engage brain circuits is not well understood. Here, we investigate this question, focusing on the cortical Vip-Sst disinhibitory circuit between vasoactive intestinal peptide-postive (Vip) interneurons and somatostatin-positive (Sst) interneurons. We characterize the behavioral strategies used by mice during a visual change detection task. Using a dynamic logistic regression model, we find that individual mice use mixtures of a visual comparison strategy and a statistical timing strategy. Separately, mice also have periods of task engagement and disengagement. Two-photon calcium imaging shows large strategy-dependent differences in neural activity in excitatory, Sst inhibitory, and Vip inhibitory cells in response to both image changes and image omissions. In contrast, task engagement has limited effects on neural population activity. We find that the diversity of neural correlates of strategy can be understood parsimoniously as the increased activation of the Vip-Sst disinhibitory circuit during the visual comparison strategy, which facilitates task-appropriate responses.

A signal-detection account of item-based and ensemble-based visual change detection: A reply to Harrison, McMaster, and Bays.

Growing empirical evidence shows that ensemble information (e.g., the average feature or feature variance of a set of objects) affects visual working memory for individual items. Recently, Harrison, McMaster, and Bays (2021) used a change detection task to test whether observers explicitly rely on ensemble representations to improve their memory for individual objects. They found that sensitivity to simultaneous changes in all memorized items (which also globally changed set summary statistics) rarely exceeded a level predicted by the so-called optimal summation model within the signal-detection framework. This model implies simple integration of evidence for change from all individual items and no additional evidence coming from ensemble. Here, we argue that performance at the level of optimal summation does not rule out the use of ensemble information. First, in two experiments, we show that, even if evidence from only one item is available at test, the statistics of the whole memory set affect performance. Second, we argue that optimal summation itself can be conceptually interpreted as one of the strategies of holistic, ensemble-based decision. We also redefine the reference level for the item-based strategy as the so-called "minimum rule," which predicts performance far below the optimum. We found that that both our and Harrison et al. (2021)'s observers consistently outperformed this level. We conclude that observers can rely on ensemble information when performing visual change detection. Overall, our work clarifies and refines the use of signal-detection analysis in measuring and modeling working memory.

Presaccadic attention does not facilitate the detection of changes in the visual field.

Planning a rapid eye movement (saccade) changes how we perceive our visual world. Even before we move the eyes visual discrimination sensitivity improves at the impending target of eye movements, a phenomenon termed "presaccadic attention." Yet, it is unknown if such presaccadic selection merely affects perceptual sensitivity, or also affects downstream decisional processes, such as choice bias. We report a surprising lack of presaccadic perceptual benefits in a common, everyday setting-detection of changes in the visual field. Despite the lack of sensitivity benefits, choice bias for reporting changes increased reliably for the saccade target. With independent follow-up experiments, we show that presaccadic change detection is rendered more challenging because percepts at the saccade target location are biased toward, and more precise for, only the most recent of two successive stimuli. With a Bayesian model, we show how such perceptual and choice biases are crucial to explain the effects of saccade plans on change detection performance. In sum, visual change detection sensitivity does not improve presaccadically, a result that is readily explained by teasing apart distinct components of presaccadic selection. The findings may have critical implications for real-world scenarios, like driving, that require rapid gaze shifts in dynamically changing environments.

Age-related hearing loss associated with differences in the neural correlates of feature binding in visual working memory

The underlying neural mechanisms underpinning the association between age-related hearing loss (ARHL) and dementia remain unclear. A limitation has been the lack of functional neuroimaging studies in ARHL cohorts to help clarify this relationship. In the present study, we investigated the neural correlates of feature binding in visual working memory with ARHL (controls = 14, mild HL = 21, and moderate or greater HL = 23). Participants completed a visual change detection task assessing feature binding while their neural activity was synchronously recorded via high-density electroencephalography. There was no difference in accuracy scores for ARHL groups compared to controls. There was increased electrophysiological activity in those with ARHL, particularly in components indexing the earlier stages of visual cognitive processing. This activity was more pronounced with more severe ARHL and was associated with maintained feature binding. Source space (sLORETA) analyses indicated greater activity in networks modulated by frontoparietal and temporal regions. Our results demonstrate there may be increased involvement of neurocognitive control networks to maintain lower-order neurocognitive processing disrupted by ARHL.

Artificial Neural Network Model with Astrocyte-Driven Short-Term Memory.

In this study, we introduce an innovative hybrid artificial neural network model incorporating astrocyte-driven short-term memory. The model combines a convolutional neural network with dynamic models of short-term synaptic plasticity and astrocytic modulation of synaptic transmission. The model's performance was evaluated using simulated data from visual change detection experiments conducted on mice. Comparisons were made between the proposed model, a recurrent neural network simulating short-term memory based on sustained neural activity, and a feedforward neural network with short-term synaptic depression (STPNet) trained to achieve the same performance level as the mice. The results revealed that incorporating astrocytic modulation of synaptic transmission enhanced the model's performance.

The influence of semantics and scene congruence on visual change detection during saccades

The influence of semantics and scene congruence on visual change detection during saccades

Topological insights into the neural basis of flexible behavior

It is widely accepted that there is an inextricable link between neural computations, biological mechanisms, and behavior, but it is challenging to simultaneously relate all three. Here, we show that topological data analysis (TDA) provides an important bridge between these approaches to studying how brains mediate behavior. We demonstrate that cognitive processes change the topological description of the shared activity of populations of visual neurons. These topological changes constrain and distinguish between competing mechanistic models, are connected to subjects' performance on a visual change detection task, and, via a link with network control theory, reveal a tradeoff between improving sensitivity to subtle visual stimulus changes and increasing the chance that the subject will stray off task. These connections provide a blueprint for using TDA to uncover the biological and computational mechanisms by which cognition affects behavior in health and disease.

Differences in the detail: Metacognition is better for seen than sensed changes to visual scenes

Metacognition is the process by which we know what we know. Knowing has both declarative and sensed components. Differences exist in the information that moves to our conscious awareness and how it is synthesised with existing knowledge. The current study measured metacognition by extending a visual change detection paradigm that promoted explicit or implicit detection by either a local or global manipulation of a scene. A within-subjects design was used to investigate how 91 participants detected change and made metacognitive judgements. Cognitive modelling, based on confidence judgements, estimated the relative contributions of discrete and continuous cognitive processes to change detection, and to metacognition. Metacognition was sensitive to both the discrete and continuous processes underlying change detection, but was more sensitive to the discrete process. These results demonstrate that metacognition attunes confidence differentially to explicit and implicit processes, and support direct-access theories for discrete processing and meta-representation theories for continuous processing.

Automatic Detection of Visual Changes between X-Ray Images to Support Antifraud Customs Control at Ports - A Preliminary Study

One of the goals of customs authorities is to identify, at borders, cargos that do not match their declaration, contain illegal items, or pose a hazard to society. Customs X-ray inspection procedures enable the detection of suspicious cargos and are an excellent support tool for customs officials. The ISACC project, funded under the Interreg IPA Cross-border Cooperation Italy-Albania-Montenegro Programme aims at developing a web platform that integrates data, coming from heterogeneous technologies and systems, in order to provide a rich information base supporting customs authorities during antifraud controls. In this paper, we propose a preliminary study, based on the SIFT algorithm, for the automatic detection of visual changes between scanner X-Ray images, that are part of this information base.

Visual Field Pointwise Analysis of the Idiopathic Intracranial Hypertension Weight Trial (IIH:WT).

This study was designed to determine if point analysis of the Humphrey visual field (HVF) is an effective outcome measure for people with idiopathic intracranial hypertension (IIH) compared with mean deviation (MD). Using the IIH Weight Trial data, we performed a pointwise analysis of the numerical retinal sensitivity. We then defined a medically treated cohort as having MDs between -2 dB and -7 dB and calculated the number of points that would have the ability to change by 7 dB. The HVF 24-2 mean ± SD MD in the worse eye was -3.5 ± 1.1 dB (range, -2.0 to -6.4 dB). Total deviation demonstrated a preference for the peripheral and blind spot locations to be affected. Points between 0 dB and -10 dB demonstrated negligible ability to improve, compared with those between -10 dB and -25 dB. For the evaluation of the feasibility for a potential medical intervention trial, only 346 points were available for analysis between -10 dB and -25 dB bilaterally, compared with 4123 points in baseline sensitivities of 0 to -10 dB. Patients with IIH have mildly affected baseline sensitivities in the visual field based on HVF analyzer findings, and the majority of points do not show substantial change over 24 months in the setting of a randomized clinical trial. Most patients with IIH who are eligible for a medical treatment trial generally have the mildest affected baseline sensitivities. In such patients, pointwise analysis offers no advantage over MD in detection of visual field change.

The role of attention control in visual mismatch negativity (vMMN) studies

The detection of unattended visual changes is investigated by the visual mismatch negativity (vMMN) component of event-related potentials (ERPs). The vMMN is measured as the difference between the ERPs to infrequent (deviant) and frequent (standard) stimuli irrelevant to the ongoing task. In the present study, we used human faces expressing different emotions as deviants and standards. In such studies, participants perform various tasks, so their attention is diverted from the vMMN-related stimuli. If such tasks vary in their attentional demand, they might influence the outcome of vMMN studies. In this study, we compared four kinds of frequently used tasks: (1) a tracking task that demanded continuous performance, (2) a detection task where the target stimuli appeared at any time, (3) a detection task where target stimuli appeared only in the inter-stimulus intervals, and (4) a task where target stimuli were members of the stimulus sequence. This fourth task elicited robust vMMN, while in the other three tasks, deviant stimuli elicited moderate posterior negativity (vMMN). We concluded that the ongoing task had a marked influence on vMMN; thus, it is important to consider this effect in vMMN studies.

Theta phase coherence in visual mismatch responses involved in access processing to visual awareness.

Introduction: The electroencephalographic brain response to a deviation from the preceding sequential regularity of visual events, called visual mismatch negativity (vMMN), is well known to reflect automatic visual change detection. Our preliminary study showed a significant correlation between the enhancement of the vMMN amplitude and facilitation of perceptual alternation in binocular rivalry when the deviant stimulus was presented unconsciously. This implies that the vMMN is relevant to access processing, in which the unconscious stimulus is consciously perceived. Recent studies have reported that theta band oscillation evoked by a deviant stimulus is involved in evoking vMMN. However, it has not been clarified whether theta band oscillation associated with vMMN is also relevant to access processing. Methods: We analyzed the correlations between event-related spectral perturbation (ERSP) and inter-trial phase coherence (ITPC) in the theta band and the proportion of perceptual alternation from before to after the presentation of deviation in the same experimental paradigm as in our previous study. Results: We found that an increase in ITPC in the theta band tended to correlate with facilitation of perceptual alternation in binocular rivalry when the deviant was presented unconsciously, but there was no significant correlation in ERSP. Discussion: The results suggest that theta phase coherence underlying the visual mismatch process is relevant to the access processing.

Colorimetric Plasmonic Hydrogen Gas Sensor Based on One-Dimensional Nano-Gratings

Plasmonic hydrogen gas sensors have become widely used in recent years due to their low cost, reliability, safety, and measurement accuracy. In this paper, we designed, optimized, and fabricated a palladium (Pd)-coated nano-grating-based plasmonic hydrogen gas sensor; and investigated using the finite-difference time-domain method and experimental spectral reflectance measurements, the calibrated effects of hydrogen gas exposure on the mechano-optical properties of the Pd sensing layer. The nanostructures were fabricated using DC sputter deposition onto a one-dimensional nano-grating optimized with a thin-film gold buffer to extend the optical response dynamic range and performance stability; the color change sensitivity of the Pd surface layer was demonstrated for hydrogen gas concentrations as low as 0.5 vol.%, up to 4 vol.%, based on the resonance wavelength shift within the visible band corresponding to the reversible phase transformation. Visual color change detection of even the smallest hydrogen concentrations indicated the high sensitivity of the gas sensor. Our technique has potential for application to high-accuracy portable plasmonic sensors compatible with biochemical sensing with smartphones.

Saccade preparation does not benefit visual change detection

Saccade preparation does not benefit visual change detection

Between the Scenes.

We constantly move our eyes to new information while inspecting a scene, but these patterns of eye movements change based on the task and goals of the observer. Inhibition of return (IOR) may facilitate visual search by reducing the likelihood of revisiting previously attended locations. However, IOR may present in any visual task, or it may be search-specific. We investigated the presence of IOR in foraging, memorization, change detection, and two versions of visual search. One version of search used a static search array that remained stable throughout the trial, but the second used a scene flickering paradigm similar to the change detection task. IOR was observed in both versions of visual search, memorization, and foraging, but not in change detection. Visual search and change detection both had temporal nonscene components, and we observed that IOR could be maintained despite the scene removal but only for search. Although IOR is maintained in scene coordinates, short disruptions to this scene are insufficient to completely remove the inhibitory tags. Finally, we compare return saccades in trials without a probe and observe fewer return saccades in tasks for which IOR was observed, providing further evidence that IOR might serve as a novelty drive.

A Sensitive Visual Method for the Detection of Hydrogen Sulfide Producing Bacteria

Hydrogen sulfide (H2S) is a toxic gas produced by bacteria in the proteolysis of sulfur-containing amino acids and proteins that plays an important role in human health. The H2S production test is one of the important bacterial biochemical identification tests. The traditional methods are not only tedious and time-consuming but also prone to inhibition of bacterial growth due to the toxic effect of heavy metal salts in sulfur-containing medium, which often leads to negative results. Here, we established a simple and sensitive method to detect H2S in bacteria. This method is a modified version of bismuth sulfide (BS) precipitation that uses 96-well transparent microtiter plates. Bacterial culture was combined with bismuth solution containing L-cysteine and cultivated for 20 min, at the end of which a black precipitate was observed.The visual detection limit for H2S was 0.2 mM. Based on the visual color change, the simple, high-throughput, and rapid detection of H2S producing bacteria can be achieved. In summary, this method can be used to identify H2S production in bacteria.

Benchmarking the effects of transcranial temporal interference stimulation (tTIS) in humans

Deep brain stimulation (DBS) provides clinical benefits for several neurological and psychiatric conditions. By overcoming the limitations and risks of conventional DBS, transcranial temporal interference stimulation (tTIS) has the potential to offer non-invasive stimulation of deep brain regions. However, research that investigates the efficacy of tTIS is limited to animal studies or computer simulations and its capability to modulate neural oscillations in humans has not been demonstrated so far. The method of tTIS is hypothesized to elicit its effects via neural entrainment, corresponding to the supposed mechanism of action underlying transcranial alternating current stimulation (tACS), another, more established non-invasive brain stimulation technique. Physiological effects of tACS are well established for cortical brain oscillations, but not for deep brain structures. In particular, aftereffects on the power of parieto-occipital alpha oscillations have been shown repeatedly. In a first attempt to test the efficacy of tTIS in the human brain, the current study thus seeks to compare the effects of tTIS to the well-studied aftereffect of tACS in the cortex. To investigate this research question, the current study compared MEG-recorded brain activity during a simple visual change detection task in 34 healthy subjects pre- and post-tTIS. Additionally, the effects of tTIS were contrasted to conventional tACS and a control stimulation. We expected that the parieto-occipital α-power will increase after tTIS and tACS, in contrast to the control stimulation. Overall, no difference between the experimental groups (tTIS, tACS and control stimulation) were found regarding the source-projected increase in α-power. Based on the results of the study two hypothesis can be made: tTIS, tACS and the control stimulation condition don't have an effect on human brain oscillations in the α-band, or, any experimental conditions of the current study can modulate brain oscillations in the α-band. Both hypotheses emphasize the importance of further studies investigating different carrier frequencies, and the comparison to sham stimulation.