Viscous Character Research Articles

Effects of soybean-oil and emulsifiers mixture on rheological properties of oil-in-water emulsions

The effects of soybean-oil and emulsifiers mixture on rheological properties of oil-in-water emulsions were investigated. Polysorbate-80 and sorbitan-monooleate in the ratio 1:3 were added to stabilize a soybean-oil emulsion by high-pressure homogenization at 50 and 100 MPa. Particle size and rheological properties were measured. The z-average size value showed all the droplets ranging from 295.5 to 302.3 nm. The emulsions were Newtonian and non-Newtonian pseudoplastic at 50 MPa, although at 100 MPa exhibited a Newtonian behavior, preferably. The highest concentrations of soybean-oil and emulsifiers mixture showed semi-solid emulsions (at 50 MPa), and the lower concentrations of soybean-oil and emulsifiers mixture, showed semi-solid emulsions (at 100 MPa), however, elastic character predominated over viscous character (G’>G’’), for both pressures. In conclusion, the emulsion systems were nanoemulsions and their droplet size distribution was bimodal. The nanoemulsions had a non-Newtonian behavior for both pressures, although at 100 MPa the emulsions were Newtonian.

Substrate stress relaxation regulates neural stem cell fate commitment

Adult neural stem cells (NSCs) reside in the dentate gyrus of the hippocampus, and their capacity to generate neurons and glia plays a role in learning and memory. In addition, neurodegenerative diseases are known to be caused by a loss of neurons and glial cells, resulting in a need to better understand stem cell fate commitment processes. We previously showed that NSC fate commitment toward a neuronal or glial lineage is strongly influenced by extracellular matrix stiffness, a property of elastic materials. However, tissues in vivo are not purely elastic and have varying degrees of viscous character. Relatively little is known about how the viscoelastic properties of the substrate impact NSC fate commitment. Here, we introduce a polyacrylamide-based cell culture platform that incorporates mismatched DNA oligonucleotide-based cross-links as well as covalent cross-links. This platform allows for tunable viscous stress relaxation properties via variation in the number of mismatched base pairs. We find that NSCs exhibit increased astrocytic differentiation as the degree of stress relaxation is increased. Furthermore, culturing NSCs on increasingly stress-relaxing substrates impacts cytoskeletal dynamics by decreasing intracellular actin flow rates and stimulating cyclic activation of the mechanosensitive protein RhoA. Additionally, inhibition of motor-clutch model components such as myosin II and focal adhesion kinase partially or completely reverts cells to lineage distributions observed on elastic substrates. Collectively, our results introduce a unique system for controlling matrix stress relaxation properties and offer insight into how NSCs integrate viscoelastic cues to direct fate commitment.

Impact of temperature on ophthalmic viscosurgical devices and clinical implications: a pilot study.

To evaluate how temperature affects the rheology of common ophthalmic viscosurgical devices (OVDs) and clinical implications. Tennent Institute of Ophthalmology, Glasgow, with Department of Mechanical and Aerospace Engineering, and Advanced Materials Research Laboratory, University of Strathclyde, Glasgow, United Kingdom. Laboratory pilot study. The viscous and elastic responses of 3 OVDs (Eyefill-SC/Eyefill-C/Eyefill-HD) were measured using rotational and extensional rheometers at clinically relevant temperatures (5°C, 25°C, 37°C). Thermal properties were evaluated using differential scanning calorimetry and laser-flash analysis. The OVDs tested exhibited viscoelastic properties and shear-thinning behavior. Apparent viscosities and relaxation time were higher at lower temperatures. The Eyefill-C and Eyefill-SC exhibited predominantly viscous character at low frequencies with a transition to predominantly elastic behavior at high frequencies. An increase in temperature led to a decrease in relaxation time under shear and extension. At low frequencies, Eyefill-C and Eyefill-SC moduli increase with decreasing temperatures. Eyefill-HD at 25°C and 37°C displays 2 crossover points, with the storage modulus dominating at low and high frequencies indicating a predominantly elastic behavior. Thermal property analysis revealed Eyefill-C had the lowest thermal conductivity. This pilot study confirms our clinical experience that OVD properties are affected by low temperatures, with increased viscosities at low shear rates and higher relaxation times. Cold OVD can cause greater resistance to initiation of intraocular lens (IOL) injection system forces (compared with warmer OVD). Excessively forced injection using cold OVD could contribute to inadvertent cannula detachment if incorrectly assembled, or uncontrolled IOL release leading to avoidable injury.

In situ interaction of pea peptides and bile salts under in vitro digestion: Potential impact on lipolysis

The present work evaluated how a native pea protein isolate (PPI) affects the key roles carried out by bile salts (BS) in lipid digestion by means of the in vitro static INFOGEST protocol. Two gastric residence times were evaluated (10 and 60 min), and then the peptides obtained (GPPP) were mixed with BS at physiological concentration in simulated intestinal fluid to understand how they interact with BS both at the bulk and at the interface. Both GPPP give rise to a film with a predominant viscous character that does not constitute a barrier to the penetration of BS, but interact with BS in the bulk duodenal fluid. When the peptides flushing from the stomach after the different gastric residence times undergo duodenal digestion, it was found that for the longer gastric residence time the percentage of soluble fraction in the duodenal phase, that perform synergistically with BS micelles, was twice that of the lower residence time, leading to an increase in the solubilization of oleic acid. These results finally lead to a greater extent of lipolysis of olive oil emulsions.This work demonstrates the usefulness of in vitro models as a starting point to study the influence of gastric residence time of pea protein on its interaction with BS, affecting lipolysis. Pea proteins were shown to be effective emulsifiers that synergistically perform with BS improving the release and bioaccessibility of bioactive lipids as olive oil.

Physicochemical and Rheological Characterization of a Novel Manna Exudate from Alhagi pseudalhagi (Iranian Tarangabin)

Tarangabin manna (TM) is a resinous substance having a yellowish sticky character with a reasonably sweet taste. It is largely collected in Iran and Afghanistan. This study for the first time presents a comprehensive investigation of the techno-functional, rheological, and interfacial characteristics of water-soluble components for TM. The composition analysis revealed protein, moisture, fat, ash, and carbohydrate contents of 1.58, 2.98, 0.51, 2.04, and 92.90%, respectively. The effects of TM concentration on the physicochemical, structural, rheological, interfacial, emulsion, and foaming ability and stability were evaluated. X-ray diffraction analysis showed an amorphous structure for the purified sample and a crystalline structure for the raw sample. TM solutions exhibited Newtonian behavior, with the apparent viscosity decreasing as temperature increased, fitting well with the Arrhenius model. The TM solutions exhibited weak viscoelastic properties, primarily demonstrating a dominant viscous character. The surface tension and interfacial tension of the TM solution prepared at a concentration of 50% were measured at 45.23 mN/m and 7.74 mN/m, respectively. The contact angle of the dry thin layer of TM was determined to be 31.74°. Remarkably, the TM solution at a concentration of 50% exhibited the highest foaming ability (76.80%), foaming stability (91.92%), and emulsifying activity index (24.53%). The findings, coupled with TM appropriate foaming ability and stability, sweetness, and characteristic flavor, suggest that TM holds potential as a special food ingredient.

Techno-functional properties of quality protein maize (QPM) (Zea mays L.) protein concentrates

Nowadays, new strategies and alternatives are being implemented to improve the protein quality of foods containing essential amino acids, like quality protein maize (QPM). The techno-functional properties of protein concentrate from QPM maize: Sac Beh (SB), Chichen Itza (ChI), and Blanco Uxmal (BU); non-nixtamalized (NN) and nixtamalized (N), were evaluated in the present work. The non-nixtamalized varieties showed higher amounts of protein in the QPM ChI (86.81%) and nitrogen solubility of 64.94% as the pH increased to 9. The emulsifying capacity was higher at pH 5 (60.74%). The non-nixtamalized SB samples showed higher foaming stability (1.82%) at pH 7, and the non-nixtamalized BU samples had higher foaming capacity at pH 5 (60.74%). Water holding capacities ranging from 1.2 to 3.13 g/g were achieved. The non-nixtamalized QPM concentrates had higher water and oil holding capacities. There was a predominance of elastic character over viscous character (G' > G'') in all treatments behaving as weak gels, which were affected in alkaline conditions by decreasing the modulus value. The techno-functional properties were affected by the processing method. These results could be beneficial for providing a better understanding of the properties of QPM proteins, allowing innovative ways of utilising these proteins as an ingredient in food systems.

Breakup of thin liquid films with viscous interfaces

Thin liquid films are ubiquitous in nature and have many practical applications. From biological films to the curtain coating process, thin films are present in both large and small scales. Despite their importance, understanding the stability of these films remains a significant challenge due to the fluid–fluid interface that is free to deform, affected by interfacial tension and complex rheological behavior. Instabilities in thin films are often caused by van der Waals attractions, which can lead to the rupture of the layer. To investigate the rupture dynamics, numerical methods are commonly used, such as asymptotic derivations of the lubrication theory or interface tracking methods. In this paper, we present a computational study of the breakup dynamics of a stationary thin liquid sheet bounded by a passive gas with a viscous interface, using the arbitrary Lagrangian–Eulerian method and the Boussinesq–Scriven constitutive law to model the rheological behavior. Our results demonstrate that the stability of thin liquid films is influenced by both surface rheology and disjoining effects and that the viscous character of the interface can delay sheet breakup, leading to more stable films.

Lose the stress: Viscoelastic materials for cell engineering.

Biomaterials are widely used to study and control a variety of cell behaviors, including stem cell differentiation, organogenesis, and tumor invasion. While considerable attention has historically been paid to biomaterial elastic (storage) properties, it has recently become clear that viscous (loss) properties can also powerfully influence cell behavior. Here we review advances in viscoelastic materials for cell engineering. We begin by discussing collagen, an abundant naturally occurring biomaterial that derives its viscoelastic properties from its fibrillar architecture, which enables dissipation of applied stresses. We then turn to two other naturally occurring biomaterials that are more frequently modified for engineering applications, alginate and hyaluronic acid, whose viscoelastic properties may be tuned by modulating network composition and crosslinking. We also discuss the potential of exploiting engineered fibrous materials, particularly electrospun fiber-based materials, to control viscoelastic properties. Finally, we review mechanisms through which cells process viscous and viscoelastic cues as they move along and within these materials. The ability of viscoelastic materials to relax cell-imposed stresses can dramatically alter migration on two-dimensional surfaces and confinement-imposed barriers to engraftment and infiltration in three-dimensional scaffolds. STATEMENT OF SIGNIFICANCE: Most tissues and many biomaterials exhibit some viscous character, a property that is increasingly understood to influence cell behavior in profound ways. This review discusses the origin and significance of viscoelastic properties of common biomaterials, as well as how these cues are processed by cells to influence migration. A deeper understanding of the mechanisms of viscoelastic behavior in biomaterials and how cells interpret these inputs should aid the design and selection of biomaterials for specific applications.

MAGNETIC-PULSED TREATMENT TO IMPROVE THE STRENGTH PROPERTIES OF DEFECTIVE SECTIONS OF OIL AND GAS PIPELINES

Link for citation: Schipachev A.M., Mohammed Aljadly. Magnetic-pulse treatment to improve the strength properties of defective sections of oil and gas pipelines. Bulletin of the Tomsk Polytechnic University. Geo Аssets Engineering, 2023, vol. 334, no. 5, рр.7-16.In Rus. The relevance. During the operation of oil and gas pipelines, continuity defects (including point and linear defects such as delamination, cracks of various nature, etc.) occur in their structure. The peculiarity of material continuity defects is caused by the fact that in the process of loading the defects cause stress concentration near their tops, which leads to a rapid increase in their number and geometric dimensions, followed by the merging of the latter and the formation of large discontinuities, and as a consequence, the strength properties of pipelines decrease. Consequently, early detection of metal continuity defects and their elimination before they reach a critical size are urgent tasks. The solution of which will significantly improve the operational and strength properties of the working elements of pipelines and extend their lifespan. The main aim of the research is to study the effectiveness of magnetic-pulse treatment to improve the strength properties of used oil and gas pipelines by reducing the defects size. Objects: defective sections of main oil and gas pipelines. Methods: magnetic pulse treatment of samples on a magnetic-pulse unit MPU-10-SSAU 10, determination of temperature changes caused by magnetic-pulse treatment, testing samples for impact strength on a pendulum-testing machine, comparison of the obtained results for treated and untreated samples, determination of the effect of magnetic-pulse treatment on the strength properties of gas pipeline metal, study of the fracture surface of samples after impact tests. Results. It was established experimentally that the impact strength of the treated samples increased by 14 % compared to the untreated samples. Snapshots of the temperature distribution during the magnetic-pulse treatment showed a significant increase in temperature near the crack tips. It was found that destruction of the metal subjected to magnetic-pulse action acquired more viscous character.

Nonlinearity in large amplitude oscillatory shear of drilling fluid: A comparative study on the oil and water base muds behavior

A viscoelastic material exhibits both fluid (viscous) and solid (elastic) like properties simultaneously. The rheological behavior of drilling fluids is customarily measured under the assumption of pure viscous flow, yet they exhibit both viscous and elastic characteristics when subjected to deformation. Some imperative properties of drilling fluids such as gel strength, yield stress, and sag tendency at near-zero shear rate region are categorically under the influence of viscoelastic behavior and have not yet been completely understood due to the lack of appropriate measurement methods. Characterizing the complete rheological profile of material requires measuring linear and nonlinear viscoelastic responses at a wide range of stress/strain levels. The viscoelastic nonlinearity can be characterized under Large Amplitude Oscillatory Shear (LAOS) tests. This study presents a large amplitude oscillatory shear rheology investigation of two water-base (Lignosulfonate and KCl/polymer) and two oil-base (low and high temperature) drilling fluids each in three states; unweighted, weighted, and weighted-contaminated. The viscoelastic nonlinearities of four fluid samples were investigated experimentally as a function of strain amplitude and strain-rate space at different temperatures. The results were described using Lissajous-Bowditch (L-B) plots and local nonlinear viscoelastic dynamic moduli through an oscillatory shear cycle. Structural stability of fluid samples was also studied using the creep-recovery test. The nonlinear viscoelastic behavior of drilling fluids was comprehensively compared and distinguished to understand their nonlinear shear mechanism. As a result of the creep-recovery test at 150 °C, high-temperature oil base mud provided higher thermo-structural stability and zero shear viscosity than those of Lignosulfonate, KCl/polymer, and low-temperature oil-base muds. While the elastic nonlinearity was found to be strain/strain rate softening, the nonlinear viscous character was recorded as shear/shear rate thinning at large strain rates for all drilling fluid systems. Quite a different shear mechanism was detected at low and moderate strain rates. Shear rate thinning was found to be the dominant mechanism for all fluids except Lignosulfonate mud samples that demonstrated shear-thickening behavior at moderate strain rates at 25 °C. At high temperatures (100 °C and 150 °C), shear rate thickening followed by shear rate thinning behavior was governing mechanism under the low and moderate strain rates in all mud samples except KCl/polymer muds. An inverse behavior (shear rate thinning followed by shear rate thickening) was observed through low and moderate strain rates in KCl/polymer muds at 100 °C and 150 °C. Therefore, as revealed from the LAOS test results, shear rate thickening behavior at low to moderate strain rates is in contradiction of the commonly known shear thinning behavior for a drilling fluid undergoing viscous deformation. This finding explains the facts underlying some important properties of drilling fluids such as gel structure formation, hole cleaning ability, and sag tendency.

Rheological Characterization of the Influence of Pomegranate Peel Extract Addition and Concentration in Chitosan and Gelatin Coatings

In this study, the effects of an agro-industrial residue with active properties, pomegranate peel extract (PPE), were evaluated on the rheological properties of potential coatings based on chitosan (C) and gelatin (G). For this, rheological properties of the polymeric solutions were investigated in relation to PPE concentration (2 or 4 mg PPE g−1 solution), and to its incorporation order into the system (in C or in CG mixture). All solutions were more viscous than elastic (G″ > G′), and the change in PPE concentration had a greater influence accentuating the viscous character of the samples in which PPE was added to the CG mixture (CGPPE2 and CGPPE4). PPE addition to the CG mixture increased the angular frequency at the moduli crossover, indicating the formation of a more resistant polymeric network. This tendency was also observed in flow results, in which PPE addition decreased the pseudoplastic behavior of the solutions, due to a greater cross-linking between the polymers and the phenolic compounds. In general, all the studied solutions showed viscosities suitable for the proposed application, and it was possible to state the importance of standardizing the addition order of the components during the preparation of a coating.

Effect of modulation of interfacial properties on the tribological properties of viscoelastic epoxy resin damping coatings

The viscoelastic materials exhibit different tribological responses when compared to the stiff materials, due to the intermediate mechanical properties between viscous liquid and elastic solid. In this work, the effect of damping materials viscoelasticity on sliding friction under dry condition was investigated. However, it was difficult to change its damping properties only while other properties (strength or surface hardness) remain unchanged, since viscoelasticity was one of its intrinsic properties. Therefore, the attention of interactions between the material components was closely paid. To achieve this, the experimental groups of damping materials with various viscoelasticity were established by adding various fillers and adjusting their surface properties. Additionally, a viscoelastic property determined friction coefficient model was obtained and validated by the molecular dynamic method. The results show that the test model is in good agreement with the experimental results. Meanwhile, tribo-pairs with higher proportion of viscous character had greater oscillations in friction. They also exhibited higher friction coefficient due to the increased contribution of viscoelastic hysteresis losses to friction.

Characteristics of gluten-free potato dough and bread with different potato starch-protein ratios

Abstract The poor retention of fermentation gases and air is a critical issue for gluten-free (GF) products. To better understand the effect of potato flour on the characteristics of GF bread, the mechanistic relations between potato starch and potato protein in different ratios at 9:1, 8:2, 7:3, 6:4 and 5:5 for GF dough were investigated for viscoelasticity, thermal properties, moisture, microstructures, and bread quality. The results reveal that potato starch had a relatively important role in both dough and bread. The viscous character of dough was highest at a proportion of 6:4, with a more compact microstructure and better bread color, volume, hardness, chewiness, resilience and springiness. With decreasing starch content, the gelatinization and retrogradation enthalpy decreased, and the relaxation time of immobilized water and free water increased significantly. These results are believed to be helpful for processors to develop and optimize GF breads with potato starch and potato protein.

Intrinsic properties of osteomalacia bone evaluated by nanoindentation and FTIRM analysis

Osteomalacia is a pathological bone condition consisting in a deficient primary mineralization of the matrix, leading to an accumulation of osteoid tissue and reduced bone mechanical strength. The amounts, properties and organization of bone constituents at tissue level, are known to influence its mechanical properties. It is then important to investigate the relationship between mechanical behavior and tissue composition at this scale in order to provide a better understanding of bone fragility mechanisms associates with this pathology.Our purpose was to analyze the links between ultra-structural properties and the mechanical behavior of this pathological bone tissue (osteomalacia) at tissue level (mineral and osteoid separately, or global). Four bone biopsies were taken from patients with osteomalacia, and subsequently embedded, sectioned, and polished. Then nanoindentation tests were performed to determine local elastic modulus E, contact hardness Hc and true hardness H for both mineralized and organic bone phases and for the global bone. The creep of the bone was also studied using a special indentation procedure in order to assess visco-elasto-plastic (creep) bone behavior. This allowed a detailed study of the rheological models adapted to the bone and to calculate the parameters associated to a Burgers model. Ultra-structural parameters were measured by Fourier Transform InfraRed Microspectroscopy (FTIRM) on the same position as the indents.The use of rheological models confirmed a significant contribution from the organic phase on the viscous character of bone tissue. The elastic E and the elasto-plastic Hc deformation were correlated to both collagen maturity and Mineral/Matrix. The pure plastic deformation H was only correlated to the mineral phase. Our data show that mineral phase greatly affects mechanical variables (moduli and viscosities) and that organic phase (as illustrated in osteoid tissue) may play an important role in the creep behavior of bone. In conclusion, this study brings mechanical and physicochemical values for osteoid and mineral phases.

Change of Microstructure and Analysis of Fracture of the Ti-50.8 at.% Ni Alloy in the Ultrafine-Grained State after Multiple Martensitic Transformations with a Large Number of Cycles

The microstructure and mechanical properties of the ultrafine-grained Ti–50.8 at.% Ni alloy after thermal cycling treatment with the number of cycles up to 250 was investigated. A fractographic analysis of the samples after tensile tests was carried out. The fracture pattern of the alloy in the UFG state has a viscous character with microdepths on the fracture surface. The average size of microdepths decreases as the number of thermal cycles increases up to n= 250.

Ispitivanje reološkog ponašanja i njegov značaj za procenu aplikativnih svojstava i fizičke stabilnosti hidrogelova sa fitosomima

Phytosomes are amphiphilic molecular complexes of substances of plant origin and phospholipids that are considered as active ingredients of dermopharmaceutical and cosmetic formulations of potentially improved efficiency. The study aim was the formulation of carbomer hydrogels with commercially available phytosomes of escin (Escin ß-Sitosterol Phytosome®) (EP) and 18-ß glycyrrhetinic acid (18-ß Glycyrrhetinic Acid Phytosome®) (GP) and evaluation of their application properties and real-time physical stability. Phytosomes incorporation did not significantly affect pH of the hydrogels, which was acceptable for cutaneous application. However, these hydrogels had significantly different organoleptic properties (opaque and softer consistency) compared to the hydrogel without active substance (C) and the hydrogels with pure active substances (E and G) used for comparison. The values of maximum and minimum apparent viscosity and yield stress were significantly lower in phytosome-loaded hydrogels. The results of oscillatory rheological analysis indicated that viscous character prevails in EP and GP hydrogels (elastic modulus (G')˂viscous modulus (G")), while in hydrogels C, E and G elastic properties were more pronounced (G'˃G"). Escin phytosome had greater influence on carbomer gel network strength. Phytosome-loaded hydrogels were physically stable during 24 months of storage under ambient conditions, although the rheological analysis also indicated a potential risk of sedimentation.

Advection kinetics induced self-assembly of colloidal nanoflakes into microscale floral structures

The article explores the governing role of the internal soluto-thermal hydrodynamics and advective transport within sessile colloidal droplets on the self-assembly of nanostructures to form floral patterns. Water–acetone mixture and Bi2O3 nanoflakes based complex fluids are used as the experimental liquids. Micro-liter sessile droplets are allowed to vaporize and the dry-out patterns are examined using scanning electron microscopy. The presence of distributed self-assembled rose-like structures is observed and is postulated to be formed by the hydrodynamic interactions within the drying droplet. The population density, structure and shape of the floral structures are noted to be dependent on the binary fluid composition and nanomaterial concentration. Detailed microscopic particle image velocimetry and infrared thermography analysis is undertaken to qualitatively and quantitatively describe the solutal Marangoni advection within the evaporating droplets. It has been shown that the kinetics, regime and spatial distribution of the internal flows are dominantly responsible factors towards the advection influenced clustering, aggregation and self-assembly of the nanoflakes. In addition, the size of the nanostructures and the viscous character of the complex fluid are also noted to play dominant roles. The resulting interplay of hydrodynamic behavior, adhesion and cohesion forces during the droplet dry-out phase, and thermodynamic energy minimization leads to formation of such floral structures. The findings may have strong implications towards modulating micro-hydrodynamics induced self-assembly in complex fluids.

Structure conformational and rheological characterisation of alfalfa seed (Medicago sativa L.) galactomannan

In the present work a galactomannan extract of low protein residue (< 1.3 % wt dry basis) was isolated from alfalfa (Medicago sativa L.) seed endosperm meal. The alfalfa gum (AAG) comprised primarily mannose and galactose at a ratio of 1.18:1, had a molecular weight of 2 × 106 Da and a radius of gyration of 48.7 nm. The average intrinsic viscosity of the dilute AAG dispersions calculated using the modified Mark-Houwink, Huggins and Kraemer equations was 9.33 dLg−1 at 25 °C. The critical overlap concentration was estimated at 0.306 % whereas the concentration dependence of specific viscosity for the dilute and semi-dilute regimes was ∝ C2.3 and C4.2, respectively. The compliance to the Cox-Merz rule was satisfied at 1% of AAG, whereas a departure from superimposition was observed at higher concentrations. Viscoelasticity measurements demonstrated that AAG dispersions exhibit a predominant viscous character at 1 % wt, whereas a weak gel-like behaviour was reached at AAG concentrations ≥3 %.

Meloxicam-loaded solvent exchange-induced in situ forming beta-cyclodextrin gel and microparticle for periodontal pocket delivery.

The in situ forming system has attracted attention for periodontitis treatment owing to its sustainable drug release localisation at a periodontal pocket. Given its low aqueous solubility, beta-cyclodextrin (β-CD) may serve as a matrix former of solvent exchange-induced in situ forming gel (ISG) and microparticle (ISM). Meloxicam (Mex)-loaded-β-CD ISG and ISM were prepared using β-CD in dimethyl sulphoxide (ISG) as the internal phase and camellia oil comprising 5% glyceryl monostearate as the external phase (ISM). Mex-loaded β-CD systems comprising 40% β-CD were easily injected via a 24-gauge needle. During solvent exchange with phosphate buffer saline (pH6.8), the highly concentrated β-CD ISG promoted the phase inversion of β-CD aggregates into matrix-like. Upon exposure to aqueous phase, the ISM system comprising 40% β-CD transformed into microparticles and extended the drug release to 7days with minimised initial burst release following Fickian diffusion. Moreover, the potential degradability was evident from the high weight loss. High maximum deformation force with high viscous character initiated the slow diffusion rate of the solvent from the ISM system. Therefore, 40% β-CD ISM is a potential local Mex-controlled release system of anti-inflammatory drug for periodontitis treatment.

Incorporation of POSS to improve thermal stability of bio‐based polymethacrylates by nitroxide‐mediated polymerization: Polymerization kinetics and characterization

AbstractNitroxide‐mediated polymerization (NMP) was used to polymerize methacrylate‐functionalized polyhedral oligomeric silsesquioxane, POSSMA, in a controlled manner with bio‐based C13 methacrylate (C13MA) to improve the thermal stability of the latter by copolymerization (using 10 mol% acrylonitrile controlling comonomer). Kinetic experiments (80–110 °C) revealed the relatively low ceiling temperature of POSSMA (135 °C). Synthesis of poly(POSSMA‐co‐AN) with f AN,0 = 0.10 at 90 °C resulted in low dispersity (1.16) and relatively high conversion (~50%) after 3 hr in 50 wt% toluene. Assuming binary statistical copolymerizations, POSSMA was slightly less reactive than C13MA toward the propagating species (r POSSMA = 0.91 ± 0.07 and r C13MA = 1.94 ± 0.13). Incorporating POSSMA up to 68 mol% improved decomposition temperature of C13MA‐based copolymers from 190 to 262 °C. Chain end fidelity of POSSMA‐rich compositions was confirmed by subsequent chain extensions to make block and gradient copolymers. Differential scanning calorimetry revealed multiple transition temperatures in block copolymers, suggesting microphase separation. Powder X‐ray diffraction confirmed crystalline domains ~30 nm in POSSMA‐rich statistical copolymers while transmission electron microscopy revealed weakly ordered lamellar morphology for poly(C13MA‐co‐AN)‐b‐(POSSMA‐co‐AN) block copolymer at a smaller length scale. Oscillatory shear measurements of block copolymers indicated primarily viscous character below 200 s−1 but crossover above this frequency, indicating POSS–POSS interactions were increasing the elasticity of the block copolymers.