An uncoupled fracture criterion based on a simple damage indicator computed using a mean-field crystal plasticity framework is proposed and applied to predict failure of an AZ31 sheet originating from the edges. The damage indicator quantifies the contribution of strain components along the axes of orthotropy leading to material failure. The model is calibrated by uniaxial tension tests. The damage indicator is validated for various mixed-mode deformation histories realized by modified Arcan tests in various loading configurations. The loading history of respective fracture sites obtained from DIC analyses is directly employed to a visco-plastic self-consistent crystal plasticity model to obtain the stress responses. The results indicate that the damage indicator requires – beside the strain history – an input of stress triaxiality, by which an improved predictive accuracy can be achieved. This effect is quantified for various loading scenarios, in which cracks are initiated near or at the edge of the sample.