The study made it possible to identify and describe factors such as risk in the student's academic performance during the pandemic scenario. Durón and Oropeza (1999), cited by Izar Landeta et al. (2012), assume the psychological, biological, sociological and pedagogical aspects. The study responds to the non-experimental design of basic level, substantive, descriptive and explanatory. The data was collected from a questionnaire for the detection of risks associated with the indicators. The population consisted of university students identified by non-probabilistic opinion sampling. The study found that the sociological factor has a greater risk impact with an estimate of 0.96; and the indicator regarding the forms of greetings, emotional approaches of the student with the highest coefficient of 0.963 p. value <0.05*** detaching due to duels to the loss of a being, to the loss of the academic semester, practice of social customs, dialogue and emotional reactions. Regarding the psychological factor, it presents an estimation risk of 0.88 to academic performance, the anxiety indicator presents a higher resonance index. Regarding the pedagogical factor, it presents a 0.91 risk index, demonstrating the lack of experimental actions, field work, laboratory practices, guided experimentations, economic disadvantages for access and use of virtual tools. Finally, there is the biological factor that presents the 0.85 risk, showing biological disorders generated by sedentary lifestyle to the detriment of academic performance. The sociological factor with the indicator forms of greetings, emotional approaches of the student, coping with duels in the loss of a being, and in the loss of the academic semester has a greater impact, within the psychological factor, the anxiety indicator has a higher resonance index, while, in the pedagogical factor, the risks are manifested by the lack of experimental actions, field work, laboratory practices, guided experimentations. Finally, in the biological factor, the sedentary lifestyle indicator is the greatest detriment to academic performance.