Children with medical complexity (CMC) and their caregivers are particularly vulnerable to the pernicious effects of disasters. This multicenter observational investigation in Ehime Prefecture, Japan, aimed to assess caregivers' perspectives on the disaster preparedness for children relying on home ventilators or home oxygen, determine their inclinations towards evacuation, and identify their concerns regarding a disaster. Caregivers of children receiving home care with a ventilator or oxygen therapy were recruited. Participants were administered multiple-choice questions and requested to provide free-text comments about their concerns. As a result, of 99 participants, 49.5 % (N = 49) reported being well-prepared for a disaster. While 27.3 % (N = 27) stated that they would evacuate, 25.2 % (N = 25) stated never evacuate. Caregivers for totally dependent children were more likely to decline evacuation. 68.7 % (N = 68) reported never having discussed with medical professionals about disaster preparedness. 44.4 % (N = 44) reported not having a backup power supply. 66.7 % (N = 66) expressed concerns about residing in an evacuation shelter. Other concerns included power outages, inadequate resources, and a lack of feasible evacuation options. In conclusion, Many caregivers perceive that they are insufficiently prepared for a disaster. Caregivers have a diverse range of concerns about disasters. Medical professionals and other stakeholders should recognize caregivers’ difficulties and promote communications about disaster preparedness.Practice Implications.Professionals engaged in the care of CMC should acknowledge unique needs of children and their caregivers, assure them of their right to survive during a disaster, and facilitate discussions about preparedness. The viewpoints of children and their caregivers should be taken into consideration when making decisions about policy and infrastructure adjustments.