Video-assisted Thorascopic Surgery Research Articles

Pain control in older adults undergoing video-assisted thorascopic surgery

Pain control in older adults undergoing video-assisted thorascopic surgery

Clinical outcome and risk factors for subcutaneous emphysema in patients with lung cancer after video-assisted thorascopic surgery.

Background and purposeWith the clinical application of minimally invasive surgery and concept of enhanced recovery after surgery, the incidence of postoperative complications in lung cancer patients has been significantly reduced. However, postoperative subcutaneous emphysema (SE) becomes the main factor affecting the early discharge of patients. The aim of this study was to analyze the clinical outcome and risk factors for postoperative SE in lung cancer patients.MethodsThe clinical data of 414 lung cancer patients who were admitted to the Department of Thoracic Surgery, West China Hospital, Sichuan University from September 2021 to December 2021 were prospectively collected. The incidence, severity and treatment of patients who had SE, surgery approach, application of drainage tube and clinical information were analyzed.ResultsThe incidence rate of postoperative SE in patients with lung cancer was 33.09% (137/414) and mild cases accounted for the vast majority (30.19%, 125/414). Multivariate analysis indicated that male [odds ratio (OR) = 2.247, P = .014] and advanced age (OR = 1.021, P = .043) were main risk factors for postoperative SE in patients with lung cancer. Conservative treatment was the main treatment option for SE (98.5%, 135/137). The average hospital stay in the subcutaneous emphysema group (5.49 ± 4.41 days) was significantly longer than that in the non-subcutaneous emphysema group (4.44 ± 3.32 days) (P = .014) and no significant statistical difference in the average total hospital cost between the two groups (7,798.31 ± 1,414.85$ vs. 7,501.14 ± 1,605.18$, P = .072).ConclusionPostoperative SE in patients with minimally invasive lung cancer is mainly mild, and conservative treatment is appropriate for most cases.

Modified subxiphoid approach for surgical resection of a retrosternal goiter.

Unilateral Video-Assisted Thorascopic Surgery (VATS) is a traditional minimally invasive transthoracic approach for the surgical resection of a subxiphoid goiter. Recently, the subxiphoid approach was recommended for an anterior mediastinal mass. This study aims to investigate the feasibility and efficacy of a modified subxiphoid VATS for the resection of a retrosternal goiter as an alternative transthoracic approach. We retrospectively collected all patients who underwent subxiphoid VATS for the resection of a retrosternal goiter from June 2017 to June 2021 in the Zhongshan Hospital or the Zhongshan Hospital Xiamen branch. Ten patients were found. Patient characteristics, perioperative data, and surgical information were collected and further analyzed. In our study, all 10 patients underwent a thoracoscopic subxiphoid resection of a retrosternal goiter. The mean age was 49.4 years, and all were female. The majority of patients (70%) were asymptomatic. All patients were assessed by CT imaging before surgery. The mean postoperative hospital stay was 4.9 days. The drainage tube was removed 3 days after operation, and the average drainage volume was 73.1 ml. Postoperative pain was mild, with an average pain grade of 2.4 (measured on a scale from 0 to 10, with lower scores indicating less pain). There were no conversions or perioperative complications in these 10 patients. Most retrosternal goiters can be completely resected through the modified subxiphoid approach after an adequate preoperative evaluation and careful intraoperative management. This thoracoscopic subxiphoid approach is feasible and safe for retrosternal goiter resection.

The cost of treatments for retained traumatic hemothorax: A decision analysis

IntroductionEarly video-assisted thorascopic surgery (VATS) is the recommended intervention for retained hemothorax in trauma patients. Alternative options, such as lytic therapy, to avoid surgery remain controversial. The purpose of this decision analysis was to assess expected costs associated with treatment strategies. MethodsA decision tree analysis estimated the expected costs of three initial treatment strategies: 1) VATS, 2) intrapleural tissue plasminogen activator (TPA) lytic therapy, and 3) intrapleural non-TPA lytic therapy. Probability parameters were estimated from published literature. Costs were based on National Inpatient Sample data and published estimates. Our model compared overall expected costs of admission for each strategy. Sensitivity analyses were conducted to explore the impact of parameter uncertainty on the optimal strategy. ResultsIn the base case analysis, using TPA as the initial approach had the lowest total cost (U.S. $37,007) compared to VATS ($38,588). TPA remained the optimal initial approach regardless of the probability of complications after VATS. TPA was an optimal initial approach if TPA success rate was >83% regardless of the failure rate with VATS. VATS was the optimal initial strategy if its total cost of admission was <$33,900. ConclusionLower treatment costs with lytic therapy does not imply significantly lower total cost of trauma admission. However, an initial approach with TPA lytic therapy may be preferred for retained traumatic hemothorax to lower the total cost of admission given its high probability of avoiding the operating room with its resultant increased costs. Future studies should identify differences in quality of life after recovery from competing interventions.

Cardiac Patch Transplantation Instruments for Robotic Minimally Invasive Cardiac Surgery: Initial Proof-of-concept Designs and Surgery in a Porcine Cadaver.

Background: Damaged cardiac tissues could potentially be regenerated by transplanting bioengineered cardiac patches to the heart surface. To be fully paradigm-shifting, such patches may need to be transplanted using minimally invasive robotic cardiac surgery (not only traditional open surgery). Here, we present novel robotic designs, initial prototyping and a new surgical operation for instruments to transplant patches via robotic minimally invasive heart surgery. Methods: Robotic surgical instruments and automated control systems were designed, tested with simulation software and prototyped. Surgical proof-of-concept testing was performed on a pig cadaver. Results: Three robotic instrument designs were developed. The first (called “Claw” for the claw-like patch holder at the tip) operates on a rack and pinion mechanism. The second design (“Shell-Beak”) uses adjustable folding plates and rods with a bevel gear mechanism. The third (“HeartStamp”) utilizes a stamp platform protruding through an adjustable ring. For the HeartStamp, rods run through a cylindrical structure designed to fit a uniportal Video-Assisted Thorascopic Surgery (VATS) surgical port. Designed to work with or without a sterile sheath, the patch is pushed out by the stamp platform as it protrudes. Two instrument robotic control systems were designed, simulated in silico and one of these underwent early ‘sizing and learning’ prototyping as a proof-of-concept. To reflect real surgical conditions, surgery was run “live” and reported exactly (as-it-happened). We successfully picked up, transferred and released a patch onto the heart using the HeartStamp in a pig cadaver model. Conclusion: These world-first designs, early prototypes and a novel surgical operation pave the way for robotic instruments for automated keyhole patch transplantation to the heart. Our novel approach is presented for others to build upon free from restrictions or cost—potentially a significant moment in myocardial regeneration surgery which may open a therapeutic avenue for patients unfit for traditional open surgery.

A World-First Surgical Instrument for Minimally Invasive Robotically-Enabled Transplantation of Heart Patches for Myocardial Regeneration: A Brief Research Report.

Background: Patch-based approaches to regenerating damaged myocardium include epicardial surgical transplantation of heart patches. By the time this therapy is ready for widespread clinical use, it may be important that patches can be delivered via minimally invasive and robotic surgical approaches. This brief research report describes a world-first minimally invasive patch transplantation surgical device design enabled for human operation, master-slave, and fully automated robotic control.Method: Over a 12-month period (2019–20) in our multidisciplinary team we designed a surgical instrument to transplant heart patches to the epicardial surface. The device was designed for use via uni-portal or multi-portal Video-Assisted Thorascopic Surgery (VATS). For preliminary feasibility and sizing, we used a 3D printer to produce parts of a flexible resin model from a computer-aided design (CAD) software platform in preparation for more robust high-resolution metal manufacturing.Results: The instrument was designed as a sheath containing foldable arms, <2 cm in diameter when infolded to fit minimally invasive thoracic ports. The total length was 35 cm. When the arms were projected from the sheath, three moveable mechanical arms at the distal end were designed to hold a patch. Features included: a rotational head allowing for the arms to be angled in real time, a surface with micro-attachment points for patches and a releasing mechanism to release the patch.Conclusion: This brief research report represents a first step on a potential pathway towards minimally invasive robotic epicardial patch transplantation. For full feasibility testing, future proof-of-concept studies, and efficacy trials will be needed.

Retention of Bovie scratch pad radio-opaque marker during VATS Pleurodesis: case report

BackgroundSurgical intervention for spontaneous pneumothorax typically includes mechanical pleurodesis that frequently utilizes a Bovie scratch pad given its universal presence, low cost and ease of use. The pad is folded on itself after dividing it in half, allowing easier passage through the smaller incisions.However, unintentional foreign body retention may occur during the course of an operation leading to reoperations or even worse complications. This case is reported to raise awareness that dividing the scratch pad may allow the embedded radio-opaque marker to fall out and become retained as a foreign body.Case presentationThe patient is a 41 year-old female who presented with shortness of breath secondary to spontaneous pneumothorax. Chest CT scan showed apical blebs. The patient underwent video assisted thorascopic surgery (VATS) with bleb resection and mechanical pleurodesis using a divided and folded bovie scratch pad. Postoperative chest x-ray showed a retained foreign body. Reoperation confirmed this to be the radio-opaque marker of the scratch pad and was removed. The patient did well and was discharged the following day.ConclusionDividing the bovie scratch pad may damage and “weaken” the product allowing the radio- opaque marker to fall out during its use for pleurodesis and should be discouraged. Recommendation is made of using the scratch pad as a whole and not dividing it.Graphical abstractRetained radio-opaque marker of bovie scratch pad during VATS mechanical pleurodesis.

Odontogenic cervical necrotizing fasciitis with descending mediastinitis: a case report and discussion

&lt;p class="abstract"&gt;Mr KE is a 46 years old gentleman with a background of type 2 diabetes mellitus who was referred to our department for severe polymicrobial cervical necrotising fasciitis with descending mediastinitis after mandibular dental extraction. He was managed with endotracheal intubation, cervicotomy and video assisted thorascopic surgery (VATS), antibiotic and antifungal therapy and myocutaneous flap coverage. This case describes a classical presentation of an uncommon pathology and discusses options for airway management, surgical debridement, antimicrobial therapy and definitive defect coverage. &lt;/p&gt;

CHILDHOOD-ONSET INTERSTITIAL LUNG DISEASE: A RARE CASE OF IDIOPATHIC, NONSPECIFIC INTERSTITIAL PNEUMONIA IN A TEENAGER

SESSION TITLE: Fellows Diffuse Lung Disease SESSION TYPE: Fellow Case Reports PRESENTED ON: October 18-21, 2020 INTRODUCTION: Childhood interstitial lung disease (chILD) is remarkably rare with a reported prevalence from 0.13 per 100,000 children under 17 years to 16.2 per 100,000 children under 15 years of age (1). Here we present a case of a teenager with idiopathic nonspecific interstitial pneumonia (NSIP). CASE PRESENTATION: A 15-year old previously healthy female presented with a three-week history of dry cough, fever, malaise and shortness of breath which progressed to dyspnea on exertion despite a course of outpatient antibiotics. She had no environmental exposures, history of smoking or vaping nor family history of pulmonary pathology. Initial vital signs were significant for hypoxemia to 80% and a chest x-ray and CT scan with bilateral consolidations and ground glass opacities. Initial laboratory tests showed elevated inflammatory markers, other tests including SARS-CoV-2 PCR were negative . Bronchoscopy, bronchoalveolar lavage, and transbronchial biopsies yielded no definitive diagnosis. Following bronchoalveolar lavage, she developed rapid clinical deterioration necessitating mechanical ventilation, paralytics, and inhaled nitric oxide. Given elevated inflammatory markers and after infection was excluded, intravenous steroids were initiated with partial improvement. After extubation, a protracted inability to wean off oxygen support, and spirometry showing ongoing, severe restrictive lung disease, lung biopsy via video-assisted thorascopic surgery was performed lending to the ultimate diagnosis NSIP. Hypersensitivity pneumonitis panel, ILD panel and genetic testing were unrevealing, as such her case was classified as idiopathic NSIP. DISCUSSION: NSIP in adolescents is very rare. A meta-analysis (2) reports the average age of patients with NSIP to be 54.8 years. In the pediatric population, NSIP can be associated with systemic disease processes such as collagen vascular disease, including systemic lupus erythematosus, juvenile rheumatoid arthritis, and dermatomyositis associated with antibodies to melanoma differentiation-associated gene 5 (anti-MDA5), as well as a complication of blood stem cell transplants and surfactant dysfunction mutations, although most cases are idiopathic (3). Given that the etiology of NSIP is broad and in most cases idiopathic, response to corticosteroids is also variable. Our patient had a partial response to corticosteroids early on in her treatment, manifested by augmented gas exchange and improved symptomatology. The relatively slow response to treatment in the first several weeks is likely consistent with her biopsy findings which showed fibroblast proliferation and fibrosis. CONCLUSIONS: ILD and particularly NSIP are rare conditions in adolescents but should be suspected in patients with hypoxemia and abnormal imaging in the absence of infectious or autoimmune etiologies. An extensive workup is recommended to determine association with systemic conditions, treatment and prognosis. Reference #1: (1) Griese M, Haug M, Brasch F, et al. Incidence and classification of pediatric diffuse parenchymal lung diseases in Germany. Orphanet J Rare Dis. 2009;4:26. Published 2009 Dec 12. doi:10.1186/1750-1172-4-26 Reference #2: (2) Ebner L, Christodoulidis S, Stathopoulou T, et al. Meta-analysis of the radiological and clinical features of Usual Interstitial Pneumonia (UIP) and Nonspecific Interstitial Pneumonia (NSIP). PLoS One. 2020;15(1):e0226084. Published 2020 Jan 13. doi:10.1371/journal.pone.0226084 Reference #3: (3) Vece TJ, Fan LL. Interstitial Lung Disease in Children Older Than 2 Years. Pediatr Allergy Immunol Pulmonol. 2010;23(1):33-41. doi:10.1089/ped.2010.0008 DISCLOSURES: No relevant relationships by Giuliana Cerro, source=Web Response No relevant relationships by Gary Goulin, source=Web Response No relevant relationships by Jack Green, source=Web Response No relevant relationships by Michael Lewis, source=Web Response No relevant relationships by Tim Shen, source=Web Response

Health-Related Quality of Life in Patients with Non-Small Cell Lung Cancer before and after Surgery - a Comparison between Thoracotomy and Video-Assisted Thoracoscopic Surgery

Earlier studies have proven that in patients with non-small cell lung cancer video-assisted thoracoscopic surgery is functionally superior to thoracotomy in terms of perioperative and postoperative complications. The objective of this work was to determine whether there is a difference in health-related quality of life (HRQoL) of patients with non-small cell lung cancer - compared to the German normal population - before and after surgery. Moreover, HRQoL after thoracotomy was compared to HRQoL after video-assisted thoracoscopic surgery (VATS). Based on retrospective data generated during a 7-year period (2010 - 2017), 327 patients with non-small cell lung cancer who underwent therapy were examined. Patients either underwent thoracotomy or video-assisted thoracoscopic surgery. 456 of short form 12 questionnaires were analysed. Via norm-based scoring, and physical and mental component summaries (PCS and MCS) were calculated before and 6, 12, and 24 months after treatment. Using t tests, potential differences in physical and mental component summaries were evaluated between patients and the German normal population as well as between patients after thoractomy and after VATS. Up to 24 months after surgery, the physical dimension of HRQoL is significantly reduced, while the mental component summary does not significantly differ from the German population. Moreover, thoracotomy and VATS gave equivalent values for health-related quality of life. With respect to health-related quality of life, thoracotomy and video-assisted thorascopic surgery are equivalent in the long term. But there was a trend to improvement with both summary scores that might indicate superiority of video-assisted thoracoscopic surgery.

A CASE OF CHRONIC PULMONARY ASPERGILLOSIS IN A HEALTHY IMMUNOCOMPETENT PATIENT

SESSION TITLE: Chest Infections: Find the Fungus SESSION TYPE: Fellow Case Reports PRESENTED ON: 10/21/2019 3:15 PM - 4:15 PM INTRODUCTION: Chronic pulmonary aspergillosis (CPA), and specifically its most common form – chronic cavitary pulmonary aspergillosis (CCPA) - is an uncommon pulmonary disease (1). It may be seen in either patients are who are immunocompromised or patients who are immunocompetent with underlying lung disease. We present a case of CCPA complicated by recurrent hemoptysis necessitating surgical resection in a healthy 19-year-old female without known underlying lung disease. CASE PRESENTATION: A 19 year-old female presented with one month of hemoptysis. She was healthy, without any known medical problems until age 17 when she was found to have a mycetoma and cavitary pneumonia. She underwent an extensive workup, including HIV and Quantiferon Gold testing, at that time which was negative and was treated with antibiotics. She was unable to complete a prolonged course of voriconazole due to financial constraints. Interval imaging demonstrated multiple cavitary lesions with air fluid levels and soft tissue density consistent with aspergilloma. She was asymptomatic between age 17 and 19, when she began to experience hemoptysis. The patient presented to our hospital with persistent hemoptysis. She underwent robotic video-assisted thorascopic surgery (VATS) with right lower lobectomy. The parenchyma was noted to contain numerous cystic cavities. Histological examination demonstrated free-floating aspergillus hyphae within a cyst wall. Although not definitive, the aspergilloma may have formed in an area of interlobar pulmonary sequestration or congenital cystic adenoid malformation. Five days following surgery, the patient had no further hemoptysis and was discharged home. DISCUSSION: CCPA is a common form of CPA, which also encompasses aspergillus nodules, simple aspergilloma, and subacute invasive aspergillosis (SAIA) or chronic necrotizing pulmonary aspergillosis. Left untreated, CCPA may progress to chronic fibrosing pulmonary aspergillosis (CFPA), which is characterized by extensive pulmonary fibrosis. It is exceedingly unusual for CCPA to develop in immunocompetent individuals without underlying pulmonary disease. Our patient is a young and healthy female who had no prior respiratory symptoms who presented at the age of 17 with an already formed aspergilloma. Oral antifungal therapy is considered standard of care for treatment of CCPA (1). Response is slow and requires a minimum of four months. Hemoptysis may necessitate surgical resection in those with adequate pulmonary function. CONCLUSIONS: CCPA may occur in imunnocompetent patients with no prior history of lung disease. The possibility of the presence of a previously unknown and asymptomatic congenital malformation may increase the risk for the development of CPA. Reference #1: Denning DW, Cadranel J, Beigelman-Aubry C, et al. Chronic pulmonary aspergillosis: rationale and clinical guidelines for diagnosis and management. Eur Respir J 2016;47:45-68. DISCLOSURES: No relevant relationships by Craig Fryman, source=Web Response No relevant relationships by Sameer Khanijo, source=Web Response No relevant relationships by Kelvin Wong, source=Web Response

PLEURAL EFFUSION WITH TRAPPED LUNG ASSOCIATED WITH METHIMAZOLE-INDUCED HYPOTHYROIDISM

SESSION TITLE: Tuesday Medical Student/Resident Case Report Posters SESSION TYPE: Med Student/Res Case Rep Postr PRESENTED ON: 10/22/2019 01:00 PM - 02:00 PM INTRODUCTION: Anti-thyroid medications can cause a variety of adverse reactions. There are only a small amount of reported cases associating the thioamides with pleural effusions [1,2,3]. None of these were associated with trapped lung. We present a case of a trapped lung with unclear etiology associated with methimazole and hypothyroidism. CASE PRESENTATION: A 36-year-old male with a history of Type 1 diabetes and Graves' disease status post radio-iodine ablation on methimazole presented to the hospital after one month of shortness of breath and cough with no associated fevers, chills, or night sweats. The patient was found to have a large right pleural effusion with mediastinal shift to the left with a completely collapsed lung. He subsequently had a chest tube placed with four liters fluid drained. Pleural fluid showed an exudative effusion by Light’s Criteria with fluid and serum protein of 4.6 g/dL and 8.6 g/dL respectively. Fluid and protein lactate dehydrogenase (LDH) were 120 U/L and 320 U/L respectively. Pleural glucose was 95 mg/dL and pH was 7.75. Gram stain and cultures were unremarkable. Cytology was non-diagnostic for malignancy. After drainage, the patient’s right lung remained collapsed with quickly reaccumulated effusion. Serum sedimentation rate, quantiferon gold, fluid adenosine deaminase, and fluid amylase were all negative. He was found to be hypothyroid with a thyroid stimulating hormone level of 20.7 IU/mL and free T4 of 0.31 ng/mL and his methimazole was stopped. An autoimmune panel was negative. Due to concern for trapped lung, the patient underwent a video-assisted thorascopic surgery converted to thoracotomy for decortication of the right upper, middle, and lower lobes. After decortication, the patient had increased aeration of the lung with no evidence of consolidation or mass. He was ultimately discharged home with resolution of the hypothyroidism and placed back on methimazole. He has only had recurrence of a mild asymptomatic effusion. DISCUSSION: The exact etiology of the effusion with trapped lung remains unclear in this case. Hypothyroidism may have been a contributing factor for which methimazole may also have been involved. Methimazole has been associated with lupus-like reactions for which pleuritis and effusion could be a possibility. There is no clear evidence that the effusion was from infection. Malignancy is another consideration although fluid analysis was non-diagnostic and no tumor was identified during decortication. With this patient’s recurrent small pleural effusion, it may be beneficial for him to have close monitoring of thyroid levels and dosing of methimazole, especially in the setting of having already experienced a trapped lung. CONCLUSIONS: Methimazole and hypothyroidism may be a cause of pleural effusion and even trapped lung. When evaluating a patient’s effusion, methimazole and possibly the other thioamides must be considered as possible culprits. Reference #1: Lee JH, Park M, Park MJ, Jo YS. Massive pleural and pericardial effusion due to hypothyroidism in a patient with a surgically treated thyroid-stimulating hormone-producing pituitary adenoma. Acta Clin Belg. 2018;73(5):398-401 Reference #2: Da Costa P, Silva F, Henriques J, et al. Methimazole associated eosinophilic pleural effusion: a case report. BMC Pharmacol Toxicol. 2017 Mar;18(1):16 Reference #3: Sen N, Ermis H, Karatasli M, Habesoglu M, Eyuboglu F. Propylthiouracil-associated eosinophilic pleural effusion: a case report. Respiration. 2007;74(6):703-5 DISCLOSURES: No relevant relationships by Waqas Adeel, source=Web Response No relevant relationships by Nathan Brewster, source=Web Response No relevant relationships by Brian Holahan, source=Web Response No relevant relationships by Alaynna Kears, source=Web Response No relevant relationships by Michal Kloska, source=Web Response

Thirty-Day Unplanned Reintubation Following Pleurodesis: A Retrospective National Registry Analysis

To examine risk factors associated with 30-day unplanned reintubation after pleurodesis. A retrospective cohort study using the American College of Surgeons National Surgical Quality Improvement Program surgical outcomes registry. United States hospitals participating in the American College of Surgeons National Surgical Quality Improvement Program. The study comprised 2,358 patients who underwent video-assisted thorascopic surgery for pleurodesis from 2007 to 2016. None. The final sample included 2,358 cases, of which 93 (3.9%) required 30-day unplanned reintubation. Cases with 30-day unplanned reintubation, compared to those without, had higher unadjusted rates of American Society of Anesthesiologists physical status (ASA PS) score ≥4 (54.8% v 27.2%), preoperative dyspnea (71% v 57%), congestive heart failure (14% v 5.4%), functional dependence (28% v 10.3%), and diabetes mellitus (29% v 17.8%) (all p < 0.05). Patients with 30-day reintubation experienced higher unadjusted rates of 30-day outcomes including mortality (50.5% v 10.1%), pneumonia (28% v 4.9%), ventilator dependence (50.5% v 10.1%), sepsis (7.5% v 1.9%), myocardial infarction (5.4% v 0.1%), cardiac arrest (18.3% v 0.6%), transfusion (14% v 4.5%), and reoperation (15.1% v 3.2%) (all p < 0.05). The odds of 30-day unplanned reintubation were increased significantly on multivariable analysis for patients with ASA PS score ≥4, functional dependence, disseminated cancer, renal dialysis, and weight loss (all p < 0.05). Given the dearth of population-based studies addressing risk factors of reintubation after pleurodesis, this study suggests further review of preoperative optimization, which is required to improve patient outcomes and safety.

Can Perioperative Oscillating Positive Expiratory Pressure Practice Enhance Recovery in Lung Cancer Patients Undergoing Thorascopic Lobectomy?

背景与目的振动正压呼气（oscillatory positive expiratory pressure, OPEP）训练是一种通过正压呼气装置（acapella）进行的呼吸训练。OPEP在慢性阻塞性肺疾病、支气管扩张症、肺囊肿等疾病的临床价值已经得到广泛探讨，但其在肺癌手术患者围术期的应用价值尚有待探索。本研究旨在探索围术期进行振动正压呼气训练对胸腔镜肺癌患者术后并发症发生率、肺功能、生活质量的影响。方法前瞻性收集2017年9月15日-2018年1月15日四川大学华西医院胸外科单个医疗组行胸腔镜肺叶切除的原发性非小细胞癌患者69例，随机分成实验组（35例）和对照组（34例）。实验组（acapella group, AG）围手术期采用振动正压呼气训练，对照组（control group, CG）进行常规围术期处理。对比分析两组在术后并发症发生率、肺功能、生活质量方面的差异。结果术后肺部并发症和肺不张在AG（2.9%, 0.0%）显著低于CG（20.6%, 14.7%）（P=0.03, P=0.03）；平均住院日和术后住院日在AG（10.86±5.64, 5.09±4.55）d显著短于CG（14.41±4.58, 7.59±3.21）d（P=0.01, P=0.01）；住院药物费用在AG（4, 413.60±1, 772.35）￥显著低于CG（6, 490.35±3, 367.66）￥（P=0.01）。出院当日第1秒用力呼气容积（forced expiratory volume in the first second, FEV1）和呼气峰流速（peak expiratory flow, PEF）在AG[(1.50±0.32) L, (252.06±75.27) L/min]显著高于CG[(1.34±0.19) L, (216.94±49.72) L/min]（P=0.03, P=0.03）。结论肺癌患者围手术期使用振动正压呼气训练有助于降低肺部并发症，同时能够加速患者康复。

CLEARING THE CAVITY: A CASE OF POSTPNEUMONECTOMY EMPYEMA

SESSION TITLE: Surgery cases SESSION TYPE: Fellow Case Reports PRESENTED ON: 10/07/2018 04:45 PM - 05:45 PM INTRODUCTION: Post-pneumonectomy Empyema (PPE), is a rare but dangerous complication. Hypothesized to be the result of microbial infection via Bronchopleural fistula (BPF) vs. direct muco-cutaneous infection. Management of this pathology varies from debridement and antibiotics to thoracoplasty. Presented is a case of PPE in a patient who underwent pneumonectomy for the treatment of metastatic colorectal cancer. CASE PRESENTATION: A 53-year-old male with prior history of metastatic colorectal cancer treated with chemotherapy and managed surgically with right pneumonectomy four years prior presented to the emergency department with five days of worsening right sided chest pain, cough, fevers, and chills. On physical exam the patient was noted to have a right chest wall palpable mass with crepitation. A computed tomography angiogram of the chest was performed showing worsening accumulation of fluid in the prior known post-surgical hydropneumothorax. Additionally, new extension of air into the surrounding soft tissue was observed, a condition called pneumothorax neccesitans (Image 1). Antibiotics were started and a surgical chest tube was placed which drained foul-smelling purulent brown fluid. Polymicrobial cultures grew methicillin-resistant staphylococcus aureus, streptococcus anginosus, streptococcus mitus, bacteroides caccae, and fusobacterium species. Video assisted thorascopic surgery (VATS) was converted to thoracotomy with creation of Eloesser flap. While irrigating the hemithorax with saline copious bubbles were seen indicating a BPF. Post-operative course complicated by pseudomonal wound infection being treated with levaquin. DISCUSSION: PPE occurs in 2%-16%(1) of post-pneumonectomy patients. Although it is rare, mortality has been reported as high as 72%(2) and management can often be complicated. The majority of PPE are due to microbial infection via BPF. The presence of BPF in patients with PPE has been documented to be 80%-100%. Other theories include direct microbial invasion of the wound. Monomicrobial infections are more common than polymicrobial, with staphylococcus and streptococcus being the most frequent culprits. A 2015 expert consensus statement published by the European Association of Cardiothoracic Surgeons suggests that for simple PPE without fistulae, conservative management can be performed with pleural space irrigation, fenestration or VATS debridement alongside antibiotics. During VATS the surgeon has the opportunity to identify an underlying BPF for closure. In the case of BPF presence or complicated PPE intervention may require more invasive techniques such as thoracoplasty. (3) CONCLUSIONS: With a high mortality rate and complex management, PPE should be addressed swiftly and with cardiothoracic involvement at time of diagnosis. Drainage and antibiotics are the cornerstones to management but many cases require more expert invasive surgical intervention. Reference #1: Stern, Jean-Baptiste, Ludovic Fournel, Benjamin Wyplosz, Philippe Girard, Malik Al Nakib, Dominique Gossot, and Agathe Seguin-Givelet. "Early and delayed post-pneumonectomy empyemas: Microbiology, management and prognosis." The clinical respiratory journal (2017). Reference #2: Jadczuk, Eugeniusz. "Postpneumonectomy empyema." European journal of cardio-thoracic surgery 14, no. 2 (1998): 123-126. Reference #3: Scarci, Marco, Udo Abah, Piergiorgio Solli, Aravinda Page, David Waller, Paul Van Schil, Franca Melfi et al. "EACTS expert consensus statement for surgical management of pleural empyema." European journal of cardio-thoracic surgery 48, no. 5 (2015): 642-653. DISCLOSURES: No relevant relationships by Elizabeth Awerbuch, source=Web Response No relevant relationships by Anupam Gupta, source=Web Response no disclosure on file for Terence McGarry; No relevant relationships by Michael Megally, source=Web Response

Through-and-through gunshot wound to the esophagus at the thoracic inlet:a novel management approach

A 42-year-old man presented to the emergency department with gunshot wound to left upper back over the scapula and palpable bullet over the right supraclavicular fossa. The patient had a...

Intercostal Nerve Blockade with Exparel® Results in Lower Opioid Usage during the First 24 Hours after Video-Assisted Thorascopic Surgery

Liposomal bupivacaine (LipoB) provides prolonged local anesthetic effects and has seen usage in several fields of surgery. We review our experience using LipoB intraoperatively for intercostal nerve blocks after video-assisted throacoscopic surgery (VATS). A retrospective, single-center review was conducted for patients undergoing VATS from August 2012 to December 2014. Patients those who received LipoB as an intercostal nerve block were compared with patients who received blocks with standard bupivacaine. Opiate amounts used within the first six hours and then subsequent 18, 48, and 72 hours were converted into morphine equivalents for comparison. Forty-seven patients met inclusion criteria: 21 receiving LipoB intercostal nerve block and 26 controls. Groups were similar for age, diabetes, hypertension, chronic kidney disease, body mass index and American Society of Anesthesiologists scores. The LipoB group had a larger portion of males (P < 0.02). Postoperatively, morphine equivalent usage was significantly less in the LipoB group compared with the standard bupivacaine within the first six hours after surgery (15.62 vs 52.41, P = 0.001) and in the subsequent 18 hours (28.98 vs 65.17, P = 0.01). After the first 24 hours there was not a significant difference in opiate usage between the two groups. There was no difference in length of stay between the two groups. In our study group of VATS patients, an intercostal nerve block with LipoB significantly reduced the usage of postoperative opioids in the first 24 hours only when compared with standard bupivacaine.

Needlescopic-assisted thoracoscopic pulmonary anatomical lobectomy and segmentectomy for lung cancer: a bridge between multiportal and uniportal thoracoscopic surgery.

Needlescopic instruments allow us to perform complex laparoscopic procedures, which are almost painless and scarless postoperatively; however, their utilization in thoracoscopic surgery has been limited to minor procedures, including bullectomy and sympathectomy. We present our initial experience of performing thoracoscopic anatomical lung resection via a single utility incision with additional needlescopic working ports and compare the operative results with those of uniportal video-assisted thorascopic surgery (VATS). We reviewed data on 75 consecutive patients with lung cancer, who underwent anatomical lung resections, including lobectomy and segmentectomy, between February 2015 and September 2017. Of the 75 patients, 39 underwent uniportal VATS (uniportal group), and 36 underwent needlescopic-assisted VATS (n-VATS group). We compared the peri- and postoperative outcomes of the two groups. The clinical characteristics did not differ significantly between the groups, except in the ages of the patients. The n-VATS group had a shorter operation time (mean 159.3min vs. 198.8min, P = 0.023) and lower intraoperative blood loss (mean 40.9mL vs. 143.2mL, P = 0.047). Two major pulmonary arterial bleeding events and one conversion to thoracotomy occurred in the uniportal group. Uniportal VATS can be performed more efficiently and safely with the assistance of additional needlescopic ports and instruments, without compromising the benefits of less postoperative pain and early recovery.

Thoracic Epidurals are Associated With Decreased Opioid Consumption Compared to Surgical Infiltration of Liposomal Bupivacaine Following Video-Assisted Thoracoscopic Surgery for Lobectomy: A Retrospective Cohort Analysis

Thoracic epidural analgesia (TEA) is considered the gold standard for postoperative pain control in thoracic surgery, however it is associated with the undesirable risks of hypotension urinary retention, and bleeding. Recently, surgical site infiltration with liposomal bupivicaine (LB) has been suggested as a comparable alternative to TEA. The authors compared total opioid consumption in patients who received either TEA or LB undergoing video-assisted thorascopic surgery (VATS) for lobectomy. Retrospective cohort study. University hospital. Patients undergoing VATS for lobectomy. TEA versus LB MEASUREMENTS AND MAIN RESULTS: The primary outcome was POD 0 to 2 total opioid requirements, measured in intravenous morphine equivalents (mg). Wilcoxon rank sum test was used to calculate the significant differences in the primary outcome. The 25-75% interquartile range (IQR) was reported with each median value. Forty-five patients were included in the analysis, in which 14 (31.1%) were in the LB group. Between the TEA and LB group, there were no differences in age, sex, or body mass. The median (25-75% IQR) total opioid consumption during POD 0 - 2 in the TEA and LB group were 28.0 mg (12.0 - 52.0 mg) and 49.5 mg (35.0 - 70.5 mg), respectively (p = 0.03), in which the median difference was 22.5 mg (95% CI 0.60 - 38.0 mg). VATs lobectomy patients consumed 43.4% less opioids on POD 0-2 with TEA when compared to surgical site infiltration of LB. Further prospective randomized controlled trials are required to demonstrate superior analgesia of TEA in this surgical population.

Perioperative Risk Factors Associated With Postoperative Unplanned Intubation After Lung Resection

Postoperative respiratory failure requiring reintubation is associated with a significant increase in mortality. However, perioperative risk factors and their effects on unplanned 30-day reintubation and postoperative outcomes after unplanned reintubation following lung resection are not described well. The aim of this study was to determine whether certain comorbidities, demographic factors, and postoperative outcomes are associated with 30-day reintubation after thoracic surgery. This was a retrospective observational study using multivariable logistic regression to identify preoperative risk factors and consequences of unplanned 30-day reintubation. Multi-institutional, prospective, surgical outcome-oriented database study. Using the American College of Surgeons National Surgical Quality Improvement Program database, video-assisted thorascopic surgery and thoracotomy lung resections (lobectomy, wedge resection, segmentectomy, bilobectomy, pneumonectomy) were analyzed by Common Procedural Terminology codes from the years 2007 to 2016 in 16,696 patients undergoing thoracic surgery. None. The final analysis included 16,696 patients, of who 593 (3.5%) underwent unplanned reintubation. Among the final study population, 137 (23%) of unplanned intubations occurred within 24 hours postoperatively and the median (25%, 75% quartile) day of reintubation was day 3 (2, 8 days). The final multivariable logistic regression analysis suggested that age, American Society of Anesthesiologists physical status classification score ≥4, dyspnea with moderate exertion and at rest, history of chronic obstructive pulmonary disease, male sex, smoking, functional dependence, steroid use, open thoracotomies, increased operation time, and preoperative laboratory results (albumin and hematocrit) were associated with unplanned intubation after lung resection (p < 0.05). Unplanned intubation was associated significantly with 30-day mortality, reoperation, postoperative blood transfusion, and increased hospital length of stay (p < 0.05). Nonmodifiable and modifiable preoperative risk factors were associated with increased odds of unplanned reintubation. Patients who experienced unplanned intubation were at considerable risk for 30-day mortality, reoperation, postoperative blood transfusion, and increased hospital length of stay.