Because of their unique dynamic properties and high-quality factors, one and two-dimensional (1D and 2D) materials have been increasingly in favorin recent years for the construction of a new generation of nano sensors. While numerous research has explored these qualities in vacuum, there is a need to analyze the influence of van der Waals interaction on their vibrational properties when they are exposed to fluids such as water which is significant as it plays a vital role in defining the stability of CNT-based nano-fluidic systems. Using molecular dynamics approach, the behavior of a single walled carbon nanotube (SWCNT) affected by water environment inside or around the structure is investigated. Moreover, the influence of nanotube dimensions and water density are examined using the newly presented method called hammer impact test in nanoscale, which is a conventional modal analysis method in macroscale. The findings show thatthe presented hammer impact test can predict the frequencies and quality factor with high precision and at a far reduced computational cost. The results show that the presence of fluid reduces the natural frequency of the nanotube, and that the natural frequency of the nanotube drops as fluid density increases. In addition, increasing the diameter of fluid carrier nanotubes leads to a rise in the natural frequency of the nanotubes in varied chiralities. At a constant density of water, comparing the results of interior fluid CNT with those of submerged CNT, the results show a meaningful reduction in natural frequency, quality factor, and vibration amplitudes, which makes the interior fluid CNT an ideal case for future investigation on CNT-based nano-fluidic systems. Our resultsreveal a novel aspect offluid-CNTinteraction and examines its impact to design high performance nano sensors.