Design parameters for vibration criteria and tolerances from footfall induced vibration have long been categorized by general use with a focus on human comfort, with guidelines for offices, residential uses and hospital patient rooms. More stringent criteria required for sensitive laboratory and research equipment has typically been limited to select locations within projects. As the life science industry continues to expand, there is a growing trend to provide a leasable core & shell space that is already suitable for these more stringent equipment requirements while maintaining flexibility within the building. This paper reviews how 3D modelling can be utilized to demonstrate the expected vibration in large structures and study various iterations to determine how steel depth, steel weight, and composite structures can reduce vibration levels across the floorplate. Also discussed will be the implications of changing the structural design goals, with project examples of how other design considerations such as ceiling height, cost, and project schedules are impacted.