Vesicular Skin Research Articles

Varicella-associated disseminated intravascular coagulation secondary to Henoch-Schönlein purpura with renal and gastrointestinal system involvement in a child: A case report.

Immunocompromised patients who developed varicella-zoster virus (VZV)-associated disseminated intravascular coagulation (DIC) previously included recipients of bone marrow, hematopoietic stem cell, or organ transplantations, patients with primary nephropathy receiving corticosteroid therapy, cancer patients receiving chemotherapy, and patients with human immune deficiency virus infection. The case reported here is novel because, to our knowledge, there has been no report of VZV-associated DIC after the onset of Henoch-Schönlein purpura (HSP). To report the successful treatment of a novel pediatric case with VZV-associated DIC secondary to HSP. An 8-year-old girl developed VZV-associated DIC 24 days after diagnosis of HSP with renal and gastrointestinal involvement. She was treated with methylprednisolone at a local hospital for 19 days, and suddenly developed fever starting from day 4 in our hospital. Her fever persisted with vesicular skin rashes on her back, strong abdominal and lower back pain, epistaxis, hematochezia, erosion and bleeding on her lips, in her mouth and at puncture sites on day 5. She was diagnosed with DIC with the laboratory evidence of dramatically decreased platelet count and fibrinogen, prolonged activated partial thromboplastin time and prothrombin time, and increased fibrin degradation products including d-dimers. She also developed multiple organ dysfunction syndrome. On day 7, the patient VZV nucleic acid result turned out to be positive. Methylprednisolone treatment was discontinued, and she was given a multi-modality therapy including medications of acyclovir and antibiotics, intravenous gamma-immunoglobulin, various blood product transfusions, continuous renal replacement therapy, plasma exchange, and administration of liver and gastrointestinal system protection drugs. The patient multi-organ function damage gradually recovered. After VZV control, the patient was treated with oral methylprednisolone again for HSP with nephritis. Urine analysis was normal 1 year later, and oral hormone was discontinued. No complication or relapse occurred during 2 years of follow-up. This case report, for the first time, adds HSP treated with corticosteroids to the spectrum of clinical conditions that progressed to life-threatening secondary varicella-associated DIC. Early identification of varicella infection and DIC, combined with timely antiviral, immunoglobulin transfusion, plasma exchange, and other combined therapies are essential for saving patients' lives.

Management of Herpes Zooster (Kaksha) through Ayurveda: A Case Study

Background: Varicella zoster virus is the virus that causes shingles or Herpes zoster. Vesicular eruption within the dermatome that occurs unilaterally and is intensely painful. Pre-eruptive, acute exudative, and chronic are the three stages of the disease manifestation. Herpes zoster clinical manifestation includes vesiculo-pustular eruptions accompanied by excruciating pain and burning sensation, which is comparable to the symptomatology described in Ayurveda while referring to the disease kaksha mentioned in kshudra roga. Analyzing symptomatology reveals that, vitiatiation of pitta due to indulging in various causative factors affects Twak and Rakta Dhatu thereby causing this illness. Consequently, pitta shamana line of therapy is advised which helps in samprapti vighatana and dosha shamana. Materials and Methods: A 38-year-old woman’s vesicular skin lesion across her right axilla, arm, and palmar aspect of her left ring finger, along with intense pain, and burning sensation associated with blackish discoloration surrounded by inflammatory signs such as rubor, calor, dolor were her primary complaints. In this case pitta-hara line of management was employed as mentioned in the management of disease Kaksha. Observation and Result: Lesions started to shrink and fall off without any indications of further spread or reoccurrence. Falling lesions had slight yellow discharge from the sight but pain and discomforts had disappeared.

Creating the "Dew Drop on a Rose Petal": the Molecular Pathogenesis of Varicella-Zoster Virus Skin Lesions.

Varicella-zoster virus (VZV) is a human alphaherpesvirus that causes varicella (chicken pox) as the primary infection in a susceptible host. Varicella is very contagious through its transmission by direct contact with vesicular skin lesions that contain high titers of infectious virus and respiratory droplets. While the clinical manifestations of primary VZV infection are well recognized, defining the molecular mechanisms that drive VZV pathogenesis in the naive host before adaptive antiviral immunity is induced has been a challenge due to species specificity. This review focuses on advances made in identifying the differentiated human host cells targeted by VZV to cause varicella, the processes involved in viral takeover of these heterogenous cell types, and the host cell countermeasures that typically culminate in a benign illness. This work has revealed many unexpected and multifaceted mechanisms used by VZV to achieve its high prevalence and persistence in the human population.

Disseminated Monkeypox Infection in a Kidney Transplant Recipient: A Case Report

Monkeypox is a rapidly spreading infection worldwide and is a public health concern, especially with newly reported fatality cases. The characteristics and disease course of monkeypox infection in transplant recipients remain elusive because no case reports have been published detailing its clinical presentation and outcome in this population. We report a case of a kidney transplant recipient who developed end-stage renal disease secondary to HIV-associated nephropathy and manifested monkeypox infection after kidney transplantation. The patient had severe clinical manifestations, including disseminated vesicular skin rash, diffuse mucosal involvement, urine retention, proctitis, and bowel obstruction. We also highlight several clinical considerations regarding the use of tecovirimat, a novel antiviral therapy with activity against orthopoxviruses that has been used in the United States to treat monkeypox infection.

373. Development of multiplex loop-mediated isothermal amplification (LAMP) based on a microfluidic chip for detection of HSV-1 and 2 and VZV.

Abstract Background In the era of universal varicella vaccination, point-of-care testing for herpes simplex viruses 1 and 2 (HSV-1, HSV-2) and varicella-zoster virus (VZV) is becoming more important because of the increase in the number of breakthrough varicella cases. The Loop-mediated isothermal amplification (LAMP) method is a reliable method for rapid diagnostic tests for infectious diseases. Meanwhile, microfluidics technology is revolutionary in total system miniaturization, including facile parallelization through multiplexing and process-reduced reagent volumes. It is easy to create miniaturized chips containing multiple chambers according to the needs. In this study, we sought to develop multiplex LAMP for the detection of HSV-1, HSV-2, and VZV DNA using in-house microfluidic chips. Methods The polydimethylsiloxane-based chip consists of microfluidic channels and 5 reaction chambers. The specific primers were pre-spotted and dried in each chamber. The condition of LAMPs and each specific primer were described previously. The sensitivity of microfluidic LAMPs was confirmed using plasmids that contain the target sequences. In order to assess the reliability of clinical use, 35 swab samples (without DNA extraction) collected from patients with vesicular skin lesions were used. The result of microfluidic multiplex LAMP was compared with conventional LAMPs and real-time PCRs. Results Detection limits of HSV-1 and 2 and VZV LAMP-based on a microfluidic chip were 500 copies per reaction. Among 35 swab samples, HSV-1, HSV-2, and VZV DNA were detected in 10 (28.6%), 4 (11.4%), and 12 (34.3%) samples, respectively. The results of microfluidic LAMPs were completely consistent with the results of conventional LAMPs. HSV-1 DNA was detected in one LAMP negative sample by real-time PCR. One HSV-1 LAMP positive sample was negative in real-time PCR. If real-time PCR was used as a standard, sensitivity of HSV-1, HSV-2, and VZV LAMPs based on microfluidic chip were 90%, 100%, and 100%, and the specificity of three methods were 96%, 100% and 100%, respectively. Conclusion Multiplex LAMP, based on a microfluidic chip that detects three alpha herpesviruses, may be useful in laboratory diagnosis of patients with vesicular skin lesions. Disclosures All Authors: No reported disclosures.

Chronicles of A.I. Pospelov Moscow Dermatovenerology and Cosmetology Society (MDCS was founded on October 4, 1891). Bulletin of the MSDC № 1145

On December 21, 2021, the 1145th meeting of the Moscow Society of Dermatovenereologists and Cosmetologists named after A.I. Pospelov took place.
 The meeting was held in a face-to-face format traditionally in the countries of the V.A. Rakhmanov Skin Clinic. There were 110 participants. Accepted as a member of the MSDV 4 people.
 Clinical observations of linear IgA-dependent dermatosis, systemic lupus erythematosus, annular granuloma were presented. Two scientific reports were heard ― about foot mycetoma; about skin reactions to tattoos.
 Linear IgA-dependent bullous dermatosis is a rare immune ― mediated vesicular skin disease characterized by the presence of homogeneous linear fixation of IgA along the basement membrane. Trigger factors: medications (vancomycin, cephalosporins, diclofenac, captopril, etc.); infectious diseases; vaccination against influenza; exposure to ultraviolet rays; paraneoplastic process (5% of cases) in lymphoproliferative diseases; inflammatory bowel diseases (ulcerative colitis and Crohns disease). The differential diagnosis in adults is Durings herpetiform dermatitis, Levers bullous pemphigoid, an atypical form of multiform exudative erythema; in children ― bullous impetigo, genetic epidermolysis bullosa.
 Systemic lupus erythematosus is a multisystem connective tissue disease with lesions of the skin and mucous membranes, joints, kidneys, heart, lungs and central nervous system. Systemic glucocorticoids, hydroxychloroquine, azathioprine, cyclophosphamide, belimumab, rituximab are used in the treatment.
 Annular granuloma is a benign inflammatory dermatosis of unknown etiology, which is characterized by the development of flesh colored or red papules on the skin, often arranged in the form of rings. Fractional laser action is used in the treatment.
 Mycetoma is a one sided, slightly painful dense tumor-like infiltrate limited on the foot or hand, edema with the formation of granulomas, microabcesses, the formation of fistulas and the release of actinomycetes or fungal mycelium from them. Differential diagnosis: chronic arthritis, arthrosis, sprain and rupture of ligaments, synovitis, chronic and postoperative osteomyelitis, bacterial mycetoma, botryomycosis, tumors, cold abscess, phlegmon, post-injection infiltrate, etc.
 Tattooing is a subspecies of avant ― garde art and a way of changing appearance, in which the integrity of the skin is violated with the help of various piercing tools and a persistent indelible pattern is applied by introducing a coloring agent. The pigments trapped in the tattoo partially exit through the lymph and are deposited in the regional lymph nodes. The nodes are imperceptibly colored along with the skin. A certain amount of pigment nanoparticles can enter the bloodstream and theoretically cause harm somewhere in the body.

A cross-sectional investigation and analysis of early treatment of partial-thickness burn wounds by professional burn medical staff in China

A cross-sectional investigation and analysis of early treatment of partial-thickness burn wounds by professional burn medical staff in China

A HIV-positive subject with dermatomal and generalized vesicular skin lesions

A 58-year old man with HIV infection diagnosed in 2018 presented in July 2021 with a 7-day history of vesicular skin lesions localized to the right side of abdomen and diffuse vesicular lesions on the face, trunk, abdomen and both arms (Fig. 1A e 1B).

Viral exanthem following influenza vaccine

Abstract Introduction: Influenza vaccination (flu vaccine) is associated with some musculoskeletal and neurological complications despite its wide use and significant safety profile. Skin is one of the most common systems for drug reactions and side effects. Skin rashes such as bullous eruptions and vasculitis have been reported, but viral exanthem are seldom reported in association with the influenza vaccine. In particular, herpes simplex virus-2 reactivation and myelitis following influenza vaccination manifesting as severe herpes simplex virus type 2 and associated with blisters on the back of a single patient have been reported before. However, data on the rate of such complications are scarce in the literature. Patient concerns: A young woman complained of an unusual presentation of eruptive vesicular skin lesions following influenza vaccination complicated by allergic contact dermatitis to lemon soap applied to the lesions. Diagnosis: Viral exanthem were diagnosed based on clinical presentation and supported by a skin biopsy. Interventions: Medical treatment with antiviral and corticosteroids. Outcomes: The patient had a favorable outcome. Conclusion: Dermatologists should be vigilant to the association with any new medications and skin lesions, observe the progression of the lesions, and revisit the medical history to establish the correct relationships for any possible new causative agent to an evolving or new developing lesion.

Ayurvedic management of herpes zoster in Rakta-pradoshajaroga (Gilbert's syndrome)

Herpes zoster is an acute viral infection of sensory ganglia and the corresponding cutaneous areas of innervations characterized by fever and localized pain with vesicular skin eruption over single dermatomes. The available conventional treatments such as the use of antiviral drugs, corticosteroids, and topical agents have certain limitations. The condition, if not treated in early stages, becomes a great challenge to the clinician due to a higher rate of complications such as the neurological sequel, palsy, stroke, and cardiovascular events. In Ayurveda, this condition closely resembles Pittajavisarpa. Gilbert's syndrome is an inherited condition in which the liver does not properly process bilirubin, which causes a slight increase in bilirubin level that can be correlated with Kamala (~jaundice) in Ayurveda. Visarpa and Kamala both diseases are Rakta-pradoshajaroga (~blood vitiated disorders). The principle of treatment is Raktapittanashak-kriya (~remedies which balance the Rakta and Pitta dosha). In this case report, a 20-year-old male patient, with Gilbert syndrome presented with herpes zoster was managed with Ayurvedic internal medications such as Sutashekhara rasa, Arogyavardhini vati, Kaishora guggulu, Avipattikara churna, Paripathadi kwatha, and local application of Shatadhouta ghrita. Improvement had been observed in symptoms and in skin lesions after 14 days, whereas hepatic biochemical parameters were restored to normal after 42 days of treatment. No adverse effect pertaining to the prescribed drug was reported during the study period, inferring that, Ayurvedic medicines offer a good approach to manage Rakta-pradoshajaroga.

Onychomadesis- A Late Manifestation of Hand, Foot and Mouth Disease: A Case Series

Hand Foot Mouth Disease (HFMD) is one of the most common viral illness that is characterised by fever below 38.3°C, painful oral lesions on the tongue and buccal mucosa and macular, maculopapular or vesicular skin lesions on the soles and palms. Many viruses are implicated in HFMD, such as Coxsackievirus A5, A6, A7, A9, A10, A16 (most common), B1, B2, B3, B5, Echoviruses E3, E4, E9 and Enterovirus 71. The illness is usually mild and self-limiting. HFMD due to Enterovirus 71, is associated with a severe illness complicated by aseptic meningitis, acute flaccid paralysis, pulmonary oedema and heart failure. Onychomadesis is a very rare complication of HFMD, typically occurring three to eight week of onset of illness. This is characterised by the detachment of the nail plate from the proximal nail fold by a full thickness sulcus. It is postulated that viral infection causes inflammation around the nail matrix either due to direct effect or due to the deposition of immune complexes secondary to distal thromboembolism. Here, authors report six children of different age groups who were affected with onychomadesis during an outbreak of HFMD in the month of February to May 2022 in Chennai, Tamil Nadu, India. All these six children developed onychomadesis following HFMD, after a couple of weeks. Both upper and lower limb nails were involved. Other causes of onychomadesis like chronic illness, nutritional deficiencies, drug ingestion, periungual dermatitis, trauma were ruled out. Children were given supportive care and were followed-up. The changes in nails spontaneously regressed after a couple of weeks.

Brucine-Loaded Ethosomal Gel: Design, Optimization, and Anti-inflammatory Activity.

Brucine, one of the natural medications obtained from Nux vomica seeds, is used as an anti-inflammatory drug. Several investigations were performed to overcome its drawbacks, which will affect significantly its pharmaceutical formulation. The goal of the current investigation was to design, optimize, and evaluate the anti-inflammatory performance of BRU ethosomal gel. Brucineethosomal formulations were prepared using thin film hydration method and optimized by central composite design approach using three independent variables (lecithin concentration, cholesterol concentration, and ethanol percentage) and three response variables (vesicular size, encapsulation efficiency, and skin permeation). The optimized formulation was examined for its stability and then incorporated into HPMC gel to get BRU ethosomal gel. The obtained BRU-loaded ethosomal gel was evaluated for its physical properties, in vitro release, and ex vivo permeation and skin irritation. Finally, carrageenan-induced rat hind paw edema test was adopted for the anti-inflammatory activity. The developed BRU ethosomal gel exhibited good physical characteristics comparable with the conventional developed BRU gel. In vitro release of BRU from ethosomal gel was effectively extended for 6h. Permeation of BRU from ethosomes was significantly higher than all formulations (p < 0.05), since it recorded steady state transdermal flux value 0.548 ± 0.03μg/cm2h with enhancement ratio 2.73 ± 0.23. Eventually, BRU ethosomal gel exhibited potent anti-inflammatory activity as manifested by a significant decrease in rat hind paw inflammation following 24h. In conclusion, the study emphasized the prospective of ethosomal gel as a fortunate carrier for intensifying the anti-inflammatory effect of Brucine.

Herpes-zoster-Update – was gibt es Neues?

AbstractShingles are triggered by the reactivation of an infection with the varicella zoster virus (VZV) and are characterized by specific vesicular skin lesions. Mostly, elderly patients are affected. Depending on the affected dermatome, some serious complications can be observed. The introduction of a vaccine against shingles in Germany offers a great potential for reducing the frequency and severity of this disease. There are both a live vaccine, which is no longer recommended, and an inactivated vaccine, which, however, is still not sufficiently recommended to the authorized patient groups and is also only available to a limited extent due to delivery bottlenecks. HZ neuralgia is a serious complication of the disease that requires rapid and effective therapy and should be handed over to experienced pain therapists rather too early than too late. Unfortunately, in everyday clinical practice only a few people are familiar with VZV vasculopathy, which is associated with a significantly increased risk of cerebral insults.

Cutaneous mastocytosis in an infant: Case report and clinicopathological correlation

Mastocytosis is a disorder of clonal proliferation of the mast cells, which can be cutaneous or systemic. Abnormal mast cell infiltration comprising multifocal compact clusters or cohesive aggregates can affect one or more organ systems. Cutaneous mastocytosis is a relatively uncommon condition in the pediatric population. We report a case of 9 month infant presented with multiple papular and vesicular skin rashes since 6 months of age. On clinical examination Darier’s sign was negative. The serum tryptase levels were within normal limits. Clinical differential diagnoses were benign cephalic histiocytosis vs cutaneous mastocytosis. Skin biopsy revealed a mononuclear cell infiltrate in the papillary dermis reaching up to the dermo-epidermal junction. Toluidine blue staining highlighted the metachromatic granules. CD117, CD30 IHC stains were positive which confirmed the diagnosis of cutaneous mastocytosis. This case is presented to highlight the histomorphology and the special stains in cases of mastocytosis.

Vesicular hand eczema transcriptome analysis provides insights into its pathophysiology.

Hand eczema is a common inflammatory skin condition of the hands whose pathogenesis is largely unknown. More insight and knowledge of the disease on a more fundamental level might lead to a better understanding of the biological processes involved, which could provide possible new treatment strategies. We aimed to profile the transcriptome of lesional palmar epidermal skin of patients suffering from vesicular hand eczema using RNA‐sequencing. RNA‐sequencing was performed to identify differentially expressed genes in lesional vs. non‐lesional palmar epidermal skin from a group of patients with vesicular hand eczema compared to healthy controls. Comprehensive real‐time quantitative PCR analyses and immunohistochemistry were used for validation of candidate genes and protein profiles for vesicular hand eczema. Overall, a significant and high expression of genes/proteins involved in keratinocyte host defense and inflammation was found in lesional skin. Furthermore, we detected several molecules, both up or downregulated in lesional skin, which are involved in epidermal differentiation. Immune signalling genes were found to be upregulated in lesional skin, albeit with relatively low expression levels. Non‐lesional patient skin showed no significant differences compared to healthy control skin. Lesional vesicular hand eczema skin shows a distinct expression profile compared to non‐lesional skin and healthy control skin. Notably, the overall results indicate a large overlap between vesicular hand eczema and earlier reported atopic dermatitis lesional transcriptome profiles, which suggests that treatments for atopic dermatitis could also be effective in (vesicular) hand eczema.

Febrile palpebral edema

Febrile palpebral edema

Congenital candidiasis – a diagnostic challenge

Introduction: Congenital candidiasis is a rare intrauterine infection characterized by vesicular and pustular skin lesions appearing in the first six days of life. Clinical case: The authors describe the case of a full-term infant presenting erythematous macules, vesicles and pustules involving the trunk and extremities and cervical burn-like dermatitis at birth. Mycological skin lesion culture was positive for Candida albicans. Blood culture was positive for methicillin-sensitive Staphylococcus aureus. After systemic antifungal and antibiotic therapy was started, the newborn remained asymptomatic with lesion improvement. Discussion/ Conclusion: Herein is reported a case of congenital candidiasis in a full-term infant, with a successful recovery. The rarity of congenital candidiasis can lead to delayed diagnosis and unnecessary treatment. This case shows that fungal infection should be considered in the differential diagnosis of vesiculopustular skin lesions in neonates. Systemic therapy should be initiated if invasive candidiasis is suspected.

Oleic Acid Vesicles as a new Approach for Transdermal Delivery of Econazole Nitrate: Development, Characterization, and In-vivo Evaluation in Wistar rats.

Cutaneous candidiasis is a deep-seated skin fungal infection that is most commonly observed in immunocompromised patients. This fungal infection is conventionally treated with various formulations like gels and creams which are having different side effects and least therapeutic efficacy. Hence, it becomes necessary to develop a novel carrier system for the treatment of this deep-seated skin fungal infection. Econazole nitrate is the most widely used antifungal for the treatment of cutaneous candidiasis, therefore, in present research work we developed and evaluated econazole nitrate loaded oleic acid vesicles for treatment of cutaneous candidiasis through transdermal route. Econazole nitrate loaded oleic acid vesicles were prepared by thin-film hydration and characterized for drug entrapment, vesicle size, zeta potential, polydispersity index (PDI), Fourier Transform-infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), X-ray diffraction (XRD) analysis. Furthermore, the oleic acid vesicular gel was evaluated for ex-vivo skin permeation/retention and in-vitro and in-vivo antifungal activity in Wistar rats. Econazole nitrate loaded oleic acid vesicles showed high encapsulation of drug (74.76 ± 3.0%), acceptable size (373.4 ± 2.9 nm), and colloidal characteristics (PDI = 0.231 ± 0.078, zeta potential = -13.27 ± 0.80 mV). The oleic acid vesicular gel showed high skin permeation (Transdermal flux = 61.98 ± 2.45 μg/cm2/h), skin retention (35.90 ± 2.06%), in-vitro, and in-vivo antifungal activity compared to marketed cream (EcodermR) of econazole nitrate for a prolonged period of time (4 days). Developed econazole nitrate loaded oleic acid vesicles could be used effectively in the treatment of cutaneous candidiasis with minimization of side effects of econazole nitrate with increased therapeutic efficacy.

S2719 A Rare Case of Disseminated Varicella Zoster in a Young Patient With Cirrhosis

INTRODUCTION: Herpes zoster, otherwise known as shingles, occurs after reactivation of the dormant, neurotropic, varicella zoster virus (VZV) that lies in the dorsal root ganglia. The typical manifestation consists of self-limiting, painful, vesicular skin lesions that follow a dermatomal pattern. Herpes zoster can present as a disseminated infection in immunocompromised patients (e.g., HIV, malignancy, chronic immunosuppressive drugs) and, very rarely, in immunocompetent individuals. Patients with cirrhosis are deemed to be at high risk for infections as a result of immune dysfunction although a nationwide, population-based study from Taiwan has shown that cirrhosis is not associated with an increased risk for herpes zoster. Furthermore, although there are case reports of post-vaccine primary varicella infection and subsequent dissemination, there appear to be none detailing a dissemination of reactivated varicella zoster in a cirrhotic patient. CASE DESCRIPTION/METHODS: We present a case of a 34 yr old male on no medications, with a twelve year history of heavy alcohol use and decompensated cirrhosis, who was admitted for higher level of care and liver transplant evaluation. Ten days into his admission, vesicular lesions were noted on his left flank. VZV PCR testing showed 438,342 copies/mL. Workup for other infections such as Hepatitis A, B, C and HIV were negative. The patient was initially started on 350 mg IV acyclovir every twelve hours which was subsequently increased to 700 mg IV due to presence of VZV in the ascitic fluid that was concerning for dissemination. Unfortunately, the patient developed multi-organ system failure and passed away. DISCUSSION: This case highlights a rare instance of VZV dissemination in a young patient with cirrhosis who only displayed a cluster of vesicles on his left flank. While VZV dissemination has been known to occur in immunocompromised patients, cirrhotic patients have not usually been considered to be at higher risk for reactivation or dissemination. Our case highlights the importance of early diagnosis and prompt, aggressive management of shingles in patients with cirrhosis to reduce the risk of disseminated VZV and mortality.

Clinical and histological characterization of vesicular COVID‐19 rashes: a prospective study in a tertiary care hospital

SummaryCOVID‐19 is an infectious disease caused by severe acute respiratory coronavirus 2 (SARS‐CoV‐2). Vesicular skin rashes have been reported as associated with COVID‐19, but there is little information about this cutaneous manifestation. We designed a prospective observational study of patients diagnosed with COVID‐19 who had vesicular lesions. Clinical characterization of skin findings was conducted by dermatologists. When possible, histological analysis and detection of SARS‐CoV‐2 in the content of the vesicles was performed. In total, 24 patients were included. A disseminated pattern was found in 18 patients (75%), and a localized pattern was found in 6 (25%). Median duration of the skin rash was 10 days. Of the 24 patients, 19 (79.2%) developed the skin rash after the onset of COVID‐19 symptoms. Histological examination in two patients was consistent with viral infection, SARS‐CoV‐2 was not detected in four patients. This single‐centre study shows the clinical characteristics of vesicular skin rashes in patients with COVID‐19.