Based on the products of joint CloudSat and CALIPSO observations from 2006 to 2017, this study investigates the global cloud macro-physical characteristics, including the spatial differences in cloud height, cloud thickness, cloud type, and cloud phase, along with the spatial-temporal variations and the land-sea discrepancy of the cloud vertical structure variables according to the study areas. The results show that the cloud frequency is higher over oceans than over land globally, but the opposite is true for cloud systems with more than two layers. Seasonal variability of global-average total cloud fraction is small, but large among different latitudinal bands. The global spatial distributions of cloud top height (CTH) and cloud base height (CBH) are similar, showing larger cloud heights over the land than over the ocean. The low clouds are mostly located in the central subtropical region, with CTH among 2.5–7.5 km, While the high clouds are mainly distributed in the equatorial region with CTH about 10–15 km. Meanwhile, the regional and seasonal variability of cloud geometric thickness (CGT) in all study areas are small, and the average thickness of higher clouds is slightly larger than that of lower clouds. By categorizing the clouds into eight types, it was found that the frequency of cirrus (Ci) and stratocumulus (Sc) is higher, followed by altocumulus (Ac), altostratus (As), nimbostratus (Ns) and cumulus (Cu), and the frequency of stratus (St) and deep convective clouds (DC) is the lowest. In addition, the occurrence frequency of clouds in phases was ranked from high to low as ice clouds, liquid clouds and mixed-phase clouds. Ice clouds are concentrated in the tropics and mid-latitudes, and located almost symmetrically around the equator during Mar-Apr-May (MAM) and Sep-Oct-Nov (SON). Liquid clouds are mainly distributed around 30°S and 30°N with large seasonal variability, and their frequency is higher over the ocean than over the land. Mixed-phase clouds are concentrated in the middle and high latitudes, with much less occurring in the equatorial regions.