Verruciform Xanthoma Research Articles

ゆうぜい型黄色腫 自験４症例と文献１５１例からみた臨床病理学的検討

Verruciform xanthoma, first described as a lesional entity by Shafer in 1971, is a verrucous lesion in appearance, which occurres often in oral cavity. Histopathologically the lesion shows moderate to severe parakeratin plugging and the presence of swollen “foam” cells in the connective tissue papillae between elongated epithelial rete pegs.One hundred fifty five cases of this lesion, including 4 of our own, that appear in the literature were clinicopathologically reviewed in this paper.The age of the patients ranged from 14 to 89 (mean age 50.5) years old and there was no sex predilection for occurrence. The lesion was most frequently found on the alveolar gingiva (55.5%), followed by the palate (20.0%), tongue (12.3%), buccal mucosa (4.5%) and so on. It is still fully unknown whether this lesional condition is a true neoplasm or chronic inflammatory tissue reaction, while most researchers would agree to the latter, and our cases might support the latter hypothesis.Simple surgical excision is recommended as the first choice in treatment because no recurrences have been reported except one case reported by Nowparast et al.

ゆうぜい性黄色腫の１例

Verruciform xanthoma is a non-tumorous lesion of unknown etiology and uncertain nature, first described by Shafer in 1971.Histologically the characteristic features of the lesion are the presence of rete pegs extremely elongated and large, swollen foam cells or xanthoma cells.This paper presented the case of an 80-year-old female with a lesion at the right lateral margin of the tongue. Histochemical and immunohistochemical detections were also made, and the origin of histiocytes as to foam cells were discussed. In addition the reports concerning it in Japan were reviewed.

舌に発生したゆうぜい状黄色腫の１例

Verruciform Xanthoma with histopathological characteristics of verruciform growth and the proliferation of xanthoma cell in the lamina propria was first described in 1971 by Shafer as Histiocytosis-Y. Though occasionally reported later in occidental countries, this disease is relatively rare. Especially in Japan this disease is rarely documented. The gingiva is a common site of occurrence. Those occurring in the tongue or buccal mucosa are very rare. Recently we encountered a 64-year-old woman with this disease in the left lateral margin of the tongue.

A well-circumscribed, asymptomatic, sessile nodule on the right side of the soft palate

An atypical presentation of a verruciform xanthoma is discussed. Usually the surface of the lesion is rougher and more warty, and the lesions generally are larger. The foregoing case, however, serves to illustrate that all lesions, regardless of how small or innocuous, should be examined microscopically to determine a diagnosis and to develop a proper treatment plan. Rarely can a definitive diagnosis be made entirely on the basis of the clinical characteristics of the lesion.

ゆうぜい性黄色しゅの１例

Verruciform xanthoma occurring at the border of the hard-soft palate in a 58-yearold female is presented. It is a rare lesion of the oral cavity which usually has a warty or papillary appearance. In 1971 Shafer first described in details its clinical and histopathological features. In Japan the first case was reported by Kikuchi et al. in 1977. Since then twenty cases have been reported.This article reports one case of Verruciform xanthoma, itslight and electron microscopic findings together with some considerations on literatures concerned in Japan.

Langerhans cells in verruciform xanthomas: an immunoperoxidase study of 10 oral cases.

Ten oral verruciform xanthomas were studied using an immunoperoxidase stain for S-100 protein. All cases exhibited positively stained dendritic cells among the mononuclear inflammatory cell infiltrate at the base of the lesions and to a lesser extent among the "foam cells". The foam cells were, however, negative for S-100 staining. We suggest that, based on these findings, verruciform xanthomas belong to a new category of "non-X histiocytoses" in which the presence of Langerhans cells suggests an immunologic pathogenesis.

Verruciform xanthoma of the oral mucosa

The verruciform xanthoma is a rather rare lesion that is mostly confined to the oral mucosa. The clinical picture may vary considerably. The diagnosis is based on the presence of numerous xanthoma cells in the connective tissue papillae. A case of verruciform xanthoma in the floor of the mouth in a 45-year-old woman is presented. The findings reported in the literature are also discussed.

Verruciform Xanthoman of the Scrotum

Verruciform xanthoma, a rare histopathologic entity first described by Shafer in 1971, consists of two major elements—a papillomatous proliferation of epithelial or epidermal cells and xanthomatous foam cell infiltrates present in the papillary dermis. Verruciform xanthoma is usually found on the oral mucosa,¹but it also occurs, on rare instances, on the skin of the vulva,²groin,³and penis,⁴and has been reported to develop in an epithelial nevus.⁵I describe three patients with verruciform xanthoma arising on the scrotum. <h3>Report of Cases</h3><h3>Case 1.—</h3> A 76-year-old healthy man had lesions on the scrotum of one year's duration. Physical examination showed a 7-mm

Verruciform xanthoma of penis Light and electron-microscopic study

A case of verruciform xanthoma of the penis diagnosed by light microscopy was studied ultrastructurally. No extra-oral verruciform xanthoma has been analyzed at the ultrastructural level before. On electron microscopy the lipidized cells were histiocytes distended with lipid vacuoles of varying sizes and electron density. Lipid vacuoles were also seen in the overlying epidermis. Viral particles were not seen in the epidermal cells.

Ｖｅｒｒｕｃｉｆｏｒｍ ｘａｎｔｈｏｍａの２症例

In this paper, two female cases of verruciform xanthoma are reported.Case No.1 was a 22 year old female who first noticed a swelling of gingival mucosa 3 years ago. Oral examination revealed a slightly whitish, broad based lesion with granular surface 11×11mm in size on the 65 site of palatal gingiva. The clinical diagnosis was papilloma and the histological diagnosis was verruciform xanthoma of papillary type.Case No. 2 was a 55 year old female with roughly surfaced gingival lesion which was first noticed 2 months ago. Oral examination revealed a slightly raised, whitish lesion of 10-15mm size on the 7 site of lingual alveolar mucosa. White sponge nevus was suspected clinically, with the histological diagnosis of verruciform xanthoma of flat type.No relapse occurred in either case after treatment.

Verruciform xanthoma: Occurrence in eroded skin in a patient with recessive dystrophic epidermolysis bullosa

Verruciform xanthoma is a rare, granular, plaque-like lesion which occurs on mucosal surfaces and is characterized by acanthosis with xanthoma cells in the dermis between rete pegs. A case of verruciform xanthoma is reported which occurred on the sacral region in a patient with recessive dystrophic epidermolysis bullosa (RDEB). Electron microscopic studies suggested that many of the xanthoma cells were fibroblasts whose vacuolated appearance was expressed in cell culture and persisted for several passages. The occurrence of a verruciform xanthoma in a patient with severe recessive dystrophic epidermolysis bullosa suggests that repeated epidermal and/or dermal damage gave rise to a reactive process involving the formation of lipid-laden cells.

Verruciform xanthoma in a young male patient with a past history of pemphigus vulgaris

A large verruciform xanthoma developed on an area of the tongue that had been extensively involved with the vesicular lesions of pemphigus vulgaris in a 15-year-old boy. A rationale is presented that supports a previously published theory that epithelial implantation from a myriad of causes (trauma, vesiculobullous disorders, etc.) may be capable of producing the lesions secondary to breakdown of the implanted epithelial cells.

Verruciform Xanthoma in an Epithelial Nevus

Verruciform xanthoma is an unusual lesion that was initially reported in 1971. Clinically, it is a verrucous, vascular, epithelial plaque or papillomatous growth commonly found on oral or mucosal tissues. Histologically, it is characterized by a verruciform epithelium with abundant parakeratosis and by foam cells occupying the vascularized dermal papillae. This is the second extramucosal verruciform xanthoma reported. Our patient had several unique features. She is the youngest patient described to date, her lesion is the largest reported, and the lesion occurred in an epithelial nevus-type eruption of a phocomelic extremity. Light and electron microscopic studies disclosed abnormal keratinization, mast cell proliferation, and the previously described foam cells. We believe that the verruciform xanthoma in our patient represents part of a reaction to the epithelial nevus occurring in association with a developmental anomaly.

Verruciform Xanthoma of the Oral Mucosa

An additional case of verruciform xanthoma in the oral cavity is presented. The clinical and light microscopic findings in this case are similar to those previously described. In addition, the clinical features of 47 cases that could be found in the literature are summarized and discussed.

Verruciform Xanthoma of the Oral Mucosa

Verruciform xanthoma is an uncommon lesion confined mainly to the oral mucosa. Only two extraoral cases have been reported, and these involved the genitalia. Clinically, verruciform xanthoma is a raised lesion with a papillary or granular surface, usually located on the gingiva or alveolar mucosa. Microscopically, it is characterized by epithelial cell proliferation and by the accumulation of xanthoma cells in the upper lamina propria. Five new cases are reported and analyzed together with an additional 29 cases found in a review of the literature.

Verruciform xanthoma of the oral mucosa. Report of five cases and review of the literature

Verruciform xanthoma of the oral mucosa. Report of five cases and review of the literature

Verruciform Xanthoma of the Penis

We describe herein a patient with a verruciform xanthoma of the penis. This histologically distinctive lesion is usually confined to the oral mucosa, although two cases occurring on the vulva have recently been reported. To our knowledge, this lesion has not been previously described in other sites. Biopsy for histopathologic examination is required to aid in the identification of this unusual entity. Verruciform xanthomas have been benign, although a squamous cell carcinoma subsequently developed in one patient whose oral lesions were associated with leukoplakia.

Verruciform xanthoma. A clinicopathologic review and report of fifty-four cases.

Verruciform xanthoma is a benign, solitary, oral lesion of unknown origin, characterized principally by verrucous configuration, parakeratosis of surface epithelium, and the presence of foam cells in connective tissue papillae. Recurrence is unusual after surgical removal. Fifty-four cases are reported, and the nature of the lesion is discussed in detail.

Verruciform Xanthoma of the Skin

Verruciform xanthoma is an unusual lesion characterized by verrucous epithelial proliferation accompanied by a prominent replacement of the dermal papillae with large numbers of foamy histiocytes. Cases have been previously reported only as occurring in the oral cavity or, more rarely, on the vulva. A 16-year-old girl developed a verruciform xanthoma of the skin. The lesion appeared to arise within a large epithelia nevus involving the left inner thigh and inguinal area. This association supports the concept that verruciform xanthoma is a rare inflammatory reaction pattern that may be seen in a variety of squamous epithelial lesions characterized by verrucous hyperplasia.

Verruciform xanthoma

Twenty-one cases of verruciform xanthoma are reported, bringing to fifty the total cases in the literature. The lesion was found most often in middle-aged persons, and the most common location was the gingiva or alveolar ridge. The cause of the verruciform xanthoma is still uncertain.