Verbal Reasoning Research Articles

Playful activities mitigate relations between parental mental health difficulties and child verbal outcomes.

This study examined the role of parental involvement in the home learning environment in the association between parental mental health and child cognitive performance. In a sample of 174 three- to five-year-old children (52% female, 97% White, 7% Hispanic, 2019-2022), playful activities moderated the relation between parental general depression and child verbal reasoning and acquired verbal knowledge. However, there was no evidence that parental involvement moderated the association between parental mental health and child spatial reasoning. These results improve our understanding of the pathways by which parental mental health, even in a non-clinical community sample, relate to child outcomes and raise the possibility of leveraging playful activities as one mechanism to alleviate the potential role of parental mental health difficulties.

Increased intra-individual variability among individuals with ADHD: first evidence from numerosity judgment and verbal and quantitative reasoning.

This article presents the results of two studies investigating increased intra-individual variability (IIV) in the performance of individuals with attention deficit hyperactivity disorder (ADHD), in two cognitive domains: numerosity judgments and quantitative and verbal reasoning. Study 1, a pre-registered experiment, involved approximately 200 participants (42.66% female; mean age: 36.86; standard deviation of age: 10.70) making numerical judgments at two time-points. ADHD-symptom severity was assessed on a continuous scale. In Study 2, we collected the data of approximately 3000 examinees who had taken a high-stakes admissions test for higher education (assessing quantitative and verbal reasoning). The sample comprised only people formally diagnosed with ADHD. The control group consisted of approximately 200 000 examinees, none of whom presented with ADHD. The results of Study 1 revealed a positive correlation between IIV (distance between judgments at the two time-points) and ADHD symptom severity. The results of Study 2 demonstrated that IIV (distance between the scores on two test chapters assessing the same type of reasoning) was greater among examinees diagnosed with ADHD. In both studies, the findings persisted even after controlling for performance level. The results indicate that individuals with ADHD, v. those without, exhibit less consistent numerosity judgments and greater fluctuation in performance on verbal and quantitative reasoning. The measurement of the same psychological constructs appears to be less precise among individuals with ADHD compared to those without. We discuss the theoretical contributions and practical implications of our results for two fields: judgment and decision-making, and assessment.

12566 Adult Growth Hormone Deficiency, Replacement Therapy Use, and IGF1 Levels in Association with Physical, Psychosocial, and Neurocognitive Outcomes Among Childhood Cancer Survivors

Abstract Disclosure: T. Yoshida: None. J.L. Baedke: None. H. Wang: None. C.H. Yu: None. C.L. Wilson: None. D.A. Mulrooney: None. S.B. Dixon: None. I. Huang: None. T.M. Brinkman: None. K.R. Krull: None. S. Mostoufi-Moab: None. J. Miguel Martínez: None. K.K. Ness: None. M.M. Hudson: None. Y. Yasui: None. A. Delaney: None. Background: Adult growth hormone deficiency (aGHD) is a common and often untreated late effect among childhood cancer survivors. Untreated aGHD likely adds to the burden of health outcomes in survivors already experiencing cancer treatment related late toxicities. As comprehensive data on the consequences of untreated aGHD in survivors are scarce, we assessed the clinical impact of untreated aGHD among survivors, together with socioeconomic factors as potential contributing factors, utilizing a large, clinically characterized cohort of childhood cancer survivors. Methods: 3902 five-year survivors ≥ 18 years old [median (25th-75th percentile) age, 31.7y (25.2-40.0); age at cancer diagnosis 8.1y (3.5-13.6); 47.5% female] were examined. We assessed the: 1) proportion of survivors with aGHD on GH therapy (GHT); 2) association between GHT and socioeconomic factors (e.g., household income, area deprivation index) by multivariable logistic regression; and 3) associations between age- and sex-adjusted insulin-like growth factor 1 (IGF1) z-score and prevalence of clinically-assessed (i.e., body composition, metabolic/cardiovascular factors, neurocognitive function) and self-reported [i.e., quality of life (QoL), emotional symptom] outcomes by multivariable logistic regression with trend test, adjusting for potential confounders (e.g., radiation to the hypothalamic-pituitary region). Results: aGHD was observed in 9.1% (354/3902) of survivors; among them, 9.0% (32/354) were on GHT. Survivors on GHT were more likely to have higher household income, hold health insurance, and reside in less socioeconomically disadvantaged neighborhoods, compared to survivors with untreated aGHD. Socioeconomic factors had significant independent associations with GHT use in multivariable analysis [e.g., annual household income <$40,000 vs. ≥$80,000, adjusted odds ratio (aOR) of GHT use, 0.28; 95% confidence interval (CI), 0.08-0.86]. Lower IGF1 z-score (IGF1 z-score ≤ -2, vs. IGF1 z-score >0) was associated with a higher prevalence of various outcomes (aOR, 95% CI), such as abdominal obesity (2.56, 1.98-5.26), weak handgrip strength (2.49, 1.65-3.73), hypertension (1.47, 1.06-2.04), abnormal glucose metabolism (2.07, 1.49-2.86), impaired health-related QoL (e.g., physical functioning, 1.97, 1.35-2.86), depression (1.58, 1.06-2.33), and impairment in multiple neurocognitive functions (e.g., verbal reasoning, a global measure of intelligence, 2.22, 1.49-3.30) with a dose-response relationship. Conclusions: Our data support a negative impact of untreated aGHD on physical, psychosocial, and neurocognitive outcomes among survivors and suggest the potential of GHT to improve QoL of survivors with aGHD. As lower socioeconomic status may affect survivors’ access to GHT, this disparity should be considered in interventions evaluating GHT for survivors with aGHD. Presentation: 6/3/2024

Implications of Prenatal Cannabis Exposure on Childhood Neurodevelopmental Outcomes: A Summary of the Clinical Evidence.

Cannabis is commonly used by pregnant patients for alleviation of pregnancy-associated symptoms. Multiple national medical associations have recommended against prenatal cannabis use, yet misinformation regarding its safety and efficacy remains prevalent in public discourse. Effective and evidence-based patient counseling on prenatal cannabis use requires a thorough understanding of the existing data on fetal neurodevelopment. The aim of this study was to summarize the existing clinical literature on the impacts of intrauterine cannabis exposure on offspring neurodevelopment. Articles were identified via literature search in PubMed and OVID; relevant articles were reviewed. Limited data have shown associations between intrauterine cannabis exposure and (1) increased startles and difficulty with consolation in the neonatal period, (2) memory challenges, verbal reasoning challenges, and diminished academic performance during early childhood, and (3) inattention, hyperactivity, and aggression during early childhood. Further research with large and diverse samples that use objective measures of cannabis use across multiple time points in pregnancy is required to assess causation, the true extent of impacts, and dose-dependent effects. The existing clinical data regarding the impacts of prenatal cannabis use on fetal neurodevelopment are limited by important confounders like genetic predisposition, concomitant tobacco and other substance use during pregnancy, and low socioeconomic status. However, the theoretical and demonstrated associations between prenatal cannabis use and adverse neurodevelopmental outcomes are compelling enough to warrant complete abstinence during pregnancy, pending further research. Providers can utilize this summary to offer data-driven guidance on prenatal cannabis use for pregnant patients.

Linguistic precursors of sixth-grade geometric and fraction skills in children with and without Developmental Language Disorder

BackgroundPrevious research has shown that foundational linguistic skills (i.e., phonological awareness and grammatical ability) indirectly (through arithmetic skills) predict growth from fifth-to sixth-grade geometric and fraction skills. AimsOur study aimed to investigate the linguistic precursors of sixth-grade geometric and fraction skills in children with and without DLD, while examining potential (cognitive) strengths within the DLD group that may partly compensate for learning geometry and fractions, at both the group and individual level. SampleParticipants were 46 children with DLD and 122 typically developing peers from 9 to 11 years of age. MethodsClassroom and individual measures were administered in both grade 4 and grade 6. ResultsAt the group level, results showed children with DLD to score below their peers on arithmetic, geometric, and fraction skills. Furthermore, indirect effects of phonological awareness and naming speed, via arithmetic skills, on geometric and fraction skills were found to be equally strong for both groups. In addition, similar strengths for both groups were found for nonverbal intelligence, academic vocabulary, and verbal reasoning in directly predicting the scores in geometric and fraction skills. Finally, at the individual level, a strength in verbal reasoning was found to partly compensate the delays in mathematics in children with DLD. ConclusionsThe educational needs of children with and without DLD in mathematics learning might be more quantitative in nature than that they are qualitative. In addition, identifying individual strengths should be integrated into standardized test batteries and treatment approaches.

Plasma markers of neurodegeneration, latent cognitive abilities and physical activity in healthy aging

Blood-based biomarkers of neurodegeneration demonstrate great promise for the diagnosis and prognosis of Alzheimer’s disease. Ultra-sensitive plasma assays now allow for quantification of the lower concentrations in cognitively unimpaired older adults, making it possible to investigate whether these markers can provide insight also into the early neurodegenerative processes that affect cognitive function and whether the markers are influenced by modifiable risk factors. Adopting an exploratory approach in 93 healthy older adults (65–75 years), we used structural equation modelling to investigate cross-sectional associations between multiple latent cognitive abilities (working memory, episodic memory, spatial and verbal reasoning) and plasma amyloid beta (Aβ42/Aβ40 ratio), phosphorylated-tau 181 (ptau-181), glial fibrillary acidic protein (GFAP), and neurofilament light (NfL), as well as the influence of device-measured habitual physical activity on these associations. The results showed that NfL was negatively associated with working memory, and that NfL interacted with moderate-to-vigorous physical activity in its association with episodic memory. The study has thereby demonstrated the potential of neurodegenerative plasma markers for improving understanding of normative cognitive aging and encourages future research to test the hypothesis that high levels of NfL, indicative of white matter pathology, limit the beneficial effect of physical activity on episodic memory in healthy aging.

Rules of Islamic creed ''Aqidah'' Between Theory and Practical (A Study of creed Issues According to Ash'arites)

The attention to the deductive method began with Imam Al-Ash’ari and the establishment of the rules of theorizing from the first moment of the emergence of the Ash’ari school of thought at the hands of the founder of the school of thought, Abu Al-Hasan Al-Ash’ari, and the scholars who followed after him who wrote theological works. This reflects the great care of the Ash’arism in rooting and theorizing the methods of theory, and setting the methodological rules of reasoning, so he dealt with The research examines the most important comprehensive theological rules through which the Ash’ari reasoned in the doctrinal issues on which Ash’ari theological thought was founded, taking into account the extent of stability or change that occurred in some of these rules along the path of the Ash’ari doctrine. The aim of this study was to answer an important methodological question in formulating the verbal thinking curriculum: It is: What is the impact of comprehensive verbal rules in achieving intellectual consistency and methodological consistency in the theory of verbal reasoning according to the Ash’arism between theory and application? The answer to the nature of this research required delving into the journey of exploring the idea of comprehensive verbal grammar in the theological heritage. It was appropriate for this task to adopt the historical approach in collecting the material and searching for comprehensive grammar in its context from the verbal works approved in the Ash’arite school. It was necessary to study the origins of the theory of verbal grammar. Comprehensive and anticipating the methodological features governing inference, adopting the analytical approach; The approach adopted in this study was a combined approach of the two approaches: historical and analytical, in order to reach the impact of comprehensive verbal rules in both theoretical and applied studies.

A - 44 Value of Repeat Neuropsychological Assessments in Children with Complex Birth and Neurological Injuries

Abstract Objective Extremely low birth weight, in-utero insult, and PVL are associated with an array of neurodevelopmental complications. PVL is most common in very premature. Associated complications in this case study include diffuse demyelination, cerebellar atrophy, and arthrogryposis. Data from serial assessments reveal preservation of intelligence, decoding, and social skills. Implications for the role of repeat assessments in guiding education and intervention are discussed. Method The subject was an 18-year-old male with extremely low birth weight, in-utero insult, PVL, cerebellar atrophy, delayed myelination, and arthrogryposis. His presentation also included craniosynostosis. Three outpatient neuropsychological assessments were completed over eight years. Assessments included measures of intellectual, academic, neurocognitive, and emotional functions. Results Despite multiple physical and neurological impairments, assessments revealed preserved verbal and nonverbal intelligence, phonemic awareness, computation skills, and social cognition. Deficits were evident in processing speed, rapid naming, math fluency, word fluency, working memory, and executive functions. Academic strengths were evident in reading and written expression. Checklists revealed inattention and impulsivity with strengths in social cognition (See data tables). Conclusions This study demonstrates both variability in outcome following a complex birth history and neurological history and the value of repeat neuropsychological assessments. Assessment data was used to identify and build upon preserved skills and focus intervention strategies. Maintained verbal and nonverbal reasoning skills, in the context of strong social cognition, significantly contributed to progress, self-esteem, and future goals. Repeat neuropsychological assessment is well-suited for such cases. Access to such assessments is critical and should be regarded as medically necessary to guide intervention and promote positive outcomes.

B - 68 Executive Functioning Skills of Verbal and Emotional Intelligence and Borderline Personality Predict Posttraumatic Growth

Abstract Objective Research found a positive connection between emotional intelligence and both borderline personality and posttraumatic growth. Prior research has not examined the combination of emotional intelligence, borderline personality, and cognitive intelligence as predictors of posttraumatic growth (PTG); our research helped fill this gap. Method American adults (N = 402; M age = 38.7 years, SD = 13.0) were recruited from Prolific to complete an online survey including Shipley Institute of Living Scale-2, Assessing Emotions Scale, Posttraumatic Growth Inventory-Expanded, and screening questionnaire for DSM-5 Personality Disorders. PTG was measured in relation to any previous trauma. Participants reported being white (67.2%), African American/Black (9.7%), Asian/Asian American (9.7%), Hispanic/Latinx (9.0%), and other ethnicities (4.5%), and men (48.0%), women (47.8%), non-binary (1.5%), transgender men (1.2%) or women (0.5%), or other genders (0.9%). Results Hierarchical regression revealed that emotional and verbal intelligence significantly predicted PTG, F(2, 391) = 78.54, p < 0.001, adj. R2 = 0.28, 95% CI [0.20, 0.35]. Adding borderline characteristics to the model resulted in significantly greater prediction of PTG, F(3, 390) = 61.22, p < 0.001, F change p < 0.001, and explained 32% of the variance in PTG, adj. R2 = 0.32, 95% CI [0.24, 0.39]. Greater emotional intelligence (beta = 0.535), more borderline personality characteristics (beta = 0.189), and lower verbal reasoning (beta = −0.159) predicted more PTG. Conclusion Our findings suggest that executive functions and borderline characteristics play a complex role in the development of posttraumatic growth after trauma.

Sports-related concussion not associated with long-term cognitive or behavioural deficits: the PROTECT-TBI study

BackgroundThe cognitive effects of sports-related concussion (SRC) have been the subject of vigorous debate but there has been little research into long-term outcomes in non-athlete populations.MethodsThis cohort study of UK...

Dose-dependent cranial irradiation associations with brain structures and neuropsychological outcomes in children with posterior fossa brain tumors.

Posterior fossa irradiation with or without whole brain irradiation results in high doses of radiation to the thalamus, hippocampus, and putamen, structures critical to cognitive functioning. As a result, children with brain tumors treated with cranial irradiation (CRT) may experience significant cognitive late effects. We sought to determine the effect of radiation to those structures on neuropsychological outcome. Forty-seven children with a history of posterior fossa tumor (17 treated with surgery; 11 with surgery and chemotherapy; and 19 with surgery, chemotherapy, and CRT) underwent neuroimaging and neuropsychological assessment at a mean of 4.8 years after treatment, along with 17 healthy sibling controls. The putamen, thalamus, and hippocampus were segmented on each participant's magnetic resonance imaging for diffusion indices and volumes, and in the radiation treatment group, radiation dose to each structure was calculated. Performance on visuoconstruction and spatial learning and memory was lower in patient groups than controls. Volume of the thalamus, when controlling for age, was smaller in the patient group treated with CRT than other groups. Higher radiation doses to the putamen correlated with higher fractional anisotropy in that structure. Higher radiation dose to the hippocampus correlated with lower spatial learning, and higher dose to thalami and putamina to lower verbal and nonverbal reasoning. All children with posterior fossa tumors, regardless of treatment modality, had cognitive deficits compared to their sibling controls. Posterior fossa irradiation may affect thalamic volume and aspects of verbal and nonverbal cognitive functioning.

Evidence of interrelated cognitive-like capabilities in large language models: Indications of artificial general intelligence or achievement?

Large language models (LLMs) are advanced artificial intelligence (AI) systems that can perform a variety of tasks commonly found in human intelligence tests, such as defining words, performing calculations, and engaging in verbal reasoning. There are also substantial individual differences in LLM capacities. Given the consistent observation of a positive manifold and general intelligence factor in human samples, along with group-level factors (e.g., crystallised intelligence), we hypothesized that LLM test scores may also exhibit positive inter-correlations, which could potentially give rise to an artificial general ability (AGA) factor and one or more group-level factors. Based on a sample of 591 LLMs and scores from 12 tests aligned with fluid reasoning (Gf), domain-specific knowledge (Gkn), reading/writing (Grw), and quantitative knowledge (Gq), we found strong empirical evidence for a positive manifold and a general factor of ability. Additionally, we identified a combined Gkn/Grw group-level factor. Finally, the number of LLM parameters correlated positively with both general factor of ability and Gkn/Grw factor scores, although the effects showed diminishing returns. We interpreted our results to suggest that LLMs, like human cognitive abilities, may share a common underlying efficiency in processing information and solving problems, though whether LLMs manifest primarily achievement/expertise rather than intelligence remains to be determined. Finally, while models with greater numbers of parameters exhibit greater general cognitive-like abilities, akin to the connection between greater neuronal density and human general intelligence, other characteristics must also be involved.

Classroom Variables And Its Influence On Verbal Reasoning Outcomes In Basic Technology Among Secondary School Students: Application Of Discriminant Analysis

Classroom Variables And Its Influence On Verbal Reasoning Outcomes In Basic Technology Among Secondary School Students: Application Of Discriminant Analysis

Interactions of gender inequality and parental discipline predicting child aggression in low- and middle-income countries.

Children in low- and middle-income countries (LMICs) are disproportionately at risk of not meeting their developmental potential. Parental discipline can promote and hinder child outcomes; however, little research examines how discipline interacts with contextual factors to predict child outcomes in LMICs. Using data from 208,156 households with children between 36 and 59 months (50.5% male) across 63 countries, this study examined whether interactions between gender inequality and discipline (shouting, spanking, beating, and verbal reasoning) predicted child aggression. Results showed aggression was higher in countries with high gender inequality, and associations between discipline and child aggression were weaker in countries where gender inequality was higher. Improvements in country-level gender parity, in addition to parenting, will be necessary to promote positive child outcomes in LMICs.

Daily cannabis use and cognitive impairment in community residents aged 50 and over

ABSTRACT Background Cannabis use is associated with cognitive dysfunction in younger adults, but little is known about its role as a risk factor for dementia. This study aimed to explore the association between daily cannabis use and cognitive impairment in a cohort study of middle-aged and older people at risk of dementia. Methods Sample drawn from a cross-sectional study involving 15,582 people aged 50 and over from PROTECT study. Lifetime heavy cannabis use was defined by daily use. Results A total of 4203 (27%) participants reported lifetime cannabis use, of whom 4097 responses to frequency of use were obtained. Among them, 259 participants reported lifetime daily, and 3838 reported less than daily use. Those with lifetime daily cannabis use were more likely than those without to be unmarried, of lower educational attainment, and current or past tobacco smokers. They were more likely to show moderate or moderate-to-severe anxiety and depression. Baseline lifetime daily cannabis use was also associated with improved verbal reasoning but not with change in other cognitive scores. Conclusions Given improved verbal reasoning in people with daily lifetime cannabis use, the relationship between quantity and frequency of cannabis use and cognitive impairment in later life warrants further examination.

The Roles of Rule Type and Word Term in the Deductive Reasoning of Adults with and without Dyslexia.

Despite its importance to everyday functioning, reasoning is underexplored in developmental dyslexia. The current study investigated verbal deductive reasoning on the Wason selection task, not previously used in dyslexia research despite its well-established pedigree. Reasoning rule was manipulated, with the conditional rules varying in the logical values presented. The word frequency and imageability of the word terms was also manipulated. Twenty-six adults with dyslexia and 31 adults without dyslexia completed Wason selection task problems. No group difference in reasoning accuracy or completion time was found. However, the participants were most accurate when reasoning with the rule type "If p, then not q" and least accurate with the rule type "If p then q". More trials were also answered correctly when the word terms were highly imageable but of average word frequency. These findings are in line with the general reasoning literature. Dyslexia status did not interact with either rule type or word term type. The study expands upon previous research by testing verbal deductive reasoning in dyslexia, highlighting the role of imageability in facilitating reasoning performance for all, regardless of the presence or absence of dyslexia. Implications for the design of educational materials are considered.

Relationship between emotion comprehension, vocabulary, and verbal working memory in intellectual developmental disorders: involvement of verbal reasoning skills

ABSTRACT This study investigated the role of language-related abilities in emotion comprehension among young people with non-specific intellectual developmental disorders (NS-IDDs). Forty children and adolescents with NS-IDDs completed tasks assessing emotion comprehension, receptive vocabulary, verbal reasoning skills, and verbal working memory. Results showed that emotion comprehension was better predicted by comprehension of abstract words and verbal working memory, and that these two predictors were themselves predicted by verbal reasoning skills. These results therefore suggest a link between emotion understanding and verbal reasoning, which could be mediated by abstract vocabulary and verbal working memory. These findings provide insight into the relationships between emotion comprehension and language-related abilities in NS-IDDs.

When Half Is at Least 50%: Effect of “Framing” and Probability Level on Frequency Estimates

ABSTRACTExpert judgment often involves estimating magnitudes, such as the frequency of deaths due to a pandemic. Three experiments (Ns = 902, 431, and 755, respectively) were conducted to examine the effect of outcome framing (e.g., half of a threatened group expected to survive vs. die), probability level (low vs. high), and probability format (verbal, numeric, or combined) on the estimated frequency of survivals/deaths. Each experiment found an interactive effect of frame and probability level, which supported the hypothesis that forecasted outcomes received by participants were implicitly quantified as lower bounds (i.e., “at least half”). Responding in a manner consistent with a lower‐bound “at least” interpretation was unrelated to incoherence (Experiments 1 and 2) and positively related to numeracy (Experiments 1 and 3), verbal reasoning (Experiment 3), and actively open‐minded thinking (Experiments 2 and 3). The correlational results indicate that implicit lower bounding is an aspect of linguistic inference and not a cognitive error. Implications for research on framing effects are discussed.

Association of Metabolic Syndrome With Neuroimaging and Cognitive Outcomes in the UK Biobank.

Metabolic syndrome (MetS) has been linked to dementia. In this study, we examined the association of MetS with neuroimaging and cognition in dementia-free adults, offering insight into the impact of MetS on brain health prior to dementia onset. We included 37,395 dementia-free adults from the UK Biobank database. MetS was defined as having at least three of the following components: larger waist circumference; elevated levels of triglycerides, blood pressure, HbA1c; or reduced HDL cholesterol levels. Multivariable-adjusted linear regression was used to assess associations of MetS with structural neuroimaging and cognitive domains. MetS was associated with lower total brain (standardized β: -0.06; 95% CI -0.08, -0.04), gray matter (β: -0.10; 95% CI -0.12, -0.08) and hippocampal (for left side, β: -0.03, 95% CI -0.05, -0.01; for right side, β: -0.04, 95% CI -0.07, -0.02) volumes, and greater white matter hyperintensity (WMH) volume (β: 0.08; 95% CI 0.06, 0.11). Study participants with MetS performed poorer on cognitive tests of working memory (β: -0.10; 95% CI -0.13, -0.07), verbal declarative memory (β: -0.08; 95% CI -0.11, -0.05), processing speed (β: -0.06; 95% CI -0.09, -0.04), verbal and numerical reasoning (β: -0.07; 95% CI -0.09, -0.04), nonverbal reasoning (β: -0.03; 95% CI -0.05, -0.01), and on tests of executive function, where higher scores indicated poorer performance (β: 0.05; 95% CI 0.03, 0.08). More MetS components were also associated with less brain volume, greater WMH, and poorer cognition across all domains. MetS was associated poorer brain health in dementia-free adults, characterized by less brain volume, greater vascular pathology, and poorer cognition. Further research is necessary to understand whether reversal or improvement of MetS can improve brain health.

QOL-30. NEUROPSYCHOLOGICAL FUNCTIONING AFTER WHOLE VENTRICULAR OR CRANIOSPINAL PROTON RADIATION FOR PEDIATRIC INTRACRANIAL GERM CELL TUMORS

Abstract BACKGROUND In Western countries, intracranial germ cell tumors (ICGT) represent 3-5% of central nervous system tumors, with peak incidence in the second decade of life. Compared to those receiving photon radiation therapy, pediatric patients receiving proton radiation therapy demonstrate stronger neurocognitive outcomes, particularly in verbal and visual reasoning. Ongoing treatment advances aim to reduce morbidity, such as neurocognitive late effects. This study characterizes memory functioning for patients with intracranial germinoma treated with either whole ventricular (WV) or craniospinal (CSI) proton radiation therapy. METHODS 29 patients received proton radiation therapy (17 WV, 12 CSI) for an ICGT (20 germinoma, 8 NGGCT, 1 mixed GCT; 3 disseminated at diagnosis). Age at diagnosis was 5-21 years (M=14.14; SD=3.91) with age at neuropsychological evaluation 8-25 years (M=17.66, SD=4.11). Evaluations occurred 0.71-7.85 years after diagnosis (M=3.52; SD=2.02). Patients (82.8% male, 65.5% white, 44.8% Very High Childhood Opportunity Index [COI]) had multiple additional interventions (surgeries, chemotherapy) prior to neuropsychological evaluation. RESULTS Patients in the WV group did not differ from patients in the CSI group on sex, COI, race, or ethnicity. Mean performance was stronger in the WV group than the CSI group for Full Scale IQ (FSIQ; t(27)=2.50, p=.019, Cohen’s d =0.94), Verbal Reasoning (VCI; t(24)=2.52, p=.019, d=1.0), Visual Memory (WRAML-2 Picture Memory Recognition; t(14)=2.51, p=.025, d=1.26), and Verbal Memory [(WRAML-2 Story Memory Delay, t(15.32)=2.82, p=.013, d=1.25); (WRAML-2 Story Memory Recognition, t(20)=2.34, p=.03, d=1.0)], all with large effect sizes. CONCLUSIONS Within this small ICGT sample with various medical treatments and comorbidities, demographic factors did not differ between groups, and WV proton radiation therapy appears to have less negative impact on aspects of reasoning and memory abilities compared to CSI proton radiation therapy.