The COVID-19 pandemic has become an integral part of medical life. At different levels of medical care, doctors of all specialties, to one degree or another, are faced with this disease. Distinctive feature of the infection is the need for respiratory support of varying severity. Objective: A retrospective analysis and comparison of pO2 and pCO2 values as well as the PaO2/FiO2 (P/F) ratio were carried out in 20 patients with a new coronavirus infection on mechanical ventilation before and after tracheostomy on the 3rd day from the moment of orotracheal intubation from July 2021 to January 2022 at the Vidnovskaya Regional Clinical Hospital, which was redesigned to provide medical care to patients with a new coronavirus infection. Results. The assessment was carried out before and after the imposition of a tracheostomy on the 3rd day from the moment of orotracheal intubation. It was found that tracheostomy performed on the 3rd day after intubation had a dynamically significant effect on the decrease in the partial pressure of carbon dioxide in patients with COVID-19 infection and also caused an increase in the P/F ratio. At the same time, there were no differences in the dynamics of pO2 of venous blood. Considering the data, a possible shift in the timing of tracheostomy in patients with coronavirus infection on mechanical ventilation for 1 day from orotracheal intubation becomes relevant. This hypothesis requires further research.