The paper presents data on the study of the thermoprotective properties of the venom of the Transcaucasian Vipeta (Macrovipera lebetina obtuse) on 120 white mongrel mice subjected to thermal exposure (30 - 50°C) for 30 minutes with the injection of zootoxin in doses (2 mg / kg and 4 mg / kg). It was found that the lifespan of mice was increased with respect to a series of experiments in which the injection of venoms under the conditions of normothermia was used for 28 - 30 minutes and 15 - 20 minutes to 120.0 ± 8.5 and 160.0 ± 19.7 minutes, respectively. It was found that in the posthyperthermic period after a 30-minute thermal exposure (30 - 50°C) in the control group of animal experiments, a 100% mortality was observed during 24 hours, and with the preliminary injection of a venom in the range of doses 2 - 4 mg / kg Survival in 30% - 50% of experimental animals was noted. Thus, the thermoprotective property of the venom of the Transcaucasian vipera has been proved.