Production and inventory routing problems consider a single-product supply chain operating under a vendor-managed inventory system. A plant creates a production plan and vehicle routes over a planning horizon to replenish its customers at minimum cost. In this paper, we present two- and three-index formulations, implement a branch-and-cut algorithm based on each formulation, and introduce a local search matheuristic-based algorithm to solve the problem. In order to combine all benefits of each algorithm, we design a parallel framework to integrate all three fronts, called the three-front parallel branch-and-cut algorithm (3FP-B&C). We assess the performance of our method on well-known benchmark instances of the inventory routing problem (IRP) and the production routing problem (PRP). The results show that our 3FP-B&C outperforms by far other approaches from the literature. For the 956 feasible small-size IRP instances, our method proves optimality for 746, being the first exact algorithm to solve all instances with up to two vehicles. 3FP-B&C finds 949 best known solutions (BKS) with 153 new BKS (NBKS). For the large-size set, our method provides two new optimal solutions (OPT), and finds 82% of BKS, being 70% of NBKS for instances with up to five vehicles. This result is more than twice the number of BKS considering all heuristic methods from the literature combined. Finally, our 3FP-B&C finds the best lower bounds (BLB) for 1,169/1,316 instances, outperforming all previous exact algorithms. On the PRP, our method obtained 278 OPT out of the 336 instances of benchmark set of small- and medium-size instances being 19 new ones in addition to 335 BKS (74 NBKS) and 313 BLB (52 new ones). On another set of PRP with medium- and large-size instances, our algorithm finds 1,105 BKS out of 1,440 instances with 584 NBKS. Besides that, our 3FP-B&C is the first exact algorithm to solve the instances with an unlimited fleet, providing the first lower bounds for this subset with an average optimality gap of 0.61%. We also address a very large-size instance set, the second exact algorithm to address this set, outperforming the previous approach by far. Finally, a comparative analysis of each front shows the gains of the integrated approach. History: This paper has been accepted for the Transportation Science Special Issue: DIMACS Implementation Challenge: Vehicle Routing. Funding: C. M. Schenekemberg was supported by the São Paulo Research Foundation (FAPESP) [Grant 2020/07145-8]. A. A. Chaves was supported by FAPESP [Grants 2018/15417-8 and 2016/01860-1] and Conselho Nacional de Desenvolvimento Científico e Tecnológico [Grants 312747/2021-7 and 405702/2021-3]. L. C. Coelho was supported by the Canadian Natural Sciences and Engineering Research Council [Grant 2019-00094]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/trsc.2022.0261 .
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