With its advantages of low engineering cost, minimal space occupancy, and aesthetically pleasing shape, the single-column pier bridge is frequently utilized in urban viaducts and interchange ramps. Due to structural peculiarities, the bridge subjected to eccentric loading, flexural and torsional interaction, and centrifugal force may undergo tipping accidents. To better comprehend the overturning resistance of the bridge, the vibration governing equation of the bridge (idealized as an orthotropic thin plate with point supports in the domain model) is established considering vehicle–bridge interaction. An approximate dynamic analysis formula is subsequently derived via a hybrid method using the grey wolf optimizer. Compared with the outcomes of finite element analysis, the maximal deviation arising from this derived analytical formula is approximately [Formula: see text]% with the greater discrepancy being observed in scenarios featuring minimal support reactions. Compared with the finite element method, the proposed method in this study has higher computational efficiency with precision. This analytical solution is then utilized in the parametric study to scrutinize the influences of span, road surface roughness, and vehicle velocity on a single-column pier bridge under four vehicles. The analysis findings indicate that the proposed approach is reasonably precise, remarkably efficient, and efficacious.
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