Due to the impact of global warming, drought has caused serious damage to China’s ecological environment and social status. This article selects Laibin City in the Guangxi Zhuang Autonomous Region as the research area, utilizing multispectral remote sensing data as the data source and Landsat series image data for relevant preprocessing. It calculates the monthly normalized vegetation index (NDVI) and surface temperature (LST) data for Laibin City. Based on the ecological environment and surface coverage conditions of the research area, the ratio vegetation index (RVI), normalized vegetation moisture index (NDWI), temperature vegetation drought index (TVDI), and conditional vegetation temperature drought index (VTCI) were selected to calculate and invert the drought monitoring results of Laibin City. The drought monitoring results were obtained and overlaid with the vegetation area map to generate the vegetation drought monitoring results of Laibin City. Based on the climate, geography, and ecological characteristics of the monitored area in Laibin City, a specific analysis will be conducted to develop an appropriate TVDI index drought level, and generate vegetation drought level result maps for Laibin City in 2021, 2022, and 2023. Then, a detailed analysis of the vegetation drought situation in Laibin City is conducted according to time and space. Among them, in the past three years, the vegetation areas in Laibin City have experienced drought seasons mostly in summer and autumn. The interannual drought is mainly mild drought, and the proportion of areas with mild drought shows a relatively stable trend. In conclusion, TVDI proves to be a valuable tool for monitoring vegetation drought in Laibin City, offering insights for efficient water resource management strategies.