The process parameters of in-vessel rotary drum composting (RDC) with vermicomposting (VC) were investigated for the conversion of vegetable waste into vermicompost. After 7-day initial thermophilic exposure (maximal 51.5 °C in 24 h), the partially degraded RDC waste was divided into R1 (no vermiculture), R2, R3, and R4 (with Eudrilus eugeniae; Eisenia fetida; and Perionyx excavates monocultures, respectively). R3 derived vermicompost displayed maximum optimal process parameters and desirable compost qualities. Against the constant 2.2% nitrogen content of R1, an increase from 1.4 to 4.15% was seen in R3, with a 52.5% reduction in total organic carbon (TOC). A clear testimony to the enhanced nutritional content and fitness of the novel combination of RDC thermophilic biodegradation and E. fetida based vermicomposting. In an environmentally compatible mode, the faster organic deconstruction in 27 days could substantially alter organic waste treatment in the immediate future.