In this article, a novel generalized model of the nonlinear fractional integro-reaction-diffusion equation (NFIRDE) with spatiotemporal variable-order (SVO) is introduced, where the variable order derivatives are equipped with the Atangana–Baleanu–Caputo (ABC) sense. This model represents a great generalization of a significant type of NFIRDE and their applications. Moreover, A novel, efficient and fully spectral shifted Legendre tau technique is developed to solve the proposed model. Despite the difficulty of applying this mechanism to solve this type of equations, due to the presence of nonlinear terms and the SVO functions that appear in the traditional differential and integral operational matrices. We deduce some new operational matrices that play the fundamental role in facilitating the implementation of the tau method. These operational matrices represent the SVO ABC-derivative, the integro term within the model, as well as the vector multiplications with the space-time Kronecker product. As a result, the proposed model is restructured into a system of nonlinear algebraic equations, which simplifying the solving process. We illustrate our method’s effectiveness and validity with numerical examples with both smooth and non-smooth solutions. Our findings show that the proposed tau method delivers accurate results and exhibits non-local properties.
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