Various types of concrete are widely used for the manufacture of bridge structures. Alkali-activated binders are now often offered in place of cement and other binders. They are formed as a result of the reaction of an aluminosilicate material with an alkaline agent such as sodium hydroxide. Currently, more attention is being paid to research on the stability of materials under the influence of biologically active media. The article describes in detail the method of testing materials for fungal resistance and fungicidal properties. This paper presents the results of studies of the biological resistance of the compositions of binders and cellular composites based on glass in comparison with traditional materials of inorganic and organic nature. In addition to the control additive-free compositions of cellular stellated composite, compositions modified with biocidal additives such as «Teflex» and «Biocic-T» were considered, and studies were conducted to study the effect of the aging process of a glass-alkali binder and traditional materials on their biological resistance. It was found that the introduction of biocidal additives did not affect the biological stability of the material and only in some cases led to an increase in the radius of the inhibition zone. The results obtained during the experiment indicate that the maximum decrease in the biological resistance of materials occurs after exposure to an aqueous solution of sulfuric acid. A comparison of the results of an experiment to study the biostability of binders based on glass waste with similar indicators of composites based on Portland cement, epoxy resins shows the consistency of using the developed binder in the manufacture of products operated under the influence of biologically active media.