Spray–wall interactions (SWI) directly affect fuel–air mixture and emissions formation. Therefore, they are considered among the most critical physical processes in engine research nowadays. However, the physics of the wall film formation, propagation, and breakup is not fully understood yet. This work aims to use a thermoregulated steel wall to study the spray–wall interaction phenomenon and its influence on the macroscopic spray behavior. A single-hole injector known as “Spray D” in the Engine Combustion Network was used. n-Dodecane was employed as fuel and the wall has been positioned in four different configurations, varying angle and distance respect to the injector tip. For this work, not only diesel combustion is reproduced in the test rig due to ambient gas engine-like thermodynamic conditions, but wall temperature has been controlled to emulate characteristic values that could be found in the piston of an internal combustion engine. This implies that the spray–wall heat transfer is simulated and its effects on ignition and spray development can be analyzed. Heat flux was measured by employing high-speed thermocouples fitted in the wall and by the use of an one-dimensional transient wall heat model. Three high speed cameras were simultaneously used to observe the SWI, one for the Schlieren optical technique which allows to study the vapor phase of the spray and to determine the ignition delay, another one to observe the natural luminosity of the flame, and finally, an intensified camera was used to determine the lift-off length by observing the chemiluminescence of the OH*. An interesting finding obtained in this work was a boundary layer formation due to the thermal diffusion that contributes to cool down the spray and to delay the high-temperature chemical reactions. Results show a substantial increment of the heat flux and the wall temperature variation with both ambient temperature and density by increasing the flame temperature and gas entrainment. The exposure to the cold wall affects the ignition delay variation with the injection pressure and the wall distance. It was found that the wall temperature (in the range of tested conditions) did not affect the lift-off length location. • The exposure to the cold wall delayed the ignition. • Flame thickness around the wall undergoes a narrowing at lower wall temperatures. • The injection pressure increments the convective coefficient. • A boundary layer due to thermal diffusion was formed on the wall.