Variant Versions Research Articles

Tri-channel visualised malicious code classification based on improved ResNet

As malicious code attacks continue to evolve, attackers leverage techniques like packing and code obfuscation to generate numerous variants, challenging traditional detection methods. Addressing the limitations of current deep learning-based malicious code classification approaches in feature extraction and accuracy, this paper introduces an innovative RGB visualization detection method based on a hybrid multi-head attention mechanism. Initially, a feature representation method utilizing RGB images is introduced. This approach focuses on semantic relationships between a malware’s binary information, assembly details, and API data, generating images with richer textural information. This technique effectively uncovers the deep dependencies between the original and variant versions of malicious code, providing stronger support for subsequent classification tasks. Furthermore, to tackle the issues of malware encryption and obfuscation, a deep neural network framework is adopted, incorporating a modular design philosophy and integrating a multi-head attention mechanism. This design not only enhances the expressiveness of critical features but also helps the model better focus on key aspects of the malicious code, thereby improving classification accuracy. Through comparative experiments and in-depth analysis, the effectiveness and superiority of the proposed RGB visualization method and MSA-ResNet model in the field of malicious code variant classification are validated. The accuracy rates achieved on the Kaggle and DataCon datasets are 99.49% and 97.70%, respectively, representing significant improvements over other methods. This approach demonstrates strong generalization capabilities and resistance to obfuscation, offering a new and effective tool for malicious code detection.Graphical

Исследование физико-химических превращений и структуры наномодифицированных эпоксидных связующих

The article presents the results of studies of epoxy binders and a comparative analysis of variant versions of basic formulations of synthetic resins and formulations modified with colloidal silicon dioxide and ultrafine zinc. The studies were carried out by instrumental methods using optical microscopy and differential scanning calorimetry, while the distribution of modifier nanoparticles in the volume of polymer matrices and their effect on the formation of the structure of cured binders were studied.

Reliability generalization meta-analysis of orthorexia nervosa using the ORTO-11/12/15/R scale in all populations and language versions

BackgroundThe ORTO scale was developed in 2004 as a self-report questionnaire to assess symptoms of orthorexia nervosa (ON). ON is an unhealthy preoccupation with eating healthy food. The scale aims to measure obsessive attitudes and behaviors related to the selection, purchase, preparation, and consumption of pure, healthy food. Since its development, the ORTO-15 has been adapted into several shorter versions. The objective was to conduct a reliability generalization meta-analysis of the ORTO scale and its variant versions in all populations and languages.MethodsA systematic literature search was conducted to identify studies reporting the internal consistency of ORTO. Random-effect models were used to evaluate summary statistics of reliability coefficients, weighting the coefficients by the inverse variance using the restricted maximum likelihood method. The heterogeneity among the reliability coefficients was evaluated and assessed using numerous statistical metrics. The tau (τ), tau2 (τ2), I2, H2, R2, df, and the Q-statistic are among those obtained. Meta-regression analyses were used to examine moderators such as age and sex.ResultsTwenty-one studies (k = 21) involving 11,167 participants (n = 11,167) were analyzed. The overall effect estimate on internal consistency was 0.59 (95% CI 0.49–0.68), with a minimum reliability coefficient of 0.23 and a maximum reliability coefficient of 0.83. The heterogeneity statistics were found to have an I2 of 99.31%, which suggested high heterogeneity owing to a decrease in the confidence interval (95% CI) and an increase in variability. Sensitivity analysis revealed that a few studies strongly influenced the overall estimate. Egger’s test suggested possible publication bias. Neither age nor sex significantly moderated reliability via meta-regression.ConclusionsThe ORTO scale has a relatively low pooled reliability coefficient. Alternative ON assessment tools with enhanced psychometric properties are needed. Clinicians should not base diagnoses or treatment decisions on ORTO alone. Comprehensive psychiatric assessment is essential for accurate ON evaluation.

Comparing the Extraction Performance in Mouse Plasma of Different Biphasic Methods for Polar and Nonpolar Compounds.

Many metabolomic studies are interested in both polar and nonpolar analyses. However, the available sample volume often precludes multiple separate extractions. Therefore, there are major advantages in performing a biphasic extraction and retaining both phases for subsequent separate analyses. To be successful, such approaches require the method to be robust and repeatable for both phases. Hence, we determined the performance of three extraction protocols, plus two variant versions, using 25 μL of commercially available mouse plasma. The preferred option for nonpolar lipids was a modified diluted version of a method employing methyl tert-butyl ether (MTBE) suggested by Matyash and colleagues due to its high repeatability for nonpolar compounds. For polar compounds, the Bligh-Dyer method performs best for sensitivity but with consequentially poorer lipid performance. Overall, the scaled-down version of the MTBE method gave the best overall performance, with high sensitivity for both polar and nonpolar compounds and good repeatability for polar compounds in particular.

A mechanism for hereditary angioedema caused by a methionine-379–to–lysine substitution in kininogens

AbstractHereditary angioedema (HAE) is associated with episodic kinin-induced swelling of the skin and mucosal membranes. Most patients with HAE have low plasma C1-inhibitor activity, leading to increased generation of the protease plasma kallikrein (PKa) and excessive release of the nanopeptide bradykinin from high-molecular-weight kininogen (HK). However, disease-causing mutations in at least 10% of patients with HAE appear to involve genes for proteins other than C1-inhibitor. A point mutation in the Kng1 gene encoding HK and low–molecular weight kininogen (LK) was identified recently in a family with HAE. The mutation changes a methionine (Met379) to lysine (Lys379) in both proteins. Met379 is adjacent to the Lys380-Arg381 cleavage site at the N-terminus of the bradykinin peptide. Recombinant wild-type (Met379) and variant (Lys379) versions of HK and LK were expressed in HEK293 cells. PKa-catalyzed kinin release from HK and LK was not affected by the Lys379 substitutions. However, kinin release from HK-Lys379 and LK-Lys379 catalyzed by the fibrinolytic protease plasmin was substantially greater than from wild-type HK-Met379 and LK-Met379. Increased kinin release was evident when fibrinolysis was induced in plasma containing HK-Lys379 or LK-Lys379 compared with plasma containing wild-type HK or LK. Mass spectrometry revealed that the kinin released from wild-type and variant kininogens by PKa is bradykinin. Plasmin also released bradykinin from wild-type kininogens but cleaved HK-Lys379 and LK-Lys379 after Lys379 rather than Lys380, releasing the decapeptide Lys-bradykinin (kallidin). The Met379Lys substitutions make HK and LK better plasmin substrates, reinforcing the relationship between fibrinolysis and kinin generation.

The PERMA + 4 Short Scale: A Cross-Cultural Empirical Validation Using Item Response Theory

A substantial body of empirical research has used the positive emotions, engagement, relationships, meaning, accomplishment (PERMA) framework to measure building blocks of well-being across diverse samples and cultures, with most studies using the 23-item PERMA-Profiler (Butler & Kern, 2016) or a workplace variant. Donaldson and Donaldson (2021a) added four additional domains (physical health, mindset, environment, economic security; PERMA + 4). Psychometric development and testing of the original, translated, and variant versions of the measure have relied on Classical Test Theory approaches, such as factor analytic methods. In the workplace, valid, brief measures are critical. The current study used item response theory to analyze data from a large sample of Canadian (n = 1,003) and Australian (n = 942) employees to create a 9-item short scale of PERMA + 4. A graded response model showed good item discrimination (a > 1.40), and similar test information compared to the full measure. A short scale of PERMA + 4 will be useful for future studies of the building blocks of well-being and positive functioning, as well as for evaluating well-being programs and interventions within the workplace.

Histone variant H2B.Z acetylation is necessary for maintenance of Toxoplasma gondii biological fitness

Through regulation of DNA packaging, histone proteins are fundamental to a wide array of biological processes. A variety of post-translational modifications (PTMs), including acetylation, constitute a proposed histone code that is interpreted by “reader” proteins to modulate chromatin structure. Canonical histones can be replaced with variant versions that add an additional layer of regulatory complexity. The protozoan parasite Toxoplasma gondii is unique among eukaryotes in possessing a novel variant of H2B designated H2B.Z. The combination of PTMs and the use of histone variants are important for gene regulation in T. gondii, offering new targets for drug development. In this work, T. gondii parasites were generated in which the 5 N-terminal acetylatable lysines in H2B.Z were mutated to either alanine (c-Myc-A) or arginine (c-Myc-R). The c-Myc-A mutant displayed no phenotype over than a mild defect in its ability to kill mice. The c-Myc-R mutant presented an impaired ability to grow and an increase in differentiation to latent bradyzoites. The c-Myc-R mutant was also more sensitive to DNA damage, displayed no virulence in mice, and provided protective immunity against future infection. While nucleosome composition was unaltered, key genes were abnormally expressed during in vitro bradyzoite differentiation. Our results show that regulation of the N-terminal positive charge patch of H2B.Z is important for these processes. We also show that acetylated N-terminal H2B.Z interacts with some unique proteins compared to its unacetylated counterpart; the acetylated peptide pulled down proteins associated with chromosome maintenance/segregation and cell cycle, suggesting a link between H2B.Z acetylation status and mitosis.

High arousal as the source of food rejection in food neophobia

Food neophobia (FN) at moderate to high levels is very common among adult populations in all cultures and is usually defined in terms of rejection of unfamiliar foods. However, food rejection in FN is only partly related to food familiarity. Experimental and survey studies have suggested that unpleasantly high arousal may be induced by food novelty, but also be produced by foods with intense or complex flavours, that are perceived as dangerous or foreign, or that have unusual ingredients. Liking for foods with these characteristics have recently been shown to be strongly negatively associated with FN. Thus, induced high arousal may underlie food rejection in FN. Here, we collected familiarity, liking and arousal ratings, and scores on the standard Food Neophobia Scale from more than 7000 consumers in four countries – Australia, United Kingdom, Singapore, Malaysia – for a series of food names that were manipulated to produce standard and ‘high arousal’ (variant) versions of the same foods. Consistent across all four countries, arousal ratings increased, and liking decreased, with decreases in food familiarity. Variant food names were always associated with ratings of higher arousal than the standard names. The variant foods were generally less familiar than the standard foods, although this was not a necessary condition for their higher arousal ratings, suggesting that the other arousal-inducing factors (e.g., flavour intensity) also played a role. Across all foods, arousal ratings increased, and liking ratings decreased, as FN increased, but these effects were accentuated for the variant foods. The consistency of these effects across multiple countries supports a view that arousal is universally a strong determinant of liking for foods and that this underlies the rejection of foods, familiar and novel, in FN.

The Graham-Hoffman-Hosoya-type theorems for the exponential distance matrix

Let $G$ be a strongly connected digraph with vertex set $\{v_1, v_2, \dots, v_n\}$. Denote by $D_{ij}$ the distance between vertices $v_i$ and $v_j$ in $G$. Two variant versions of the distance matrix were proposed by Yan and Yeh (Adv. Appl. Math.), and Bapat et al. (Linear Algebra Appl.) independently, one is the $q$-distance matrix, and the other is the exponential distance matrix. Given a nonzero indeterminate $q$, the $q$-distance matrix $\mathscr{D}_G=(\mathscr{D}_{ij})_{n\times n}$ of $G$ is defined as\[\mathscr{D}_{ij}=\left\{\begin{array}{cl}1+q+\dots+q^{D_{ij}-1}&\text{if $i\ne j$},\\0&\text{otherwise}.\end{array}\right.\]In particular, when $q = 1$, it would be reduced to the distance matrix of $G$. The exponential distance matrix $\mathscr{F}_G=(\mathscr{F}_{ij})_{n\times n}$ of $G$ is defined as\[\mathscr{F}_{ij}= q^{D_{ij}}.\] In $1977$, Graham et al. (J. Graph Theory) established a classical formula connecting the determinants and cofactor sums of the distance matrices of strongly connected digraphs in terms of their blocks, which plays a powerful role in the subsequent researches on the determinants of distance matrices. Sivasubramanian (Electron. J. Combin.) and Li et al. (Discuss. Math. Graph Theory) independently extended it from the distance matrix to the $q$-distance matrix. In this note, three formulae of such types for the exponential distance matrices of strongly connected digraphs will be presented.

Several improved asymptotic normality criteria and their applications to graph polynomials

As widely regarded, one of the most classical and remarkable tools to measure the asymptotic normality of combinatorial statistics is due to Harper's real-rooted method proposed in 1967. However, this classical theorem exists some obvious shortcomings, for example, it requests all the roots of the corresponding generating function, which is impossible in general.Aiming to overcome this shortcoming in some extent, in this paper we present an improved asymptotic normality criterion, along with several variant versions, which usually just ask for one coefficient of the generating function, without knowing any roots. In virtue of these new criteria, the asymptotic normality of some usual combinatorial statistics can be revealed and extended. Among which, we introduce the applications to matching numbers and Laplacian coefficients in detail. Some relevant conjectures, proposed by Godsil (Combinatorica, 1981) and Wang et al. (J. Math. Anal. Appl., 2017), are generalized and verified as corollaries.

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The key feature of human consciousness is our ability to access and practice svyaznost’ (coherence, connectivity) grounded in tselostnost’ (wholeness). This ability is common to humans and animals in one of its aspects (comprehending the world as an order of things), though animals do not share its other core mani­festations (coherent speech and thought as a practice of svyaznost’). The com­monplace understanding of language as a sign system falls short of grasping the development of svyaznost’ and therefore needs to be reconsidered. Though universal for humans in its unfolded state, svyaznost’ ability may be practiced only in one the few variant versions and never as an invariant universal. Any of its variant versions lays down the foundations of one of the big cultures which are re­flected upon in its philosophical tradition. Plato’s and Aristotle’s teachings mark major milestones of elaborating the substance version of svyaznost’. The founda­tions of Arab-Islamic big culture, its autochthonic philosophy included, were laid down by elaboration of the process version of svyaznost’. Tkachenko paradox (any big culture cannot be described and analyzed using the theoretical means of a different big culture) and Jullien paradox (foundations of any philosophical tra­dition cannot be grounded and justified by the means of that tradition) are ana­lyzed. Only the logic of sense is capable of finding the way around both para­doxes by elaborating on svyaznost’ and tselostnost’ through their variant versions to escape the limits of the initial circle of logical laws and basic categories that form the basis of any philosophic tradition in this or that big culture.

Revisiting Wansbrough’s Perspective on the Qurʾān’s Synoptic Problem

Abstract The occurrence of variant versions of the same story is not uncommon in the Qurʾān. In response to this phenomenon, different approaches have been developed; one of which was Wansbrough’s variant traditions hypothesis. The hypothesis, which emerged mainly from an analysis of three accounts of the prophet Shuʿayb’s story in the Qurʾān, posits that the different tellings of the same story existed as independent pericopes that later found their way into the text of the Qurʾān, a claim that has many implications on the authorship and composition of the Qurʾān. Consequently, the reactions to this hypothesis were varied. In this paper, I present one of the critiques to the hypothesis, that of Stewart. Then, I employ elements of textual criticism to provide further ways for viewing the variant traditions. I do this by drawing attention to empirical evidence from the Near East, pre-Islamic poetry, orality theory, and to some of the internal characteristics of the Qurʾān. The general conclusion is neither surprising nor new: Wansbrough’s findings regarding the genealogy of the variant traditions and the authorship of the Qurʾān are far from self-evident.

Revisiting the amalgaviral landscapes in plant transcriptomes expands the host range of plant amalgaviruses

Plant amalgaviruses are monopartite, double-stranded RNA viruses, capable of vertical transmission through seeds. An attempt to revisit plant transcriptome-assembled contigs for amalgaviral sequences identified 40 putative novel amalgaviruses in 35 plant species, nearly doubling the number of plant amalgaviruses. Of the 35 plant species, 33 are reported to host amalgaviruses for the first time, including a pteridophytic and two gymnospermic species. Coding-complete genomes of all identified viruses were recovered and the putative +1 programmed ribosomal frameshift (PRF) sites were determined. Genomes of 35 identified amalgaviruses contained the conserved +1 PRF motif ‘UUU_CGN’, while variant versions were predicted in five genomes. Phylogenetic analysis grouped pteridophyte- and gymnosperm-infecting amalgaviruses together in divergent sub-clades while few of the related angiosperm-infecting amalgaviruses infect members of the same plant family, reiterating the co-evolution of plant amalgaviruses and their hosts. The current study paves way for further studies on understanding biological properties of identified viruses.

Gendhing Sekaten. (2010) 2020Gendhing Pahargyan. (2012) 2020Gendhing Kurmat Dalem. 2020Gendhing Gati. (2015) 2020Gendhing Gati Volume 2. 2020Gendhing Soran Volume 1. 2021

Gendhing Sekaten. (2010) 2020Gendhing Pahargyan. (2012) 2020Gendhing Kurmat Dalem. 2020Gendhing Gati. (2015) 2020Gendhing Gati Volume 2. 2020Gendhing Soran Volume 1. 2021

Sarah Cowper's "Character" of John Locke

Lady Sarah Cowper (1644-1720) is best known for her commonplace books, which preserve unique and variant versions of poems by Restoration “wits.” She also kept a diary, in which she recorded her readings and meditations. The diary contains an unnoticed encomiastic “Character” of John Locke, composed at his death. It is one of the earliest obituaries of him, but it was commonplaced from other sources. Her use of her sources exemplifies aspects of the manuscript circulation of texts and the ways in which the active selection and redaction of textual material reflected a reader’s own religious, political, and personal preoccupations. Cowper portrays Locke as a moral exemplar and Christian virtuoso, whose orthodoxy she defends, and whose latitudinarian and Whig commitments she shares.

Christian Sources in al-Maqrīzī’s Kitāb al-Ḫiṭaṭ and al-Ḫabar ʿan al-bašar

Abstract It is widely known that al-Maqrīzī relied extensively on the work by the Coptic author Ibn al-ʿAmīd for the chapter on the Copts included in his Kitāb al-Ḫiṭaṭ. Some scholars have assessed that the text known as Kitāb Hurūšiyūš, which was compiled by a Christian from al-Andalus, was also a major source for large fragments of al-Maqrīzī’s al-Ḫiṭaṭ. More recently, it has been argued that al-Maqrīzī also relied on those two Christian sources for his last major work, al-Ḫabar ʿan al-bašar. In this article, I intend to offer a more comprehensive survey of the use of both sources by al-Maqrīzī. By providing a good many examples, I aim to demonstrate that al-Maqrīzī built on them entire sections or long passages of his books, but also turned to them frequently to add in short reports, variant versions, a date, a nasab, or any information he considered relevant to his work.

The Cambridge Edition of the Works of Anne Finch, Countess of Winchilsea, Volume 1: Early Manuscript Books. Ed. Jennifer Keith, with Claudia Thomas Kairoff.

<i>The Cambridge Edition of the Works of Anne Finch, Countess of Winchilsea, Volume 1: Early Manuscript Books</i>. Ed. Jennifer Keith, with Claudia Thomas Kairoff.

Clinical and molecular relevance of genetic variants in the non-coding transcriptome of patients with cytogenetically normal acute myeloid leukemia

Expression levels of long non-coding RNA (lncRNA) have been shown to associate with clinical outcome of patients with cytogenetically normal acute myeloid leukemia (CN-AML). However, the frequency and clinical significance of genetic variants in the nucleotide sequences of lncRNA in AML patients is unknown. Herein, we analyzed total RNA sequencing data of 377 younger adults (aged <60 years) with CN-AML, who were comprehensively characterized with regard to clinical outcome. We used available genomic databases and stringent filters to annotate genetic variants unequivocally located in the non-coding transcriptome of AML patients. We detected 981 variants, which are recurrently present in lncRNA that are expressed in leukemic blasts. Among these variants, we identified a cytosine-to-thymidine variant in the lncRNA RP5-1074L1.4 and a cytosine-to-thymidine variant in the lncRNA SNHG15, which independently associated with longer survival of CN-AML patients. The presence of the SNHG15 cytosine-to-thymidine variant was also found to associate with better outcome in an independent dataset of CN-AML patients, despite differences in treatment protocols and RNA sequencing techniques. In order to gain biological insights, we cloned and overexpressed both wild-type and variant versions of the SNHG15 lncRNA. In keeping with its negative prognostic impact, overexpression of the wild-type SNHG15 associated with higher proliferation rate of leukemic blasts when compared with the cytosine-to-thymidine variant. We conclude that recurrent genetic variants of lncRNA that are expressed in the leukemic blasts of CN-AML patients have prognostic and potential biological significance.

Clinical and molecular relevance of genetic variants in the non-coding transcriptome of patients with cytogenetically normal acute myeloid leukemia.

Expression levels of long non-coding RNA (lncRNA) have been shown to associate with clinical outcome of patients with cytogenetically normal acute myeloid leukemia (CN-AML). However, the frequency and clinical significance of genetic variants in the nucleotide sequences of lncRNA in AML patients is unknown. Herein, we analyzed total RNA sequencing data of 377 younger adults (aged <60 years) with CN-AML, who were comprehensively characterized with regard to clinical outcome. We used available genomic databases and stringent filters to annotate genetic variants unequivocally located in the non-coding transcriptome of AML patients. We detected 981 variants, which are recurrently present in lncRNA that are expressed in leukemic blasts. Among these variants, we identified a cytosine-to-thymidine variant in the lncRNA RP5-1074L1.4 and a cytosine-to-thymidine variant in the lncRNA SNHG15, which independently associated with longer survival of CN-AML patients. The presence of the SNHG15 cytosine-to-thymidine variant was also found to associate with better outcome in an independent dataset of CN-AML patients, despite differences in treatment protocols and RNA sequencing techniques. In order to gain biological insights, we cloned and overexpressed both wild-type and variant versions of the SNHG15 lncRNA. In keeping with its negative prognostic impact, overexpression of the wild-type SNHG15 associated with higher proliferation rate of leukemic blasts when compared with the cytosine-to-thymidine variant. We conclude that recurrent genetic variants of lncRNA that are expressed in the leukemic blasts of CN-AML patients have prognostic and potential biological significance.

A Local-Global Influence Indicator Based Constrained Evolutionary Algorithm for Budgeted Influence Maximization in Social Networks

Given a fixed total budget and a predefined cost model, the budgeted influence maximization problem aims to find a subset of nodes to maximize the influence spread in social networks while its cost should be no more than the fixed total budget. In this paper, we propose a local-global influence indicator based constrained evolutionary algorithm, named IICEA, to solve the budgeted influence maximization problem effectively and efficiently. In IICEA, a novel influence indicator is firstly designed by considering two components: local neighbor information and global community information, which can be used to better measure the influence of nodes in social networks. Based on the proposed local-global influence indicator, we propose a constrained evolutionary framework by designing several novel strategies such as mutation strategy, crossover strategy and repairment strategy to promote the evolution of population. Experimental results on 10 real-world social networks demonstrate the effectiveness of the proposed local-global influence indicator and also verify the effectiveness and efficiency of the proposed algorithm IICEA in comparison with several variant versions of IICEA and several representative baseline algorithms.