Variance In Uptake Research Articles

Consistency and efficacy of two methods of intranasal oxytocin application in dogs

Over the last few years, oxytocin (OT) administration to investigate the role of the oxytocinergic system in the social behavior of dogs has become of more and more interest. To date, the most common OT administration method for dogs is the intranasal spray commonly used for humans. Due to the different nasal conformation of dogs and the unpleasantness of the procedure, most dogs need to be restrained to allow administration. This has 2 main drawbacks—it may hinder reliable administration, which might lead to tremendous variance in the uptake of OT across individuals and it is likely to be stressful for the dogs. Alternatively, a vaporizer mask can be used to administer aerolized OT and dogs can be trained to voluntarily enter the mask, which might enable a more reliable administration without having to restrain the dogs. The aim of this study was to compare the efficacy of these 2 methods to identify a reliable non-invasive method for exogenous OT administration, thereby assisting future research on the role of OT in canines. We administered OT to pet dogs using either an intranasal spray bottle or a vaporizer mask and assessed urinary OT concentrations as a measure of OT uptake. We found that only when administered using a vaporizer mask, OT significantly increased in all subjects, while using a spray bottle led to considerable variance in OT uptake and an inconsistent increase in urinary OT concentrations across individuals. These results suggest that using a vaporizer mask should be preferred over using an intranasal spray bottle for OT administration in dogs. If not available, experimenters should at least monitor OT uptake after administration using spray bottles, to evaluate the success of the method.

Cancer worry frequency vs. intensity and self-reported colorectal cancer screening uptake: A population-based study.

ObjectivesMany studies of cancer worry use items measuring frequency or intensity. Little is known about how each of these relate to cancer screening uptake. This study compared the association between worry frequency vs. intensity and colorectal cancer screening intention/uptake.MethodsAcross four surveys (2014–2016), we collected data from 2878 screening-eligible men and women (aged 60–70) in England. Measures included single-items assessing cancer worry frequency and intensity, and a derived combination of both. We also assessed self-reported past faecal occult blood testing uptake (ever vs. never), intention to participate when next invited (yes vs. no), and demographics. Using logistic regression, we compared a model containing sociodemographic characteristics (Model 1), with four models adding cancer worry frequency (Model 2), intensity (Model 3), both (Model 4), or the combined measure (Model 5).ResultsA model with cancer worry intensity and demographics (Model 3) explained significantly more variance in uptake and intention (R2 = 0.068 and 0.062, respectively) than demographics alone (Model 1: R2 = 0.058 and 0.042; p < 0.001), or a model with demographics and cancer worry frequency (Model 2: R2 = 0.059 and 0.052; p < 0.001). The model was also equally as effective as models including both the frequency and intensity items (Model 4: R2 = 0.070 n.s. and 0.062 n.s.), or using the derived combination of both (Model 5: R2 = 0.063 n.s. and 0.053 n.s.).ConclusionA single item measure of cancer worry intensity appeared to be most parsimonious for explaining variance in colorectal cancer screening intention and uptake.

Parents’ uptake of human papillomavirus vaccines for their children: a systematic review and meta-analysis of observational studies

ObjectiveTo examine factors associated with parents’ uptake of human papillomavirus (HPV) vaccines for their children.DesignSystematic review and meta-analysis.Data sourcesCochrane Library, AIDSLINE, CINAHL, EMBASE, PsycINFO, Social Sciences s, Ovid MEDLINE, Scholars...

A longitudinal study on determinants of HPV vaccination uptake in parents/guardians from different ethnic backgrounds in Amsterdam, the Netherlands

BackgroundHuman papillomavirus (HPV) vaccination coverage in the Netherlands is low (~60%) compared to other childhood vaccinations (>90%), and even lower among ethnic minorities. The aim of this study was to explore the possible impact of ethnicity on the determinants of both HPV vaccination intention and HPV vaccination uptake among parents/guardians having a daughter that is invited for the HPV vaccination.MethodsIn February 2014, parents/guardians living in Amsterdam were invited to complete a questionnaire about social-psychological determinants of their decision making process regarding the HPV vaccination of their daughter and socio-demographic characteristics. This questionnaire was sent approximately one month before the daughter was scheduled to receive her first HPV vaccine dose. Their daughters’ HPV vaccination status was retrieved from the national vaccination database. We distinguished four ethnic groups: Dutch (NL), Surinamese, Netherlands Antillean, and Aruban (SNA), Middle-Eastern and North-African (MENA), and Other. To assess the impact of determinants on both intention and uptake, linear and logistic regression analyses were used respectively. Missing data were imputed using multiple imputation by chained equation.ResultsIn total 1,309 parents/guardians participated (33% participation rate). In all groups we found the mothers’ intention to be the strongest predictor of their daughters’ HPV vaccination uptake. Explained variance of uptake was highest in the NL-group (pseudo-R2:0.56) and lower in the other ethnic groups (pseudo-R2 varied between 0.23 and 0.29). The lower explained variance can be attributed to the relative large proportion of participants with a positive intention that finally did not go for vaccination in the SNA-group (11%) and MENA-group (30%). Explained variance (R2) of intention varied between 0.66 and 0.77 across ethnic groups, and was best explained by the proximal social-psychological determinants. The strength of association of these determinants with both intention and uptake were largely similar across ethnic groups.ConclusionWe conclude that the same determinants should be targeted in the different ethnic groups, although the mode of delivery of the intervention needs to be tailored to the different cultural backgrounds. Further research is needed to explain the observed discrepancy between intention and uptake, especially among parents/guardians in the non-Dutch groups.

Level of awareness and uptake of the female condom in women aged 18 to 49 years in Bindura district, Mashonaland Central province, Zimbabwe

Zimbabwe introduced the female condom in 1997, but acceptance was slow. A study was conducted to determine its level of awareness and uptake in women aged 18 to 49 years at Bindura Provincial Hospital, and at Chipadze and Chiwaridzo council clinics. A descriptive cross-sectional study design was used. A total of 242 eligible consenting respondents were selected using simple random sampling. Data were processed using the Statistical Package for Social Sciences (SPSS) software version 16. Data revealed that 81.4% of the respondents had heard about the method. Most respondents 88 (36.4%) had heard about female condoms from nurses. However, 53.3% had not received health education on the method from healthcare providers. Knowledge of the female condom was low at 36.3% and most respondents (83.5%) had not used it. The major reasons cited for failure to use the method were unavailability (19.8%) and partner refusal (17.8%). Of the 16.5% who used the female condom only 4.1% used it consistently. Female condom uptake was very low at 16.1%. Knowledge of the method was associated with its uptake (χ2 = 86, p < 0.05). Pearson's correlation was used to examine the relationship between awareness and uptake of the method. It indicated a weak positive linear relationship (r = 0.309, p < 0.01). A regression coefficient (R2 = 0.095, p < 0.05) showed that female condom awareness accounts for 9.5% of the variance in uptake. This study revealed that women with increased level of awareness on the method are likely to use it. Therefore, healthcare providers need to strengthen health education on female condoms and make them readily available.

A comparative study of bioradiography in human brain slices and preoperative PET imaging

Novel autoradiography (bioradiography) images in human neocortical brain slices which were obtained at operation from seven patients with intractable epilepsy who had received a 2-[ 18F]fluoro-2-deoxy- d-glucose-positron emission tomography (FDG-PET) examination preoperatively, were acquired in Krebs–Ringer medium (control condition) and that with high K + (high K + condition) containing FDG and compared with FDG-PET uptake. The FDG uptake images in rat brain slices were also acquired as a reference and compared with that in humans. In the slices incubated under high K +, FDG uptake in both human and rat gray matter was significantly enhanced, whereas that in the white matter was not. But the variance of uptake was larger in humans than the rats. This might indicate the different degree of progress of epilepsy in the sampled brain tissues. The uptake rates of FDG in human gray matter under the control condition showed an inverse correlation with those seen in PET, which were evaluated as sampled and contralateral gyri (SG/CG) and sampled gyri and cerebellar cortex (SG/CB) ratio. On the contrary, it showed a weak positive correlation with PET under the high K + condition. The uptake rates of FDG in human gray matter expressed as a high K +/control ratio, closely matched that observed by FDG-PET, which were evaluated as the SG/CG ratio and the SG/CB ratio. Our experimental system provides useful information for the interpretation of PET data in epileptics and the theoretical basis to interpret the results of metabolic studies using living human brain tissues for further use in pharmacological manipulation.

Agency Utilization of Free Internet Web Sites

ABSTRACT A social services department in the United Kingdom established a web portal and provided resources to enable agencies to publish their own pages on the Internet. Numerous web features were available, but few agencies utilized them. The portal is described, features identified, and several explanatory factors that may explain variance in uptake are considered.

Distribution of polycyclic aromatic hydrocarbons in soils and terrestrial biota after a spill of crude oil in Trecate, Italy

Ecological and human health exposures from soil-based petroleum-derived contaminants commonly are estimated by using soil-to-biota transfer factors that usually are based on octanol-water partitioning. Few studies of biota have been conducted in relation to spills of crude oils in terrestrial environments. After a large blowout of crude oil in northern Italy in 1994, the distribution of polycyclic aromatic hydrocarbons (PAHs) was examined over time and space in soils, uncultivated wild vegetation, insects, mice, and frogs in the area. Within two years of the blowout, PAH concentrations declined to background levels over much of the area where initial concentrations were within an order of magnitude above background, but had not declined to background in areas where starting concentrations exceeded background by two orders of magnitude. Octanol-water partitioning and extent of alkylation explained much of the variance in uptake of PAHs by plants and animals. The PAHs with lower octanol-water partition coefficients (K(ow)s) and higher-alkylated PAHs had higher biota-soil accumulation factors (BSAFs) than did high-K(ow) and unalkylated forms. The BSAFs for PAHs with higher K(ow)s were very low for plants, but much higher for animals, with frogs accumulating more of these compounds than other species.

Statistical Parametric Mapping of Hypoxic Tissue Identified by [18F]Fluoromisonidazole and Positron Emission Tomography Following Acute Ischemic Stroke

Positron emission tomography (PET) and the ligand [18F]fluoromisonidazole (18F-FMISO) have been used to image hypoxic tissue in the brain following acute stroke. Existing region of interest (ROI)-based methods of analysis are time consuming and operator-dependent. We describe and validate a method of statistical parametric mapping to identify regions of increased 18F-FMISO uptake. The 18F-FMISO PET images were transformed into a standardized coordinate space and intensity normalized. Then t statistic maps were created using a pooled estimate of variance. Statistical inference was based on the theory of Gaussian Random Fields. We examined the homogeneity of variance in normal subjects and the influence of normalization by mean whole brain activity versus mean activity in the contralateral hemisphere. Validity of the distributional assumptions inherent in parametric analysis was tested by comparison with a non-parametric method. The results of parametric analysis were also compared with those obtained with the existing ROI-based method. Variance in uptake at each voxel in normal subjects was homogeneous and not affected by mean voxel activity or distance from the centre of the image. The method of normalization influenced results significantly. Normalization by whole brain mean activity resulted in a smaller volume of tissue being classified as hypoxic compared to normalisation by mean activity in the contralateral hemisphere. The ROI-based method was subject to interobserver variability with a coefficient of variability of 16%. The volumes of hypoxic tissue identified by parametric and nonparametric methods were highly correlated (r = 0.99). These findings suggest that using a pooled variance and contralateral hemisphere normalisation, statistical parametric mapping can be used to objectively identify regions of increased 18F-FMISO uptake following acute stroke in individual subjects.

Predicting uptake of a routine cervical smear test: A comparison of the health belief model and the theory of planned behaviour

This paper reports on a study carried out to identify predictors of uptake of cervical screening among 142 women (59% response rate) in inner London. Two social cognition models were used: The Health Belief Model (HBM; Becker, 1974) and the Theory of Planned Behaviour (TPB; Ajzen, 1991) and in addition anticipated affect following non-attendance for screening was assessed. The TPB emerged as by far the superior model for predicting screening intentions, explaining 51% of the variance in comparison with only 4% explained by the HBM variables. However, neither model was able to predict a significant amount of variance in uptake of screening three months later. Possible reasons for the poor prediction of this type of behaviour are discussed.

Psychological models in predicting uptake of prenatal screening

Abstract The purpose of the current study was to determine which psychological models are most useful in predicting uptake of a prenatal screening test, maternal-serum alphafetoprotein screening for spina bifida and Down's syndrome. 1000 women eligible for the test completed standardised self-report questionnaires at two routine clinic visits to an antenatal clinic prior to the time when the test could take place. 902 underwent the screening test; 51 declined the test; and 47 did not undergo the test, giving no reason for this to staff. Knowledge of the test, the subjective expected utility attached to the test, and attitudes to doctors and medicine were all significant predictors of uptake behaviour. Results of a discriminant function analysis demonstrated distinct psychological processes underlying each of these three uptake behaviours, explaining 21% of the variance in uptake of screening. If uptake of screening is examined not as a dichotomous variable but as a group of behaviours, predictive models a...