This paper presents a robust sliding mode fault-tolerant control (FTC) strategy for a class of linear parameter variant (LPV) systems with variable time-delays and uncertainties. First fault estimation (FE) is conducted using a robust sliding mode observer, synthesized to simultaneously estimate the states and actuator faults of LPV polytopic delayed systems. Second, a sliding mode FTC is developed, ensuring all states of the closed-loop system converge to the origin. This paper presents an integrated sliding mode FTC strategy to achieve optimal robustness between the observer and controller models. The integrated design approach offers several advantages over traditional separated FTC methods. Our novel approach is based on incorporating adaptive law into the design of the Lyapunov–Krasovskii functional to improve both robustness and performance. This is achieved by combining the concept of sliding mode control (SMC) with the Lyapunov–Krasovskii function under the H∞ criteria, which plays a key role in guaranteeing the stability of this class of system. The effectiveness of the proposed method is demonstrated through a diesel engine example, which highlights the validity and benefits of the integrated and separated FTC strategy for uncertain nonlinear systems with time delays and the sliding mode control.