The interaction of the V0.95Cu0.05, V0.94Co0.06, and V0.9W0.1 alloys with hydrogen has been studied at hydrogen pressures of up to 250 MPa. We have constructed hydrogen absorption/desorption isotherms at different temperatures and determined the thermodynamic parameters of the systems. According to X-ray diffraction data, the high-pressure hydride phases V0.94Co0.06H1.4 and V0.9W0.1H1.2 consist of a face-centered cubic phase similar in structure to the γ-phase of vanadium dihydride. In the case of the vanadium-copper alloy, the maximum composition of the hydride is V0.95Cu0.05H0.5.