Catalysts are severely poisoned by ammonium sulfate (AS) and ammonium bisulfate (ABS) during selective catalytic NOX reduction (SCR) at low temperatures. To circumvent this issue, metal-substituted vanadates (MV2O6, M = Mn, Co, Ni, or Cu) supported on TiO2 were synthesized and functionalized with SOY2− to form M1 (S) catalysts (Y = 3 or 4). The Mn1 (S) could balance pre-factor and energy barrier required for the SCR, thereby exhibiting the highest NOX consumption rate (activity) among the M1 (S) catalysts. The Mn1 (S) also had desirable redox property, leading to the best SCR performance maximum-obtainable at low temperatures. Notably, the Mn1 (S) substantially reduced the thermal energy needed to decompose AS/ABS poisons. Such unique feature of the Mn1 (S) was pronounced when the Mn1 (S) was promoted by Sb (Mn1-Sb (S)). The resulting Mn1-Sb (S) showed the best SCR performance among all catalysts tested. The Mn1-Sb (S) could minimize the deposition of AS/ABS on the surface and unprecedentedly recovered its performance after regeneration even in the presence of NOX, NH3, SO2, and H2O at 260−280 °C. The temperatures required for the regeneration of the Mn1-Sb (S) were reduced by 100 °C or more in comparison with those of SCR catalysts reported previously.