Van Der Meij Research Articles

ALDH1 EXPRESSION IN LAMINA PROPRIA OF LICHEN PLANUS, LICHENOID REACTION, LEUCOPLAKIA, AND INFLAMMATORY PROCESSES

Objective To evaluate the differences in ALDH1 expression in lamina propria of oral lichen planus (OLP), oral lichenoid reaction (OLR), leucoplakia, and the nonspecific chronic inflammatory process (NCIP). Study Design This study selected 16 samples from each group. The OLP and OLR followed van der Meij and van der Waal criteria, the leucoplakia and NCIP presented subepithelial chronic inflammatory infiltrate. The ALDH1 expression of the samples was investigated by immunohistochemistry. The percentage of positive cells in the selected fields from the lamina propria were evaluated and categorized in 1 to 3. The final score from each sample was defined as the fields' mean score. Only the cells located at the inflammatory infiltrate were considered. Results The OLP presented a higher median expression of ALDH1 in lamina propria (2.00) than RLO (1.25; p=0.012), leucoplakia (1.32; p=0.027), and NCIP (1.15; p=0.005). Moreover, in 4 RLO samples (25.0%), 6 leucoplakia (37.5%), and 5 NCIP (31.25%), all the evaluated fields showed less than 10% of the cells expressing ALDH1. In OLP, this event did not occur. Conclusion the ALDH1 expression in lamina propria was higher in OLP cases, raising the hypothesis that this protein is involved in an autoimmune response. Funding FAPEMIG To evaluate the differences in ALDH1 expression in lamina propria of oral lichen planus (OLP), oral lichenoid reaction (OLR), leucoplakia, and the nonspecific chronic inflammatory process (NCIP). This study selected 16 samples from each group. The OLP and OLR followed van der Meij and van der Waal criteria, the leucoplakia and NCIP presented subepithelial chronic inflammatory infiltrate. The ALDH1 expression of the samples was investigated by immunohistochemistry. The percentage of positive cells in the selected fields from the lamina propria were evaluated and categorized in 1 to 3. The final score from each sample was defined as the fields' mean score. Only the cells located at the inflammatory infiltrate were considered. The OLP presented a higher median expression of ALDH1 in lamina propria (2.00) than RLO (1.25; p=0.012), leucoplakia (1.32; p=0.027), and NCIP (1.15; p=0.005). Moreover, in 4 RLO samples (25.0%), 6 leucoplakia (37.5%), and 5 NCIP (31.25%), all the evaluated fields showed less than 10% of the cells expressing ALDH1. In OLP, this event did not occur. the ALDH1 expression in lamina propria was higher in OLP cases, raising the hypothesis that this protein is involved in an autoimmune response.

Editorial introductions.

Editorial introductions.

A Clinicohistopathological Characterization of Oral Lichen Planus: A Cross-Sectional Study.

Based on the modified diagnostic criteria for oral lichen planus (OLP) proposed by Van der Meij and Van der Waal, the objective of the current investigation was to demonstrate a clinicohistopathological association in the diagnosis of OLP. Data were retrieved from 250 individuals who visited the Department of Oral Medicine and Radiology and were diagnosed with OLP between September 2018 and December 2021. Upon completion of the histopathological analysis, the precise diagnosis of OLP was made. Repeat biopsies were performed in the cases suspecting malignant transformation during the follow-up phase. The data were analyzed using SPSS software. The Fisher's exact test and chi-square test of association were used to establish the significant differences between the variables at a 5% significance level. Of the 250 patients, 48% and 52% were males and females, respectively. The two clinical manifestations observed were reticular (n=145, 58%) and erosive types (n=105, 42%). The most frequently impacted locations were the buccal mucosa (n=150, 60%) and labial mucosa (n=100, 40%). Fourteen individuals (two with reticular form and 12 with erosive form) later during follow-up showed dysplasia, with moderate (n=2) to mild (n=12) dysplastic alterations. Koilocytes were reported in 84 cases (34%), which included 35 (24%) reticular cases and 49 (47%) erosive lesions. The histopathological features such as acanthosis, epithelial atrophy, hyperkeratosis, presence of neutrophils, koilocytes, and epithelial dysplasia were shown to be statistically significant between the clinical forms (p<0.001). The results of the current study highlight the concordance of histopathological and clinical diagnoses, especially for early definitive diagnosis of OLP. More research studies are warranted to validate the trend of epithelial dysplasia in OLP associated with human papillomavirus (HPV) and to explore the course of the lesions that might be affected by this trait.

Eleven Guidelines for the Design of Instructional Videos for Software Training

Purpose: Video is a popular medium for instructing people how to use software. In 2013, van der Meij and van der Meij proposed eight guidelines for the design of instructional videos for software training. Since then, production techniques and video features evolved, and new insights about characteristics of effective video instructions emerged. Methods: Based on recent study outcomes and our reflections on instructional video designs, the original set of eight guidelines was restructured, updated, and extended. Results:A new framework with 11 guidelines was constructed. For these guidelines the article provides scientifically-based advice for the design of instructional videos for software training. Conclusion: The new framework and the illustrations of how the guidelines were applied in videos should provide useful insights for further practice and research on instructional video design.

Patch test of dental materials in Oral Lichen Planus with considering the role of saliva

Lichen planus is the most common skin disease that affects the oral mucosa. Oral Lichen Planus is a T-cell-mediated autoimmune disorder. In the current study, for the first time, an oral cavity condition in skin patch tests with adding saliva is simulated. In addition, the patch results are compared with healthy subjects. Forty-one OLP patients and 63 healthy subjects were enrolled in the study. All participants were provided with patch tests, including allergens, in combination with saliva in chambers. Allergens from the European baseline (standard) series selected according to the most prevalent positive results in the previous study were applied. Positive results of Mercury and Cobalt tests were significantly higher in the case group. In this study, the differentiation of patients with lichen planus and lichenoid was identified according to the Van der Meij & Van der Waal criteria. The patch test was conducted for healthy individuals as well. The most important of all was the use of patients' saliva in the patch test, done for the first time in this field. In the case of OLP, a patch test can help identify positive reactions to dental materials; thus, the replacement of dental restorations may be needed.

Intermicrobial Hitchhiking: How Nonmotile Microbes Leverage Communal Motility.

Motility allows many microbes to traverse their environment to find nutrient sources or escape unfavorable environments. However, some microbes are nonmotile and are restricted to their immediate conditions. Intriguingly, sporadic reports have demonstrated that many nonmotile microbes can utilize the motility machinery of other microbes in their vicinity. This form of transportation, called hitchhiking, has been observed with both prokaryotic and eukaryotic microbes. Importantly, many hitchhiking microbes are pathogenic to humans or plants. Here, we discuss reports of intermicrobial hitchhiking to generate a comprehensive view of hitchhiking mechanisms and how such interactions may influence human and plant health. We hypothesize that microbial hitchhiking is ubiquitous in nature and may become the subject of an independent subfield of research in microbiology.

The natural history of oral mucosal lesions with both lichenoid and epithelial dysplastic features: a systematic review.

BackgroundAssessing the natural history of oral mucosal lesions with both lichenoid and epithelial dysplastic features through a systematic review of published literature.MethodsScopus, PubMed, and Web of Science were searched for oral mucosal lesions showing both lichenoid and epithelial dysplastic features from original studies using the keywords “oral lichenoid dysplasia; oral epithelial dysplasia (OED) with lichenoid features; oral lichen planus (OLP) with dysplastic features; oral lichenoid lesions (OLL) with dysplastic features”.ResultsThe search yielded 152 articles (PubMed-84, Scopus-32, Web of Science-36). Among these only 5 studies complied with the selection criteria including the provision of sufficient clinical and histopathological data. Out of these 5 studies, 181 cases were described to exhibit both lichenoid and epithelial dysplastic features. The most common diagnostic criterion employed was of van der Meij et al. Although some studies accepted the presence of epithelial dysplasia in OLL, most rejected the notion of epithelial dysplasia in OLP and designated such lesions as an OLL or oral lichenoid dysplasia. The few studies which accepted the presence of epithelial dysplasia in OLP rendered a diagnosis of OLP with dysplasia.ConclusionsThe review shows that several diagnoses were used for lesions with similar clinicopathological features and distinct clinicopathological entities were designated similar diagnosis. These diagnostic variations are the primary cause for the discrepancies in the prevalence and malignant transformation rates of these enigmatic entities which in turn often leads to erroneous treatment.

Indonesian Manuscripts from the Islands of Java, Madura, Bali and Lombok, by Dick van der Meij

Indonesian Manuscripts from the Islands of Java, Madura, Bali and Lombok, by Dick van der Meij

Getting ahead of yourself: Parafoveal word expectancy modulates the N400 during sentence reading.

An important question in the reading literature regards the nature of the semantic information readers can extract from the parafovea (i.e., the next word in a sentence). Recent eye-tracking findings have found a semantic parafoveal preview benefit under many circumstances, and findings from event-related brain potentials (ERPs) also suggest that readers can at least detect semantic anomalies parafoveally (Barber, Van der Meij, & Kutas, Psychophysiology, 50(1), 48-59, 2013). We use ERPs to ask whether fine-grained aspects of semantic expectancy can affect the N400 elicited by a word appearing in the parafovea. In an RSVP-with-flankers paradigm, sentences were presented word by word, flanked 2° bilaterally by the previous and upcoming words. Stimuli consisted of high constraint sentences that were identical up to the target word, which could be expected, unexpected but plausible, or anomalous, as well as low constraint sentences that were always completed with the most expected ending. Findings revealed an N400 effect to the target word when it appeared in the parafovea, which was graded with respect to the target's expectancy and congruency within the sentence context. Furthermore, when targets appeared at central fixation, this graded congruency effect was mitigated, suggesting that the semantic information gleaned from parafoveal vision functionally changes the semantic processing of those words when foveated.

The Clinical Profile of Oral Lichen Planus

OBJECTIVESThe objective of the study was to determine the clinical profile of oral lichen planus.METHODOLOGYThis retrospective cohort study was carried from January 2011 to December 2015 at the Department of Oral and Maxillofacial Surgery, Sardar Begum Dental College, Peshawar.A total of 36 with 14 male and 22 female patients having oral lichen planus from were selected. On defined and population-based sample the age selected was ≥ 20 years and divided into four categories i.e..,20-29 years,30-39 years,40-49 years and 50-59 years. The diagnostic criteria proposed by van der Meij et al 23 in 2003 based on the WHO definition of oral lichen planus were used to identify the cases of oral lichen planus.That entire patient’s with incomplete records and aged &gt; 60 years were excluded. The data was analyzed through SPSS 22 at the significance level of p &lt; 0.05 and Chi-square statistics was applied for site and gender association.RESULTSThe mean age presentation was 39.2 (SD± 15.49) years. The female to male ratio was 1:57:1. The dominant aged group was 30-39 years with n=16 (44.44%).The buccal mucosa was the most common site involved n=28(77.8%).Reticular type of oral lichen planus was the most common form and was present in n=22(61.1%) patients however, bilaterally involved mucosa was commonly seen. Chi-square statistics showed a significant association between bilateral involvement of oral mucosa in oral lichen planus with both male and female (x2= 5.833, p= 0.016).CONCLUSIONThe most common site involved in oral lichen planus was buccal mucosa, most common form was atrophic with female predominance and bilaterally involved oral mucosa was significantly associated with gender.

Dick van der Meij and N. Lamboij (eds), with the assistance of Oman Fathurachman, The Malay Hikayat Miʻrāj Nabi Muhammad; The prophet Muḥammad’s nocturnal journey to Heaven and hell: text and translation [from the Malay] of Cod. Or. 1713 in the Library o

Dick van der Meij and N. Lamboij (eds), with the assistance of Oman Fathurachman, The Malay Hikayat Miʻrāj Nabi Muhammad; The prophet Muḥammad’s nocturnal journey to Heaven and hell: text and translation [from the Malay] of Cod. Or. 1713 in the Library o

Clinical profile of 108 cases of oral lichen planus.

Oral lichen planus (OLP) is a T cell-mediated chronic inflammatory disease with a varied clinical presentation. The present clinical study was carried out to clarify the demographic and clinical profile of 108 patients with OLP. The patients were identified based on the diagnostic criteria proposed by van der Meij et al. (2003) modified from the WHO (1978) clinical and histopathologic definition of OLP. Information such as age, gender, clinical presentation and type of OLP, site of involvement, symptoms, extraoral involvement, history of systemic disease, familial occurrence and risk factors like chewing and smoking tobacco, chewing betel quid, alcohol consumption were obtained. Mean age of OLP patients was 45.4 years, and among the identified patients, 70.4% were females. The most frequent clinical type was the reticular form (80.6%). The OLP lesions were symptomatic in 77.8% of the patients. The buccal mucosa was the most affected site (87.9%) and multiple oral lesions were observed in 41.7% of the patients. Among the OLP patients, 36.1% and 4.7% reported chewing tobacco and smoking tobacco, respectively. Histopathologically, epithelial dysplasia was seen in two cases. The chronic nature of OLP warrants patient education, psychological support and long-term follow up. (J Oral Sci 58, 43-47, 2016).

A new species of Fizesereneia Takeda & Tamura, 1980 (Crustacea: Brachyura: Cryptochiridae) from the Red Sea and Oman.

A new species of cryptochirid crab, Fizesereneia panda van der Meij, is described and illustrated based on specimens collected from the scleractinian corals Lobophyllia cf. hemprichii and L. cf. corymbosa from the Farasan Banks, Farasan Islands, and the reefs off Thuwal in the Saudi Arabian Red Sea, and from Symphyllia recta from reefs in the Gulf of Oman. This is the second cryptochirid species with the Red Sea as type locality. It can be separated from its congeners by the subrectangular carapace, raised midline and the complete division of the carapace depressions, and reddish black colour pattern of these concavities in live specimens. This new species is the seventh assigned to Fizesereneia. A DNA barcode for the new species has been deposited in GenBank.

The Malay Hikayat Miʿrāj Nabi Muḥammad. The Prophet Muḥammad’s nocturnal Journey to Heaven and Hell. Text and translation of Cod. Or. 1713 in the Library of Leiden University, written by Th.C. van der Meij and N. Lambooij (editors and translators), with the assistance of Oman Fathurahman

The Malay Hikayat Miʿrāj Nabi Muḥammad. The Prophet Muḥammad’s nocturnal Journey to Heaven and Hell. Text and translation of Cod. Or. 1713 in the Library of Leiden University, written by Th.C. van der Meij and N. Lambooij (editors and translators), with the assistance of Oman Fathurahman

Clinico-pathological study to evaluate oral lichen planus for the establishment of clinical and histopathological diagnostic criteria.

Lichen planus and lichenoid lesions affecting the oral cavity show similar clinico-pathological features creating a diagnostic dilemma. Hence, the aim of the present study was to establish a clinical and histopathological correlation in the diagnosis of oral lichen planus, based on the modified WHO diagnostic criteria of oral lichen planus and oral lichenoid lesions proposed by Van der Meij and Van der Waal in 2003. In the present study, 100 cases of oral lichen planus were clinically and histopathologically analyzed. Out of the 100 cases, 50 were prospective and 50 were retrospective cases. Prospective cases were collected based on the clinical diagnosis of oral lichen planus and oral lichenoid lesion. Retrospective cases were collected based on the histopathological diagnosis of oral lichen planus. Both the clinical and histopathological analyses were performed based on a proposal for a set of modified diagnostic criteria of oral lichen planus and oral lichenoid lesion. A final diagnosis of oral lichen planus was made only after the correlation of the clinical diagnosis with the histopathological diagnosis. The interobserver agreement among three observers for both prospective and retrospective cases in the final diagnosis of oral lichen planus was found to be "good" to "very good" indicating high reproducibility. However, the final diagnoses of true oral lichen planus after clinico-pathological correlation in prospective and retrospective study groups appeared to be 38.0% and 54.0% respectively. The results of the present study revealed mild to moderate clinico-pathological correlation in the final diagnosis of oral lichen planus for the prospective and retrospective study groups respectively.

The Romanisation of Indic Script Used in Ancient Indonesia

The paper calls the attention of Javanists, and Indonesianists at large, to theoretical as well as practical issues connected with conventions for the Romanisation of Old Javanese, Old Malay, Old Sundanese and other Indonesian languages which were traditionally written in Indic scripts, and underscores the difference between transliteration, on the one hand, and transcription or orthography (‘spelling’) on the other. In doing so, it replies to the points of criticism raised by Dick van der Meij in his review (2012) of From Laṅkā Eastwards, edited by Acri, Creese & Griffiths (2011).

Caractère potentiellement malin du lichen plan buccal et des lésions lichénoïdes

Many authors have reported the possible malignant transformation of oral lichen. The incidence of this event remains controversial. Many authors make a distinction between the "true" oral lichen planus (OLP) and lichenoid lesions (LL) according to the WHO clinical and histological classification. For these authors an increased risk of development of oral cancer could occur only on LL. Our aim was to check this hypothesis on a cohort followed for 10 years. We included patients who were referred to our team for the first time between 1995 and 1997, still followed in 2010, with a histological diagnosis of buccal lichen planus. We classified lesions as OLP or LL according to the WHO clinical and histological classification: the two clinical criteria for OLP were a reticulated aspect and bilateral and symmetric lesions. Three histological criteria were necessary for the diagnosis: dense inflammatory infiltrate in the upper lamina propria, liquefaction degeneration of basal keratinocytes, and no signs of dysplasia. The final diagnosis was OLP, when all clinical ad histological criteria were met otherwise it was LL. We studied the patient's outcome between their first consultations and May 2010. Thirty-two patients, whose data was available, met inclusion criteria. Eight were diagnosed with OLP and 24 with LL. The mean follow-up was 164 months [154-183]. No oral cancer was observed in the OLP group. Two patients in the LL group presented with oral cancer after 45 and 143 months of follow-up. Malignant transformations were observed only in the LL group. Our results correlate with those of Van Der Meij et al. published in 2006. The strict use of the WHO diagnostic criteria seems to allow identifying patients at risk of developing oral cancer (LL) and others with only a benign course of this chronic oral mucosal disease. These results need to be confirmed by prospective multicentric studies.

Correction: Testosterone Levels Are Negatively Associated with Childlessness in Males, but Positively Related to Offspring Count in Fathers

There was an error in the article title. The correct title is: Levels Are Negatively Associated with Fatherhood in Males, but Positively Related to Offspring Count in The correct citation is: Pollet TV, Cobey KD, van der Meij L (2013) Testosterone Levels Are Negatively Associated with Fatherhood in Males, but Positively Related to Offspring Count in Fathers. PLoS ONE 8(4): e60018. doi:10.1371/journal.pone.0060018.

Differential Correlations of Digit Ratio (2D:4D) with Aggressive Dominance and Sociable Dominance Are Not Demonstrated: Commentary on van der Meij, Almela, Buunk, Dubbs, and Salvador (2012, Aggressive Behavior, 38(3), 208–212)

Van der Meij, Almela, Buunk, Dubbs, and Salvador reported that, among young men (N = 84), a putative biomarker for prenatal androgen exposure (second-to-fourth digit ratio; 2D:4D) correlated negatively to self-reported aggressive dominance, but not to sociable dominance. A critical examination of this allegedly differential effect shows it to be unsupported and unlikely to be replicable. Statistical power of the sample was so low that the nominally significant correlation coefficient with aggressive dominance and the nominally not significant one with sociable dominance actually did not differ significantly from each other. Apart from these data-analytic and statistical power issues, a number of further substantive comments are raised, including conceptual and study design issues, 2D:4D measurement and reliability issues, and biased presentation (i.e. selective citation) of prior related research evidence. More generally, it is suggested that 2D:4D research would benefit from adopting publishing standards requiring discovery and replication samples (i.e. successful replication of novel findings by the initial researchers themselves), as is now increasingly required for publishing in various fields of inconsistent, hard-to-replicate evidence.

The malignant potential of oral lichen planus - reply

We read the correspondence letter by Venkatraman Sreenivasan1 about our article2 and welcome the opportunity to address the issues raised. Dr. Sreenivasan questions the validity of distinction between oral lichen planus (OLP) and oral lichenoid lesions (OLLs).1 We disagree. In the Materials and Methods section of our original article,2 we clearly stated that we excluded 78 of 493 patients from the study because of “ineligible microscopic appearance.”2 Therefore, these 78 patients were classified according to the differentiation criteria proposed by van der Meij et al.