Van De Wall Research Articles

Tuning of Delicate Host-Guest Interactions in Hydrated MIL-53 and Functional Variants for Furfural Capture from Aqueous Solution.

Capture of high-boiling-point furfural from diluted aqueous solution is a critical but challenging step in sustainable bio-refinery processes, but conventional separation methods such as distillation and liquid-liquid extraction requires prohibitive energy consumption. We report control over the microenvironment of hydrated MIL-53 and isoreticular variants with diversified functional terephthalic acid linkers for the purpose of preferential binding of furfural through delicate host-guest interactions. Methyl-bounded MIL-53 with improved binding energy in the hydrated form results in highly efficient capture ratio (ca. 98 %) in the extremely low concentration of furfural solution (0.5-3 wt %) and 100 % furfural specificity over xylose. The distinct hydrogen bonding sites and multiple Van de Wall interactions for furfural adsorption was testified by computational modeling. Furthermore, the recovery ratio of furfural reaches ca. 93 % in desorption.

Tuning of Delicate Host–Guest Interactions in Hydrated MIL‐53 and Functional Variants for Furfural Capture from Aqueous Solution

AbstractCapture of high‐boiling‐point furfural from diluted aqueous solution is a critical but challenging step in sustainable bio‐refinery processes, but conventional separation methods such as distillation and liquid‐liquid extraction requires prohibitive energy consumption. We report control over the microenvironment of hydrated MIL‐53 and isoreticular variants with diversified functional terephthalic acid linkers for the purpose of preferential binding of furfural through delicate host‐guest interactions. Methyl‐bounded MIL‐53 with improved binding energy in the hydrated form results in highly efficient capture ratio (ca. 98 %) in the extremely low concentration of furfural solution (0.5–3 wt %) and 100 % furfural specificity over xylose. The distinct hydrogen bonding sites and multiple Van de Wall interactions for furfural adsorption was testified by computational modeling. Furthermore, the recovery ratio of furfural reaches ca. 93 % in desorption.

Prescribing Sound: Willem Van de Wall and the Carceral Origins of American Music Therapy

From 1921 until 1936, musician Willem Van de Wall pioneered the modern use of therapeutic music in American prisons and psychiatric institutions. His therapy was steeped in the methods and philosophy of social control, and after World War II, it shaped the professionalizing field of music therapy. Van de Wall's influence reveals an overlooked connection between modern clinical practice and the techniques of control employed in prisons and psychiatric hospitals of the early twentieth century. Given music therapy's broader impact as an element of postwar self-help culture, its relationship to social control practices also disrupts longstanding scholarly ideas about the so-called “therapeutic ethos.” The therapeutic ethos did not originate solely in efforts by the middle classes to adjust to bourgeois modernity. The case of music therapy suggests that some elements of “therapeutic culture” were always coercive and always directed toward the maintenance of race, gender, and class hierarchies.

Van Dijk, Poell, and de Wall, The Platform Society: Public Values in a Connective World (2018)

Van Dijk, Poell, and de Wall, The Platform Society: Public Values in a Connective World (2018)

Role of Obesity and Lipotoxicity in the Development of Nonalcoholic Steatohepatitis: Pathophysiology and Clinical Implications

As obesity reaches epidemic proportions, nonalcoholic fatty liver disease (NAFLD) is becoming a frequent cause of patient referral to gastroenterologists. There is a close link between dysfunctional adipose tissue in NAFLD and common conditions such as metabolic syndrome, type 2 diabetes mellitus, and cardiovascular disease. This review focuses on the pathophysiology of interactions between adipose tissue and target organs in obesity and the resulting clinical implications for the management of nonalcoholic steatohepatitis. The release of fatty acids from dysfunctional and insulin-resistant adipocytes results in lipotoxicity, caused by the accumulation of triglyceride-derived toxic metabolites in ectopic tissues (liver, muscle, pancreatic beta cells) and subsequent activation of inflammatory pathways, cellular dysfunction, and lipoapoptosis. The cross talk between dysfunctional adipocytes and the liver involves multiple cell populations, including macrophages and other immune cells, that in concert promote the development of lipotoxic liver disease, a term that more accurately describes the pathophysiology of nonalcoholic steatohepatitis. At the clinical level, adipose tissue insulin resistance contributes to type 2 diabetes mellitus and cardiovascular disease. Treatments that rescue the liver from lipotoxicity by restoring adipose tissue insulin sensitivity (eg, significant weight loss, exercise, thiazolidinediones) or preventing activation of inflammatory pathways and oxidative stress (ie, vitamin E, thiazolidinediones) hold promise in the treatment of NAFLD, although their long-term safety and efficacy remain to be established. Better understanding of pathways that link dysregulated adipose tissue, metabolic dysfunction, and liver lipotoxicity will result in improvements in the clinical management of these challenging patients.

Histone Deacetylase 9 Is a Negative Regulator of Adipogenic Differentiation

Differentiation of preadipocytes into mature adipocytes capable of efficiently storing lipids is an important regulatory mechanism in obesity. Here, we examined the involvement of histone deacetylases (HDACs) and histone acetyltransferases (HATs) in the regulation of adipogenesis. We find that among the various members of the HDAC and HAT families, only HDAC9 exhibited dramatic down-regulation preceding adipogenic differentiation. Preadipocytes from HDAC9 gene knock-out mice exhibited accelerated adipogenic differentiation, whereas HDAC9 overexpression in 3T3-L1 preadipocytes suppressed adipogenic differentiation, demonstrating its direct role as a negative regulator of adipogenesis. HDAC9 expression was higher in visceral as compared with subcutaneous preadipocytes, negatively correlating with their potential to undergo adipogenic differentiation in vitro. HDAC9 localized in the nucleus, and its negative regulation of adipogenesis segregates with the N-terminal nuclear targeting domain, whereas the C-terminal deacetylase domain is dispensable for this function. HDAC9 co-precipitates with USF1 and is recruited with USF1 at the E-box region of the C/EBPα gene promoter in preadipocytes. Upon induction of adipogenic differentiation, HDAC9 is down-regulated, leading to its dissociation from the USF1 complex, whereas p300 HAT is up-regulated to allow its association with USF1 and accumulation at the E-box site of the C/EBPα promoter in differentiated adipocytes. This reciprocal regulation of HDAC9 and p300 HAT in the USF1 complex is associated with increased C/EBPα expression, a master regulator of adipogenic differentiation. These findings provide new insights into mechanisms of adipogenic differentiation and document a critical regulatory role for HDAC9 in adipogenic differentiation through a deacetylase-independent mechanism.

Effect of Loading Concentration on the Electrical and Hardness Properties of MWCNT/Epoxy Nanocomposites

Carbon nanotubes have excellent mechanical and electrical properties, and are also a good reinforcement material for composites than conventional materials. The matrix used in this study was epoxy and reinforcement filler in multi-walled carbon nanotubes (MWCNTs). The different MWCNTs loading concentrations (0 ~ 10 wt. %) were added into the epoxy resin. The dispersion of MWCNTs in epoxy resin was conducted using high speed mixer through mechanical shearing mechanism. The mixture of epoxy/MWNTs suspension was poured into the mold and compression molding was conducted for fabrication of MWCNTs/epoxy nanocomposites. The electrical conductivity of nanocomposite by variation of CNTs concentration was measured by the four point probe. Dispersion state of CNTs in epoxy matrix was observed on fractured surface by scanning electron microscopic. Hardness of the composite was tested using the Dinamic Ultra Micro Hardness machine. Non conductive epoxy polymer becomes conductor as addition of CNTs.. Electrical conductivity of nanocomposite plates increased with increasing CNTs concentration. Agglomerations of CNTs were observed on fractured surfaces. This phenomenon due to CNTs which used in this study was at as produced state where no modification is being done on it. Long and entanglement of individual CNTs easily lead to agglomerations. Van de Wall’s force interactions between CNTs also contribute to the agglomerations of CNTs. Hardness of the composite increases with the CNTs loading concentrations until it reaches a maximum peak at the composition of 5wt% of CNTs but the hardness decreases rapidly with loading greater than 5wt% of CNTs.

An intrinsic gut leptin-melanocortin pathway modulates intestinal microsomal triglyceride transfer protein and lipid absorption

Fat is delivered to tissues by apoB-containing lipoproteins synthesized in the liver and intestine with the help of an intracellular chaperone, microsomal triglyceride transfer protein (MTP). Leptin, a hormone secreted by adipose tissue, acts in the brain and on peripheral tissues to regulate fat storage and metabolism. Our aim was to identify the role of leptin signaling in MTP regulation and lipid absorption using several mouse models deficient in leptin receptor (LEPR) signaling and downstream effectors. Mice with spontaneous LEPR B mutations or targeted ablation of LEPR B in proopiomelanocortin (POMC) or agouti gene related peptide (AGRP) expressing cells had increased triglyceride in plasma, liver, and intestine. Furthermore, melanocortin 4 receptor (MC4R) knockout mice expressed a similar triglyceride phenotype, suggesting that leptin might regulate intestinal MTP expression through the melanocortin pathway. Mechanistic studies revealed that the accumulation of triglyceride in the intestine might be secondary to decreased expression of MTP and lipid absorption in these mice. Surgical and chemical blockade of vagal efferent outflow to the intestine in wild-type mice failed to alter the triglyceride phenotype, demonstrating that central neural control mechanisms were likely not involved in the observed regulation of intestinal MTP. Instead, we found that enterocytes express LEPR, POMC, AGRP, and MC4R. We propose that a peripheral, local gut signaling mechanism involving LEPR B and MC4R regulates intestinal MTP and controls intestinal lipid absorption.

Community music during the New Deal: the contributions of Willem Van de Wall and Max Kaplan

Willem Van de Wall (18871953) and Max Kaplan (191198) built careers spanning music performance, music education, adult education, sociology, social work, music therapy and community music. Willem Van de Wall was a seminal influence on the development of the fields of music therapy and adult education researching the role of music in institutional settings, including prisons, psychiatric hospitals and general hospitals. Throughout his illustrious career, Max Kaplan was dedicated to community music and is lauded for his sociological research on music and music education, most notably, his study of leisure. By giving us a glimpse into their community music activities during the New Deal, these two scholars offer important lessons for today's community music scholars, practitioners and policy makers.

Yin-Yang Regulation of Adiponectin Signaling by APPL Isoforms in Muscle Cells

APPL1 is a newly identified adiponectin receptor-binding protein that positively mediates adiponectin signaling in cells. Here we report that APPL2, an isoform of APPL1 that forms a dimer with APPL1, can interacts with both AdipoR1 and AdipoR2 and acts as a negative regulator of adiponectin signaling in muscle cells. Overexpression of APPL2 inhibits the interaction between APPL1 and AdipoR1, leading to down-regulation of adiponectin signaling in C2C12 myotubes. In contrast, suppressing APPL2 expression by RNAi significantly enhances adiponectin-stimulated glucose uptake and fatty acid oxidation. In addition to targeting directly to and competing with APPL1 in binding with the adiponectin receptors, APPL2 also suppresses adiponectin and insulin signaling by sequestrating APPL1 from these two pathways. In addition to adiponectin, metformin also induces APPL1-APPL2 dissociation. Taken together, our results reveal that APPL isoforms function as an integrated Yin-Yang regulator of adiponectin signaling and mediate the cross-talk between adiponectin and insulin signaling pathways in muscle cells.

Deletion of N-type Ca2+ Channel Cav2.2 Results in Hyperaggressive Behaviors in Mice

Voltage-dependent N-type Ca(2+) channels play important roles in the regulation of diverse neuronal functions in the brain, but little is known about its role in social aggressive behaviors. Mice lacking the alpha1B subunit (Ca(v)2.2) of N-type Ca(2+) channels showed markedly enhanced aggressive behaviors to an intruder mouse in the resident-intruder test. The dorsal raphe nucleus (DRN), which contains serotonin neurons, is known to be involved in aggression in animals. We thus examined the DRN neurons in the Ca(v)2.2-deficient (Ca(v)2.2(-/-)) mice. Microinjection of omega-conotoxin GVIA, an N-type Ca(2+) channel-specific blocker, into the DRN of wild type mice resulted in escalated aggression, mimicking the phenotypes of Ca(v)2.2(-/-). Electrophysiological analysis showed increased firing activity of serotonin neurons with a reduced inhibitory neurotransmission in the Ca(v)2.2(-/-) DRN. Ca(v)2.2(-/-) mice showed an elevated level of arginine vasopressin, an aggression-related hormone, in the cerebrospinal fluid. In addition, Ca(v)2.2(-/-) mice showed an increase of serotonin in the hypothalamus. These results suggest that N-type Ca(2+) channels at the DRN have a key role in the control of aggression.

Paradoxical Effect of Mitochondrial Respiratory Chain Impairment on Insulin Signaling and Glucose Transport in Adipose Cells

Adipocyte function is crucial for the control of whole body energy homeostasis. Pathway analysis of differentiating 3T3-L1 adipocytes reveals that major metabolic pathways induced during differentiation involve mitochondrial function. However, it is not clear why differentiated white adipocytes require enhanced respiratory chain activity relative to pre-adipocytes. To address this question, we used small interference RNA to interfere with the induction of the transcription factor Tfam, which is highly induced between days 2 and 4 of differentiation and is crucial for replication of mitochondrial DNA. Interference with Tfam resulted in cells with decreased respiratory chain capacity, reflected by decreased basal oxygen consumption, and decreased mitochondrial ATP synthesis, but no difference in many other adipocyte functions or expression levels of adipose-specific genes. However, insulin-stimulated GLUT4 translocation to the cell surface and subsequent glucose transport are impaired in Tfam knockdown cells. Paradoxically, insulin-stimulated Akt phosphorylation is significantly enhanced in these cells. These studies reveal independent links between mitochondrial function, insulin signaling, and glucose transport, in which impaired respiratory chain activity enhances insulin signaling to Akt phosphorylation, but impairs GLUT4 translocation. These results indicate that mitochondrial respiratory chain dysfunction in adipocytes can cause impaired insulin responsiveness of GLUT4 translocation by a mechanism downstream of the Akt protein kinase.

Ira Maximilian Altshuler: psychiatrist and pioneer music therapist.

The purpose of this study was to examine the life of Ira Maximilian Altshuler, psychiatrist and pioneer music therapist. In 1938, Dr. Altshuler initiated one of the first large-scale music therapy programs for mentally ill persons in the country at Detroit's Eloise Hospital. His innovative programs combined psychoanalytic techniques and music therapy methods specifically designed for use with large groups of clients. He later trained some of the first music therapy interns in the country, including Carol Collins, who served for many years as Professor of Music Therapy at Wayne State University, and Esther Goetz Gilliland, who later became President of NAMT. Dr. Altshuler promoted the practice and profession tirelessly, speaking to numerous audiences over the years and writing 19 articles about music therapy. Altshuler participated in the National Association for Music Therapy (NAMT) organizational meeting held in New York City in 1950. An active member of the organization for many years, he served on the Research Committee and hosted the 1955 national NAMT conference in Detroit. Even after Altshuler's retirement from Eloise Hospital in 1963, he remained active in numerous civic, music, and music therapy activities until his death 5 year later. Ira Altshuler should be remembered along with other music therapists from the time-Willem Van de Wall, Harriet Ayer Seymour and others-who vigorously embraced and advanced the status of the profession.

On the mechanism of transformation of icosahedral rare-gas clusters into fcc aggregations

The experimental diffraction patterns from Kr cluster beams are compared with the diffraction functions calculated for rare-gas clusters with dimensions of 3×103 and 1×104 atoms/cluster. The experimental results are found to correlate well with the calculation if it is assumed that the clusters have a face-centered cubic structure with a constant number of intersecting stacking faults. Additional confirmation is obtained for the decisive role of the kinetic factor in the formation of the crystalline phase of the clusters. Conjectures are offered concerning the possible reasons why the densitometer traces presented by M-F. de Feraudy, G. Torchet, and B. W. van de Wall at the conference ISSPIC (1998) showed no substantial changes when the cluster size was increased by more than an order of magnitude.

Willem van de Wall: Organizer and Innovator in Music Education and Music Therapy

This research is an analysis and description of the unique role of Willem van de Wall in the development of music education and his influence on the development of music therapy in the first half of the twentieth century. During his career, he served as a professional harpist, a choral director, and a professor of music education. During the course of his professional life, van de Wall wrote numerous articles and several books that advocated the structured and controlled use of music in institutions, including schools, psychiatric hospitals, general hospitals, and prisons. Although his early writings focused on development of handicapped individuals, his later work shifted to a broader application of music in the education of normal children and adults. Van de Wall believed that musical behaviors were influenced by biological and emotional factors. He strongly encouraged research to establish credibility for the influence of music on normal and aberrant human behavior. Van de Wall's writings contributed significantly to music education and shaped the practice of hospital musicians, who later established the field of music therapy.

Food Production in South Africa

A Survey of the Food and Feed Resources of the Union of South Africa By G. Van de Wall and E. D. Alvord Jnr. (Pretoria: J. L. van Schaik, Ltd.) 31s. 6d.

Reviews of Recent Publications

ELEMENTS OF RETAIL SELLING. By Paul H. Nystrom.HOW TO TEACH OCCUPATIONS. A MANUAL FOR TEACHERS TO ACCOMPANY BREWER'S OCCUPATIONS. By Mildred E. Lincoln and John M. Brewer.LEWIS VOCATIONAL CHART. By David Shaw Lewis. Erie, Pa., David Shaw LewisMUSIC IN INSTITUTIONS. By Willem Van de Wall, assisted by Clara Maria Liepmann.YOUR WORK ABILITIES AND HOW TO EXPRESS AND APPLY THEM THROUGH MAN POWER SPECIFICATIONS. By A. W. Rahn.WHO ARE THE JOB SEEKERS? Directed by William H. Stead.FILLING NINE MILLION JOBS. Directed by William H. Stead.UNEMPLOYMENT AND INCREASING PRODUCTIVITY. By David Weintraub and Harold L. Posner.BUSINESS EDUCATION FOR EVERYBODY. Edited by H. G. Shields.

Dutch and Flemish Painters, by Carel van Mander, Translation from the Schilderboeck and introduction by Constant van de Wall

"Dutch and Flemish Painters, by Carel van Mander, Translation from the Schilderboeck and introduction by Constant van de Wall." Parnassus, 8(7), p. 36

THE USE OF MUSIC IN A CASE OF PSYCHO-NEUROSIS

Back to table of contents Previous article Next article ARTICLENo AccessTHE USE OF MUSIC IN A CASE OF PSYCHO-NEUROSISWillem Van De Wall, and Earl D. BondWillem Van De WallSearch for more papers by this author, and Earl D. BondSearch for more papers by this authorPublished Online:1 Apr 2006https://doi.org/10.1176/ajp.91.2.287AboutSectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail PDFThis content is only available as a PDF. Access content To read the fulltext, please use one of the options below to sign in or purchase access. Personal login Institutional Login Sign in via OpenAthens Purchase Save for later Item saved, go to cart PPV Articles - American Journal of Psychiatry $35.00 Add to cart PPV Articles - American Journal of Psychiatry Checkout Please login/register if you wish to pair your device and check access availability. Not a subscriber? Subscribe Now / Learn More PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development. Need more help? PsychiatryOnline Customer Service may be reached by emailing [email protected] or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.). FiguresReferencesCited byDetailsCited byNone Volume 91Issue 2 September 1934Pages 287-302 Metrics PDF download History Published online 1 April 2006 Published in print 1 September 1934

The Utilization of Music in Prisons and Mental Hospitals. By Willem van de Wall. New York: Published by the National Bureau for the Advancement of Music. Pp. 67. - Music in Correctional Institutions. The Musician's Contribution to Modern Mental Treatment. Music as a Means of Discipline. A Systematic Music Program for Mental Hospitals. Educational Features of an Institutional Music Program.

The Utilization of Music in Prisons and Mental Hospitals. By Willem van de Wall. New York: Published by the National Bureau for the Advancement of Music. Pp. 67. - Music in Correctional Institutions. The Musician's Contribution to Modern Mental Treatment. Music as a Means of Discipline. A Systematic Music Program for Mental Hospitals. Educational Features of an Institutional Music Program. Six pamphlets by Willem van de Wall. - Volume 74 Issue 306