In this paper, the stress and the local liquid residue of the diaphragm plug valve were simulated. Simulation of the diaphragm plug valve opening process was performed by using a bidirectional fluid-structure interaction based on dynamic mesh technique. The pressure and velocity distribution of the internal flow were obtained with boundary conditions for the fluid–structure interaction during the opening process. The finite element method was used to compare the equivalent stress with FSI method. The results indicate that mechanical tensile stress plays a prominent role in determining the equivalent stress of the diaphragm, with the highest stress concentration occurring in the root region. The electrolyte flow in the valve tends to be stable when reaching an opening degree of 56.6 %. Crystallization accumulation will occur due to the existence of vortices in the flow field around the diaphragm which affects the fluidity of the fluid, this area needs to be focused on.