Ternary hybrid nanofluid flow over a wedge surface facilitates optimization, promotes industrial processes such as heat transfer, temperature regulation, material compatibility, energy efficiency and is very useful in equipment design. Due to this attention the current study focalizes the heat diffusion and mass transportation in ternary hybrid (TiO2-AL2O3-SiO2) nanofluid flow over a stretching/shrinking wedge geometry. Additionally, Ternary hybrid flow is examined under the impact of activation energy together with chemical reactions. The nanofluid flow process is structured using Modified Boungiorno Model together with framed set of partial differential equation (PDEs). The resulting systems is altered into non dimensional form of ordinary differential equation (ODEs) using transform functions and linearization is obtained through shooting technique. MATLAB bvp4c solver scheme is utilized for numerical findings of the problem. Influence of key parameters are analyzed on velocity, temperature, and concentration field. Fluid concentration intensifies via augmentation in activation rate whereas wedge stretching due to larger values of wedge angle, lessens velocity of fluid. Heat transportation escalate with higher values of fluid index, whereas negative trend is seen in case of higher value of Brownian parameter.