Values Of Blood Parameters Research Articles

Multivariate analysis of blood parameters for predicting mortality in patients with hip fractures.

The present retrospective cross-sectional study aimed to evaluate the predictive value of blood parameters and ratios for predicting mortality in patients with hip fractures. In total, 758 patients with hip fractures attending the Department of Orthopedics and Traumatology, Kütahya Health Sciences University Faculty of Medicine (Kütahya, Turkey) between January 2016 and January 2023 were included in the present study. Patients were then divided into two groups, namely the mortality (n=464; 61.2%) and survivor (n=294; 38.8%) groups. Patients in the mortality group were further sub-divided into the following three subgroups: i) Those who succumbed in <1 month (n=117; 25.2%); ii) those who succumbed between 1 and 12 months (n=185; 39.9%); and iii) those who succumbed >12 months later (n=162; 34.9%). In addition, the RDW coefficient of variation, mean platelet volume (MPV), MPV/platelet ratio, neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, platelet-to-lymphocyte ratio (PLR), mean platelet volume-to-lymphocyte ratio and monocyte-to-eosinophil ratio means were all found to be significantly higher in the mortality group (P<0.05). MPV (P<0.01), HGB (P<0.05), eosinophil, EOS (P<0.01), HRR (P<0.01), and PLR (P<0.05) were all revealed to exert significant effects on mortality. An age cut-off of 74.50 years had a sensitivity of 81.5% and specificity of 37.1%, whereas an MPV cut-off of 8.85 yielded a sensitivity of 73.5% and specificity of 36.1%. By contrast, an HGB cutoff of 11.05 had a sensitivity of 55.6% and specificity of 35.7%, an eosinophil cut-off of 0.065 had a sensitivity of 47.6% and specificity of 35.4%, whilst a HRR cut-off of 0.7587 had a sensitivity of 55.2% and specificity of 30.3%. Furthermore, a PLR cut-off of 152.620 had a sensitivity of 67.2% and specificity of 41.8% for hip fracture-associated mortality. An age cut-off of 79.50 years had a sensitivity of 70.9% and specificity of 41.5%, while an age cut-off of 83.50 years had a sensitivity of 46.2% and specificity of 64.0% for mortality occurring <1 month after hip fractures. To conclude, results from the present study suggested that HRR has potential predictive value for hip fracture-associated mortality and 30-day mortality, whereas the PLR could only predict hip fracture-associated mortality.

Immunological indicators of the risk of the transition from chronic gastritis to gastric ulcer in adolescents

As is known, gastric ulcer (GCC) and duodenal ulcer (duodenal ulcer) are chronic, complex-etiology diseases, the mechanism of which is based on complex transformations of nervous, hypothalamic-pituitary, hypothalamic-pituitary-adrenal and local gastroduodenal processes that lead to a change in trophism in the mucous membrane of the stomach and duodenum. In turn, the incipient ulcerative defect is a source of irritation of the enteric receptors, supporting disorders of neurohormonal regulation. Thus, the resulting “vicious circle” causes the chronic course of peptic ulcer disease. During the study of chronic diseases of gastroduodenal localization, including peptic ulcer disease, many doctrines of its occurrence have been proposed. However, the issue of the origin of peptic ulcer disease still remains insufficiently studied; approaches and tactics for managing patients with erosive and ulcerative lesions of the upper gastrointestinal tract are being developed. The aim of the study was to evaluate immunological indicators that determine the risk of chronic gastritis turning into gastric ulcer. The study included 120 children aged 14-17 years, permanently residing in the Bukhara region of the Republic of Uzbekistan. Taking into account the importance of H. Pylori in the development of HCG, patients were distributed depending on the association of HCG with H. Pylori. To study cytokines, blood tests of patients were performed to determine the titer of antibodies (IgG and IdM) to H. Pylori, immunoglobulins A, M, G in blood serum, secretory IgA in oral fluid, IL-1β, IL-10, TNFα, VEGF in the serum of patients. At the same time, blood sampling was carried out in the periods before and 3 weeks (21 days) after treatment. Thus, the study of the value of immunological blood parameters in the progression of HCG to gastric ulcer disease dictates the need to develop immunological indicators for predicting the progression of HCG to gastric ulcer in adolescents. An increase in TNFα levels indicates a high risk of developing gastric ulcer as a result of vascular damage and impaired local circulation. In the study, an established increase in the level of IL-1β indicates activation of the synthesis of proinflammatory cytokines in HCG, especially in HCG associated with H. Pylori. The use of these recommendations contributes to the monitoring of HCG, improving the effectiveness of diagnosis and the correct choice of treatment for patients with HCG, reducing mortality and disability at the same time.

Potential Impacts of Dried Green Coleus forskolin Leaves on Thermo-tolerance Parameters, Blood and Plasma Profiles in Anesthetized Mice

Background: Transient negative side effects of hypothermia, hyperglycemiaand bradycardia due to general anesthesia using diazepam and xylazine drugs has been reported in mice. Methods: Twenty albino male mice of 31.52±0.25 g body weight were classified into two groups; control group (G1) fed basal control diet versus C. forskolin group fed basal control diet containing C. forskolin leaves (G2; 1.5%) for four weeks. The mice were general anesthetized using xylazine and diazepam (XD) drugs (13.3 mg/kg BW diazepam and 26.6 mg/kg BW xylazine). Changes of rectal temperature (°C), glucose (mg/dl), pulse rate (pulse/min.) and partial pressure of oxygen (SPO2) were recorded at 0.0, 0.5h, 1.0h, 2.0h, 3.0h, 5.0h and 7.0h over general anesthesia. In addition, blood samples were collected and were subjected to blood and plasma analyses. Result: The results indicated that dietary C. forskolin caused significant decrease (P less than 0.05) in glucose values in addition to significant increase (P less than 0.05) in rectal temperature, pulse rate and SPO2 during the period hypothermia, hyperglycemiaand bradycardia over general anesthesia. In addition, values of blood (RBCs, WBCs, PCV and Hb) and plasma parameters (TP, BUN, creatinine, AST and ALT, LDH) were normal due to C. forskolin supplementation compared to control diet. It could be concluded that 1.5% C. forskolin supplementation modulates thermo-tolerance responses, blood glucose indices, blood and plasma metabolites over general anesthesia.

Prognostication in Epilepsy with Integrated Analysis of Blood Parameters and Clinical Data.

Background/Objectives: Determining the outcome of epilepsy is crucial for making proactive and timely treatment decisions and for counseling patients. Recent research efforts have focused on using various imaging techniques and EEG for prognostication; however, there is insufficient evidence regarding the role of blood parameters. Our study aimed to investigate the additional prognostic value of routine blood parameters in predicting epilepsy outcomes. Methods: We analyzed data from 1782 patients who underwent routine blood tests within 90 days of their first visit and had a minimum follow-up duration of three years. The etiological types were structural (35.1%), genetic (14.2%), immune (4.7%), infectious (2.9%), and unknown (42.6%). The outcome was defined as the presence of seizures in the last year. Results: Initially, a multivariate analysis was conducted based on clinical variables, MRI data, and EEG data. This analysis revealed that sex, age of onset, referred cases, epileptiform discharge, structural etiology, and the number of antiseizure medications were related to the outcome, with an area under the curve (AUC) of 0.705. Among the blood parameters, fibrinogen, bilirubin, uric acid, and aPTT were significant, with AUCs of 0.602, 0.597, 0.455, and 0.549, respectively. Including these blood parameters in the analysis slightly improved the AUC to 0.710. Conclusions: Some blood parameters were found to be related to the final outcome, potentially paving the way to understanding the mechanisms of epileptogenesis and drug resistance.

Routine blood parameters as auxiliary diagnostic tools for Mycoplasma pneumoniae infection in children.

Introduction. Recently, the incidence of Mycoplasma pneumoniae (M. pneumoniae) infection in children has been increasing annually. Early differential diagnosis of M. pneumoniae infection can not only avoid the abuse of antibiotics, but also is essential for early treatment and reduction of transmission.Gap statement. The change of routine blood parameters may have important clinical significance for the diagnosis of M. pneumoniae infection, but it has not been reported so far.Aim. This study aims to establish a predictive model for M. pneumoniae infection and explore the changes and clinical value of routine blood parameters in children with M. pneumoniae infection, serving as auxiliary indicators for the diagnosis and differentiation of clinical M. pneumoniae infection.Methodology. A total of 770 paediatric patients with respiratory tract infections were enrolled in this study, including 360 in the M. pneumoniae group, 40 in the SARS-CoV-2 group, 200 in the influenza A virus group, and 170 in the control group. The differences of routine blood parameters among all groups were compared, and risk factors were analysed using multivariate logistics analysis, and the diagnostic efficacy of differential indicators using ROC curves.Results. This study revealed that Mono% (OR: 3.411; 95% CI: 1.638-7.102; P=0.001) was independent risk factor associated with M. pneumoniae infection, and Mono% (AUC=0.786, the optimal cutoff at 7.8%) had a good discriminative ability between patients with M. pneumoniae infection and healthy individuals. Additionally, Mono% (OR: 0.424; 95% CI: 0.231-0.781; P=0.006) and Lymp% (OR: 0.430; 95% CI: 0.246-0.753; P=0.003) were independent risk factors for distinguishing M. pneumoniae infection from influenza A virus infection, and the Lymp% (AUC=0.786, the optimal cutoff at 22.1%) and Net% (AUC=0.761, the optimal cutoff at 65.2%) had good discriminative abilities between M. pneumoniae infection and influenza A infection. Furthermore, platelet distribution width (OR: 0.680; 95% CI: 0.538-0.858; P=0.001) was independent risk factor for distinguishing M. pneumoniae infection from SARS-CoV-2 infection. Meanwhile, the ROC curve demonstrated that PDW (AUC=0.786, the optimal cutoff at 15%) has a good ability to differentiate between M. pneumoniae infection and SARS-CoV-2 infection.Conclusion. This study demonstrates that routine blood parameters can be used as auxiliary diagnostic indicators for M. pneumoniae infection and provide reference for the diagnosis and differentiation of clinical M. pneumoniae infection.

A preliminary prediction model of pediatric Mycoplasma pneumoniae pneumonia based on routine blood parameters by using machine learning method

BackgroundThe prevalence and severity of pediatric Mycoplasma pneumoniae pneumonia (MPP) poses a significant threat to the health and lives of children. In this study, we aim to systematically evaluate the value of routine blood parameters in predicting MPP and develop a robust and generalizable ensemble artificial intelligence (AI) model to assist in identifying patients with MPP.MethodsWe collected 27 features, including routine blood parameters and hs-CRP levels, from patients admitted to The Affiliated Dazu’s Hospital of Chongqing Medical University with or without MPP between January, 2023 and January, 2024. A classification model was built using seven machine learning (ML) algorithms to develop an integrated prediction tool for diagnosing MPP. It was evaluated on both an internal validation set (982 individuals) and an external validation set (195 individuals). The primary outcome measured the accuracy of the model in predicting MPP.ResultsThe GBDT is state-of-the-art based on 27 features. Following inter-laboratory cohort testing, the GBDT demonstrated an AUC, accuracy, specificity, sensitivity, PPV, NPV, and F1-score of 0.980 (0.938–0.995), 0.928 (0.796–0.970), 0.929 (0.717-1.000), 0.926 (0.889–0.956), 0.922 (0.727-1.000), 0.937 (0.884–0.963), and 0.923 (0.800-0.966) in stratified 10-fold cross-validation. A GBDT-based AI Lab was developed to facilitate the healthcare providers in remote and impoverished areas.ConclusionsThe GBDT-based AI Lab tool, with high sensitivity and specificity, could help discriminate between pediatric MPP infection and non-MPP infection based on routine blood parameters. Moreover, a user-friendly webpage tool for AI Lab could facilitate healthcare providers in remote and impoverished areas where advanced technologies are not accessible.

Use of blood parameters for the prediction of mortality in patients with below‑knee amputation.

The present retrospective study aimed to investigate the value of blood parameters in predicting mortality in patients with below-knee amputation (BKA). A total of 178 patients with BKA were included in the present study. The patients were divided into two groups, namely the exitus group (n=136; 76.4%) and the survivors group (n=42; 23.6%). Patients in the exitus group were further divided into three subgroups: i) Those who experienced mortality in <1 month (n=55; 40.4%); ii) those who experienced mortality between 1-12 months (n=48; 35.3%); and iii) those who experienced mortality in >12 months after surgery (n=33; 24.3%). Binary logistic regression and a generalized linear model were used for relational analysis, and a receiver operator characteristic curve was used for diagnostic tests. It was found that the parameters of age (B=0.061; P=0.01), eosinophil-to-lymphocyte ratio (ELR) (B=-2.861; P<0.05), C-reactive protein (CRP)/albumin ratio (B=0.027; P<0.01) and mean platelet volume (MPV)/lymphocyte ratio (B=0.310; P<0.01) had a significant effect on mortality at the multivariate level. Moreover, regression coefficients showed that the effect of age, CRP/albumin and MPV/lymphocyte ratios on mortality were positive, whereas the effect of the ELR was negative. The mortality predictive values of age [area under the curve (AUC)=0.681; P=0.01], ELR (AUC=0.630; P=0.01), CRP/albumin ratio (AUC=0.746; P=0.01) and MPV/lymphocyte ratio (AUC=0.676; P<0.01) were also found to be statistically significant. For the 27.51 CRP/albumin cut-off value, the sensitivity was found to be 80.1%, whereas the specificity was 54.8%. For the 36.93 CRP/albumin cut-off value, the sensitivity was 71.3%, and the specificity was 73.8%. Furthermore, MPV (B=-0.37; P<0.01) and hemoglobin/red-blood-cell distribution width (RDW) ratio (B=5.20; P<0.01) were found to have a significant effect on the time to death at the multivariate level. The parameters MPV (AUC=0.648; P<0.01) and hemoglobin/RDW (AUC=0.673; P=0.01) had predictive value in terms of the time to death. The predictive value for MPV was found to be 64.8%, whereas that for the hemoglobin/RDW ratio was 67.3%. For the 0.54 cut-off value for hemoglobin/RDW, the sensitivity was 74.5%, and the specificity was 11.1%. By contrast, for the 0.84 cut-off value for the hemoglobin/RDW ratio, the sensitivity was 10.9% and the specificity was 81.5%. In conclusion, the CRP/albumin ratio was identified as a significant mortality parameter, whereas the hemoglobin/RDW ratio was a significant time to death predictor, according to the results of the present analysis. These results may guide clinical practices and further research in terms of predicting mortality in patients with BKA.

The Role of Lepidium Sativum as Free Radical Scavenger in Laboratory Mice

Background: Lepidium sativum is a by-product remaining after the oil is extracted from Garden cress seeds. This herb is considered one of the popular medicinal herbs used in Arabian countries and has traditionally been used to control many clinical problems. The present study aims to uncover these seeds' free radical-scavenging properties and their Role in improving the testicular tissues and seminal properties. Material and Methods: Thirty-two sexually mature mice were used, and the treated groups were divided into three groups; the first one (G1) was treated with 0.1 ml of GC seed extraction in a dose of 5mg/kg BW, the second one(G2) was treated with 0.1 ml sodium nitrate as oxidant, and the last treated group (G3) was treated with 0.1 ml of GC seed extraction after one hour of injection of 0.1 ml sodium nitrate. Results: The results showed improvement of the testicular tissue and a significant elevation in sperm viability, in addition to significant enhancements of RBC count and Hb concentration. By its Role as a free radical scavenger, sodium nitrate removed the negative effect on blood parameter values.

Nutrient utilization, growth performance, and antioxidative status of Barki lambs fed diets supplemented with black (Nigella sativa) and rocket (Eruca sativa) seeds

The current study aimed to determine the polyphenol compounds in Nigella sativa (NS) and Eruca sativa (ES) seeds, and evaluate the impact of their addition either as a sole additive or in combination on the growth performance, digestibility, some rumen and blood parameters and antioxidative status of Barki lambs. Forty-eight male lambs (27.18 ± 0.22 kg, 5–6 months), were divided into 4 balanced groups. The experimental diets were randomly distributed to the control group (CON); fed alfalfa hay plus concentrate feed mixture at a ratio of 30:70% without additives, while, NSD, ESD, and NESD groups: fed CON diet plus 2% NS, 2% ES or 1% NS + 1% ES, respectively as a ratio from total mixed ration (TMR). Results indicated that rutin and catechin were the most phenolic compounds observed either in NS or ES seeds. The NS and ES-supplemented groups recorded the highest (P < 0.05) values for dry matter digestibility, nutritive values, average daily gain, and the best feed conversion ratio. However, growth performance, nutritive value, and all nutrient digestibility except for dry matter were not significantly altered with the NESD group. Concentrations of ruminal NH3-N and TVFA were significantly (P < 0.05) reduced with the NESD group, with no significant differences in pH values among different groups. Values of blood parameters showed significant increases in WBCs, PCV, and T-AOC, and decreases in cholesterol, triglycerides, and MDA with the addition of NS and ES seeds or both. Therefore, the addition of NS and ES seeds is recommended to improve lambs’ health and antioxidant status.

Single-Dose Oral Toxicity Study of Chloroform Extract of Kaffir Lime (Citrus hystrix DC.) Leaves in Wistar Rats (Rattus norvegicus Berkenhout, 1769)

Leaves of kaffir lime (Citrus hystrix) are commonly used as a seasoning in various Indonesian and Southeast Asian dishes. Phytochemical studies reported various secondary metabolites that possess medicinal properties. Before exploring their potential as therapeutic agent, a series of toxicity studies must be conducted to assess the toxicity and safety levels. This research aimed to study the single-dose acute oral toxicity of chloroform extract of kaffir lime leaves (CECHL) in female Wistar rats (Rattus norvegicus) as experimental animals. The procedure followed OECD Test Guideline No.420 with the dose 2000 mg/kg bw for 14 days (Sighting study). Parameters consisted of mortality, clinical signs of sublethal effect based on changes in general appearance and daily activity/behavior, hematological profile, and blood clinical biochemistry. Neither mortality nor sublethal effects were found during the experiment. All blood parameter values (erythrocytes, leukocytes, thrombocytes, ALT, AST, creatinine, BUN, glucose, cholesterol, and triglycerides) were within reference interval, indicating that CECHL is not harmful to normal physiology. In conclusion, single-dose oral administration of CECHL is safe, no-observed-adverse-effect-level (NOAEL) at dose 2000 mg/kg bw or included in Category 5 based on the Globally Harmonized System of Classification and Labeling of Chemicals (GHS).

The predictive value of peripheral blood CD4 cells ATP concentration for immune-related adverse events in advanced non-small cell lung cancer patients

ObjectiveLung cancer with the highest incidence and mortality in the world. Immune checkpoint inhibitors (ICIs), can bring long-term survival benefits to patients, but also can bring immune-related adverse events (irAEs) in some patients during therapy. Therefore, the aim of this study was to investigate the predictive effect of peripheral blood WBC, NLR, sATPCD4 and nATPCD4 on irAEs in advanced non-small cell lung cancer (NSCLC).MethodsClinical data of 112 patients with advanced NSCLC who were treated with PD -1/PD -L1 inhibitor in the Fifth Affiliated Hospital of Guangzhou Medical University from December 15, 2019 to April 30, 2023 were retrospectively analyzed. These patients were divided into the irAEs group (n = 27) and non-irAEs group (n = 85). The clinical data of the two groups were compared. Receiver operating characteristic (ROC) curves were drawn to determine the threshold value of baseline peripheral blood parameters to predict the occurrence of irAEs. Multivariate logistic regression analysis was used to explore the relationship between peripheral blood markers and the incidence of irAEs.ResultsThe patient characteristics have no significant difference between irAEs and non-irAEs group. But the baseline peripheral blood WBC, sATPCD4 and nATPCD4 of patients in the irAEs group were higher than those in the non-irAEs group (p < 0.05), and the NLR in irAEs group was similar to in the non-irAEs group (p = 0.639).Univariate analysis showed that high WBC, sATPCD4 and nATPCD4 may the risk factors for the occurrence of irAEs (p < 0.05). Multivariate logistic regression analysis showed that high sATPCD4 and nATPCD4 were independent risk factors for the occurrence of irAEs (p < 0.05). The best critical values of WBC, sATPCD4 and nATPCD4 before treatment for predicting the occurrence of irAEs were 8.165 × 109cells/L (AUC = 0.705) ,484.5 ng/mL (AUC = 0.777), and 156 ng/mL (AUC = 0.840), respectively.ConclusionssATPCD4 and nATPCD4 were independent risk factors for the occurrence of irAEs in advanced NSCLC patients. This discovery provides a new method to predict the occurrence of irAEs in patients. Based on the prediction results, corresponding treatment measures can be taken to reduce the incidence of adverse events.

Features of blood morphological and biochemical parameters of yaks of the new Bay-Talsky type in the Republic of Tyva

The purpose of this research was to study the morphological and biochemical parameters of Bay-Talsky type yaks bred in the Bay-Tal yak breeding enterprise located in the Bay-Taiga mountain range. The BayTal type yak was created on the basis of purebred breeding in the Sarlyk breed in 2021. 43 heads of yaks of 18 months of age were used as experimental animals, from which two groups of yaks were formed, of which 23 heads of a new intra-breed Bay-Tal type and 20 heads of yaks of the Sarlyk breed. Of the yaks indicated in this experiment, blood counts were previously studied only in yaks of the Sarlyk breed. We have conducted the study of morphological and biochemical parameters of the Bay-Tal type yaks for the first time. As a result of the study, it was revealed that the average values of blood parameters in yaks were within the physiological norm. Nevertheless, the Bay-Tal yaks showed a higher level of hemoglobin – by 9.8% (P&lt;0.05), the content of erythrocytes – by 10.9% (P&lt;0.05) and leukocytes – by 34.4% (P&lt;0.01) compared with Sarlyk yaks. Along with morphological parameters, the yaks of the new Bay-Tal type are characterized by a high content of biochemical blood parameters: total protein - by 16.4% (P&lt;0.05), urea – by 40.6% (P&lt;0.01), cholesterol and glucose – by 60% (P&lt;0.001). The results obtained are important for establishing the average population level of a number of morphological and biochemical blood parameters in Bay-Tal yaks.

Acute exposure to fluoxetine leads to oxidative stress and hematological disorder in Danio rerio adults

Fluoxetine (FLX), a selective serotonin reuptake inhibitor (SSRI), is consistently introduced into the environment due to its ongoing consumption and inadequate removal by wastewater treatment plants. As a result, the scientific community has displayed a keen interest in investigating the potential toxicological effects associated with this medication. Nevertheless, there is a scarcity of available data regarding the impact of FLX on blood parameters. With this in mind, this study aimed to evaluate the potential toxicological consequences of FLX at environmentally significant concentrations (5, 16, and 40 ng/L) following a 96-hour acute exposure blood parameters in Danio rerio fish. Moreover, the investigation encompassed an assessment of oxidative stress parameters to determine whether the drug could induce disruptions in the REDOX status of the fish. The findings unveiled that FLX prompted the induction of oxidative stress in various organs of the fish, encompassing the liver, gut, brain, and gills. Notably, the gills and brain exhibited heightened susceptibility to the drug's effects compared to other organs. Furthermore, following acute exposure to FLX, there was an upregulation of antioxidant-related genes (sod, cat, gpx, nrf1, and nrf2), thereby providing additional evidence supporting the induction of oxidative stress in the organs of the fish. Lastly, FLX significantly impacted the customary values of various blood parameters, including glucose, blood urea nitrogen, alanine aminotransferase, alkaline phosphatase, red blood cell count, hemoglobin, and hematocrit. Thus, it can be inferred that FLX harmed the overall health status of the fish, resulting in the development of liver disease, anemia, and other associated illnesses.

Impact of Water Pollution on Fish Physiology - A Study

The freshwater air-breathing teleost, Channa punctatus were exposed to mercuric chloride (0.15 ppm) and cadmium chloride (35.5 ppm) for 1, 2, 7, 15 and 30 days so as to determine short and long-term effects of sub-lethal doses of these industrial pollutants on different haematological parameters. The selection of pollutants and their concentrations was based on the real data, in relation to the degree of water pollution of Damodar River. Blood samples were collected from the fishes exposed to various exposure periods for each pollutant and the blood glucose, haemoglobin content, cholesterol, HDL-cholesterol, LDL- cholesterol, VLDL- cholesterol, triglycerides, total RBC and WBC counts were measured. The blood glucose, haemoglobin content, total RBC and WBC counts progressively decreased. Blood cholesterol, HDL-cholesterol, LDL- cholesterol, VLDL-cholesterol and triglycerides were also depleted. Linear regression analysis with appreciable values of R2 and tratios revealed that the values of different blood parameters were reduced radically with the progress of days, except haemoglobin, signifying negative impact of pollutant of HgCl2. Strong correlation between different blood parameters calls for that adverse variations. Histopathological changes in the hepatopancreas induced by the heavy metals like mercuric chloride and cadmium chloride include degeneration of hepatic cells, clumping of cytoplasmic materials, displacement of nucleus towards the periphery, derangement of the pancreatic acini and coagulation of blood in the sinusoids. Analysis of experimental data suggests the depletion of energy resources and disturbance of the metabolic pathway as indicated by the adverse effects on haematological parameters and histopathological lesions in the haepatopancreas.

Red Cell Distribution Width, Mean Platelet Volume, and Neutrophil/Lymphocyte Ratio in Patients With Irritable Bowel Syndrome.

Introduction Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder characterized by persistent abdominal pain and variable bowel patterns, impacting individuals' quality of life. Despite its functional nature, recent research has indicated the role of inflammatory processes in IBS development. This study aims to investigate the potential diagnostic value of routine blood parameters and their relationship with IBS. Methods In this retrospective analysis, patients diagnosed with IBS based on the ROME IV criteria were identified from the outpatient clinic of Hitit University Erol Olçok Teaching and Research Hospital between January 1, 2023, and May 1, 2023. Exclusion criteria encompassed specific medical conditions, psychiatric disorders, and organic bowel pathologies. A cohort of 100 IBS patients and 100 healthy controls were included for comparison. Comprehensive blood data, including neutrophil count, lymphocyte count, hemoglobin level, red cell distribution width (RDW), mean corpuscular volume (MCV), mean platelet volume (MPV), and platelet count, were collected. Statistical analyses were conducted using SPSS for Windows version 26.0 (IBM Corp., Armonk, NY). Descriptive statistics, Pearson's or Spearman's correlation coefficients, Mann-Whitney U test, and Chi-square test were used to analyze data. Results The study cohort consisted of 70 men (35%) and 130 women (65%). The average age was 51.65 ± 14.64 years (52 years). The mean neutrophil count was 4.6 ± 1.5 (4.29) in the control group and 4.7 ± 2.03 (4.12) in the IBS group. The mean lymphocyte count was 2.3 ± 0.86 (2.21) in the control group and 2.3 ± 0.82 (2.23) in the IBS group, indicating no statistically significant difference (p = 0.732). The mean RDW was measured as 13.62 ± 1.07 (13.4) in the control group and 13.68 ± 1.18 (13.55) in the IBS group, again demonstrating no significant difference (p = 0.915). Mean MCV and MPV values showed no substantial variation between the control and IBS groups (p = 0.649 and p = 0.406, respectively). Conclusion While this study did not yield statistically robust outcomes, it underscores the potential of utilizing neutrophil-to-lymphocyte ratio (NLR), RDW, and MPV as adjunctive diagnostic markers for IBS. These routine and cost-effective parameters could enhance the diagnostic process, especially in cases with suspected IBS. Continued research is essential to unravel their complete diagnostic potential and clinical applicability.

A rare case of acute osteomyelitis in a 13-year-old with physeal involvement

Osteomyelitis of epiphyses in adolescents is a rare finding. We evaluate one such case in which high degree of clinical suspicion and prompt surgical intervention yielded good functional results. This is a case report of 13-year-old girl diagnosed with osteomyelitis of right knee. MRI is suggestive of physeal involvement. Physeal involvement makes the management very challenging. Surgical intervention was planned to reduce bacterial load and minimize possibility of damage to knee joint (articular cartilage and joint capsule). Lateral and posterior compartment of leg was decompressed, fibular osteotomy done, drilling in tibial epiphyseal and metaphyseal region of tibia done avoiding any injury to growth plate. Pus for culture and sensitivity and specific antibiotics started with monitoring of blood parameters for infection like ESR, CRP, TLC. Patient taken up for second debridement after one week of index surgery. After 6 weeks of intravenous antibiotic patient discharged in afebrile state with reduced values of blood parameters and acceptable range of knee movement. Lower extremity functional scoring (LEFS) of 45/80 i. e., 56.83 % at the end of 4 months. Good functional outcome at the end of 1 year. Early clinical suspicion with prompt investigation, surgical and medical management gives promising result.

Blood Parameter Profiles and Their Clinical Implications in Hypertensive Patients: A Retrospective Chart Review.

Introduction Hypertension (HTN) is a chronic condition that serves as a major risk factor for cardiovascular diseases, leading to increased mortality and morbidity. It is a frequent modifiable illness affecting global health, resulting in catastrophic fatalities and morbidity. Aim This study aims to investigate blood parameter profiles and their clinical implications in hypertensive patients at the Prince Faisal bin Khalid Cardiac Center in Abha, Saudi Arabia. Methods Utilizing retrospective data from 121 patients at the Prince Faisal bin Khalid Cardiac Center in Abha, Saudi Arabia. The hematological parameter examined were hemoglobin (HB), platelets, hematocrit (HCT), calcium, phosphorus, sodium, potassium, urea, creatinine, and uric acid. The SPSS version 28 software was used for data analysis. Results Significant correlations between various hematological parameters were found in the results, pointing to potential connections between kidney function, the production of blood cells, and electrolyte balance in hypertensive patients. The results align with earlier studies carried out in the area and offer insightful information for clinicians and researchers interested in managing HTN and its complications. Conclusion The study emphasized the significance of considering hypertensive patients' age, gender, and lifestyle when interpreting their blood parameter profiles. The findings imply that a thorough comprehension of these blood parameter values and their potential effects on HTN is necessary for effectively managing HTN in this population. This study on the blood parameter profiles in hypertensive patients in Saudi Arabia provides the relationships between various hematological parameter and their clinical implications. These findings should be considered when creating targeted interventions and strategies to address the specific requirements and difficulties of managing HTN and its associated complications in this population. More research is required to comprehend the underlying reasons for the observed variations in hematological parameter profiles and their effects on the management of HTN.

Over tümörlerinin ayırıcı tanısında sistemik inflamatuar belirteçlerin rolü

Aim: The aim of this study is evaluating the predictive value of preoperative inflammatory blood parameters for differential of serous cystadenoma, serous borderline ovarian tumor (BOT) and high-grade serous ovarian (HGSOC) carcinoma.&#x0D; Materials and Method: In this single-center study, we retrospectively enrolled 370 patients with ovarian tumors were divided into three groups. The groups were classified as serous cystadenoma, serous BOT and HGSOC. The potential association of preoperative hemoglobin (Hb), red cell distribution width (RDW), Hb/RDW ratio, ratio of neutrophils to lymphocytes (N/L) and ratio of platelets to lymphocytes (P/L) were analyzed.&#x0D; Results: P/L and N/L were significantly lower in benign serous cystadenoma or serous BOT than HGSOC (p

Response Prediction Model of Atezolizumab plus Bevacizumab in Patients with Unresectable Hepatocellular Carcinoma: Multicenter Retrospective Study

Introduction: Atezolizumab plus bevacizumab (ATZ+BV) treatment has become the first-line regimen for unresectable hepatocellular carcinoma (u-HCC). Prediction of response to it might be clinically beneficial. Using peripheral blood parameters, we aimed to construct a prediction model for ATZ+BV treatment. Methods: Clinical records of 119 patients with u-HCC treated by ATZ+BV were retrospectively analyzed. The primary outcome measurement was defined as any-size reduction at the initial image evaluation. Using baseline values of peripheral blood parameters, a prediction model was constructed by univariate and multivariate logistic regression analysis. Validation was performed internally by bootstrap method. Results: The primary outcome was achieved in 46 patients. Univariate analysis showed that C-reactive protein (CRP), alpha-fetoprotein (AFP), des-gamma-carboxy prothrombin (DCP), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) were possible predictors. CRP and DCP, and NLR and PLR had correlation (correlation coefficient >0.3), so we used CRP and NLR as representative factors, respectively. Multivariate analysis constructed the following prediction model: Logit = 1.62–0.61×[CRP] −0.38×[Log₁₀AFP] −0.37×[NLR]. Bootstrapped median (95% confidence interval) of coefficients of CRP, Log₁₀AFP, NLR were −0.64 (−1.46 ∼ −0.11), −0.40 (−0.82 ∼ −0.03), and −0.38 (−0.74 ∼ −0.05), respectively. The area under the receiver operating characteristic curve (95% confidence interval) was 0.73 (0.60–0.80). Median overall survival of the favorably and unfavorably predicted groups were 17.0 and 11.0 months (p = 0.03), respectively. Discussion: In patients with u-HCC treated by ATZ+BEV, a prediction model constructed using baseline values of CRP, AFP, and NLR had impact on any-size reduction at the initial image evaluation and on prognosis.

Alterations and predictive value of blood routine parameters in patients with lupus enteritis: A retrospective study

Background Lupus enteritis (LE) is prone to incorrect and missed diagnoses. LE primarily occurs during the active stage of systemic lupus erythematosus (SLE), which often manifests with alterations in peripheral blood cell that may serve as indicators of disease activity and organ damage. This study aims to investigate the alterations and predictive value of routine blood parameters for LE diagnosis. Methods This exploratory study retrospectively analyzed the medical records of 36 patients with SLE who were admitted to Suining Central Hospital between January 2006 and April 2023. Additionally, a control group consisting of 72 SLE patients without LE, matched for sex and age, was enrolled. A comparison was made between the two groups regarding clinical characteristics and changes in routine blood parameters. Binary logistic regression and receiver operating characteristic (ROC) curve analyses were conducted to identify independent risk factors and evaluate their diagnostic performance for LE. Results The LE group exhibited significantly higher neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), along with a lower lymphocyte count (LYM), compared to the control group ( p &lt; .05). Binary logistic regression analysis revealed that NLR independently predicted the onset of LE, with an odds ratio of 1.347 and a 95% confidence interval of 1.070–1.696 ( p &lt; .01). ROC curve analysis demonstrated that NLR had an area under the curve of 0.68 for diagnosing LE ( p &lt; .05). When the cutoff value was set at 2.44, the Youden Index was only 0.31. Conclusion Significant differences were observed in several routine parameters between patients with LE and the control group, which can be attributed to the occurrence of LE during the active stage of SLE. However, only the NLR emerged as an independent risk factor for LE,and its predicting vulue for was insufficient; no blood routine parameter has been identified as an reliable predictor for LE.