Aim . The presented study aims to develop mechanisms for improving the efficiency of measures taken during the implementation of regional policies in the field of labor and employment. Tasks . Based on the analysis of scientific literature, the authors identify global and local trends in the labor market; determine positive and negative consequences of labor and employment trends for the economy; formulate recommendations for efficient regulation of the labor market at the regional level with allowance for the HR policies and strategies of enterprises and or- ganizations. Methods . This study is based on the analysis of the current laws and regulations and the prac- tices of implementing regional labor and employment policies in the subjects of the Northwest- ern Federal District (NWFD). The HR policy in the Northwestern Federal District at small, medium, and large enterprises operating in the field of innovation is examined by interviewing managers and HR experts. The authors also propose to study value orientations in the field of labor activity and professional preferences of the younger generation and older age groups. Results . Based on the results of the study, the authors formulate proposals that can improve the efficiency of interaction between stakeholders in the implementation of regional employment policies and regulation of labor relations. Conclusions . The study provides recommendations for improving the efficiency of state regula- tion of the regional labor market and implementing the national employment policy. After be- ing discussed by the expert community, these recommendations can most likely be successfully implemented at the regional level through educational activities and the work of specialized and interdepartmental commissions without significant financial and time expenditures. The proposed approaches are relevant due to the need to find new guidelines for the social policy and to react swiftly to emerging challenges and demands of labor market participants, while also making use of opportunities and prospects for the digitalization of the national economy.