ABSTRACT The study of patent value plays a significant role in technology planning and business strategy. However, the relations between patent value indicators and the performance of high-tech enterprises have not been fully explored in the literature, especially from the perspective of configuration thinking. To fill this gap, this study examines how various patent value indicators combine to affect the performance of high-tech enterprises. After considering the strategic, technological and protective dimensions of patenting, we conduct a comparative configurational analysis of high-tech start-ups and mature firms through a fuzzy-set qualitative comparative analysis (fsQCA) method. Result shows different pathways of high-tech start-ups and mature firms to obtain competitive advantage through patents, in which strategy-oriented patents lead to start-ups’ growth, whereas protection-oriented patents contribute to mature firms’ high performance. Further, we find five solutions of patent values through which high-tech start-ups can achieve high performance, yet only one for high-tech mature firms. This finding indicates that start-ups have more choices to promote firm performance by enhancing patent value. On the basis of this approach, we shed light on high-tech enterprises’ patent strategy formulating and technology planning.