Abstract This paper develops a new topology optimization approach for minimal compliance problems based on the parameterized level set method in isogeometric analysis. Here, we choose the basis functions as level set functions. The design variables are obtained with Greville abscissae based on the corresponding collocation points. The zero-level set boundaries are derived from the level set function values of the interpolation points in all knot spans. In the optimization iteration process, the whole design domain is discretized into two types of subdomains around the zero-level set boundaries, undesign area with void materials and redesign domain with solid materials. To decrease the size of equations and the computational consumptions, only the solid material area is recalculated and the void material area is discarded according to the high accuracy of isogeometric analysis. Numerical examples demonstrate the validity of the proposed optimization method.