Count Values Research Articles

Pengaruh Penggunaan Aplikasi Otentikasi dan Benefits Offered Terhadap Kepuasan Nasabah dalam Bertransaksi pada PT Taspen Persero Cabang Gorontalo

This research aims to. Analyze and find out how the use of authentication applications and benefits offered affect customer satisfaction. The population consists of 63,569 active pensioners at PT Taspen Persero Gorontalo Branch from 2019-2023, and the sample is 100 pensioners obtained using a purposive sampling technique. The analysis is done using a quantitative method using multiple linear regression analysis. According to the result, it shows that (1) the authentication application variable partially contributed a positive and significant effect on customer satisfaction with a significance level of 0.000 <0.05 and the value of table count, with the result of 2.727> 1.660. (2) the Benefits Offered variable partially contributed a positive and significant effect on customer satisfaction with a significance level of 0.008 <0.05 and the value of stable> count, with the result of 4.010 > 1,660. (3) it was simultaneously concluded that there was a positive and significant influence between the authentication application variable and the Benefits Offered variable on Customer Satisfaction with a significance level of 0.000 <0.05 and a value of Fiable Fcount, or18.328 3.09. The R square determination coefficient was 0.574, which means that the influence contribution percentage of the authentication application and Benefits Offered affects customer satisfaction by 57.4%. In other words, the correlation level of the R square value was sufficient, and the other 42.6% came from other variables that were not examined.

Innovative Personalized Medicine for Immunosuppressive Drugs Based on Novel Control Theory of Pharmacokinetics

Tacrolimus is widely recognized as an anti-rejection agent due to its immunosuppressive characteristics. It binds to the immunophilin FK506-binding protein (FKBP) and thus to calcineurin, and inhibits its activity. Tacrolimus' therapeutic concentration range in blood is narrow, and its pharmacokinetics are highly variable among individuals. First, because tacrolimus primarily distributes to red blood cells (RBCs), anemia and blood transfusions can cause fluctuations in tacrolimus blood concentrations. Variations in blood tacrolimus concentration significantly correlated with variations in RBC count, hemoglobin level, and hematocrit value, but not with variations in white blood cell or platelet counts. Interestingly, FKBP played an important role in tacrolimus distribution to RBCs. The effects of intracellular and extracellular FKBP levels on RBC distribution of tacrolimus in circulating blood were substantial. Secondly, proteins affecting pharmacokinetics can differ at the genetic level in their expression and functional potency. Genetic polymorphisms that influence tacrolimus pharmacokinetics have been reported. A polymorphism in the gene encoding the metabolic enzyme cytochrome P450 (CYP) 3A5 is a particularly influential factor affecting tacrolimus pharmacokinetics in Japanese patients. CYP3A5 polymorphisms correlated with individual differences in tacrolimus blood concentration changes after starting continuous infusion in allogeneic hematopoietic stem cell transplantation (HSCT) recipients. In addition, CYP3A5*3 polymorphism also correlated with differences in the frequency of acute graft-versus-host disease (GVHD) development in allogeneic HSCT recipients.

Evaluation of the immature granulocyte count in idiopathic sudden sensorineural hearing loss

Aims: The purpose of our study was to show whether the immature granulocyte count (IGC) can be used as a prognostic marker in idiopathic sudden sensorineural hearing loss (ISSNHL). Methods: This study is a retrospective case-control clinical study. Patients presenting to our clinic between June 2019 and June 2022, diagnosed with ISSNHL, and receiving the same treatment protocol were investigated. Preoperative complete blood count values of 40 normal individuals with normal hearing who presented to our clinic due to nasal septum deviation were adopted as the control group. Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) (platelet × neutrophil / lymphocyte) values were calculated in addition to IGC values in complete blood counts from the patient and control groups. The patient group was classified into treatment-responsive and non-responsive subgroups according to the results of audiological examinations performed after one month based on Siegel’s criteria. IGC, SII, NRL, and PLT values were compared between all groups. Results: Comparison of the patient and control group’s complete blood count data revealed higher leukocyte and neutrophil counts, IGC and also NLR, PLR, and SII values in the patient group compared to the control group. However, lymphocyte counts were lower in the patient group. None of the parameters previously emerging as significant in the data of patients with healing and non-healing idiopathic sudden hearing loss were statistically significant, and IGC is of no prognostic value in ISSNHL. Conclusion: IGC may be a novel and inexpensive indicator of ISSNHL and one easily determined with complete blood count, but it is of no prognostic value in the disease.

Analysis of Return on Asset and Inflation on Stock Returns in Telecommunication Sector Companies on IDX

Aims: The primary objective of this study was to assess the impact of return on assets (ROA) and inflation on stock returns for telecoms businesses listed on the IDX from 2019 to 2023. Study Design: This research is a quantitative study that intends to investigate the effect of Return on Asset and Inflation on Stock Returns. Place and Duration of Study: Indonesia Stock Exchange (IDX) between March to October 2024. Methodology: The research method used is descriptive method with a quantitative approach, with the classical assumption test data analysis method, multiple linear regression analysis and hypothesis testing. The sampling technique in this study was purposive sampling where only 10 of the 16 populations were sampled. Results: The Sig. result for ROA is 0.010 <0.05 and the t count value is 2.679> t table 2.012, meaning that ROA on variable Stock Return has a significant effect partially, while for inflation it is 0.011> 0.05 and the t count value is 2.657 > t table 2.012 means that Inflation on variable Stock Return does not have a significant effect partially. As for the F test results, the calculated F value is 6.233. While in the distribution table the value of F at a significant level of 5% is 3.195. The significant value is at a value of 0.004> 0.05, it can be concluded that ROA (X1), and inflation (X2) simultaneously have a significant effect on Stock Returns (Y). Conclusion: Both ROA and Inflation Partially has a negative and significant effect on stock returns. In addition, simultaneously the results showed that ROA and Inflation simultaneously had a significant effect on Stock Returns.

Correlation between Haematological Features and Severity of RT-PCR Positive COVID-19 Patients

Background: Haematological tests have an important role in early diagnosis of the COVID-19 patient’s disease condition, considering the information they provide to physicians regarding the inflammatory process. This information includes leukocyte count and characteristics such as neutrophil or lymphocyte-dominance, inflammation (CRP) Serum ferritin and coagulation profile (D-dimer). Aim of this study was to investigate the association of hematological parameters with severity of the disease and identify the association of magnitude of any cytopenia and pancytopenia with the severity of COVID-19 patients. Materials and methods: This prospective observational study was conducted at dedicated COVID unit of Chattogram Maa O Shishu General Hospital from March 2021 to August 2021. A total of 100 RT-PCR(+ve) COVID cases were included in this study. Automated hematology analyzer was used to determine complete blood count (Total WBC count, absolute and relative count of each WBC type, RBC, and platelet count). Results: Majority patient were female (61%). Among all patient 87% patients were above 35 years of age. Patient with mild disease were comparatively younger than patient with severe disease. Major presenting complaints were cough (88%) shortness of breath (60%) fever (59%) sore throat (30%) and fatigue (26%). Raised pulse and respiratory rate were seen according to disease severity. Total WBC (p=0.0038) Neutrophil (p=0.0001) serum ferritin (p=0.0205) CRP (p=0.0004) and Ddimer (p=0.0004) were significantly increased in severe group and the patient with critical condition. No statistically significant difference was seen in the median value of platelet count (p=0.4364). Conclusion: Leukocytosis, Neutrophilia, elevated serum ferritin, CRP and D-dimer are significantly increased in patients with severe and critical disease condition of COVID-19 patient. Lymphopenia also featured in these patients, which is associated with the severity of disease. Chatt Maa Shi Hosp Med Coll J; Vol.22 (2); July 2023; Page 8-13

Exploring Influenceability: Key Factors Shaping the Effectiveness of Social Media Influencer Endorsements

Purpose: This study explores how different factors collectively influence the effectiveness of social media influencer endorsements as well as shaping consumer behavior and brand perception.Study design/methodology/approach: The research employs a qualitative hybrid thematic approach, integrating inductive strategies from interviews with a deductive framework based on existing theories. This method allows for a thorough exploration of the factors affecting influencer endorsement effectiveness.Sample and data: The sample includes 14 female Instagram users, aged 18-30, selected through non-probability purposive sampling. Semi-structured interviews were used to gather data.Results: Four key themes emerged: Influencer Fame, Engagement, Credibility, and First Impressions. Fame is shaped by content quality, follower count, and message value. Engagement builds trust through interactive, meaningful content. Credibility is tied to perceived expertise, trustworthiness, and authenticity. First impressions strongly influence consumer perceptions.Originality/value: This study fills a gap by examining multiple factors simultaneously, offering a comprehensive understanding of influencer effectiveness and valuable insights for marketers seeking to refine their strategies.Research limitations/implications: The study’s qualitative nature and specific demographic limit generalizability. Future research with larger, more diverse samples and quantitative methods is recommended. Additionally, the fast-changing social media landscape may challenge the ongoing relevance of findings, suggesting the need for longitudinal studies.

THE INFLUENCE OF KURIKULUM MERDEKA ON THE UNDERSTANDING OF EDUCATIONAL CONCEPTS OF GRADE IV STUDENTS OF SDN 71 PALEMBANG

This study aims to determine the effect of Merdeka Curriculum learning on understanding the concept of education for fourth grade students of SD Negeri 71 Palembang. The Merdeka Curriculum is expected to increase student involvement and creativity in learning, especially in subjects that are often considered boring and theoretical. The method used in this research is a quantitative experiment with a pretest-posttest control group design. The research sample consists of two groups, namely the experimental group taught using the Merdeka Curriculum approach and the control group using conventional learning. Data were collected through multiple choice tests that measured students' understanding of the principles of Pancasila and citizenship. The results showed that learning with the Merdeka Curriculum had a significant effect on student understanding, with a t_count value of 12.430 which is greater than the t_table of 2.015. This study concludes that the application of Merdeka Curriculum can improve students' understanding of the concept of Citizenship, especially in understanding bad behavior in oneself and the environment.

Controlled Coffee Intake Enhances Erythrocyte Deformability, Na,K-ATPase Activity, and GSH/GSSG Ratio in Healthy Young Adults.

Published studies suggest that regular coffee consumption may reduce the risk of various diseases. However, many of these studies relied on questionnaire-based data, limiting their ability to identify the specific biological mechanisms behind the observed effects. This study focuses on controlled coffee consumption among healthy young adults to clarify its effects on erythrocyte properties. The functional condition of erythrocytes is important as it affects both macro- and microcirculation. Additionally, since erythrocytes are not true cells, they are particularly sensitive to biochemical and biophysical changes when exposed to biologically active substances. After a washout period, 33 healthy young volunteers were asked to consume a standardized dose of a coffee beverage daily for 3 weeks. Basic hematological and body composition parameters were recorded before and after the intervention. Erythrocyte functional status was evaluated based on the following measurements: deformability, osmotic resistance, Na,K-ATPase activity, and nitric oxide production, along with monitoring oxidative stress markers. After a coffee consumption period, both erythrocyte count and hematocrit value increased, while body composition remained unchanged. Erythrocyte deformability improved across a range of shear stress values typical of human circulation. This improvement was accompanied with enhanced Na,K-ATPase activity in erythrocyte membranes in the wide range of sodium ion concentrations, as well as increased nitric oxide production by erythrocytes. Additionally, a higher GSH/GSSG ratio, indicating a shift towards a more favorable antioxidant balance, was observed in erythrocytes following the coffee intake period. The results of this study suggest that controlled coffee intake in healthy young adults can positively influence various indices of erythrocyte functional status. Although the observed statistically significant changes were modest, the findings consistently indicate a positive modulation of erythrocyte properties-cell deformability, oxidative resilience, and active membrane transport of cations-following coffee consumption.

The Role of Aspartate Aminotransferase / Platelet Ratio Index Score in Predicting Intrahepatic Cholestasis of Pregnancy and its Relationship with Total Bile Acid Level: A Case-Control Study from a Tertiary Center

OBJECTIVES: The aim of this study is to examine the value of the first-trimester aspartate aminotransferase to platelet ratio index (APRI) score in predicting intrahepatic cholestasis of pregnancy (ICP) occurring later in pregnancy. Another aim of the study is to determine the relationship between APRI scores and total bile acid (TBA) levels in pregnant women with ICP. STUDY DESIGN: This retrospective case-control study was conducted by examining the hospital records of women diagnosed with ICP (n=66) and healthy controls (n=70) among women followed during pregnancy. Hemoglobin (Hb), platelet count (PLT), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) values of all patients were obtained from routine blood test data taken in the first and third trimesters. The first and third-trimester APRI scores of the patients were calculated. Demographic data, laboratory findings, and APRI scores of women with and without ICP during pregnancy were compared. Using Roc analysis, the values of AST, ALT, PLT values, and APRI scores were examined in predicting ICP among the first trimester findings of the patients. In addition, TBA levels of patients with ICP at the time of diagnosis were obtained from hospital records. The relationship between the first and third-trimester APRI scores and TBA levels in patients with ICP was evaluated using correlation analysis. RESULTS: In the first and third-trimester laboratory values, AST and ALT levels and APRI scores were found to be higher and PLT values were lower in patients with ICP compared to healthy controls. Among the first trimester measurements of these data, the APRI score had the highest predictive value in predicting ICP (AUC values are 0.648 for AST, 0.655 for ALT, 0.633 for PLT, and 0.705 for APRI). In an examination of patients with ICP, the APRI score calculated in the first and third trimesters showed a positive correlation with the TBA level at diagnosis (r=0.435 p<0.001 for the first trimester and r=0.433 p<0.001 for the third trimester in the Spearman analysis). CONCLUSIONS: In the future, the APRI score calculated in the first trimester of pregnancy may be used as a tool to predict ICP that may occur in the following weeks. There may be a positive correlation between APRI score and serum TBA level in patients with ICP.

PENGARUH RASIO PROFITABILITAS DAN RASIO AKTIVITAS TERHADAP PERTUMBUHAN LABA PADA PT GUDANG GARAM TBK PERIODE TAHUN 2013-2022

This research aims to determine the effect of the Profitability Ratio proxied by Net Profit Margin and the Activity Ratio proxied by Total Asset Turnover on PT Gudang Garam Tbk's Profit Growth, both partially and simultaneously. The population chosen was the financial report of PT Gudang Garam Tbk, with the sample used being the financial position report and profit and loss report for the 2013-2022 period. This research uses a quantitative approach and documentation data collection techniques. The analytical methods used are Multiple Linear Regression Analysis. Based on partial research results using the t test, it was concluded that Net Profit Margin had a significant effect on Profit Growth with a significance value of 0.001 < 0.05. Meanwhile, Total Asset Turnover has no significant effect on Profit Growth with a significance value of 0.413 > 0.05. Simultaneous test results (F test) show that Net Profit Margin and Total Asset Turnover together have a significant effect on Profit Growth with a significance value of 0.001 < 0.05 with an F_count value of 21.160 > F_table 4.74.

Aneuploid Circulating Endothelial Cells with Prognostic Value in Locally Advanced Breast Cancer Patients After Neoadjuvant Chemotherapy.

Aneuploid circulating endothelial cells (CECs) are an indicator in breast cancer (BC). Significant changes of aneuploid CECs occurred during neoadjuvant chemotherapy (NCT). This study aimed to explore the predictive and prognostic values of aneuploid CECs in locally advanced breast cancer (LABC) patients with different NCT responses. Breast cancer patients received an EC4-T4 NCT regimen. A novel subtraction enrichment and immunostaining fluorescence in situ hybridization (SE-iFISH) strategy was applied for the detection of CECs (CD45-/CD31+/DAPI+). Receiver operating characteristic (ROC) curves were plotted to evaluate the predictive value of aneuploid CEC counts in distinguishing NCT-resistant patients from sensitive ones. All patients were observed for progression-free survival (PFS) and overall survival (OS). The CEC counts at any time point did not show the ability to predict the efficacy of NCT. The difference in the CECs between post-chemotherapy levels and baseline could be sufficient to distinguish chemotherapy-resistant cases from other cases in Hormone+Her-2-/+ (HR+) BC patients. Patients with reduction of CECs after all courses of NCT were associated with higher probability of PFS. Variations in aneuploid CECs during NCT may predict chemotherapy response in patients with HR+ breast cancer. The decrease in the number of aneuploid CECs after all courses of NCT indicates better treatment outcomes in patients with LABC.

Estimation of HbA1c Levels in Transfusion-Dependent Thalassemia Patients in Comparison With Normal Healthy Individuals.

Introduction HbA1c values used for diagnosing and treating diabetes can be affected by factors such as red blood cell lifespan, hemolysis, red cell transfusion, and the presence of minor Hb species like HbA2 and HBF inhemoglobinopathies like sickle cell disease, homozygous HbC disease, HbSC disease, and β-thalassemia. This study aims to compare HbA1c levels in transfusion-dependent thalassemia (TDT) patients and healthy individuals. Materials and methods This is a cross-sectional comparative study. This study comprisestwopopulation groups. The first group includes 35 TDTpatients and the second group consists of 35 non-thalassemicindividuals who were matched for age (±1 year), gender, and BMI (±1 kg/m2). The patients were selected from the pediatric outpatient department (OPD), thalassemia ward in the pediatric department, and medicine OPD. Written informed consent/assent was obtained from the participants. A 3 ml fasting venous blood sample for fasting blood sugar(FBS), HbA1c, and complete blood count (CBC) values was obtained in ethylenediaminetetraacetic acid(EDTA) vials on the scheduled blood transfusion day (pretransfusion samples). Samples were then sent to an in-house accredited lab for testing and analysis. HbA1c was performed using the high-performance liquid chromatography (HPLC) technique. Data was compared using a t-test. Qualitative parameters were compared between groups by X2 square analyses. A multivariate linear regression model was used to explore the independent contribution of an individual predictor to HbA1c variability. Results In the study, 85.7% of patients with TDThad HbA1c levels in the diabetic range (>6.4%). In comparison, none of the control group patients had HbA1c values in the diabetic range. The mean HbA1c level was 6.94% in TDT cases and 5.3% in the control group, which was statistically significant (p < 0.001). Elevated FBS levels in the prediabetic range (>100 mg/dl, <126mg/dl) were observed in 25.7% TDT cases. All 35 controls had normal FBS levels(<100 mg/dl). No significant difference was found in FBS levels between cases (92.97 (±9.141) mg/dL) and controls (89.20 (±7.584) mg/dL) (p = 0.065). However moderately positive correlation exists between FBS and HbA1C (r =.470, p = 0.004) and between age and HbA1C (r = 0.335, p = 0.049). Conclusions The use of HbA1c as a screening tool for diabetes mellitus (DM) or assessment of glycemic control is inappropriate in TDT patients. The levels could be falsely elevated, as we found out in our study. In conditions where there is a mismatch between HbA1c and FBS levels, as seen in TDT patients, plasma glucose criteria should be used to diagnose diabetes. It is advised to use alternative indices such as fructosamine levels, glycated albumin, and continuous glucose monitoring.

Practicability of Serum Kallistatin Levels as a Biomarker in the Diagnosis of Tubo-Ovarian Abscess.

Objective: This study investigates the practicability of serum kallistatin as a biomarker in the diagnosis of tubo-ovarian abscess (TOA) because C-reactive protein (CRP) is insufficiently specific for diagnosis. Methods: Thirty patients (control group) who presented for elective gynecological surgeries and 30 who were hospitalized due to TOA (study group) at the Antalya Training and Research Hospital Gynecology Clinic, Türkiye, between January 1 and December 31, 2022, were included in the study. Blood samples were collected for the calculation of complete blood count, biochemistry, CRP, and serum kallistatin values, and the results were recorded in a database. Results: Although no significant differences were observed between the control and study groups in terms of age or body mass index, significant differences were observed in terms of marital status, number of pregnancies, parity number, intrauterine device history, and previous surgical history (p > 0.05). Serum hemoglobin levels (12.61 ± 1.30 vs. 11.47 ± 1.77; p = 0.008), white blood cell (7.9 [6.15 ± 9.7] vs. 17.0 [11.6-19.6]; p < 0.001), neutrophil (4.6 [3.6-6.12] vs. 13.6 [9.25-16.1]; p < 0.001), lymphocyte (2.51 ± 0.71 vs. 2.33 ± 0.69; p = 0.307), and platelet counts (285.63 ± 78.0 vs. 407.03 ± 131.96; p < 0.001), neutrophil-lymphocyte ratio (2.11 ± 0.93 vs. 6.18 ± 2.20; p < 0.001), neutrophil-lymphocyte ratio (123.16 ± 52.63 vs. 184.39 ± 63.90; p < 0.001), hs-CRP (1.20 [5.55-1.92] vs. 240 [138.25-291.0]; p < 0.001), kallistatin (7.18 ± 3.15 vs. 3.83 ± 3.69; p = 0.006), and urine leukocyte values (1 [0.75-3] vs. 3 [1-6.5]; p = 0.038) also differed significantly between the control and study groups. Conclusion: The study findings show that serum kallistatin levels can be used as a biomarker in the diagnosis of TOA. Further studies involving more participants are now needed to test the accuracy of our results.

Prevalence and predictors of precancerous cervical lesions among women living with HIV in Libreville, Gabon

BackgroundHIV-infected women are at an increased risk of developing precancerous cervical lesions (PCL) than non-infected women. In Gabon, no data exists on the prevalence of PCL among women living with HIV. The aim of this study was to assess the prevalence and risk factors associated with the development of PCL among HIV-positive women in Libreville, Gabon.MethodologiesThis was a retrospective study carried out within the Gynecology and Obstetrics Department of University Hospital Center of Libreville (CHUL) from January to August 2016. It included women registered at the HIV Clinic of Nkembo, and screened for PCL or cervical cancer (CC). Descriptive statistics were used to characterize sociodemographic data and the prevalence of PCL. The chi square and odd-ratio tests were used to evaluate the associations between PCL, CD4 count, antiretroviral use, age at first sexual intercourse, number of sexual partner tobacco, and contraception use.ResultsAmong the 115 HIV-positive women recruited, 33 (28.70%; SD ± 0.45) were diagnosed with PCL. 79.1% of them were on antiretroviral therapy (ART), and the mean CD4 cell count value was 411.74 cells/mm3 (SD ± 241.77). Being on ART, age, number of sexual partners, contraceptive use and smoking were not risk-factors linked with the development of PCL. CD4 cell count was the only associated risk-factors (p-value: 0.02).ConclusionThe incidence of PCL among HIV-infected is high in Libreville, Gabon, especially among those with baseline CD4 counts < 200 cells/mm3. This study recommends screening for cervical cancer for all HIV-infected women.

Effectiveness of partial splenic embolization in colorectal cancer patients with chemotherapy-induced thrombocytopenia: results of a single institution retrospective study.

To evaluate the safety and efficacy of partial splenic embolization (PSE) in treating chemotherapy-induced thrombocytopenia (CIT) in patients with colorectal cancer who failed to respond to platelet growth factor therapy. 56 patients who underwent PSE were retrospectively analyzed. Based on the inclusion and the exclusion criteria, 29 patients were eligible for the study, of whom one underwent twice PSE procedures due to recurrent thrombocytopenia. The clinical characteristics were retrospectively analyzed with respect to efficacy, safety and outcome. 60.0% of patients restarted antineoplastic therapy after PSE. There was a positive correlation between difference value of platelet count and embolization material size (Eta Squared = 0.252, p < 0.05). The correlation between the absolute volume of spleen embolized and postoperative complications was analyzed, with a statistically significant result (p < 0.001). The mean preoperative spleen volume, the preoperative platelet count, postoperative platelet count and difference value of platelet count in the non-cirrhotic group were larger than those in the cirrhotic group (p < 0.001). The mean overall survival was 47.7 ± 7.7 months. PSE is safe and effective in the treatment of CIT patients with colorectal cancer. The larger the embolized particle, the more platelets grew. The severity of complication was also positively correlated with the absolute volume of spleen embolized. Therefore, large particle embolization materials can be used to improve the efficacy of PSE and reduce complications. For CIT patients with cirrhosis, PSE was less effective in improving platelet count than those without cirrhosis.

The impact of multimorbidity on cardiac remodelling in the UK Biobank

Abstract Background/Introduction Previous work has suggested that multimorbidity is associated with higher all-cause mortality and cardiovascular mortality in the UK Biobank (UKB). The impact of multimorbidity on cardiac remodelling as measured by cardiovascular magnetic resonance (CMR) has not been studied in large cohorts. Purpose To determine if CMR biomarkers act as surrogates for adverse cardiovascular outcomes in multimorbidity. Method We analysed 44957 UKB participants who had CMR. Self-reported cancer (UKB field ID 20001) and non-cancer illnesses (UKB field ID 20002) were used to calculate comorbidity count with multi-morbidity defined as 2 or more illnesses. The predictive value of comorbidity count (exposure counts measured in quintiles) on CMR traits (outcomes) was evaluated using a univariable and multivariable generalised linear model. Covariates included sex, age, BMI, smoking status, regular alcohol intake, and the Townsend deprivation index, a measure of socioeconomic deprivation. The first model utilised univariable regression without covariates with subsequent iterations including age and sex and then all covariates. An interaction term was included for age and sex and a quadratic term for age in the models. CMR outcome measures were indexed left ventricular mass (LVM), indexed left ventricular end diastolic volume (LVEDV), indexed left ventricular end systolic volume (LVESV), indexed left ventricular stroke volume (LVSV), left ventricular ejection fraction (LVEF), global longitudinal strain (GLS), and indexed maximal left atrial volume (LA). The absolute value of GLS was used in the regression models. Variance inflation factor testing was used to check for collinearity. Analyses were completed using R v4.1.1. Results Median comorbidity count was 2. The burden of long-term conditions in this population of European ancestry with largely healthy individuals is lower than in other large population cohorts. Table 1 summarises multivariable analyses for comorbidity count, LVM and GLS. Due to high collinearity relating to age in the model, we centred age around the mean. LVM was higher with multimorbidity (top quintile Beta 0.63 (95% CI 0.23 to 1.04), P = 2.21x10-03). GLS was lower with multimorbidity (top quintile Beta -0.29 (95%CI -0.42 to 0.16), P = 8.10x10-6). LA volume was lower with multimorbidity (top quintile Beta -0.63(95% CI -1.22 to 0.04), P = 3.53 x 10-2). LVEF and other volume measures were not associated with multimorbidity. Conclusion Multimorbidity in this large cohort was associated with adverse cardiac structural and functional remodelling on CMR. These include a lower global longitudinal strain and higher LV mass.

The added value of device measured physical activity to the prediction of incident cardiovascular disease.

Abstract Background Conventional risk prediction models for Major Adverse Cardio/Cerebrovascular Events (MACCE) primarily rely on non-modifiable factors such as age, sex, and physiological measurements, including LDL/HDL cholesterol and blood pressure readings, that are prone to variations across medical practices and are often unavailable in many parts of the world. In this study, we investigate the potential of inexpensive wearable measurements of physical activity to enhance MACCE prediction when physiological measurements are unavailable. Purpose To assess the added value of physical activity measurements, collected via wrist-worn accelerometers, to established cardiovascular risk prediction models. Additionally, we seek to investigate whether physical activity measurements can substitute for common physiological measurements in established cardiovascular risk models. Methods We obtained accelerometer-measured physical activity over 7 days between 2013 and 2015 from 69,898 UK Biobank (UKB) participants without a prior history of MACCE, defined as death or hospitalisation due to (1) myocardial infarction, (2) heart failure, or (3) Stroke/transient ischaemic attack. We assessed the added value of daily step counts, sleep duration, and a deep learning-derived activity health score (Fig 1), calculated from complete 7-day accelerometer recordings, to established clinical risk models (SCORE2, QRISK3 and AHA) before and after excluding measurements of cholesterol and systolic blood pressure (SBP). The primary outcome was the first recorded MACCE within 6 years. Risk scores were developed in men and women using Cox proportional hazards models. We assessed predictive performance using Harrel’s C-index, net reclassification index (NRI), and net benefit at the recommended treatment threshold for each model. Results Of the 69,898 UKB participants in the study, 3,386 (4.8%) experienced a MACCE over a 6-year follow-up period. In place of HDL ratio and SBP, the addition of deep-learned activity health scores modestly improved performance in the best clinical baseline, QRISK3 for Female participants ΔC-index women:0.003 (95% CI 0.002-0.004); Δnet benefit 0.02(0.01-0.03); NRI 0.04, (0.02-0.07), and outperformed manually extracted steps and sleep measurements. We report no significant improvements for men. We find a greater increase in model performance when both HDL ratio and SBP, plus activity health scores, are included in the model. ΔC-index women:0.008, (0.007-0.009); men: 0.003 (0.002-0.004) (Fig 2). Conclusion Our findings indicate that in the absence of cholesterol and systolic blood pressure, the addition of device-measured physical activity modestly improves the performance of clinical risk scores among individuals without prior cardiovascular disease (CVD). These findings could further refine intervention strategies for targeted prevention of CVD, particularly in settings where physiological measurements may be unavailable.

Association Of Eosinophil And Total Ige Values With Allergy Test Results In Patients With Atopic Dermatitis

AOBJECTIVES: Atopic dermatitis (AD) is a chronic, recurrent, allergic inflammatory skin disease that may have a genetic predisposition. Eosinophilia is a common finding in patients with atopy. In our study, we aimed to investigate the relationship between eosinophil and IgE levels and allergy test results in patients with atopic dermatitis. METHODS: In this descriptive study, the files of patients diagnosed with atopic dermatitis and followed up in our Pediatric Allergy and Immunology Clinic between January 2021 and December 2022 were retrospectively reviewed. Age, gender, eosinophil, total IgE and specific IgE (for food and inhaled allergens) values were analyzed in the study. Skin prick test (SPT) was also performed in patients who had negative results for allergen-specific IgE. RESULTS: The absolute eosinophil count, eosinophil (%) and total IgE values of patients sensitized to at least one of the food and aeroallergens were significantly higher than those without allergen sensitization. The cut-off point of total IgE in predicting allergen sensitization was found to be 91.5 by ROC analysis. The sensitivity and specificity values for the cut-off point of total IgE were 73.3% and 72.9%. CONCLUSION: In this study, allergen sensitization was detected in 3 out of every 4 AD patients with total IgE and eosinophil values above the cut-off point we analyzed. Accordingly, we think that total IgE and eosinophil values are successful in predicting allergen sensitization. In clinics where specific IgE or SPT cannot be performed, eosinophil and total IgE values in whole blood will be useful for preliminary diagnosis.

Modeling of Some Egg Characteristics in Henna Partridges

In this study, the distributions of egg count (daily and cumulative), width, length and weight values of chukar partridges obtained in two different egg production seasons were statistically modeled. For this purpose, in modeling cumulative egg production curves; Logistic, Gompertz, Gamma, Schunute, Brody, Richard, Negative Exponential, von Bertalanffy, Cubic Piecewise and Cubic models were used, and in evaluating daily egg production curves; Gompertz, Logistic, Richard, McNally, Gamma, Cubic Piecewise, Quadratic, Quadratic Piecewise and Modified Compartmental models were used. In modeling egg width values; Gompertz, Gamma, Cubic Piecewise and Cubic models were used, in modeling length values; Logistic, Gamma, Cubic Piecewise and Cubic models were used, and in modeling weight values; McNally, Gamma, Cubic Piecewise and Cubic models were used. In all modeling studies, as comparison and evaluation criteria; Error Mean Square, Corrected Coefficient of Determination, Accuracy Factor, Deviation Factor, Durbin-Watson, Akaike Information Criterion, Corrected Akaike Information Criterion and Bayesian Information Criterion were taken into consideration. As a result of the study; Gamma was determined as the most suitable model for modeling cumulative egg yields and length values, McNally for modeling daily egg yields and weight values, and Gompertz and Gamma models for modeling egg width values.

The Influence of Working Capital On The Profitability Ratio of Consumer Goods Industry Sector Companies Listed On The IDX

This research aims to determine and analyze the influence of working capital on the profitability ratio of companies in the consumer goods industry listed on the IDX. The type of data in this research is secondary data, namely data obtained indirectly and through intermediaries in the form of company annual report data. The type of research used in this research is quantitative with an explanatory approach. Based on the results of data research using statistical calculations through the SPSS application. The results of the research show that cash turnover and accounts receivable turnover have a positive and significant effect on profitability as evidenced by the Cash Turnover regression coefficient value (X1) of 0.068 and the calculated t value of 7.156 &gt; 1 table 2.055 with a significant value of 0.000 &lt; 0.05 and the coefficient value Receivables Turnover regression (X2) is 0.199 with a 1 count value of 7.1411 table 2.055 with a significant value of 0.000 0.05. Meanwhile, Inventory Turnover (X3) has a negative and significant effect on profitability as evidenced by the regression coefficient value of -0.970 and the 1 count value of -16,135 &gt; 1 table 2.055 with a significant value of 0.000 &lt;0.05