Patient Age Values Research Articles

116P Is young age an independent adverse prognostic factor in carcinoma breast? A single institute retrospective comparative study from South India

The incidence of breast cancer is as low as 0.50% in females younger than 40 years old. Young age in patients with breast cancers is thought to be associated with poor prognosis, but the reason is not well defined. Adverse pathological features like more TNBC and Her2 positivity as well as a lack of reliable screening methods in young women leads to the poor prognosis in this group of patients. This study aimed to analyse the prognostic value of age in patients with carcinoma breast.

The prognostic value of age for 1030 patients with early stage breast cancer after postoperative radiotherapy

Objective To analyze the prognostic value of age in patients with early stage breast cancer. Methods The clinical characteristics of 1030 patients with early stage breast cancer (the number of positive axillary lymph nodes was less than 3) were retrospectively reviewed. Of all the patients, 468(stage Ⅰ, n = 227; and stage Ⅱ , n = 241) received breast conserving surgery (BCS) and 562 (stage Ⅰ, n =184; and stage Ⅱ, n= 378) received modified mastectomy. Patients were divided into young-age group (≤35,136 patients), middle-age group (> 35-≤60,738 patients) and old-age group (> 60,156 patients).The number of patients without postoperative radiation therapy after BCS is 16, 60 and 39 in the three groups, respectively. Two-dimensional conventional fractionated radiotherapy was administered. The prognostic value of the tumor size, status of axillary lymph nodes or hormonal receptors, postoperative radiation therapy were analyzed. Results The follow-up rate was 97.86%. Of 795 patients followed up more than 5 years, 110,569 and 116 patients were devided into the three groups, respectively. There were 40, 202 and 87 patients without radiation therapy in the three groups. The 5-year recurrence rates of the three groups were 6. 2%, 8. 7% and 10. 4% (χ2 = 1.14, P= 0.567). The 5-year distant metastasis rates were4.3% , 9.5 % and2. 5% (χ2 = 5.31 , P = 0. 070) . The5 - year survival rates were9l. 2% , 92. 6%and 82. 1% (χ2 = 6. 83, P = 0.033). The young-age group had more tumors smaller than 2. 0 cm (65.4%), less positive axillary lymph nodes (13.2%), poorer differential tumor and less positive hormone acceptors (48.0%). Of patients with tumor larger than 2. 0 cm who had no radiotherapy after BCS, the 5-year survival rates were 94%, 87% and 71% (χ2= 20.69, P= 0.000) in the three groups. The corresponding recurrence rates were 23%, 18% ,7%, (χ2 = 9. 97, P = 0. 007), and distant metastasis rates were23%, 25% and 10% (χ2 =8.51, P=0. 014). Conclusions The age is an important prognostic factor in patients with early stage breast cancer undergoing BCS, but not in those undergoing modified mastectomy. Key words: Breast neoplasms/surgery; Surgery, breast conserving; Surgery, mastectomy; Breast neoplasms/radiotherapy; Prognostic analysis

EFFECT OF AGE ON PROGNOSIS IN PATIENTS WITH GASTRIC CANCER

The incidence of gastric cancer among the elderly has recently been increasing; however, the prognostic value of age in patients with gastric cancer remains elusive. A total of 1473 patients with gastric cancer, who had undergone curative gastrectomy were reviewed to investigate the prognostic significance of age. Blood vessel invasion and differentiated type were more frequently observed in elderly than nonelderly patients (P < 0.0001) and elderly patients underwent limited lymph node dissection compared with nonelderly patients (P < 0.001). Moreover, chemotherapy was carried out in nonelderly patients more frequently than in elderly patients (P < 0.005). Ten-year survival rates were 70.2 and 81.4% in elderly and nonelderly patients, respectively, and the differences were statistically significant (P < 0.001). Postoperative mortality rates were 3.2 and 2.0% in elderly and nonelderly patients, respectively. Hematogenous recurrence was more frequently observed in elderly patients than nonelderly patients (P < 0.05). Multivariate analysis showed that age was an independent prognostic factor. Age clinically serves as a simple predictor of survival in patients with gastric cancer and should be taken into account along with conventional clinicopathological variables such as depth of invasion and lymph node metastasis.

Influence of Age on the Prognosis of Patients with Renal Cell Carcinoma (RCC)

Objective: Aim of this study was to analyze the prognostic value of age in patients with renal cell carcinoma (RCC). Patients and Methods: A group of 15 patients (age ≤ 40 years, group I) and a group of 103 patients (age ≧ 50 years, group II) with sporadic RCC who underwent radical nephrectomy between 1985 and 1997 were compared. The two groups were analyzed with respect to histologic cell type, tumor grade, stage and outcome. Results: In group I low-stage tumors (stage I and II) were diagnosed in 93% of patients and in group II in 65% of the patients (p = 0.017). High-grade tumors (stage III and IV) were diagnosed in 7% and 35% of patients in group I and group II, respectively (p < 0.01). In group I only one patient (7%) with stage II disease died of cancer. In group II the distribution of cancer-specific mortality was as follows: 6 patients (100%) with stage IV, 13 patients (42%) with stage III, and 12 patients (17%) with stage I and II died of disease. The 5-year-survival in group I was 93% and in group II was 77% (p = 0.05). Conclusion: According to our data we conclude that RCC is diagnosed at a lower stage in young patients than in the older patient group. RCC may exhibit a more favorable prognosis in young patients, possible due to the lower stage at time of diagnosis.